JP2006510601A5 - - Google Patents
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- JP2006510601A5 JP2006510601A5 JP2004541625A JP2004541625A JP2006510601A5 JP 2006510601 A5 JP2006510601 A5 JP 2006510601A5 JP 2004541625 A JP2004541625 A JP 2004541625A JP 2004541625 A JP2004541625 A JP 2004541625A JP 2006510601 A5 JP2006510601 A5 JP 2006510601A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- group
- peg
- polyalkylene glycol
- kda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41442402P | 2002-09-30 | 2002-09-30 | |
| US60/414,424 | 2002-09-30 | ||
| US10/317,092 US20040062748A1 (en) | 2002-09-30 | 2002-12-12 | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| US10/317,092 | 2002-12-12 | ||
| PCT/US2003/029989 WO2004030617A2 (en) | 2002-09-30 | 2003-09-25 | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011082665A Division JP5603823B2 (ja) | 2002-09-30 | 2011-04-04 | 抗原性が低下したポリマー結合体、その調製方法および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006510601A JP2006510601A (ja) | 2006-03-30 |
| JP2006510601A5 true JP2006510601A5 (enExample) | 2006-12-07 |
| JP5366352B2 JP5366352B2 (ja) | 2013-12-11 |
Family
ID=32033300
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004541625A Expired - Fee Related JP5366352B2 (ja) | 2002-09-30 | 2003-09-25 | 抗原性が低下したポリマー結合体、その調製方法および使用方法 |
| JP2011082665A Expired - Fee Related JP5603823B2 (ja) | 2002-09-30 | 2011-04-04 | 抗原性が低下したポリマー結合体、その調製方法および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011082665A Expired - Fee Related JP5603823B2 (ja) | 2002-09-30 | 2011-04-04 | 抗原性が低下したポリマー結合体、その調製方法および使用方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20040062748A1 (enExample) |
| EP (2) | EP1572728B1 (enExample) |
| JP (2) | JP5366352B2 (enExample) |
| KR (1) | KR101022577B1 (enExample) |
| CN (2) | CN1997661B (enExample) |
| AU (1) | AU2003275176B8 (enExample) |
| BR (1) | BRPI0314831B8 (enExample) |
| CA (2) | CA2836959C (enExample) |
| CR (1) | CR7776A (enExample) |
| DK (1) | DK1572728T3 (enExample) |
| EA (1) | EA009122B1 (enExample) |
| EC (1) | ECSP055717A (enExample) |
| ES (1) | ES2504165T3 (enExample) |
| GE (1) | GEP20074016B (enExample) |
| HR (1) | HRP20050353B1 (enExample) |
| IL (1) | IL167723A (enExample) |
| IS (1) | IS2944B (enExample) |
| MA (1) | MA27521A1 (enExample) |
| MX (1) | MXPA05003394A (enExample) |
| NO (1) | NO20052089L (enExample) |
| NZ (1) | NZ539133A (enExample) |
| PT (1) | PT1572728E (enExample) |
| RS (1) | RS20050263A (enExample) |
| TW (1) | TWI362942B (enExample) |
| WO (1) | WO2004030617A2 (enExample) |
Families Citing this family (74)
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| US20060002935A1 (en) * | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| US8129330B2 (en) | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| US20040062748A1 (en) * | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| CN102319437B (zh) * | 2002-12-26 | 2017-10-13 | 山景医药公司 | 具有增强的生物学效用的干扰素‑β的聚合物缀合物 |
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| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
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| US7919118B2 (en) | 2003-05-12 | 2011-04-05 | Affymax, Inc. | Spacer moiety for poly (ethylene glycol) modified peptide based compounds |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
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| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
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| CA2552892C (en) | 2004-01-08 | 2014-08-05 | Neose Technologies, Inc. | O-linked glycosylation of peptides |
