JP2006512891A5 - - Google Patents
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- JP2006512891A5 JP2006512891A5 JP2003586327A JP2003586327A JP2006512891A5 JP 2006512891 A5 JP2006512891 A5 JP 2006512891A5 JP 2003586327 A JP2003586327 A JP 2003586327A JP 2003586327 A JP2003586327 A JP 2003586327A JP 2006512891 A5 JP2006512891 A5 JP 2006512891A5
- Authority
- JP
- Japan
- Prior art keywords
- assay
- enzyme
- antigen
- present
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000003556 assay Methods 0.000 description 11
- 229940088598 enzyme Drugs 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 9
- 230000027455 binding Effects 0.000 description 9
- 239000000427 antigen Substances 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 102000036639 antigens Human genes 0.000 description 7
- 108091007433 antigens Proteins 0.000 description 7
- 150000007523 nucleic acids Chemical group 0.000 description 6
- 108060003951 Immunoglobulin Proteins 0.000 description 5
- 102000018358 immunoglobulin Human genes 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 4
- 102100022624 Glucoamylase Human genes 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 108090000746 Chymosin Proteins 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000007790 solid phase Substances 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 2
- 235000020054 awamori Nutrition 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229940080701 chymosin Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 description 2
- 108010064037 prorennin Proteins 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 101000914103 Bos taurus Chymosin Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 241001022421 Ictiobus niger Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical class C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000007707 calorimetry Methods 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- -1 dioxetane compounds Chemical class 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000012886 linear function Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 229940043517 specific immunoglobulins Drugs 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37388902P | 2002-04-18 | 2002-04-18 | |
| US41154002P | 2002-09-18 | 2002-09-18 | |
| US41153702P | 2002-09-18 | 2002-09-18 | |
| US45213403P | 2003-03-04 | 2003-03-04 | |
| PCT/US2003/012246 WO2003089614A2 (en) | 2002-04-18 | 2003-04-17 | Production of functional antibodies in filamentous fungi |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006512891A JP2006512891A (ja) | 2006-04-20 |
| JP2006512891A5 true JP2006512891A5 (enExample) | 2006-06-08 |
Family
ID=29255585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003586327A Pending JP2006512891A (ja) | 2002-04-18 | 2003-04-17 | 糸状菌における機能性抗体の生産 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20040018573A1 (enExample) |
| EP (1) | EP1495055B1 (enExample) |
| JP (1) | JP2006512891A (enExample) |
| AU (1) | AU2003222664A1 (enExample) |
| DK (1) | DK1495055T3 (enExample) |
| WO (1) | WO2003089614A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1495055B1 (en) * | 2002-04-18 | 2013-08-14 | Genencor International, Inc. | Production of functional antibodies in filamentous fungi |
| US7208585B2 (en) * | 2002-09-18 | 2007-04-24 | Genencor International, Inc. | Protein purification |
| AU2003272454A1 (en) * | 2002-09-18 | 2004-04-08 | Genencor International, Inc. | Protein purification |
| AU2004261980A1 (en) * | 2003-08-01 | 2005-02-10 | Genentech, Inc. | Antibody CDR polypeptide sequences with restricted diversity |
| US7820800B2 (en) * | 2003-11-05 | 2010-10-26 | Ares Trading S.A. | Process for the purification of IL-18 binding protein |
