JP2006521111A5 - - Google Patents
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- JP2006521111A5 JP2006521111A5 JP2006507160A JP2006507160A JP2006521111A5 JP 2006521111 A5 JP2006521111 A5 JP 2006521111A5 JP 2006507160 A JP2006507160 A JP 2006507160A JP 2006507160 A JP2006507160 A JP 2006507160A JP 2006521111 A5 JP2006521111 A5 JP 2006521111A5
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- JP
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- Prior art keywords
- ephb4
- shows
- ephrin
- seq
- human
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Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45430003P | 2003-03-12 | 2003-03-12 | |
| US45443203P | 2003-03-12 | 2003-03-12 | |
| PCT/US2004/007755 WO2004080425A2 (en) | 2003-03-12 | 2004-03-12 | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011157200A Division JP2011256179A (ja) | 2003-03-12 | 2011-07-15 | 血管形成及び腫瘍増殖阻害用ポリペプチド化合物及びその応用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006521111A JP2006521111A (ja) | 2006-09-21 |
| JP2006521111A5 true JP2006521111A5 (https=) | 2007-05-24 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507160A Pending JP2006521111A (ja) | 2003-03-12 | 2004-03-12 | 血管形成及び腫瘍増殖阻害用ポリペプチド化合物及びその応用 |
| JP2006507095A Expired - Fee Related JP4762889B2 (ja) | 2003-03-12 | 2004-03-12 | 血管形成及び腫瘍成長を阻止するための核酸化合物 |
| JP2011157200A Pending JP2011256179A (ja) | 2003-03-12 | 2011-07-15 | 血管形成及び腫瘍増殖阻害用ポリペプチド化合物及びその応用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507095A Expired - Fee Related JP4762889B2 (ja) | 2003-03-12 | 2004-03-12 | 血管形成及び腫瘍成長を阻止するための核酸化合物 |
| JP2011157200A Pending JP2011256179A (ja) | 2003-03-12 | 2011-07-15 | 血管形成及び腫瘍増殖阻害用ポリペプチド化合物及びその応用 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US7585967B2 (https=) |
| EP (2) | EP1606305A4 (https=) |
| JP (3) | JP2006521111A (https=) |
| AU (3) | AU2004220525B2 (https=) |
| CA (2) | CA2518912A1 (https=) |
| WO (2) | WO2004080425A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887674B1 (en) * | 1998-04-13 | 2005-05-03 | California Institute Of Technology | Artery- and vein-specific proteins and uses therefor |
| AU2002951409A0 (en) * | 2002-09-16 | 2002-09-26 | North Western Adelaide Health Services | Methods for regulating cancer |
| WO2004028551A1 (en) | 2002-09-24 | 2004-04-08 | The Burnham Institute | Novel agents that modulate eph receptor activity |
| US7381410B2 (en) | 2003-03-12 | 2008-06-03 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| CA2518912A1 (en) | 2003-03-12 | 2004-09-23 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| KR20120123619A (ko) | 2004-03-12 | 2012-11-08 | 바스진 테라퓨틱스, 인크. | 혈관형성 및 종양 성장을 억제하기 위한 폴리펩티드 화합물 |
| AU2005224081B2 (en) * | 2004-03-12 | 2011-06-30 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| JP2007320850A (ja) * | 2004-08-24 | 2007-12-13 | Kyowa Hakko Kogyo Co Ltd | 抗エフリンｂ２抗体 |
| EP1799867A2 (en) * | 2004-09-23 | 2007-06-27 | Vasgene Therapeutics, Inc. | Compositions and methods for detecting and treating tumors |
| WO2006034455A2 (en) | 2004-09-23 | 2006-03-30 | Vasgene Therapeutics, Inc. | Polipeptide compounds for inhibiting angiogenesis and tumor growth |
| DE102004054016A1 (de) * | 2004-11-09 | 2006-05-11 | Robert Bosch Gmbh | Steuergerät zum Steuern und/oder regeln mindestens einer Fahrzeugfunktion |
| WO2006055727A2 (en) * | 2004-11-18 | 2006-05-26 | The Board Of Trustees Of The University Of Illinois | MULTICISTRONIC siRNA CONSTRUCTS TO INHIBIT TUMORS |
| EP1833996B1 (en) * | 2005-01-06 | 2012-12-05 | Genentech, Inc. | Cancer prognostic methods |
