JP2006520807A5 - - Google Patents
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- Publication number
- JP2006520807A5 JP2006520807A5 JP2006507637A JP2006507637A JP2006520807A5 JP 2006520807 A5 JP2006520807 A5 JP 2006520807A5 JP 2006507637 A JP2006507637 A JP 2006507637A JP 2006507637 A JP2006507637 A JP 2006507637A JP 2006520807 A5 JP2006520807 A5 JP 2006520807A5
- Authority
- JP
- Japan
- Prior art keywords
- iminomethylcamptothecin
- compound
- group
- formula
- aminophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- -1 ter-butyl Chemical group 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229940127093 camptothecin Drugs 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 239000002207 metabolite Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- ZYHQGITXIJDDKC-UHFFFAOYSA-N 2-[2-(2-aminophenyl)ethyl]aniline Chemical group NC1=CC=CC=C1CCC1=CC=CC=C1N ZYHQGITXIJDDKC-UHFFFAOYSA-N 0.000 claims 2
- AFHVIXVGKVAMKH-MHZLTWQESA-N 7-phenyliminomethylcamptothecin Chemical compound O=C([C@]1(O)CC)OCC(C(N2CC3=4)=O)=C1C=C2C3=NC1=CC=CC=C1C=4C=NC1=CC=CC=C1 AFHVIXVGKVAMKH-MHZLTWQESA-N 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 1
- 125000006304 2-iodophenyl group Chemical group [H]C1=C([H])C(I)=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229930194542 Keto Natural products 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000037841 lung tumor Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 0 CC[C@](C(C=C(C1=C)N2CC1=C(C)c1c(*)ccc(C)c1*)=C(CO1)C2=O)(C1=O)O Chemical compound CC[C@](C(C=C(C1=C)N2CC1=C(C)c1c(*)ccc(C)c1*)=C(CO1)C2=O)(C1=O)O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/388,587 US7105492B2 (en) | 1999-03-09 | 2003-03-17 | Camptothecin derivatives having antitumor activity |
| US10/388,587 | 2003-03-17 | ||
| PCT/IT2004/000118 WO2004083214A1 (en) | 2003-03-17 | 2004-03-10 | 7-imino derivatives of camptothecin having antitumor activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006520807A JP2006520807A (ja) | 2006-09-14 |
| JP2006520807A5 true JP2006520807A5 (https=) | 2007-05-10 |
| JP4791355B2 JP4791355B2 (ja) | 2011-10-12 |
Family
ID=33029646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507637A Expired - Fee Related JP4791355B2 (ja) | 2003-03-17 | 2004-03-10 | 抗腫瘍活性を有するカンプトテシンの７−イミノ誘導体 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7105492B2 (https=) |
| EP (1) | EP1603919B1 (https=) |
| JP (1) | JP4791355B2 (https=) |
| KR (1) | KR101174112B1 (https=) |
| CN (1) | CN100372855C (https=) |
| AR (1) | AR043620A1 (https=) |
| AT (1) | ATE417851T1 (https=) |
| AU (1) | AU2004222044B2 (https=) |
| BR (1) | BRPI0408380A (https=) |
| CA (1) | CA2517450C (https=) |
| CY (1) | CY1108890T1 (https=) |
| DE (1) | DE602004018468D1 (https=) |
| DK (1) | DK1603919T3 (https=) |
| ES (1) | ES2319293T3 (https=) |
| PL (1) | PL1603919T3 (https=) |
| PT (1) | PT1603919E (https=) |
| SI (1) | SI1603919T1 (https=) |
| TW (1) | TWI341840B (https=) |
| WO (1) | WO2004083214A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
| ITRM20030344A1 (it) * | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
| ITRM20040288A1 (it) * | 2004-06-11 | 2004-09-11 | Sigma Tau Ind Farmaceuti | Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero. |
| US8975248B2 (en) * | 2004-12-15 | 2015-03-10 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Combinations of therapeutic agents for treating cancer |
| US7291936B1 (en) * | 2006-05-03 | 2007-11-06 | Robson John H | Submersible electrical power generating plant |
| CN102731516B (zh) * | 2011-04-07 | 2014-07-02 | 宁波天衡药业股份有限公司 | 一类具有抗肿瘤活性的喜树碱衍生物 |
| WO2022140504A1 (en) * | 2020-12-23 | 2022-06-30 | Shanghai Ruotuo Biosciences Co., Ltd. | Antibody-drug conjugates, pharmaceutical compositions, and therapeutic applications |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
| JPS58154582A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造法 |
| DK0612248T3 (da) * | 1991-11-15 | 2003-12-08 | Smithkline Beecham Corp | Præparat, der indeholder cisplatin og topotecan som antitumormiddel |
| US5614529A (en) * | 1994-09-22 | 1997-03-25 | Research Triangle Institute | Inhibition of plasmodia parasites by camptothecin compounds |
| US5972955A (en) * | 1995-06-06 | 1999-10-26 | Dr. Reddy's Research Foundation | Water soluble C-ring analogues of 20(S)-camptothecin |
| IT1282673B1 (it) | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
| IL127800A (en) | 1996-08-19 | 2005-11-20 | Bionumerik Pharmaceuticals Inc | Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them |
| ATE216998T1 (de) | 1999-03-09 | 2002-05-15 | Sigma Tau Ind Farmaceuti | Camptothecin-derivate mit antitumor-wirkung |
| US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
-
2003
- 2003-03-17 US US10/388,587 patent/US7105492B2/en not_active Expired - Fee Related
-
2004
- 2004-03-04 TW TW093105744A patent/TWI341840B/zh not_active IP Right Cessation
- 2004-03-10 SI SI200431027T patent/SI1603919T1/sl unknown
- 2004-03-10 AT AT04719039T patent/ATE417851T1/de active
- 2004-03-10 WO PCT/IT2004/000118 patent/WO2004083214A1/en not_active Ceased
- 2004-03-10 PT PT04719039T patent/PT1603919E/pt unknown
- 2004-03-10 US US10/546,211 patent/US7351714B2/en not_active Expired - Fee Related
- 2004-03-10 AU AU2004222044A patent/AU2004222044B2/en not_active Ceased
- 2004-03-10 BR BRPI0408380-6A patent/BRPI0408380A/pt not_active IP Right Cessation
- 2004-03-10 KR KR1020057015243A patent/KR101174112B1/ko not_active Expired - Fee Related
- 2004-03-10 JP JP2006507637A patent/JP4791355B2/ja not_active Expired - Fee Related
- 2004-03-10 CN CNB2004800071482A patent/CN100372855C/zh not_active Expired - Fee Related
- 2004-03-10 EP EP04719039A patent/EP1603919B1/en not_active Expired - Lifetime
- 2004-03-10 DE DE602004018468T patent/DE602004018468D1/de not_active Expired - Lifetime
- 2004-03-10 PL PL04719039T patent/PL1603919T3/pl unknown
- 2004-03-10 CA CA2517450A patent/CA2517450C/en not_active Expired - Fee Related
- 2004-03-10 DK DK04719039T patent/DK1603919T3/da active
- 2004-03-10 ES ES04719039T patent/ES2319293T3/es not_active Expired - Lifetime
- 2004-03-16 AR ARP040100864A patent/AR043620A1/es not_active Application Discontinuation
-
2009
- 2009-03-17 CY CY20091100298T patent/CY1108890T1/el unknown
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