| EP1711529A1 (en) * | 2004-01-21 | 2006-10-18 | Novozymes A/S | Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell |
| US7858360B2 (en) * | 2005-10-17 | 2010-12-28 | Novozymes A/S | Use of fungal mutants for expression of antibodies |
| EP3056568B1 (en) | 2006-03-31 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| US8198046B2 (en) | 2006-07-11 | 2012-06-12 | Danisco Us Inc. | KEX2 cleavage regions of recombinant fusion proteins |
| US20080026376A1 (en) | 2006-07-11 | 2008-01-31 | Huaming Wang | KEX2 cleavage regions of recombinant fusion proteins |
| BRPI0714870A2 (pt) * | 2006-07-21 | 2013-05-28 | Novozymes Inc | mÉtodo para produzir um polipeptÍdeo secretado tendo atividade biolàgica, proteÍna de fusço isolada, polinucleotÍdeo isolado, construÇço de proteÍna de fusço, vetor de expressço, cÉlula hospedeira féngica, mÉtodos para degradar ou conventer um material celulàsico e para produzir uma substÂncia |
| EP2102240A2 (en) * | 2007-01-05 | 2009-09-23 | Novozymes A/S | Overexpression of the chaperone bip in a heterokaryon |
| US8546126B2 (en) * | 2007-03-21 | 2013-10-01 | Danisco Us Inc. | Over expression of foldases and chaperones improves protein production |
| JP5769142B2 (ja) * | 2007-09-04 | 2015-08-26 | 独立行政法人酒類総合研究所 | ピヒア属酵母において異種タンパク質を高分泌させる方法 |
| RU2526512C2 (ru) | 2007-09-26 | 2014-08-20 | Чугаи Сейяку Кабусики Кайся | Модифицированная константная область антитела |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| WO2009082209A1 (en) * | 2007-12-21 | 2009-07-02 | Fujifilm Manufacturing Europe B.V. | Improvement of the secretion yield of a protein of interest by in vivo proteolytic processing of a multimeric precursor |
| EP2899209A1 (en) | 2008-04-29 | 2015-07-29 | Abbvie Inc. | Dual Variable Domain Immunoglobulins and uses thereof |
| BRPI0913406A2 (pt) | 2008-06-03 | 2018-01-09 | Abbott Lab | imunoglobulinas de domínio variável duplo e usos das mesmas |
| EP2297208A4 (en) | 2008-06-03 | 2012-07-11 | Abbott Lab | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES |
| US8822645B2 (en) | 2008-07-08 | 2014-09-02 | Abbvie Inc. | Prostaglandin E2 dual variable domain immunoglobulins and uses thereof |
| JP2010183885A (ja) * | 2009-02-13 | 2010-08-26 | Kobe Univ | タンパク質の製造方法およびそれに用いる発現ベクター |
| SG175716A1 (en) * | 2009-05-07 | 2011-12-29 | Novozymes Biopharma Dk As | Method of controlling o-linked glycosylation of antibodies |
| EP2427486B1 (en) | 2009-05-07 | 2015-02-25 | Novozymes Biopharma DK A/S | Method for purifying albumin |
| WO2010141468A1 (en) * | 2009-06-01 | 2010-12-09 | Way Jeffrey C | Methods and molecules for yield improvement involving metabolic engineering |
| RU2012112550A (ru) | 2009-09-01 | 2013-10-10 | Эбботт Лэборетриз | Иммуноглобулины с двумя вариабельными доменами и их применение |
| US8716450B2 (en) | 2009-10-15 | 2014-05-06 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| TW201206473A (en) | 2010-08-03 | 2012-02-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| PE20140229A1 (es) | 2010-08-26 | 2014-03-27 | Abbvie Inc | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| DK2663579T3 (en) | 2011-01-14 | 2017-07-31 | Univ California | THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF |
| TW201333035A (zh) | 2011-12-30 | 2013-08-16 | Abbvie Inc | 針對ｉｌ－１３及／或ｉｌ－１７之雙特異性結合蛋白 |
| US9567596B2 (en) | 2012-01-05 | 2017-02-14 | Glykos Finland Oy | Protease deficient filamentous fungal cells and methods of use thereof |
| KR101505157B1 (ko) | 2012-05-08 | 2015-03-24 | 주식회사 종근당 | 항―ＥｒｂＢ２ 항체 변이체 |
| DK2852610T3 (en) | 2012-05-23 | 2018-09-03 | Glykos Finland Oy | PRODUCTION OF FUCOSYLED GLYCOPROTEIN |
| UY35110A (es) | 2012-11-01 | 2014-05-30 | Abbvie Inc | Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas |
| CA2904448A1 (en) | 2013-03-15 | 2014-09-18 | Tariq Ghayur | Dual specific binding proteins directed against il-1.beta. and/or il-17 |
| US20140273093A1 (en) * | 2013-03-15 | 2014-09-18 | Bristol-Myers Squibb Company | Methods of producing antibodies in yeast |
| MX2016000306A (es) | 2013-07-10 | 2016-08-08 | Novartis Ag | Celulas de hongos filamentosos deficientes en multiples proteasas y métodos de uso de las mismas. |
| SG11201700446XA (en) | 2014-07-21 | 2017-02-27 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| KR101515535B1 (ko) | 2015-01-28 | 2015-05-06 | 주식회사 종근당 | 항―ＥｒｂＢ２ 항체 변이체 |
| WO2016159213A1 (ja) | 2015-04-01 | 2016-10-06 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| BR112018009312A8 (pt) | 2015-12-28 | 2019-02-26 | Chugai Pharmaceutical Co Ltd | método para promover eficiência de purificação de polipeptídeo contendo região de fc |
| SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
| CN107674900B (zh) * | 2017-06-12 | 2021-05-14 | 诺利如一（安阳）生物科技有限公司 | 一种采用串联膜浓缩大豆肽的工艺方法 |
| JP7234932B2 (ja) | 2017-10-10 | 2023-03-08 | 味の素株式会社 | タンパク質の製造法 |
| TWI887899B (zh) | 2018-03-15 | 2025-06-21 | 日商中外製藥股份有限公司 | 對茲卡病毒具有交叉反應性的抗登革病毒抗體之用途 |
| CN113874392B (zh) | 2019-03-28 | 2025-10-21 | 丹尼斯科美国公司 | 工程化抗体 |
| US20230203191A1 (en) | 2020-03-30 | 2023-06-29 | Danisco Us Inc | Engineered antibodies |
| AU2021289499A1 (en) | 2020-06-11 | 2023-02-02 | Ajinomoto Co., Inc. | Method for producing protein |
| EP4525615A2 (en) | 2022-05-14 | 2025-03-26 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| EP4554619A1 (en) | 2022-07-15 | 2025-05-21 | Danisco US Inc. | Methods for producing monoclonal antibodies |
| JPWO2024038839A1 (enExample) | 2022-08-15 | 2024-02-22 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3009104C2 (de) | 1980-03-10 | 1990-10-04 | Odenwald-Chemie GmbH, 6901 Schönau | Verwendung eines Epoxydharzes zur Herstellung von feuerhemmenden Schichten oder Überzügen und Verfahren zur Herstellung derselben |
| CA1338400C (en) | 1983-08-31 | 1996-06-18 | David H. Gelfand | Recombinant fungal cellulases |
| US5364770A (en) * | 1985-08-29 | 1994-11-15 | Genencor International Inc. | Heterologous polypeptides expressed in aspergillus |
| EP0625577A1 (en) | 1985-08-29 | 1994-11-23 | Genencor International, Inc. | Heterologous polypeptides expressed in filamentous fungi, processes for their preparation, and vectors for their preparation |
| US20020061560A1 (en) * | 1985-08-29 | 2002-05-23 | Genencor, Inc. | DNA sequences, vectors, and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi |
| US5679543A (en) * | 1985-08-29 | 1997-10-21 | Genencor International, Inc. | DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi |
| US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US5610034A (en) * | 1987-04-29 | 1997-03-11 | Alko Group Ltd. | Immunoglobulin production by trichoderma |
| US5218093A (en) | 1989-03-01 | 1993-06-08 | Allelix Biopharmaceuticals, Inc. | EGF variants and pharmaceutical use thereof |
| GB9215540D0 (en) * | 1992-07-22 | 1992-09-02 | Celltech Ltd | Protein expression system |
| ES2162863T3 (es) * | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
| US5643745A (en) * | 1994-02-03 | 1997-07-01 | University Of Hawaii | Heterologous dimeric proteins produced in heterokaryons |
| US5683899A (en) * | 1994-02-03 | 1997-11-04 | University Of Hawaii | Methods and compositions for combinatorial-based discovery of new multimeric molecules |
| US6300114B1 (en) * | 1994-07-29 | 2001-10-09 | Rohm Enzyme Finland Oy | Sequences of xylanase and xylanase expression vectors |
| DK0877801T3 (da) * | 1996-01-19 | 2005-08-29 | Novozymes Biotech Inc | Morfologiske mutanter af trådsvampe |
| US6140113A (en) * | 1996-03-28 | 2000-10-31 | The Johns Hopkins University | Polynucleotides encoding molecular complexes which modify immune responses |