| WO2006081418A2 (en) * | 2005-01-27 | 2006-08-03 | The Burnham Institute | Ephb receptor-binding peptides |
| FR2889200B1 (fr) | 2005-07-27 | 2008-01-04 | Inst Vaisseaux Et Du Sang Ass | Systeme marqueur cellulaire/ligand, ou le marqueur est du type eph, materiau cellulaire comprenant ce systeme, procede de preparation et utilisation proangiogenique |
| WO2007038395A2 (en) * | 2005-09-23 | 2007-04-05 | Vasgene Therapeutics, Inc. | Use of ephrinb2 directed agents for the treatment or prevention of viral infections |
| AR059096A1 (es) | 2006-01-20 | 2008-03-12 | Genentech Inc | Anticuerpos anti- efrina -b2 y metodos que usan estos |
| EP3342415B1 (en) | 2006-08-08 | 2022-01-26 | Rheinische Friedrich-Wilhelms-Universität Bonn | Structure and use of 5' phosphate oligonucleotides |
| WO2009006336A1 (en) * | 2007-06-28 | 2009-01-08 | Sylgen Laboratories, Inc. | Compositions and methods for inhibiting angiogenesis and tumorigenesis |
| AU2008287427B2 (en) | 2007-08-13 | 2014-10-09 | Vasgene Therapeutics, Inc. | Cancer treatment using humanized antibodies that bind to EphB4 |
| EP2109690B9 (en) * | 2007-11-29 | 2012-10-24 | MOLECULAR HEALTH GmbH | Eph-b4 specific sirna for reducing epo-induced tumor cell growth during anemia treatment in cancer patients, tissue protective erythropoietin receptor (nepor) and methods of use. |
| US8357501B2 (en) | 2007-11-29 | 2013-01-22 | Molecular Health Gmbh | Tissue protective erythropoietin receptor (NEPOR) and methods of use |
| EP2297323A1 (en) | 2008-05-21 | 2011-03-23 | Hartmann, Gunther | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| WO2012112434A1 (en) * | 2011-02-14 | 2012-08-23 | Allergan, Inc. | Inhibiting aberrant blood vessel formation using retargeted endopeptidases |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| JP2015071566A (ja) * | 2013-10-03 | 2015-04-16 | 住友ベークライト株式会社 | Ｆｇｆ４遺伝子増幅腫瘍の医薬組成物 |
| DK3556855T3 (da) * | 2016-12-14 | 2026-02-23 | Univ Shinshu | Kimærisk antigenreceptor genmodificeret lymfocyt der har cytocidal effekt |
| US20200224239A1 (en) * | 2019-01-10 | 2020-07-16 | Massachusetts Institute Of Technology | Functional analysis of cancer cells |
| WO2020154111A2 (en) | 2019-01-23 | 2020-07-30 | Massachusetts Institute Of Technology | Rapid analysis of live cells |
| CA3181420A1 (en) * | 2020-05-28 | 2021-12-02 | Cytobay Inc. | Cytopathological staining |
| EP4105328A1 (en) * | 2021-06-15 | 2022-12-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Antisense-oligonucleotides for prevention of kidney dysfunction promoted by endothelial dysfunction by ephrin-b2 suppression |
| CN119384291A (zh) * | 2022-05-18 | 2025-01-28 | 国立研究开发法人国立癌症研究中心 | 利用通用癌抗原鸡尾酒的癌症疫苗、tcr/car-t细胞治疗药、伴随诊断方法和基于血中循环癌细胞检测的癌症发病风险诊断方法 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JPH04218000A (ja) | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
| EP0590030B1 (en) | 1991-06-21 | 2004-09-29 | The Walter and Eliza Hall Institute of Medical Research | A receptor-type tyrosine kinase [human eph/elk-like kinase - hek] and use thereof |
| US6331302B1 (en) | 1992-01-22 | 2001-12-18 | Genentech, Inc. | Protein tyrosine kinase agonist antibodies |
| CA2128722A1 (en) | 1992-01-22 | 1993-08-05 | William I. Wood | Novel protein tyrosine kinases |
| US5635177A (en) | 1992-01-22 | 1997-06-03 | Genentech, Inc. | Protein tyrosine kinase agonist antibodies |
| WO2002081494A1 (en) * | 2001-03-26 | 2002-10-17 | Sirna Therapeutics, Inc. | Oligonucleotide mediated inhibition of hepatitis b virus and hepatitis c virus replication |
