JP2006517415A - ポリペプチドの精製 - Google Patents

ポリペプチドの精製 Download PDF

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Publication number
JP2006517415A
JP2006517415A JP2006508590A JP2006508590A JP2006517415A JP 2006517415 A JP2006517415 A JP 2006517415A JP 2006508590 A JP2006508590 A JP 2006508590A JP 2006508590 A JP2006508590 A JP 2006508590A JP 2006517415 A JP2006517415 A JP 2006517415A
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JP
Japan
Prior art keywords
polypeptide
homogenate
lactate
broth
antibody
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JP2006508590A
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English (en)
Japanese (ja)
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JP2006517415A5 (enExample
Inventor
レスター，フィリップ，エム．
パーソン，ジョセフィン
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Genentech Inc
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Genentech Inc
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Publication of JP2006517415A publication Critical patent/JP2006517415A/ja
Publication of JP2006517415A5 publication Critical patent/JP2006517415A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2006508590A 2003-01-09 2004-01-08 ポリペプチドの精製 Withdrawn JP2006517415A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43941803P 2003-01-09 2003-01-09
PCT/US2004/000499 WO2004092393A1 (en) 2003-01-09 2004-01-08 Purification of polypeptides

Publications (2)

Publication Number Publication Date
JP2006517415A true JP2006517415A (ja) 2006-07-27
JP2006517415A5 JP2006517415A5 (enExample) 2006-11-16

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ID=33299572

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006508590A Withdrawn JP2006517415A (ja) 2003-01-09 2004-01-08 ポリペプチドの精製

Country Status (18)

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US (2) US7169908B2 (enExample)
EP (1) EP1581644B1 (enExample)
JP (1) JP2006517415A (enExample)
KR (1) KR20050095605A (enExample)
CN (1) CN100467611C (enExample)
AT (1) ATE364092T1 (enExample)
AU (1) AU2004230670B2 (enExample)
BR (1) BRPI0406470A (enExample)
CA (1) CA2511946A1 (enExample)
DE (1) DE602004006831T2 (enExample)
DK (1) DK1581644T3 (enExample)
ES (1) ES2287687T3 (enExample)
MX (1) MXPA05007378A (enExample)
NZ (1) NZ540895A (enExample)
PL (1) PL377653A1 (enExample)
RU (1) RU2337968C2 (enExample)
WO (1) WO2004092393A1 (enExample)
ZA (1) ZA200504990B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012504586A (ja) * 2008-10-06 2012-02-23 フジフィルム・ダイオシンス・バイオテクノロジーズ ・ユーケイ・リミテッド 断片抗体のための精製方法
JP2015525213A (ja) * 2012-05-31 2015-09-03 エイジェンシー フォー サイエンス，テクノロジー アンド リサーチ タンパク質製剤中の凝集物含量を低減するために混合型多官能表面を使用する方法
JP2016506953A (ja) * 2013-02-06 2016-03-07 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ タンパク質精製方法
JP2016507588A (ja) * 2013-02-26 2016-03-10 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 非イオン性有機ポリマーおよび電気陽性表面の存在下でのタンパク質精製
JP2016509069A (ja) * 2013-02-28 2016-03-24 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 非イオン性有機ポリマー存在下、高導電率でのタンパク質精製
JP2016509068A (ja) * 2013-02-28 2016-03-24 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ クロマチン欠損細胞培養採取物からの抗体のクロマトグラフィー精製

