CA2620132C - Lactoferrin complex and method of producing the same - Google Patents
Lactoferrin complex and method of producing the same Download PDFInfo
- Publication number
- CA2620132C CA2620132C CA2620132A CA2620132A CA2620132C CA 2620132 C CA2620132 C CA 2620132C CA 2620132 A CA2620132 A CA 2620132A CA 2620132 A CA2620132 A CA 2620132A CA 2620132 C CA2620132 C CA 2620132C
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- Prior art keywords
- lactoferrin
- complex
- hydrophilic polymer
- poly
- peptide hydrophilic
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- 210000002966 serum Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000007863 steatosis Effects 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 229920001897 terpolymer Polymers 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005-258103 | 2005-09-06 | ||
| JP2005258103A JP4261531B2 (ja) | 2005-09-06 | 2005-09-06 | ラクトフェリン複合体及びその製造方法 |
| PCT/JP2006/316367 WO2007029484A1 (ja) | 2005-09-06 | 2006-08-22 | ラクトフェリン複合体及びその製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2620132A1 CA2620132A1 (en) | 2007-03-15 |
| CA2620132C true CA2620132C (en) | 2017-11-21 |
Family
ID=37835608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2620132A Expired - Fee Related CA2620132C (en) | 2005-09-06 | 2006-08-22 | Lactoferrin complex and method of producing the same |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8673839B2 (enExample) |
| EP (1) | EP1932855B1 (enExample) |
| JP (1) | JP4261531B2 (enExample) |
| CA (1) | CA2620132C (enExample) |
| WO (1) | WO2007029484A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007111199A1 (ja) | 2006-03-24 | 2007-10-04 | Ngk Insulators, Ltd. | 焼結体、発光管及びその製造方法 |
| CA2717699A1 (en) * | 2008-03-14 | 2009-09-17 | Nrl Pharma, Inc. | Polyethylene glycolated lactoferrin complex and method of producing the same |
| JP2009221159A (ja) * | 2008-03-17 | 2009-10-01 | Yokohama Tlo Co Ltd | Ｐｅｇ化ラクトフェリンを主成分とする医薬製剤 |
| US8614189B2 (en) * | 2008-09-24 | 2013-12-24 | University Of Connecticut | Carbon nanotube composite scaffolds for bone tissue engineering |
| US20110190192A1 (en) * | 2009-12-15 | 2011-08-04 | Cebix Inc. | Methods for treating erectile dysfunction in patients with insulin-dependent diabetes |
| AU2011251991B2 (en) | 2010-05-10 | 2014-05-22 | University Of Connecticut | Lactoferrin -based biomaterials for tissue regeneration and drug delivery |
| MX2012013375A (es) * | 2010-05-17 | 2013-04-11 | Cebix Inc | Peptido c pegilado. |
| EP2441443A1 (en) * | 2010-10-07 | 2012-04-18 | Nestec S.A. | Lactoferrin based complex coacervates and their uses |
| EP2780030A4 (en) | 2011-11-17 | 2015-11-18 | Cebix Ab | PEGYLATED C-PEPTIDE |
| EP2842969B1 (en) | 2012-04-23 | 2018-03-14 | NRL Pharma, Inc. | Lactoferrin fusion protein and method for preparation thereof |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
| ES2738287T3 (es) | 2013-04-09 | 2020-01-21 | Shinji Kagaya | Inhibidor de la formación de trampas extracelulares en leucocitos |
| WO2018079702A1 (ja) | 2016-10-28 | 2018-05-03 | 株式会社Ｎｒｌファーマ | ラクトフェリン／アルブミン融合タンパク質及びその製造方法 |
| WO2020096672A1 (en) | 2018-11-09 | 2020-05-14 | The Wistar Institute Of Anatomy And Biology | Use of lactoferrin for generating myeloid-derived suppressor cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| AR014621A1 (es) | 1997-12-12 | 2001-03-28 | Macromed Inc | Un poli (etilenglicol) con forma de estrella, heterofuncional, biocompatible, metodo para su obtencion y metodo para conjugarlo con una proteina |
| AU1325400A (en) | 1998-10-26 | 2000-05-15 | University Of Utah Research Foundation | Method for preparation of polyethylene glycol aldehyde derivatives |
| US7053150B2 (en) * | 2000-12-18 | 2006-05-30 | Nektar Therapeutics Al, Corporation | Segmented polymers and their conjugates |
| JP2005258103A (ja) | 2004-03-12 | 2005-09-22 | Kyocera Mita Corp | 画像形成装置 |
-
2005
- 2005-09-06 JP JP2005258103A patent/JP4261531B2/ja not_active Expired - Fee Related
-
2006
- 2006-08-22 WO PCT/JP2006/316367 patent/WO2007029484A1/ja not_active Ceased
- 2006-08-22 EP EP06782871.5A patent/EP1932855B1/en not_active Ceased
- 2006-08-22 US US12/065,877 patent/US8673839B2/en not_active Expired - Fee Related
- 2006-08-22 CA CA2620132A patent/CA2620132C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4261531B2 (ja) | 2009-04-30 |
| CA2620132A1 (en) | 2007-03-15 |
| EP1932855A1 (en) | 2008-06-18 |
| EP1932855A4 (en) | 2009-12-02 |
| EP1932855B1 (en) | 2013-07-24 |
| WO2007029484A1 (ja) | 2007-03-15 |
| US8673839B2 (en) | 2014-03-18 |
| US20090281029A1 (en) | 2009-11-12 |
| JP2007070277A (ja) | 2007-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20200831 |