| BR9207175A (pt) | 1992-10-28 | 1995-12-12 | Genentech Inc | Composição contendo antagonista de fator de crescimento de célula endotelial vascular sequência aminoácida de anticorpo monoclonal polipeptídeo e método de tratamento de tumor em mamífero |
| CA2149333C (en) | 1992-11-13 | 2002-01-22 | Timothy D. Bartley | Eck receptor ligands |
| US5824303A (en) | 1992-11-13 | 1998-10-20 | Amgen Inc. | Eck receptor ligands |
| US5512591A (en) | 1993-02-18 | 1996-04-30 | President And Fellows Of Harvard College | Treatments for diseases characterized by neovascularization |
| ES2152753B1 (es) | 1993-03-29 | 2001-09-01 | Ct Investig Energeticas Ciemat | Animales transgenicos para la determinacion de agentes que estimulan o reprimen la hiperproliferacion epidermica y el crecimiento del pelo |
| US5801154A (en) * | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| US6303769B1 (en) | 1994-07-08 | 2001-10-16 | Immunex Corporation | Lerk-5 dna |
| US5624899A (en) | 1994-07-20 | 1997-04-29 | Genentech Inc. | Method for using Htk ligand |
| WO1996003043A1 (en) | 1994-07-26 | 1996-02-08 | Rutgers, The State University Of New Jersey | Human brain specific kinase |
| US5795734A (en) | 1994-09-19 | 1998-08-18 | President And Fellows Of Harvard College | EPH receptor ligands, and uses related thereto |
| WO1996013518A1 (en) | 1994-10-27 | 1996-05-09 | Genentech, Inc. | Al-1 neurotrophic factor, a ligand for an eph-related tyrosine kinase receptor |
| US6057124A (en) | 1995-01-27 | 2000-05-02 | Amgen Inc. | Nucleic acids encoding ligands for HEK4 receptors |
| WO1996026958A2 (en) | 1995-02-27 | 1996-09-06 | President And Fellows Of Harvard College | Eph RECEPTOR LIGAND ELF-2 |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| DE69628652T3 (de) | 1995-09-08 | 2012-05-03 | Genentech, Inc. | Vegf-verwandtes protein |
| US6346398B1 (en) * | 1995-10-26 | 2002-02-12 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor |
| US5837534A (en) | 1995-11-14 | 1998-11-17 | The Board Of Regents Of The University Of Texas System | Smooth muscle 22α promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells |
| AUPN727795A0 (en) | 1995-12-22 | 1996-01-18 | Walter And Eliza Hall Institute Of Medical Research, The | A novel receptor-type tyrosine kinase and use thereof |
| US6696557B1 (en) * | 1996-04-19 | 2004-02-24 | Genentech, Inc. | AL-2 neurotrophic factor nucleic acid |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| CA2259157A1 (en) | 1996-07-05 | 1998-01-15 | Mount Sinai Hospital Corporation | Oligomerized receptors which affect pathways regulated by transmembrane ligands for elk-related receptor tyrosine kinases |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| JP3957765B2 (ja) | 1997-04-07 | 2007-08-15 | ジェネンテク・インコーポレイテッド | 抗ｖｅｇｆ抗体 |
| AU6887698A (en) | 1997-04-08 | 1998-10-30 | Sugen, Inc. | Study and treatment of diseases related to specific cellular functions of receptor protein tyrosine kinases |
| US6440954B1 (en) | 1997-04-18 | 2002-08-27 | President And Fellows Of Harvard College | Inhibition of vascular smooth muscle cell proliferation |
| US6555321B1 (en) * | 1997-08-19 | 2003-04-29 | Vanderbilt University | Methods for determining cell responses through EphB receptors |
| AU9594598A (en) | 1997-10-02 | 1999-04-27 | Millennium Pharmaceuticals, Inc. | Modulation of lerk-2-mediated cell adhesion |
| JP2002505338A (ja) | 1998-03-05 | 2002-02-19 | カイロン コーポレイション | 生物学的に活性な分子の血清半減期を増加するための方法 |
| US6887674B1 (en) | 1998-04-13 | 2005-05-03 | California Institute Of Technology | Artery- and vein-specific proteins and uses therefor |
