WO2005121366A8 - 遺伝子マーカー及びその利用 - Google Patents

遺伝子マーカー及びその利用

Info

Publication number
WO2005121366A8
WO2005121366A8 PCT/JP2005/009871 JP2005009871W WO2005121366A8 WO 2005121366 A8 WO2005121366 A8 WO 2005121366A8 JP 2005009871 W JP2005009871 W JP 2005009871W WO 2005121366 A8 WO2005121366 A8 WO 2005121366A8
Authority
WO
WIPO (PCT)
Prior art keywords
immunosuppressant
gene marker
rejection reaction
absence
drug effect
Prior art date
Application number
PCT/JP2005/009871
Other languages
English (en)
French (fr)
Other versions
WO2005121366A1 (ja
Inventor
Yusuke Tanigawara
Osamu Iketani
Kiyoshi Mihara
Original Assignee
Univ Keio
Yusuke Tanigawara
Osamu Iketani
Kiyoshi Mihara
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Keio, Yusuke Tanigawara, Osamu Iketani, Kiyoshi Mihara filed Critical Univ Keio
Priority to US11/628,206 priority Critical patent/US20090053695A1/en
Priority to EP05743891A priority patent/EP1767652A4/en
Publication of WO2005121366A1 publication Critical patent/WO2005121366A1/ja
Publication of WO2005121366A8 publication Critical patent/WO2005121366A8/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82—Translation products from oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466—Cysteine endopeptidases (3.4.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

【課題】拒絶反応の診断、免疫抑制剤の薬効の評価、及び免疫寛容の有無の判定を行うことができる遺伝子マーカー、並びに、遺伝子マーカーを指標として迅速かつ簡便に行うことができる、拒絶反応の診断方法、免疫抑制剤の薬効を評価する方法、免疫抑制剤の同定方法、免疫抑制剤の選択方法、免疫抑制剤の用量決定方法、免疫寛容の有無を判定する方法、及びキットを提供すること。 【解決手段】拒絶反応により発現量が１．５倍以上上昇し、免疫抑制剤により発現量が１．５倍以上抑制された免疫関連遺伝子を遺伝子マーカーとして同定した。その遺伝子マーカーの発現量を指標とすることにより、拒絶反応の診断、免疫抑制剤の薬効の評価、及び免疫寛容の有無の判定を迅速かつ簡便に行うことが可能になる。
PCT/JP2005/009871 2004-06-02 2005-05-30 遺伝子マーカー及びその利用 WO2005121366A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/628,206 US20090053695A1 (en) 2004-06-02 2005-05-30 Gene Marker and Use Thereof
EP05743891A EP1767652A4 (en) 2004-06-02 2005-05-30 GENMARKER AND ITS USE

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2004-165013 2004-06-02
JP2004165013 2004-06-02
JP2005-006727 2005-01-13
JP2005006727A JP2006014722A (ja) 2004-06-02 2005-01-13 遺伝子マーカー及びその利用

Publications (2)

Publication Number Publication Date
WO2005121366A1 WO2005121366A1 (ja) 2005-12-22
WO2005121366A8 true WO2005121366A8 (ja) 2006-02-16

Family

ID=35503073

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/009871 WO2005121366A1 (ja) 2004-06-02 2005-05-30 遺伝子マーカー及びその利用

Country Status (4)

Country Link
US (1) US20090053695A1 (ja)
EP (2) EP2302077A1 (ja)
JP (1) JP2006014722A (ja)
WO (1) WO2005121366A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101357038B1 (ko) * 2004-12-08 2014-02-03 아벤티스 파마슈티칼스 인크. 도세탁셀에 대한 내성 또는 감수성을 측정하는 방법
FR2891641B1 (fr) * 2005-10-04 2007-12-21 Lvmh Rech Procede et appareil de caracterisation des imperfections de la peau et procede d'appreciation de l'effet anti-vieillissement d'un produit cosmetique.
CA2767616A1 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
CN103751783B (zh) * 2014-01-23 2015-10-21 武汉大学 Irf1在主动脉弓缩窄疾病中的功能及其抑制剂的应用
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US10330364B2 (en) 2014-06-26 2019-06-25 Hudson Technologies, Inc. System and method for retrofitting a refrigeration system from HCFC to HFC refrigerant
DE102020205364B4 (de) * 2020-04-28 2022-01-20 Universität Rostock Verfahren zur Überwachung des Verlaufs einer Kardiomyozyten-Transplantation und Methode zur Bestimmung, ob ein Proband für einer Kardiomyozyten-Transplantation geeignet ist

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
GB9204466D0 (en) 1992-03-02 1992-04-15 Sandoz Ltd Improvements in or relating to organic compounds
US6187534B1 (en) * 1997-09-24 2001-02-13 Cornell Research Foundation, Inc. Methods of evaluating transplant rejection
US20030104371A1 (en) * 1997-09-24 2003-06-05 Strom Terry B. Methods of evaluating transplant rejection
US7705120B2 (en) * 2001-06-21 2010-04-27 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
ES2380929T3 (es) * 2002-08-22 2012-05-21 Novartis Ag Diagnóstico de rechazo crónico

Also Published As

Publication number Publication date
EP1767652A4 (en) 2008-04-16
EP1767652A1 (en) 2007-03-28
EP2302077A1 (en) 2011-03-30
JP2006014722A (ja) 2006-01-19
US20090053695A1 (en) 2009-02-26
WO2005121366A1 (ja) 2005-12-22

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