JP2006517995A5 - - Google Patents
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- Publication number
- JP2006517995A5 JP2006517995A5 JP2006502450A JP2006502450A JP2006517995A5 JP 2006517995 A5 JP2006517995 A5 JP 2006517995A5 JP 2006502450 A JP2006502450 A JP 2006502450A JP 2006502450 A JP2006502450 A JP 2006502450A JP 2006517995 A5 JP2006517995 A5 JP 2006517995A5
- Authority
- JP
- Japan
- Prior art keywords
- peg
- linker
- nucleophile
- conjugate
- activated ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012038 nucleophile Substances 0.000 claims 15
- 239000000562 conjugate Substances 0.000 claims 13
- 239000002202 Polyethylene glycol Substances 0.000 claims 12
- 229920001223 polyethylene glycol Polymers 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 150000002148 esters Chemical class 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 5
- OMAHFYGHUQSIEF-UHFFFAOYSA-N bis(2,5-dioxopyrrolidin-1-yl) oxalate Chemical compound O=C1CCC(=O)N1OC(=O)C(=O)ON1C(=O)CCC1=O OMAHFYGHUQSIEF-UHFFFAOYSA-N 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- PMKKIDFHWBBGDA-UHFFFAOYSA-N 2-(2,5-dioxopyrrol-1-yl)ethyl methanesulfonate Chemical compound CS(=O)(=O)OCCN1C(=O)C=CC1=O PMKKIDFHWBBGDA-UHFFFAOYSA-N 0.000 claims 1
- MNTLSHJBDKQYOF-UHFFFAOYSA-N 2-oxo-2-[[6-(trifluoromethyl)-2H-benzotriazol-4-yl]oxy]acetic acid Chemical compound C1=C(C=C(C2=NNN=C21)OC(=O)C(=O)O)C(F)(F)F MNTLSHJBDKQYOF-UHFFFAOYSA-N 0.000 claims 1
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-dimethylaminopyridine Substances CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000037824 growth disorder Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- 239000000863 peptide conjugate Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44835403P | 2003-02-19 | 2003-02-19 | |
| PCT/IB2004/000424 WO2004074345A2 (en) | 2003-02-19 | 2004-02-13 | Carbonate esters of polyethylene glycol activated by means of oxalate esters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006517995A JP2006517995A (ja) | 2006-08-03 |
| JP2006517995A5 true JP2006517995A5 (enExample) | 2007-03-01 |
Family
ID=32908577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006502450A Withdrawn JP2006517995A (ja) | 2003-02-19 | 2004-02-13 | 活性化されたポリエチレングリコールエステル類 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7094872B2 (enExample) |
| EP (1) | EP1597299A2 (enExample) |
| JP (1) | JP2006517995A (enExample) |
| AR (1) | AR043216A1 (enExample) |
| BR (1) | BRPI0407511A (enExample) |
| CA (1) | CA2515612A1 (enExample) |
| MX (1) | MXPA05008785A (enExample) |
| TW (1) | TW200426155A (enExample) |
| WO (1) | WO2004074345A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60041715D1 (de) | 1999-12-22 | 2009-04-16 | Nektar Therapeutics Al Corp | Verfahren zur herstellung von 1-benzotriazolcarbonatestern von wasserlöslichen polymeren |
| ES2291613T3 (es) * | 2002-01-16 | 2008-03-01 | Biocompatibles Uk Limited | Conjugados de polimeros. |
| GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
| ITPD20040159A1 (it) * | 2004-06-21 | 2004-09-21 | Univ Degli Studi Trieste | Derivati bifunzionali del polietilenglicole loro preparazione e uso. |
| US8133707B2 (en) * | 2006-01-17 | 2012-03-13 | Enzon Pharmaceuticals, Inc. | Methods of preparing activated polymers having alpha nitrogen groups |
| JP2007209543A (ja) * | 2006-02-09 | 2007-08-23 | Hidetoshi Tsuchida | 表面修飾アルブミンからなる固相膜および酸素吸着膜 |
| JP2009533347A (ja) | 2006-04-07 | 2009-09-17 | ネクター セラピューティックス エイエル，コーポレイション | 抗ＴＮＦα抗体の複合体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
| US5618697A (en) * | 1982-12-10 | 1997-04-08 | Novo Nordisk A/S | Process for preparing a desired protein |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| CA2102808A1 (en) * | 1991-05-10 | 1992-11-11 | Hanne Bentz | Targeted delivery of bone growth factors |
| US5281698A (en) * | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
| US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| US5650234A (en) * | 1994-09-09 | 1997-07-22 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces |
| US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US6180095B1 (en) * | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| GB0013810D0 (en) * | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
-
2004
- 2004-02-13 CA CA002515612A patent/CA2515612A1/en not_active Abandoned
- 2004-02-13 BR BRPI0407511-0A patent/BRPI0407511A/pt not_active IP Right Cessation
- 2004-02-13 JP JP2006502450A patent/JP2006517995A/ja not_active Withdrawn
- 2004-02-13 EP EP04710945A patent/EP1597299A2/en not_active Withdrawn
- 2004-02-13 WO PCT/IB2004/000424 patent/WO2004074345A2/en not_active Ceased
- 2004-02-13 MX MXPA05008785A patent/MXPA05008785A/es not_active Application Discontinuation
- 2004-02-18 TW TW093103934A patent/TW200426155A/zh unknown
- 2004-02-18 AR ARP040100501A patent/AR043216A1/es unknown
- 2004-02-19 US US10/782,268 patent/US7094872B2/en not_active Expired - Fee Related
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