| US6864227B1 (en) | 1998-04-13 | 2005-03-08 | California Institute Of Technology | Artery-and vein-specific proteins and uses therefor |
| AU8788998A (en) | 1998-10-02 | 2000-04-06 | Universite Paris 7 | Vascular specific regulatory elements contained in the desmin 5' flanking region |
| AUPP674898A0 (en) | 1998-10-27 | 1998-11-19 | Walter And Eliza Hall Institute Of Medical Research, The | A method of treatment |
| DE69925024T2 (de) * | 1998-11-20 | 2006-03-02 | Genentech, Inc., South San Francisco | Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten |
| US6150162A (en) * | 1998-12-17 | 2000-11-21 | Isis Pharmaceuticals Inc. | Antisense modulation of CD44 expression |
| US6770633B1 (en) * | 1999-10-26 | 2004-08-03 | Immusol, Inc. | Ribozyme therapy for the treatment of proliferative skin and eye diseases |
| EP1246637A2 (en) * | 2000-01-06 | 2002-10-09 | The Hospital for Sick Children | Methods of modulation of the immune system |
| WO2002081628A2 (en) * | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| JP2004509604A (ja) * | 2000-03-28 | 2004-04-02 | アイシス・ファーマシューティカルス・インコーポレーテッド | ｍＲＮＡプロセッシングのアンチセンスモジュレーションによる、細胞行動の改変 |
| EP2206720A1 (en) * | 2000-04-12 | 2010-07-14 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CA2407086A1 (en) | 2000-04-21 | 2001-11-01 | Amgen, Inc. | Integrin/adhesion antagonists |
| US6271030B1 (en) * | 2000-06-14 | 2001-08-07 | Isis Pharmaceuticals, Inc. | Antisense inhibition of C/EBP beta expression |
| US6277640B1 (en) * | 2000-07-31 | 2001-08-21 | Isis Pharmaceuticals, Inc. | Antisense modulation of Her-3 expression |
| AU2001283108A1 (en) | 2000-08-03 | 2002-02-18 | The University Of Utah Research Foundation | Manipulation of arterial-venous identity |
| US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| AU2002212292A1 (en) | 2000-09-29 | 2002-04-08 | Novartis Ag | Extracellular polypeptides of eph b receptors and ephrin b ligands and the corresponding nucleic acid molecules |
| US7136808B2 (en) * | 2000-10-20 | 2006-11-14 | Microsoft Corporation | Detection and correction of errors in german grammatical case |
| IL156009A0 (en) | 2000-11-20 | 2003-12-23 | California Inst Of Techn | Artery smooth muscle and vein smooth muscle specific proteins and uses therefor |
| US20040259247A1 (en) * | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| AU2002243623A1 (en) | 2001-01-26 | 2002-08-06 | Regeneron Pharmaceuticals, Inc. | Methods of imaging and targeting vasculature |
| CA2437194A1 (en) | 2001-01-31 | 2002-08-08 | Mount Sinai Hospital | Methods for regulating the kinase domain of ephb2 |
| US20040110177A1 (en) | 2001-02-02 | 2004-06-10 | Axel Ullrich | Method for identifying functional nucleic acids |
| US6919313B2 (en) | 2001-03-30 | 2005-07-19 | President & Fellows Of Harvard College | Protein waving a PDZ and a RGS domain |
| CA2448320A1 (en) * | 2001-05-29 | 2002-12-05 | Sirna Therapeutics, Inc. | Ribozyme based treatment of female reproductive diseases |
| CA2633171C (en) | 2001-06-20 | 2012-11-20 | Genentech, Inc. | Antibodies against tumor-associated antigenic target (tat) polypeptides |
| AU2002329540A1 (en) | 2001-06-20 | 2003-01-02 | Morphosys Ag | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| CA2452578A1 (en) | 2001-07-03 | 2003-01-16 | The Hospital For Sick Children | Ephrin and eph receptor mediated immune modulation |
| JP3876656B2 (ja) * | 2001-07-13 | 2007-02-07 | 住友金属工業株式会社 | 管用ねじ継手 |
| AU2002353972A1 (en) * | 2001-11-02 | 2003-05-19 | Pfizer Products Inc. | Lung cancer therapeutics and diagnostics |
