CA2511946A1 - Purification of polypeptides - Google Patents
Purification of polypeptides Download PDFInfo
- Publication number
- CA2511946A1 CA2511946A1 CA002511946A CA2511946A CA2511946A1 CA 2511946 A1 CA2511946 A1 CA 2511946A1 CA 002511946 A CA002511946 A CA 002511946A CA 2511946 A CA2511946 A CA 2511946A CA 2511946 A1 CA2511946 A1 CA 2511946A1
- Authority
- CA
- Canada
- Prior art keywords
- polypeptide
- homogenate
- broth
- antibody
- ethacridine lactate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| PCT/US2004/000499 WO2004092393A1 (en) | 2003-01-09 | 2004-01-08 | Purification of polypeptides |
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| CA2511946A1 true CA2511946A1 (en) | 2004-10-28 |
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| HUE027196T2 (hu) * | 2002-09-06 | 2016-10-28 | Genentech Inc | Eljárás fehérjeextrakcióra |
| US9534013B2 (en) * | 2006-04-12 | 2017-01-03 | Horizon Pharma Rheumatology Llc | Purification of proteins with cationic surfactant |
| TWI418564B (zh) * | 2005-04-11 | 2013-12-11 | Savient Pharmaceuticals Inc | 利用陽離子界面活性劑之蛋白質純化 |
| NZ562292A (en) | 2005-04-11 | 2009-11-27 | Savient Pharmaceuticals Inc | Variant forms of urate oxidase and use thereof |
| EP1973942B1 (en) | 2005-12-22 | 2011-02-09 | Genentech, Inc. | Recombinant production of heparin binding proteins |
| FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
| NZ573639A (en) | 2006-07-14 | 2012-03-30 | Genentech Inc | Refolding of recombinant proteins |
| US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
| WO2008079302A2 (en) | 2006-12-21 | 2008-07-03 | Millipore Corporation | Purification of proteins |
| DK2104739T3 (da) * | 2006-12-21 | 2013-10-07 | Novozymes Inc | Modificerede messenger-RNA-stabiliseringssekvenser til ekspression af gener i bakterieceller |
| US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
| AU2008209404B2 (en) * | 2007-01-22 | 2012-08-16 | Genentech, Inc. | Polyelectrolyte precipitation and purification of antibodies |
| PL2188302T3 (pl) | 2007-07-09 | 2018-04-30 | Genentech, Inc. | Zapobieganie redukcji wiązań disiarczkowych podczas rekombinacyjnego wytwarzania polipeptydów |
| US7887821B2 (en) * | 2007-12-20 | 2011-02-15 | Alk-Abello A/S | Process for producing an allergen extract |
| WO2009151514A1 (en) | 2008-06-11 | 2009-12-17 | Millipore Corporation | Stirred tank bioreactor |
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| EP2337787A1 (en) * | 2008-10-17 | 2011-06-29 | Percivia LLC. | Clarification process |
| US20100190963A1 (en) | 2008-12-16 | 2010-07-29 | Millipore Corporation | Stirred Tank Reactor And Method |
| KR101861547B1 (ko) | 2009-06-25 | 2018-07-02 | 크레알타 파마슈티칼스 엘엘씨 | 페길화된 유리카아제 치료 중에 혈청 요산을 모니터링하여 주입 반응의 위험성 및 반응의 항체매개 상실을 예측하는 방법 및 키트 |
| KR101858598B1 (ko) * | 2010-02-01 | 2018-05-16 | 디그나 비오테크, 에스.엘. | 인터페론 알파 5의 제조방법 |
| ES2395093T3 (es) * | 2010-02-12 | 2014-12-22 | Laboratorios Leti, S.L. | Proceso para producir un extracto de alérgenos |
| EP2545066B1 (en) * | 2010-03-10 | 2017-09-20 | F. Hoffmann-La Roche AG | Method for purifying immunoglobulin solutions |
| JO3131B1 (ar) | 2010-04-27 | 2017-09-20 | Glaxosmithkline Llc | مركبات كيميائية |
| EP2571903B1 (en) | 2010-05-17 | 2019-09-04 | EMD Millipore Corporation | Stimulus responsive polymers for the purification of biomolecules |
| GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
| DE102011001743A1 (de) * | 2011-04-01 | 2012-10-04 | Technische Universität Dortmund | Verfahren zur Trennung/Reinigung von Biomolekühlen |
| KR102492792B1 (ko) | 2011-10-11 | 2023-01-30 | 제넨테크, 인크. | 이중특이적 항체의 개선된 어셈블리 |
| CN102443055B (zh) * | 2011-10-26 | 2017-07-28 | 浙江海正药业股份有限公司 | 一种重组人肿瘤坏死因子相关凋亡诱导配体的纯化工艺 |
| WO2013180648A1 (en) * | 2012-05-31 | 2013-12-05 | Agency For Science, Technology And Research | Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations |
| CN102701501A (zh) * | 2012-06-26 | 2012-10-03 | 天津市津华盛生物科技有限公司 | 工业乳酸链球菌素废水综合利用的方法 |
| CN105026418B (zh) * | 2013-02-06 | 2019-01-11 | 新加坡科技研究局 | 蛋白质纯化方法 |
| EP2961759A4 (en) | 2013-02-26 | 2016-09-28 | Agency Science Tech & Res | PROTEIN CLEANING IN THE PRESENCE OF NON-ORGANIC POLYMERS AND ELECTROPOSITIVE SURFACES |
| CN105189530B (zh) * | 2013-02-28 | 2019-06-07 | 新加坡科技研究局 | 从缺乏染色质的细胞培养收获物中色谱纯化抗体 |
| WO2014133460A1 (en) * | 2013-02-28 | 2014-09-04 | Agency For Science, Technology And Research | Protein purification in the presence of nonionic organic polymers at elevated conductivity |
| EP2992021B1 (en) * | 2013-04-30 | 2020-07-22 | Intas Pharmaceuticals Limited | Novel cloning, expression & purification method for the preparation of ranibizumab |
| RU2687153C2 (ru) * | 2014-04-30 | 2019-05-07 | Новозимс А/С | Способ снижения содержания днк в ферментационном бульоне |
| US20200237881A1 (en) | 2019-01-30 | 2020-07-30 | Horizon Pharma Rheumatology Llc | Reducing immunogenicity to pegloticase |
| EP3538135A4 (en) | 2016-11-11 | 2020-07-29 | Horizon Pharma Rheumatology LLC | POLYTHERAPIES OF PREDNISONE AND URICASE MOLECULES AND THEIR USES |
| CN108333263A (zh) * | 2017-01-20 | 2018-07-27 | 北京蛋白质组研究中心 | 一种尿蛋白制备方法及尿蛋白质组的检测方法 |
| TW201927335A (zh) * | 2017-10-02 | 2019-07-16 | 美商拜耳保健有限責任公司 | 防止雙硫鍵於細胞培養收集物中還原之方法 |
| BR112020010615A2 (pt) * | 2017-12-22 | 2020-10-27 | Regeneron Pharmaceuticals, Inc. | produto farmacêutico proteico, método e sistema para caracterizar impurezas de produto farmacêutico proteico e de fármaco de baixo peso molecular, método para produzir um anticorpo, anticorpo, e, usos do método e do sistema |
| CN111363024A (zh) * | 2018-12-26 | 2020-07-03 | 深圳翰宇药业股份有限公司 | 多肽的纯化方法 |
| WO2020247983A1 (en) * | 2019-06-05 | 2020-12-10 | Viome, Inc. | Sample collection methods and devices |
| EP4136211B1 (en) | 2020-04-15 | 2025-07-09 | Genentech, Inc. | Copper loss mitigation |
| CN112708566A (zh) * | 2021-01-25 | 2021-04-27 | 西南林业大学 | 一种黑曲霉生产胞外多聚物的优化培养基及培养方法 |
| CN114774500A (zh) * | 2022-04-26 | 2022-07-22 | 成都蜀星饲料有限公司 | 多肽及制备方法、有机复合微量元素及制备方法 |
| US12269875B2 (en) | 2023-08-03 | 2025-04-08 | Jeff R. Peterson | Gout flare prevention methods using IL-1BETA blockers |
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| IL34079A (en) * | 1969-04-01 | 1973-02-28 | Upjohn Co | Purification of ypsilon-globulins |
| US3607857A (en) * | 1970-03-03 | 1971-09-21 | Upjohn Co | Process of removing acrinol from gamma globulin using siliceous material such as silica gel |
| US3903254A (en) * | 1971-07-23 | 1975-09-02 | Upjohn Co | Separation of erythrocyte stroma from lysing medium and hemoglobin with acrinol |
| DE2308013A1 (de) * | 1973-02-17 | 1974-09-12 | Behringwerke Ag | Katalasearme glucoseoxidase und verfahren zu ihrer gewinnung |
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| SU944580A1 (ru) | 1980-02-07 | 1982-07-23 | Кировский научно-исследовательский институт переливания крови | Способ получени поверхностного антигена гепатита В |
| US4563303A (en) * | 1984-04-14 | 1986-01-07 | Judicial Foundation The Chemosero-Therapeutic Research Institute | Method for purification of filamentous hemagglutinin |
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| WO1986007093A1 (fr) * | 1985-05-29 | 1986-12-04 | The Green Cross Corporation | Procede de preparation d'une proteine heterogene |
| WO1987000553A1 (fr) * | 1985-07-16 | 1987-01-29 | The Green Cross Corporation | Procede de preparation d'hetero-proteine |
| DE3604947A1 (de) | 1986-02-17 | 1987-08-20 | Biotest Pharma Gmbh | Verfahren zur herstellung eines immunglobulinhaltigen praeparates und dessen verwendung zur prophylaxe und therapie von aids |
| FR2600078B1 (fr) | 1986-06-12 | 1989-07-13 | Merieux Inst | Procede de preparation de facteur xiii a partir du placenta |
