JP2006519762A - アミロイドβペプチド及びその組成物に対する抗体を使用して、アルツハイマー病を治療する方法 - Google Patents

アミロイドβペプチド及びその組成物に対する抗体を使用して、アルツハイマー病を治療する方法 Download PDF

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JP2006519762A
JP2006519762A JP2005501148A JP2005501148A JP2006519762A JP 2006519762 A JP2006519762 A JP 2006519762A JP 2005501148 A JP2005501148 A JP 2005501148A JP 2005501148 A JP2005501148 A JP 2005501148A JP 2006519762 A JP2006519762 A JP 2006519762A
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antibody
peptide
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ローゼンタール，アーノン
レブコビッツ，ギル
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ライナット ニューロサイエンス コーポレイション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2005501148A 2002-10-09 2003-10-09 アミロイドβペプチド及びその組成物に対する抗体を使用して、アルツハイマー病を治療する方法 Withdrawn JP2006519762A (ja)

Applications Claiming Priority (5)

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US41723202P 2002-10-09 2002-10-09
US44761103P 2003-02-13 2003-02-13
US46475403P 2003-04-22 2003-04-22
US48035303P 2003-06-20 2003-06-20
PCT/US2003/032080 WO2004032868A2 (en) 2002-10-09 2003-10-09 Methods of treating alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof

Publications (2)

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JP2006519762A true JP2006519762A (ja) 2006-08-31
JP2006519762A5 JP2006519762A5 (https=) 2006-11-16

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US (3) US20040146512A1 (https=)
EP (1) EP1633786A4 (https=)
JP (1) JP2006519762A (https=)
KR (1) KR20050071564A (https=)
AU (1) AU2003279216A1 (https=)
BR (1) BR0315157A (https=)
CA (1) CA2501945A1 (https=)
MX (1) MXPA05003621A (https=)
NO (1) NO20052220L (https=)
PL (1) PL377769A1 (https=)
WO (1) WO2004032868A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
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WO2009104736A1 (ja) * 2008-02-22 2009-08-27 財団法人ヒューマンサイエンス振興財団 組織アミロイドプラーク親和性抗体及びそれを用いた医薬組成物
JP2011506387A (ja) * 2007-12-11 2011-03-03 グラクソ グループ リミテッド 抗原結合タンパク質
JP2021529543A (ja) * 2018-07-17 2021-11-04 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． 抗ａベータ抗体、その抗原結合フラグメントおよびそれらの用途

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