JP2006509719A5 - - Google Patents
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- JP2006509719A5 JP2006509719A5 JP2004501400A JP2004501400A JP2006509719A5 JP 2006509719 A5 JP2006509719 A5 JP 2006509719A5 JP 2004501400 A JP2004501400 A JP 2004501400A JP 2004501400 A JP2004501400 A JP 2004501400A JP 2006509719 A5 JP2006509719 A5 JP 2006509719A5
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- Prior art keywords
- compound according
- optionally substituted
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37649702P | 2002-04-30 | 2002-04-30 | |
| PCT/GB2003/001817 WO2003093261A1 (en) | 2002-04-30 | 2003-04-29 | Phthalazinone derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006509719A JP2006509719A (ja) | 2006-03-23 |
| JP2006509719A5 true JP2006509719A5 (OSRAM) | 2006-05-11 |
| JP4500161B2 JP4500161B2 (ja) | 2010-07-14 |
Family
ID=29401357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004501400A Expired - Fee Related JP4500161B2 (ja) | 2002-04-30 | 2003-04-29 | フタラジノン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7196085B2 (OSRAM) |
| EP (1) | EP1501822B1 (OSRAM) |
| JP (1) | JP4500161B2 (OSRAM) |
| AT (1) | ATE491703T1 (OSRAM) |
| AU (1) | AU2003229953A1 (OSRAM) |
| CA (1) | CA2482806A1 (OSRAM) |
| DE (1) | DE60335359D1 (OSRAM) |
| ES (1) | ES2357057T3 (OSRAM) |
| WO (1) | WO2003093261A1 (OSRAM) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7151102B2 (en) * | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| GB0119865D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| GB0119863D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| AU2003229953A1 (en) | 2002-04-30 | 2003-11-17 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| EP1633724B1 (en) * | 2003-03-12 | 2011-05-04 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
| GB0317466D0 (en) | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
| JP2007501836A (ja) * | 2003-08-13 | 2007-02-01 | クドス ファーマシューティカルズ リミテッド | アミノピロン類及びａｔｍ阻害剤としてのその使用 |
| ES2371469T3 (es) * | 2003-12-01 | 2012-01-03 | Kudos Pharmaceuticals Limited | Inhibidores de reparación de daños en adn para el tratamiento del cáncer. |
| CN1905864B (zh) * | 2003-12-01 | 2011-04-06 | 库多斯药物有限公司 | 用于治疗癌症的dna损伤修复抑制剂 |
| JP2008510783A (ja) * | 2004-08-26 | 2008-04-10 | クドス ファーマシューティカルズ リミテッド | ４−ヘテロアリールメチル置換フタラジノン誘導体 |
| GB0419072D0 (en) * | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| CN101061111A (zh) * | 2004-09-20 | 2007-10-24 | 库多斯药物有限公司 | Dna－pk抑制剂 |
| GB0428111D0 (en) * | 2004-12-22 | 2005-01-26 | Kudos Pharm Ltd | Pthalazinone derivatives |
| TW200638938A (en) * | 2005-02-09 | 2006-11-16 | Kudos Pharm Ltd | ATM inhibitors |
| AR053358A1 (es) | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
| WO2007001684A2 (en) * | 2005-05-19 | 2007-01-04 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Inhibiting dna polymerase beta to enhance efficacy of anticancer agents |
| UY29774A1 (es) * | 2005-08-31 | 2007-03-30 | Kudos Pharm Ltd | Inhibidor de atm |
| GB0521373D0 (en) * | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
| EP2329818A1 (en) * | 2006-01-17 | 2011-06-08 | Abbott Laboratories | Combination therapy with PARP inhibitors |
| AU2007266840B2 (en) | 2006-05-31 | 2012-09-20 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Pyrrolo[1,2-A]pyrazin-1(2H)-one and pyrrolo[1,2-D][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase(PARP) |
| GB0610680D0 (en) | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| JP2009539962A (ja) * | 2006-06-15 | 2009-11-19 | クドス ファーマシューティカルズ リミテッド | Ｐａｒｐ阻害剤としての２−オキシヘテロアリールアミド誘導体 |
| EP2041087A1 (en) * | 2006-06-15 | 2009-04-01 | Kudos Pharmaceuticals Limited | 2 -oxybenzamide derivatives as parp inhibitors |
| WO2007144652A2 (en) * | 2006-06-15 | 2007-12-21 | Kudos Pharmaceuticals Limited | Parp inhibitors |
| UY30639A1 (es) * | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
| PL2120579T3 (pl) * | 2006-12-28 | 2014-04-30 | Abbvie Inc | Inhibitory polimerazy poli(ADP-rybozy) |
| US8466150B2 (en) * | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| EP2125750B1 (en) | 2007-02-26 | 2014-05-21 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US20080280910A1 (en) * | 2007-03-22 | 2008-11-13 | Keith Allan Menear | Phthalazinone derivatives |
| WO2008124836A2 (en) * | 2007-04-10 | 2008-10-16 | Uwm Research Foundation, Inc. | Methods of reducing virulence in bacteria |
