MXPA05010385A - Metodo y estuche para detectar el inicio temprano de lesion celular tubular renal. - Google Patents

Metodo y estuche para detectar el inicio temprano de lesion celular tubular renal.

Info

Publication number
MXPA05010385A
MXPA05010385A MXPA05010385A MXPA05010385A MXPA05010385A MX PA05010385 A MXPA05010385 A MX PA05010385A MX PA05010385 A MXPA05010385 A MX PA05010385A MX PA05010385 A MXPA05010385 A MX PA05010385A MX PA05010385 A MXPA05010385 A MX PA05010385A
Authority
MX
Mexico
Prior art keywords
ngal
cell injury
renal
kit
detecting
Prior art date
Application number
MXPA05010385A
Other languages
English (en)
Inventor
Prased Devarajan
Original Assignee
Childrens Hosp Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33135089&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA05010385(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Childrens Hosp Medical Center filed Critical Childrens Hosp Medical Center
Publication of MXPA05010385A publication Critical patent/MXPA05010385A/es

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Abstract

Un metodo y estuche para detectar el inicio temprano de la lesion celular tubular renal, haciendo uso de NGAL, como un biomarcador urinario temprano. El NGAL es un polipeptido secretado pequeno que es resistente a la proteasa y por consecuencia detectado facilmente en la orina que fluye de la lesion celular del tubulo renal. La expresion de la proteina NGAL es detectada predominantemente en las celulas del tubulo proximal, en una distribucion citoplasmica punteada evocadora de una proteina secretada. La apariencia del NGAL en la orina se relaciona con la dosis y duracion de la isquemia y nefrotoxemia renal, y es diagnostico de la lesion celular tubular renal y falla renal. La deteccion de NGAL es tambien un marcador util para monitorear los efectos laterales nefrotoxicos de los farmacos u otros agentes terapeuticos.
MXPA05010385A 2003-03-27 2004-03-26 Metodo y estuche para detectar el inicio temprano de lesion celular tubular renal. MXPA05010385A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45814303P 2003-03-27 2003-03-27
US48159603P 2003-11-04 2003-11-04
PCT/US2004/009191 WO2004088276A2 (en) 2003-03-27 2004-03-26 A method and kit for detecting the early onset of renal tubular cell injury

Publications (1)

Publication Number Publication Date
MXPA05010385A true MXPA05010385A (es) 2006-03-08

Family

ID=33135089

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05010385A MXPA05010385A (es) 2003-03-27 2004-03-26 Metodo y estuche para detectar el inicio temprano de lesion celular tubular renal.

Country Status (14)

Country Link
US (11) US20040219603A1 (es)
EP (3) EP2360475B1 (es)
JP (2) JP5392980B2 (es)
CN (1) CN102183656B (es)
AT (1) ATE437371T1 (es)
AU (1) AU2004225472B2 (es)
BR (1) BRPI0408802B8 (es)
CA (1) CA2520658A1 (es)
DE (1) DE602004022150D1 (es)
DK (2) DK2360475T3 (es)
ES (3) ES2330005T5 (es)
MX (1) MXPA05010385A (es)
NZ (1) NZ543028A (es)
WO (1) WO2004088276A2 (es)

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ES2703434T3 (es) * 2004-12-20 2019-03-08 Antibodyshop As Determinación de lipocalina asociada a gelatinasa de neutrófilos (NGAL) como marcador diagnóstico para trastornos renales
US7977110B2 (en) * 2008-06-02 2011-07-12 Children's Hospital Medical Center Method for distinguishing between kidney dysfunctions

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ATE437371T1 (de) 2009-08-15
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ES2330005T3 (es) 2009-12-03
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