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PT2158923E (pt) 1998-08-06 2013-06-04 Univ Duke Conjugados de peg-urato oxidase e sua utilização
EP2292637B1 (en) * 2002-09-06 2016-01-06 Genentech, Inc. Process for protein extraction
ES2538357T3 (es) 2005-04-11 2015-06-19 Crealta Pharmaceuticals Llc Formas variantes de urato oxidasa y uso de las mismas
TWI418564B (zh) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc 利用陽離子界面活性劑之蛋白質純化
EP1973942B1 (en) 2005-12-22 2011-02-09 Genentech, Inc. Recombinant production of heparin binding proteins
EP2013225B1 (en) * 2006-04-12 2014-12-17 Crealta Pharmaceuticals LLC Purification of proteins with cationic surfactant
FR2902799B1 (fr) 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
CN101506222B (zh) 2006-07-14 2013-10-02 健泰科生物技术公司 重组蛋白的重折叠
US8569464B2 (en) * 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
US8268586B2 (en) * 2006-12-21 2012-09-18 Novozymes, Inc. Modified messenger RNA stabilizing sequences for expressing genes in bacterial cells
WO2008079302A2 (en) 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins
KR101431856B1 (ko) 2007-01-22 2014-08-27 제넨테크, 인크. 항체의 고분자전해질 침전 및 정제
PL4365189T3 (pl) 2007-07-09 2025-05-26 F. Hoffmann-La Roche Ag Zapobieganie redukcji wiązania disiarczkowego podczas rekombinacyjnego wytwarzania polipeptydów
US7887821B2 (en) * 2007-12-20 2011-02-15 Alk-Abello A/S Process for producing an allergen extract
WO2009151514A1 (en) 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
EP2337787A1 (en) * 2008-10-17 2011-06-29 Percivia LLC. Clarification process
CN105037535A (zh) 2008-12-16 2015-11-11 Emd密理博公司 搅拌槽反应器及方法
US9377454B2 (en) 2009-06-25 2016-06-28 Crealta Pharmaceuticals Llc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
KR101858598B1 (ko) * 2010-02-01 2018-05-16 디그나 비오테크, 에스.엘. 인터페론 알파 5의 제조방법
BR112012019848B1 (pt) * 2010-02-12 2022-03-15 LETI Pharma S.L. Processo para produção de um extrato de alérgeno, extrato de alérgeno despigmentado polimerizado, composição farmacêutica, e vacina
WO2011110598A1 (en) * 2010-03-10 2011-09-15 F. Hoffmann-La Roche Ag Method for purifying immunoglobulin solutions
JO3131B1 (ar) 2010-04-27 2017-09-20 Glaxosmithkline Llc مركبات كيميائية
KR101551295B1 (ko) 2010-05-17 2015-09-08 이엠디 밀리포어 코포레이션 생체분자 정제용 자극 반응성 중합체
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
DE102011001743A1 (de) * 2011-04-01 2012-10-04 Technische Universität Dortmund Verfahren zur Trennung/Reinigung von Biomolekühlen
JP6216321B2 (ja) 2011-10-11 2017-10-18 ジェネンテック， インコーポレイテッド 二重特異性抗体の構築の改善
CN102443055B (zh) * 2011-10-26 2017-07-28 浙江海正药业股份有限公司 一种重组人肿瘤坏死因子相关凋亡诱导配体的纯化工艺
CN102701501A (zh) * 2012-06-26 2012-10-03 天津市津华盛生物科技有限公司 工业乳酸链球菌素废水综合利用的方法
RU2646098C2 (ru) * 2013-04-30 2018-03-01 Интас Фармасьютикалс Лтд Новый способ клонирования, экспрессии и очистки для получения ранибизумаба
US10259841B2 (en) 2014-04-30 2019-04-16 Novozymes A/S Method for reducing the DNA content of a fermentation broth
JP2019535819A (ja) 2016-11-11 2019-12-12 ホライゾン ファーマ リューマトロジー リミテッド ライアビリティ カンパニーＨｏｒｉｚｏｎ Ｐｈａｒｍａ Ｒｈｅｕｍａｔｏｌｏｇｙ Ｌｌｃ プレドニゾンおよびウリカーゼ分子の併用療法ならびにその使用
CN108333263A (zh) * 2017-01-20 2018-07-27 北京蛋白质组研究中心 一种尿蛋白制备方法及尿蛋白质组的检测方法
TW201927335A (zh) * 2017-10-02 2019-07-16 美商拜耳保健有限責任公司 防止雙硫鍵於細胞培養收集物中還原之方法
WO2019126123A1 (en) 2017-12-22 2019-06-27 Regeneron Pharmaceuticals, Inc. System and method for characterizing drug product impurities
CN111363024A (zh) * 2018-12-26 2020-07-03 深圳翰宇药业股份有限公司 多肽的纯化方法
WO2020160325A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
US20220228195A1 (en) * 2019-06-05 2022-07-21 Viome Life Science, Inc. Sample collection methods and devices
ES3036955T3 (en) 2020-04-15 2025-09-26 Genentech Inc Copper loss mitigation
CN112708566A (zh) * 2021-01-25 2021-04-27 西南林业大学 一种黑曲霉生产胞外多聚物的优化培养基及培养方法
CN114774500A (zh) * 2022-04-26 2022-07-22 成都蜀星饲料有限公司 多肽及制备方法、有机复合微量元素及制备方法
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Citations (1)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012504586A (ja) * 2008-10-06 2012-02-23 フジフィルム・ダイオシンス・バイオテクノロジーズ ・ユーケイ・リミテッド 断片抗体のための精製方法
JP2015525213A (ja) * 2012-05-31 2015-09-03 エイジェンシー フォー サイエンス，テクノロジー アンド リサーチ タンパク質製剤中の凝集物含量を低減するために混合型多官能表面を使用する方法
US9920125B2 (en) 2012-05-31 2018-03-20 Agency For Science, Technology And Research Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations
JP2016506953A (ja) * 2013-02-06 2016-03-07 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ タンパク質精製方法
JP2016507588A (ja) * 2013-02-26 2016-03-10 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 非イオン性有機ポリマーおよび電気陽性表面の存在下でのタンパク質精製
US10112971B2 (en) 2013-02-26 2018-10-30 Agency For Science, Technology And Research Protein purification in the presence of nonionic organic polymers and electropositive surfaces
JP2016509069A (ja) * 2013-02-28 2016-03-24 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 非イオン性有機ポリマー存在下、高導電率でのタンパク質精製
JP2016509068A (ja) * 2013-02-28 2016-03-24 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ クロマチン欠損細胞培養採取物からの抗体のクロマトグラフィー精製
US10253063B2 (en) 2013-02-28 2019-04-09 Agency For Science, Technology And Research Protein purification in the presence of nonionic organic polymers at elevated conductivity

Also Published As

Publication number Publication date
EP1581644B1 (en) 2007-06-06
DE602004006831D1 (de) 2007-07-19
CN100467611C (zh) 2009-03-11
CN1759186A (zh) 2006-04-12
DK1581644T3 (da) 2007-10-08
AU2004230670B2 (en) 2010-11-25
RU2337968C2 (ru) 2008-11-10
NZ540895A (en) 2007-03-30
KR20050095605A (ko) 2005-09-29
AU2004230670A1 (en) 2004-10-28
US7169908B2 (en) 2007-01-30
ZA200504990B (en) 2006-08-30
DE602004006831T2 (de) 2008-02-14
CA2511946A1 (en) 2004-10-28
WO2004092393A1 (en) 2004-10-28
US7579448B2 (en) 2009-08-25
ATE364092T1 (de) 2007-06-15
MXPA05007378A (es) 2005-11-23
PL377653A1 (pl) 2006-02-06
ES2287687T3 (es) 2007-12-16
RU2005125210A (ru) 2006-01-10
US20050037456A1 (en) 2005-02-17
BRPI0406470A (pt) 2005-12-06
US20070077625A1 (en) 2007-04-05
EP1581644A1 (en) 2005-10-05

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