| US20060241027A1 (en) | 2002-02-07 | 2006-10-26 | Hans-Peter Hauser | Hiv inhibiting proteins |
| WO2004014292A2 (en) | 2002-05-10 | 2004-02-19 | Purdue Research Foundation | EphA2 AGONISTIC MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF |
| US20040028685A1 (en) | 2002-05-10 | 2004-02-12 | Kinch Michael S. | EphA2 monoclonal antibodies and methods of use thereof |
| US20040110150A1 (en) | 2002-12-10 | 2004-06-10 | Isis Pharmaceuticals Inc. | Modulation of Ephrin-B2 expression |
| AU2003254641A1 (en) | 2002-08-28 | 2004-03-19 | Maxygen Aps | Interferon beta-like molecules for treatment of cancer |
| AU2003260169B9 (en) * | 2002-09-16 | 2011-06-09 | The Queen Elizabeth Hospital Research Foundation Inc. | Methods for regulating cancer |
| AU2002951409A0 (en) | 2002-09-16 | 2002-09-26 | North Western Adelaide Health Services | Methods for regulating cancer |
| EP2305812A3 (en) * | 2002-11-14 | 2012-06-06 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| US7250289B2 (en) * | 2002-11-20 | 2007-07-31 | Affymetrix, Inc. | Methods of genetic analysis of mouse |
| CA2518912A1 (en) | 2003-03-12 | 2004-09-23 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| KR20050120663A (ko) | 2003-03-24 | 2005-12-22 | 세쿠오이아 파마큐티컬스 인코오퍼레이티드 | 장기간 작용하는 생물학적 활동 컨쥬게이트들 |
| US20050059592A1 (en) | 2003-04-11 | 2005-03-17 | Kiener Peter A. | EphA2 and hyperproliferative cell disorders |
| AU2004230539A1 (en) | 2003-04-11 | 2004-10-28 | Medimmune, Llc | EphA2, hypoproliferative cell disorders and epithelial and endothelial reconstitution |
| WO2005048917A2 (en) | 2003-06-06 | 2005-06-02 | Medimmune, Inc. | Use of epha4 and modulator or epha4 for diagnosis, treatment and prevention of cancer |
| EP1677735B1 (en) | 2003-10-17 | 2014-07-23 | Joslin Diabetes Center, Inc. | Methods and compositions for modulating adipocyte function |
| KR20060135671A (ko) | 2003-11-20 | 2006-12-29 | 메디뮨 인코포레이티드 | ＥｐｈＡ２ 작동성 모노클로날 항체 및 이의 사용 방법 |
| AU2005224081B2 (en) | 2004-03-12 | 2011-06-30 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| WO2006034455A2 (en) | 2004-09-23 | 2006-03-30 | Vasgene Therapeutics, Inc. | Polipeptide compounds for inhibiting angiogenesis and tumor growth |
-
2004
- 2004-03-12 CA CA002518912A patent/CA2518912A1/en not_active Abandoned
- 2004-03-12 WO PCT/US2004/007755 patent/WO2004080425A2/en not_active Ceased
- 2004-03-12 JP JP2006507160A patent/JP2006521111A/ja active Pending
- 2004-03-12 US US10/800,077 patent/US7585967B2/en not_active Expired - Fee Related
- 2004-03-12 AU AU2004220525A patent/AU2004220525B2/en not_active Ceased
- 2004-03-12 EP EP04720327A patent/EP1606305A4/en not_active Withdrawn
- 2004-03-12 AU AU2004220459A patent/AU2004220459B2/en not_active Ceased
- 2004-03-12 WO PCT/US2004/007491 patent/WO2004080418A2/en not_active Ceased
- 2004-03-12 CA CA002518898A patent/CA2518898A1/en not_active Abandoned
- 2004-03-12 US US10/800,350 patent/US7862816B2/en not_active Expired - Fee Related
- 2004-03-12 EP EP20040720444 patent/EP1605961A4/en not_active Withdrawn
- 2004-03-12 JP JP2006507095A patent/JP4762889B2/ja not_active Expired - Fee Related
-
2006
- 2006-10-06 US US11/544,855 patent/US8063183B2/en not_active Expired - Fee Related
-
2009
- 2009-09-01 US US12/552,185 patent/US20100093831A1/en not_active Abandoned
-
2010
- 2010-11-01 AU AU2010238577A patent/AU2010238577B2/en not_active Ceased
- 2010-11-23 US US12/952,593 patent/US20110129482A1/en not_active Abandoned
-
2011
- 2011-07-15 JP JP2011157200A patent/JP2011256179A/ja active Pending
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