| US6265204B1 (en) * | 1997-01-17 | 2001-07-24 | Genencor International, Inc. | DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi |
| GB9703406D0 (en) * | 1997-02-19 | 1997-04-09 | Chiron Spa | Expression of heterologous proteins |
| US5994511A (en) * | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
| US6232112B1 (en) * | 1997-11-24 | 2001-05-15 | Flinders Technologies Pty Ltd Of Flinders University | Reagents and methods for diversification of DNA |
| ZA9811162B (en) * | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| JP2002505086A (ja) * | 1998-02-25 | 2002-02-19 | レキシジェン ファーマシューティカルズ コーポレイション | 抗体ベースの融合タンパク質の循環半減期の増強 |
| AU1219000A (en) | 1998-10-22 | 2000-05-08 | Regents Of The University Of California, The | Functionally assembled antigen-specific intact recombinant antibody and a methodfor production thereof |
| US6767701B1 (en) * | 1998-10-26 | 2004-07-27 | Novozymes A/S | Methods of constructing and screening a DNA library of interest in filamentous fungal cells |
| WO2000025574A1 (en) * | 1998-10-30 | 2000-05-11 | Thomas Jefferson University | Production of biomedical peptides and proteins in plants using plant virus vectors |
| US7094571B2 (en) * | 2000-10-27 | 2006-08-22 | The Board Of Regents Of The University Of Texas System | Combinatorial protein library screening by periplasmic expression |
| US7083945B1 (en) * | 2000-10-27 | 2006-08-01 | The Board Of Regents Of The University Of Texas System | Isolation of binding proteins with high affinity to ligands |
| ES2329012T3 (es) * | 2000-11-07 | 2009-11-20 | Zymogenetics, Inc. | Receptor del factor de necrosis tumoral humano. |
| JP4368196B2 (ja) * | 2000-11-17 | 2009-11-18 | ユニバーシティー オブ ロチェスター | 真核細胞において免疫グロブリン分子を製造および同定するインビトロにおける方法 |
| PL403488A1 (pl) * | 2001-05-24 | 2013-07-08 | Zymogenetics, Inc. | Zastosowanie bialka fuzyjnego TACI-immunoglobulina, bialko fuzyjne, czasteczka kwasu nukleinowego kodujaca bialko fuzyjne, kompozycja farmaceutyczna i sposób wytwarzania bialka fuzyjnego TACI-immunoglobulina |
| EP1495055B1 (en) * | 2002-04-18 | 2013-08-14 | Genencor International, Inc. | Production of functional antibodies in filamentous fungi |
| US7611866B2 (en) * | 2002-07-15 | 2009-11-03 | Board Of Regents, The University Of Texas System | Selection of bacterial inner-membrane anchor polypeptides |
| AR042485A1 (es) * | 2002-12-16 | 2005-06-22 | Genentech Inc | Anticuerpo humanizado que se une al cd20 humano |
| BRPI0406662A (pt) * | 2003-01-09 | 2005-12-20 | Macrogenics Inc | Vetor, célula, método de identificar um mab, e, composição |
| US20060024782A1 (en) * | 2004-01-21 | 2006-02-02 | Novozymes A/S | Production of a monoclonal antibody in a heterokaryon filamentous fungus or in a filamentous fungal host cell |
| EP1745066A2 (en) * | 2004-03-18 | 2007-01-24 | Board of Regents, The University of Texas System | Combinatorial protein library screening by periplasmic expression |
| US8067179B2 (en) * | 2006-11-30 | 2011-11-29 | Research Development Foundation | Immunoglobulin libraries |
| US8629245B2 (en) * | 2007-05-01 | 2014-01-14 | Research Development Foundation | Immunoglobulin Fc libraries |
-
2003
- 2003-04-17 EP EP03719861.1A patent/EP1495055B1/en not_active Revoked
- 2003-04-17 AU AU2003222664A patent/AU2003222664A1/en not_active Abandoned
- 2003-04-17 US US10/418,836 patent/US20040018573A1/en not_active Abandoned
- 2003-04-17 JP JP2003586327A patent/JP2006512891A/ja active Pending
- 2003-04-17 WO PCT/US2003/012246 patent/WO2003089614A2/en not_active Ceased
- 2003-04-17 DK DK03719861.1T patent/DK1495055T3/da active
-
2004
- 2004-12-09 US US11/007,886 patent/US7977067B2/en not_active Expired - Lifetime
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