| TW200900396A (en) * | 2007-04-10 | 2009-01-01 | Kudos Pharm Ltd | Phthalazinone derivatives |
| US20090023727A1 (en) * | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
| UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones | |
| US8329897B2 (en) | 2007-07-26 | 2012-12-11 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 |
| GB0716532D0 (en) | 2007-08-24 | 2007-10-03 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
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| WO2009050469A1 (en) * | 2007-10-17 | 2009-04-23 | Kudos Pharmaceuticals Limited | 4- [3- (4-cyclopropanecarbonyl-piperazine-i-carbonyl) -4 -fluoro-benzyl] -2h-phthalaz in-1-one |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| KR101641596B1 (ko) | 2007-11-15 | 2016-07-21 | 엠에스디 이탈리아 에스.알.엘. | Ｐａｒｐ 억제제로서의 피리다지논 유도체 |
| EP2222639A1 (en) | 2007-11-21 | 2010-09-01 | Decode Genetics EHF | Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| AR070221A1 (es) | 2008-01-23 | 2010-03-25 | Astrazeneca Ab | Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas. |
| JP5490020B2 (ja) | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター |
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| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| US8242111B2 (en) | 2008-05-01 | 2012-08-14 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| CA2723034A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| PL2300461T3 (pl) | 2008-05-01 | 2013-09-30 | Vitae Pharmaceuticals Inc | Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1 |
| US8569292B2 (en) | 2008-05-01 | 2013-10-29 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
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| PL2346495T5 (pl) | 2008-10-07 | 2024-06-10 | Kudos Pharmaceuticals Limited | Preparat farmaceutyczny 514 |
| EP2393807B1 (en) | 2009-02-04 | 2013-08-14 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1 |
| MA33216B1 (fr) | 2009-04-30 | 2012-04-02 | Boehringer Ingelheim Int | Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1 |
| JP5656986B2 (ja) | 2009-06-11 | 2015-01-21 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| JP5749263B2 (ja) | 2009-07-01 | 2015-07-15 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
| WO2011007145A1 (en) * | 2009-07-15 | 2011-01-20 | Astrazeneca Ab | Phthalazinone compound as parp inhibitor |
| CN102883602B (zh) | 2010-02-16 | 2017-07-18 | Uwm研究基金会有限公司 | 降低细菌的毒力的方法 |
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| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン |
| WO2012059416A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| CA2875025C (en) | 2011-05-31 | 2021-08-03 | Newgen Therapeutics, Inc. | Tricyclic inhibitors of poly(adp-ribose)polymerase |
| CN103130723B (zh) * | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
| KR101670126B1 (ko) | 2013-09-13 | 2016-10-27 | 일동제약(주) | 신규 프탈라지논 유도체 및 그 제조방법 |
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| CN114302744B (zh) | 2019-07-10 | 2025-08-26 | 赛博克萨3公司 | 作为治疗剂的微管靶向剂的肽缀合物 |
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| JP7626783B2 (ja) | 2020-04-21 | 2025-02-07 | アイディーエンス カンパニー リミテッド | フタラジノン誘導体及びその中間体を調製するプロセス |
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| DK4143182T3 (da) * | 2020-04-28 | 2025-03-03 | Rhizen Pharmaceuticals Ag | Nye forbindelser, der er anvendelige som poly(adp-ribose)-polymerase (parp)-hæmmere |
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| WO2024033374A1 (en) | 2022-08-11 | 2024-02-15 | Syngenta Crop Protection Ag | Novel arylcarboxamide or arylthioamide compounds |
| WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
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2003
- 2003-04-29 AU AU2003229953A patent/AU2003229953A1/en not_active Abandoned
- 2003-04-29 DE DE60335359T patent/DE60335359D1/de not_active Expired - Lifetime
- 2003-04-29 WO PCT/GB2003/001817 patent/WO2003093261A1/en not_active Ceased
- 2003-04-29 AT AT03722792T patent/ATE491703T1/de not_active IP Right Cessation
- 2003-04-29 US US10/426,147 patent/US7196085B2/en not_active Expired - Fee Related
- 2003-04-29 CA CA002482806A patent/CA2482806A1/en not_active Abandoned
- 2003-04-29 EP EP03722792A patent/EP1501822B1/en not_active Expired - Lifetime
- 2003-04-29 ES ES03722792T patent/ES2357057T3/es not_active Expired - Lifetime
- 2003-04-29 JP JP2004501400A patent/JP4500161B2/ja not_active Expired - Fee Related