| EP1771066A2 (en) | 2004-07-13 | 2007-04-11 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1 |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| DK2586456T3 (en) | 2004-10-29 | 2016-03-21 | Ratiopharm Gmbh | Conversion and glycopegylation of fibroblast growth factor (FGF) |
| WO2006074467A2 (en) | 2005-01-10 | 2006-07-13 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
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| US20070154992A1 (en) | 2005-04-08 | 2007-07-05 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| US7858080B2 (en) * | 2005-05-20 | 2010-12-28 | Agency For Science, Technology And Research | Aldehyde conjugated flavonoid preparations |
| JP5216580B2 (ja) | 2005-05-25 | 2013-06-19 | ノヴォ ノルディスク アー/エス | グリコペグ化第ix因子 |
| US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
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| BRPI0720282B8 (pt) | 2006-12-15 | 2021-05-25 | Baxalta GmbH | construção proteica, composição farmacêutica, e, kit |
| JP2010523582A (ja) | 2007-04-03 | 2010-07-15 | バイオジェネリクス アクチェンゲゼルシャフト | グリコpeg化g−csfを用いた治療方法 |
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| RU2573587C2 (ru) | 2008-02-27 | 2016-01-20 | Ново Нордиск А/С | Конъюгированные молекулы фактора viii |
| CA2744235A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
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| US9795683B2 (en) | 2009-07-27 | 2017-10-24 | Lipoxen Technologies Limited | Glycopolysialylation of non-blood coagulation proteins |
| HRP20160916T1 (hr) | 2009-07-27 | 2016-11-18 | Baxalta GmbH | Konjugati proteina za koagulaciju krvi |
| CN104530182A (zh) | 2009-07-27 | 2015-04-22 | 利普森技术有限公司 | 非凝血蛋白的糖基多唾液酸化 |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| PL2521568T3 (pl) | 2010-01-06 | 2019-03-29 | Dyax Corp. | Białka wiążące kalikreinę osocza |
| US9981017B2 (en) | 2010-04-02 | 2018-05-29 | Hanmi Science Co., Ltd. | Insulin conjugate using an immunoglobulin fragment |
| AR081066A1 (es) * | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| US8846941B2 (en) | 2010-12-13 | 2014-09-30 | Quiapeg Ab | Functionalized polymers |
| SG191298A1 (en) | 2010-12-22 | 2013-07-31 | Baxter Int | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
| KR102502293B1 (ko) | 2011-01-06 | 2023-02-21 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
| JP5949037B2 (ja) | 2011-03-30 | 2016-07-06 | 日油株式会社 | 末端に複数の水酸基を有するポリオキシエチレン誘導体 |
| EP3628332A1 (en) | 2012-06-12 | 2020-04-01 | QuiaPEG Pharmaceuticals AB | Conjugates of biologically active molecules to functionalized polymers |
| PT2966083T (pt) * | 2013-03-05 | 2019-09-17 | Hanmi Pharm Ind Co Ltd | Método de preparação melhorado para produção de alto rendimento de conjugado de polipéptido fisiologicamente ativo |
| KR20230109785A (ko) | 2014-03-27 | 2023-07-20 | 다케다 파머수티컬 컴패니 리미티드 | 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법 |
| CN106470649A (zh) * | 2014-06-04 | 2017-03-01 | 兹姆生物科学公司 | 用于改善皮肤质量的组合物和方法 |
| EP3240579B1 (en) | 2014-12-31 | 2022-07-27 | Lantheus Medical Imaging, Inc. | Lipid-encapsulated gas microsphere compositions and related methods |
| WO2017100679A1 (en) | 2015-12-11 | 2017-06-15 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
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| US20210352892A1 (en) * | 2019-04-10 | 2021-11-18 | University Of Utah Research Foundation | Macromolecular and nonparticulate agrochemicals to reduce vapor drift |
| CN110376369B (zh) * | 2019-07-30 | 2022-02-15 | 重庆派金生物科技有限公司 | 一种抗聚乙二醇抗体的抗原区免疫原性分析方法 |
| CN114667281B (zh) * | 2019-10-29 | 2025-10-24 | 国立大学法人熊本大学 | 具有抗hiv活性的cd4模拟物化合物 |
