JP2006519824A - アデノシン受容体アゴニストの治療上の使用 - Google Patents

アデノシン受容体アゴニストの治療上の使用 Download PDF

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JP2006519824A
JP2006519824A JP2006505924A JP2006505924A JP2006519824A JP 2006519824 A JP2006519824 A JP 2006519824A JP 2006505924 A JP2006505924 A JP 2006505924A JP 2006505924 A JP2006505924 A JP 2006505924A JP 2006519824 A JP2006519824 A JP 2006519824A
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compound
administered
disease
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JP2006519824A5 (cg-RX-API-DMAC10.html
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ピーター・リチャードソン
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Cambridge Biotechnology Ltd
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Cambridge Biotechnology Ltd
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
JP2006505924A 2003-03-07 2004-03-05 アデノシン受容体アゴニストの治療上の使用 Ceased JP2006519824A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0305150.5A GB0305150D0 (en) 2003-03-07 2003-03-07 Use of therapeutic compounds
PCT/GB2004/000952 WO2004078184A1 (en) 2003-03-07 2004-03-05 Use of adenosine receptor agonists in therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012001451A Division JP2012111764A (ja) 2003-03-07 2012-01-06 アデノシン受容体アゴニストの治療上の使用

Publications (2)

Publication Number Publication Date
JP2006519824A true JP2006519824A (ja) 2006-08-31
JP2006519824A5 JP2006519824A5 (cg-RX-API-DMAC10.html) 2007-05-10

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JP2006505924A Ceased JP2006519824A (ja) 2003-03-07 2004-03-05 アデノシン受容体アゴニストの治療上の使用
JP2012001451A Pending JP2012111764A (ja) 2003-03-07 2012-01-06 アデノシン受容体アゴニストの治療上の使用

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JP2012001451A Pending JP2012111764A (ja) 2003-03-07 2012-01-06 アデノシン受容体アゴニストの治療上の使用

Country Status (11)

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US (2) US7790698B2 (cg-RX-API-DMAC10.html)
EP (1) EP1603576A1 (cg-RX-API-DMAC10.html)
JP (2) JP2006519824A (cg-RX-API-DMAC10.html)
KR (1) KR20050115895A (cg-RX-API-DMAC10.html)
CN (2) CN1809365A (cg-RX-API-DMAC10.html)
AU (1) AU2004216891B2 (cg-RX-API-DMAC10.html)
CA (1) CA2514848A1 (cg-RX-API-DMAC10.html)
GB (1) GB0305150D0 (cg-RX-API-DMAC10.html)
NO (1) NO20054475L (cg-RX-API-DMAC10.html)
NZ (1) NZ541587A (cg-RX-API-DMAC10.html)
WO (1) WO2004078184A1 (cg-RX-API-DMAC10.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018193330A (ja) * 2017-05-17 2018-12-06 小林製薬株式会社 筋痙攣治療剤
WO2022050230A1 (ja) * 2020-09-03 2022-03-10 学校法人埼玉医科大学 アデノシン受容体の活性化を抑制する組成物

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0228723D0 (en) * 2002-12-09 2003-01-15 Cambridge Biotechnology Ltd Treatment of pain
GB0305150D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Use of therapeutic compounds
GB0305153D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Identification of therapeutic compounds
KR20070004792A (ko) * 2004-03-05 2007-01-09 캠브리지 바이오테크놀로지 리미티드 아데노신 수용체 작용제
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
BRPI0517639A (pt) * 2004-11-08 2008-10-14 Can Fite Biopharma Ltd método para o tratamento de ressorção óssea acelerada, composição farmacêutica, e, uso de um agonista de a3ar
AU2006204699B2 (en) * 2005-01-13 2012-04-26 Sirtris Pharmaceuticals, Inc. Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
JP5339916B2 (ja) * 2005-11-30 2013-11-13 キャン−ファイト・バイオファーマ・リミテッド 骨関節炎の治療におけるa3アデノシン受容体アゴニストの使用
NZ573308A (en) 2006-06-27 2012-02-24 Biovitrum Ab Publ Adenosine derivatives for the treatment of pain
CN101479268B (zh) 2006-06-27 2012-08-08 Cbt发展有限公司 2-0’-甲基腺苷衍生物及其用作制备腺苷受体的激动剂或拮抗剂的应用
US7906518B2 (en) 2006-06-27 2011-03-15 Cbt Development Limited Therapeutic compounds
EP2451456A1 (en) * 2009-07-09 2012-05-16 CBT Development Limited Combined preparation for use as a medicament
CN101947230B (zh) * 2010-08-25 2012-10-10 苗志敏 5’-amp用于治疗痛风性关节炎的用途
CN103342727A (zh) * 2013-07-01 2013-10-09 淮海工学院 一种2-甲氧基腺苷的合成方法
CN108329372B (zh) * 2017-01-20 2022-07-26 浙江省亚热带作物研究所 N6-(2-羟乙基)腺苷及其衍生物在制备治疗痛风药物中的应用
WO2020176544A1 (en) * 2019-02-25 2020-09-03 Saint Louis University Treatment of alzheimer's disease
CN113116900B (zh) * 2021-04-14 2022-07-08 兰州大学 一类核苷类似物在制备预防和/或治疗脑血管疾病药物中的应用
DE202025102658U1 (de) 2025-04-02 2026-08-13 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft mit beschränkter Haftung Darreichungsform, insbesondere für die muskuläre Balance