| DE3929504A1 (de) * | 1989-09-06 | 1991-03-07 | Behringwerke Ag | Verfahren zur reinigung von plasminogen-aktivator-inhibitor 2 (pai-2) |
| DE4030264A1 (de) * | 1990-09-25 | 1992-04-23 | Hoechst Ag | Verfahren zur herstellung gereinigter glycolipide durch membrantrennverfahren |
| GB9215540D0 (en) | 1992-07-22 | 1992-09-02 | Celltech Ltd | Protein expression system |
| US5861263A (en) * | 1992-10-20 | 1999-01-19 | Universidad Autonoma De Nuevo Leon | Preparation of preserved entamoeba histolytica antigens without enzymatic inhibitors and their use in immunological methods |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5760189A (en) | 1995-06-02 | 1998-06-02 | Genetics Institute, Inc. | Protein recovery & purification methods |
| US5714583A (en) | 1995-06-07 | 1998-02-03 | Genetics Institute, Inc. | Factor IX purification methods |
| DK0998486T4 (da) | 1997-06-13 | 2012-05-14 | Genentech Inc | Proteinoprensning ved kromatografi efterfulgt af filtrering på en ladet fase |
| JPH11341947A (ja) * | 1998-06-02 | 1999-12-14 | Yakult Honsha Co Ltd | 発酵管理方法 |
| US6156514A (en) * | 1998-12-03 | 2000-12-05 | Sunol Molecular Corporation | Methods for making recombinant cells |
| AU2001231016A1 (en) * | 2000-01-20 | 2001-07-31 | Regents Of The University Of Minnesota | Peptides with antibacterial activity |
-
2004
- 2004-01-08 JP JP2006508590A patent/JP2006517415A/ja not_active Withdrawn
- 2004-01-08 PL PL377653A patent/PL377653A1/pl not_active Application Discontinuation
- 2004-01-08 DK DK04700878T patent/DK1581644T3/da active
- 2004-01-08 WO PCT/US2004/000499 patent/WO2004092393A1/en not_active Ceased
- 2004-01-08 CN CNB2004800063965A patent/CN100467611C/zh not_active Expired - Fee Related
- 2004-01-08 RU RU2005125210/13A patent/RU2337968C2/ru not_active IP Right Cessation
- 2004-01-08 CA CA002511946A patent/CA2511946A1/en not_active Abandoned
- 2004-01-08 MX MXPA05007378A patent/MXPA05007378A/es active IP Right Grant
- 2004-01-08 AU AU2004230670A patent/AU2004230670B2/en not_active Expired - Fee Related
- 2004-01-08 BR BR0406470-4A patent/BRPI0406470A/pt not_active Application Discontinuation
- 2004-01-08 DE DE602004006831T patent/DE602004006831T2/de not_active Expired - Lifetime
- 2004-01-08 AT AT04700878T patent/ATE364092T1/de active
- 2004-01-08 EP EP04700878A patent/EP1581644B1/en not_active Expired - Lifetime
- 2004-01-08 NZ NZ540895A patent/NZ540895A/en not_active IP Right Cessation
- 2004-01-08 ZA ZA200504990A patent/ZA200504990B/en unknown
- 2004-01-08 ES ES04700878T patent/ES2287687T3/es not_active Expired - Lifetime
- 2004-01-08 US US10/754,212 patent/US7169908B2/en not_active Expired - Fee Related
- 2004-01-08 KR KR1020057012831A patent/KR20050095605A/ko not_active Ceased
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2006
- 2006-12-12 US US11/609,529 patent/US7579448B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0406470A (pt) | 2005-12-06 |
| US7169908B2 (en) | 2007-01-30 |
| AU2004230670B2 (en) | 2010-11-25 |
| ATE364092T1 (de) | 2007-06-15 |
| EP1581644B1 (en) | 2007-06-06 |
| DK1581644T3 (da) | 2007-10-08 |
| NZ540895A (en) | 2007-03-30 |
| DE602004006831D1 (de) | 2007-07-19 |
| EP1581644A1 (en) | 2005-10-05 |
| US20070077625A1 (en) | 2007-04-05 |
| DE602004006831T2 (de) | 2008-02-14 |
| ZA200504990B (en) | 2006-08-30 |
| JP2006517415A (ja) | 2006-07-27 |
| CN1759186A (zh) | 2006-04-12 |
| RU2005125210A (ru) | 2006-01-10 |
| PL377653A1 (pl) | 2006-02-06 |
| MXPA05007378A (es) | 2005-11-23 |
| US20050037456A1 (en) | 2005-02-17 |
| RU2337968C2 (ru) | 2008-11-10 |
| AU2004230670A1 (en) | 2004-10-28 |
| ES2287687T3 (es) | 2007-12-16 |
| KR20050095605A (ko) | 2005-09-29 |
| CN100467611C (zh) | 2009-03-11 |
| WO2004092393A1 (en) | 2004-10-28 |
| US7579448B2 (en) | 2009-08-25 |
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