JP2007070277A5 - - Google Patents

Info

Publication number

JP2007070277A5

JP2007070277A5 JP2005258103A JP2005258103A JP2007070277A5 JP 2007070277 A5 JP2007070277 A5 JP 2007070277A5 JP 2005258103 A JP2005258103 A JP 2005258103A JP 2005258103 A JP2005258103 A JP 2005258103A JP 2007070277 A5 JP2007070277 A5 JP 2007070277A5

Authority

JP

Japan

Prior art keywords

lactoferrin

hydrophilic polymer

branched non

biologically active

peptide

Prior art date

2005-09-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 102000010445 Lactoferrin Human genes 0.000 claims 10
• 108010063045 Lactoferrin Proteins 0.000 claims 10
• CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims 10
• 229940078795 lactoferrin Drugs 0.000 claims 10
• 235000021242 lactoferrin Nutrition 0.000 claims 10
• 229920001477 hydrophilic polymer Polymers 0.000 claims 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims 7
• 238000004519 manufacturing process Methods 0.000 claims 4
• 238000000034 method Methods 0.000 claims 3
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
• 238000005341 cation exchange Methods 0.000 claims 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
• 238000002523 gelfiltration Methods 0.000 claims 2
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
• 125000005647 linker group Chemical group 0.000 claims 2
• -1 poly (alkylene glycol Chemical compound 0.000 claims 2
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 230000000996 additive effect Effects 0.000 claims 1
• 239000012141 concentrate Substances 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229910052742 iron Inorganic materials 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1