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877180A (en) * 1994-07-11 1999-03-02 University Of Virginia Patent Foundation Method for treating inflammatory diseases with A2a adenosine receptor agonists
JP2002500188A (ja) * 1998-01-08 2002-01-08 ザ・ユニバーシティ・オブ・バージニア・パテント・ファウンデーション A2aアデノシンレセプター作動因子

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792155A (fr) 1971-12-01 1973-05-30 Takeda Chemical Industries Ltd Nouveaux derives de l'adenosine et leur procede de production
JPS4861498A (cg-RX-API-DMAC10.html) 1971-12-01 1973-08-28
DE2359536C2 (de) 1972-12-08 1984-08-02 Takeda Chemical Industries, Ltd., Osaka 2,6-Diaminonebularinderivate
JPS5461195A (en) 1977-10-21 1979-05-17 Takeda Chem Ind Ltd N2-substituted phenyl-2,6-diaminonebularin
JPS5461194A (en) 1977-10-21 1979-05-17 Takeda Chem Ind Ltd Preparation of n22substituted 2*66diaminonebularin
US4705758A (en) 1984-06-19 1987-11-10 Warner-Lambert Company Adenosine receptor assay and kit
US5104859A (en) * 1985-09-24 1992-04-14 Solimedco Aktiebolag Continuous administration of adenosine to reduce pulmonary vascular resistance
US5231086A (en) * 1985-09-24 1993-07-27 Item Development Aktiebolag Continuous administration adenosine to increase myocardial blood flow
US6180616B1 (en) * 1990-05-10 2001-01-30 Atsuo F. Fukunaga Use of purine receptor agonists to alleviate or normalize physiopathologically excited sensory nerve function
US5679650A (en) * 1993-11-24 1997-10-21 Fukunaga; Atsuo F. Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine
US5677290A (en) * 1990-05-10 1997-10-14 Fukunaga; Atsuo F. Therapeutic use of adenosine compounds as surgical anesthetics
US6004945A (en) * 1990-05-10 1999-12-21 Fukunaga; Atsuo F. Use of adenosine compounds to relieve pain
US5683989A (en) * 1993-12-17 1997-11-04 Novo Nordisk A/S Treatment of ischemias by administration of 2,N6 -substituted adenosines
IT1275420B (it) 1995-06-02 1997-08-05 Schering Plough S P A Metodo per misurare l'affinita' di legame al recettore a2a dell'adenosina di componenti di interesse farmacologico mediante l'uso del ligando triziato (3h)-sch 58261
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
GB0305153D0 (en) 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Identification of therapeutic compounds
GB0305149D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Compounds for the treatment of pain
GB0305150D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Use of therapeutic compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877180A (en) * 1994-07-11 1999-03-02 University Of Virginia Patent Foundation Method for treating inflammatory diseases with A2a adenosine receptor agonists
JP2002500188A (ja) * 1998-01-08 2002-01-08 ザ・ユニバーシティ・オブ・バージニア・パテント・ファウンデーション A2aアデノシンレセプター作動因子

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN5006003902, RIEGER J M, JOURNAL OF MEDICINAL CHEMISTRY, 2001, V44, P531−539, US, AMERICAN CHEMICAL SOCIETY *
JPN6010060446, J. Med. Chem., 1991, 34, 1334−1339 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018193330A (ja) * 2017-05-17 2018-12-06 小林製薬株式会社 筋痙攣治療剤
JP7025129B2 (ja) 2017-05-17 2022-02-24 小林製薬株式会社 筋痙攣治療剤
WO2022050230A1 (ja) * 2020-09-03 2022-03-10 学校法人埼玉医科大学 アデノシン受容体の活性化を抑制する組成物

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CA2514848A1 (en) 2004-09-16
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US7790698B2 (en) 2010-09-07
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