| TW202228784A (zh) * | 2020-09-23 | 2022-08-01 | 奧地利商艾柏力維亞生技有限公司 | 用以於一患者中螯合非預期的抗peg抗體的化合物 |
| CN114392237B (zh) * | 2021-12-28 | 2024-02-02 | 上海允英生物医药科技有限公司 | 一种冻干病毒制剂及其制备方法 |
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| HU229888B1 (en) * | 1998-10-16 | 2014-11-28 | Biogen Idec Ma Inc Cambridge | Polymer conjugates of interferon betha-1a and uses |
| GB9822963D0 (en) | 1998-10-20 | 1998-12-16 | Agner Erik | Improvements in or relating to chromatography |
| US6596849B1 (en) * | 1999-05-28 | 2003-07-22 | Academia Sinica | Monoclonal-antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules |
| CA2386762C (en) | 1999-10-08 | 2009-06-16 | Shearwater Corporation | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
| US6638906B1 (en) * | 1999-12-13 | 2003-10-28 | Nobex Corporation | Amphiphilic polymers and polypeptide conjugates comprising same |
| US6639493B2 (en) | 2001-03-30 | 2003-10-28 | Arizona State University | Micro machined RF switches and methods of operating the same |
| WO2003002716A2 (en) * | 2001-06-28 | 2003-01-09 | Mountain View Pharmaceuticals, Inc. | Polymer stabilized proteinases |
| US6913915B2 (en) * | 2001-08-02 | 2005-07-05 | Phoenix Pharmacologics, Inc. | PEG-modified uricase |
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| US20040062748A1 (en) * | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
-
2002
- 2002-12-12 US US10/317,092 patent/US20040062748A1/en not_active Abandoned
-
2003
- 2003-09-25 PT PT37594454T patent/PT1572728E/pt unknown
- 2003-09-25 BR BRPI0314831A patent/BRPI0314831B8/pt not_active IP Right Cessation
- 2003-09-25 CN CN038248565A patent/CN1997661B/zh not_active Expired - Lifetime
- 2003-09-25 CA CA2836959A patent/CA2836959C/en not_active Expired - Lifetime
- 2003-09-25 MX MXPA05003394A patent/MXPA05003394A/es active IP Right Grant
- 2003-09-25 HR HRP20050353AA patent/HRP20050353B1/hr not_active IP Right Cessation
- 2003-09-25 JP JP2004541625A patent/JP5366352B2/ja not_active Expired - Fee Related
- 2003-09-25 CN CNA038248565A patent/CN1997661A/zh active Granted
- 2003-09-25 EA EA200500519A patent/EA009122B1/ru not_active IP Right Cessation
- 2003-09-25 CA CA2500389A patent/CA2500389C/en not_active Expired - Lifetime
- 2003-09-25 GE GEAP20038766A patent/GEP20074016B/en unknown
- 2003-09-25 NZ NZ539133A patent/NZ539133A/en not_active IP Right Cessation
- 2003-09-25 EP EP03759445.4A patent/EP1572728B1/en not_active Expired - Lifetime
- 2003-09-25 WO PCT/US2003/029989 patent/WO2004030617A2/en not_active Ceased
- 2003-09-25 DK DK03759445.4T patent/DK1572728T3/da active
- 2003-09-25 KR KR1020057005504A patent/KR101022577B1/ko not_active Expired - Fee Related
- 2003-09-25 RS YUP-2005/0263A patent/RS20050263A/sr unknown
- 2003-09-25 AU AU2003275176A patent/AU2003275176B8/en not_active Ceased
- 2003-09-25 ES ES03759445.4T patent/ES2504165T3/es not_active Expired - Lifetime
- 2003-09-25 EP EP12183751A patent/EP2535347A1/en not_active Withdrawn
- 2003-09-30 TW TW092127073A patent/TWI362942B/zh not_active IP Right Cessation
-
2005
- 2005-03-29 IL IL167723A patent/IL167723A/en active IP Right Grant
- 2005-03-29 CR CR7776A patent/CR7776A/es unknown
- 2005-03-30 IS IS7778A patent/IS2944B/is unknown
- 2005-04-05 EC EC2005005717A patent/ECSP055717A/es unknown
- 2005-04-28 NO NO20052089A patent/NO20052089L/no not_active Application Discontinuation
- 2005-04-29 MA MA28243A patent/MA27521A1/fr unknown
-
2011
- 2011-04-04 JP JP2011082665A patent/JP5603823B2/ja not_active Expired - Fee Related
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