JP2006508161A5 - - Google Patents
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- Publication number
- JP2006508161A5 JP2006508161A5 JP2004556337A JP2004556337A JP2006508161A5 JP 2006508161 A5 JP2006508161 A5 JP 2006508161A5 JP 2004556337 A JP2004556337 A JP 2004556337A JP 2004556337 A JP2004556337 A JP 2004556337A JP 2006508161 A5 JP2006508161 A5 JP 2006508161A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- group
- aryl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003446 ligand Substances 0.000 claims description 16
- 239000000758 substrate Substances 0.000 claims description 7
- 239000003054 catalyst Substances 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 19
- 125000005842 heteroatom Chemical group 0.000 claims 17
- 125000003118 aryl group Chemical group 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 229910052698 phosphorus Inorganic materials 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- -1 dicycloalkylamino Chemical group 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000005366 cycloalkylthio group Chemical group 0.000 claims 3
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 3
- 150000002576 ketones Chemical class 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004437 phosphorous atom Chemical group 0.000 claims 3
- 229910052710 silicon Inorganic materials 0.000 claims 3
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
- 125000005248 alkyl aryloxy group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 238000005984 hydrogenation reaction Methods 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- UQRONKZLYKUEMO-UHFFFAOYSA-N 4-methyl-1-(2,4,6-trimethylphenyl)pent-4-en-2-one Chemical group CC(=C)CC(=O)Cc1c(C)cc(C)cc1C UQRONKZLYKUEMO-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 150000001491 aromatic compounds Chemical class 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000004986 diarylamino group Chemical group 0.000 claims 1
- 239000003574 free electron Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000002466 imines Chemical class 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 229910052762 osmium Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052707 ruthenium Inorganic materials 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH20332002 | 2002-12-02 | ||
| PCT/EP2003/050902 WO2004050585A1 (en) | 2002-12-02 | 2003-11-27 | Catalytic hydrogeneration of carbon-heteroatom double bonds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006508161A JP2006508161A (ja) | 2006-03-09 |
| JP2006508161A5 true JP2006508161A5 (enExample) | 2006-11-02 |
Family
ID=32399972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004556337A Pending JP2006508161A (ja) | 2002-12-02 | 2003-11-27 | 炭素−ヘテロ原子二重結合の接触水素化 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7446236B2 (enExample) |
| EP (1) | EP1567464B1 (enExample) |
| JP (1) | JP2006508161A (enExample) |
| CN (1) | CN100384791C (enExample) |
| AT (1) | ATE359986T1 (enExample) |
| AU (1) | AU2003298328A1 (enExample) |
| CA (1) | CA2507908A1 (enExample) |
| DE (1) | DE60313357T2 (enExample) |
| ES (1) | ES2283867T3 (enExample) |
| WO (1) | WO2004050585A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1697358A1 (en) | 2003-12-19 | 2006-09-06 | Altana Pharma AG | Intermediates for the preparation of tricyclic dihydropyrano -imidazo -pyridines derivatives |
| KR101426220B1 (ko) | 2005-02-16 | 2014-08-05 | 아나코르 파마슈티칼스 인코포레이티드 | 보론함유 소분자 |
| CN106008583A (zh) | 2005-12-30 | 2016-10-12 | 安纳考尔医药公司 | 含硼的小分子 |
| CA2933994A1 (en) | 2006-02-16 | 2007-08-23 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
| WO2007104690A1 (en) * | 2006-03-10 | 2007-09-20 | Solvias Ag | Asymmetric catalytic hydrogenation of prochiral ketones and aldehydes |
| RU2015109165A (ru) | 2008-03-06 | 2015-11-10 | Анакор Фармасьютикалз, Инк. | Борсодержащие малые молекулы в качестве противовоспалительных агентов |
| WO2010028005A1 (en) * | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2010027975A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| ES2863542T3 (es) * | 2009-03-17 | 2021-10-11 | Johnson Matthey Plc | Proceso para la hidrogenación de cetonas en presencia de catalizadores de Ru (II) |
| AP4039A (en) | 2009-08-14 | 2017-02-28 | Daitao Chen | Boron-containing small molecules as antiprotozoal agents |
| WO2011049971A1 (en) | 2009-10-20 | 2011-04-28 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| WO2011060196A1 (en) * | 2009-11-11 | 2011-05-19 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2011094450A1 (en) | 2010-01-27 | 2011-08-04 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules |
| AP2012006482A0 (en) | 2010-03-19 | 2012-10-31 | Anacor Pharmacueticals Inc | Boron-containing small molecules as anti-protozoalagent |
| AU2011237681B2 (en) * | 2010-04-07 | 2015-01-22 | Glaxosmithkline Llc | Process for preparing benzoxaboroles |
| MX338209B (es) | 2010-09-07 | 2016-04-07 | Anacor Pharmaceuticals Inc | Derivados de benzoxaborol para tratar infecciones bacterianas. |
| SG11201600787PA (en) | 2013-08-09 | 2016-03-30 | Glaxosmithkline Ip No 2 Ltd | Tricyclic benzoxaborole compounds and uses thereof |
| GB201401230D0 (en) * | 2014-01-24 | 2014-03-12 | Givaudan Sa | Improvements in or relating to organic compounds |
| MA41494B1 (fr) | 2015-02-12 | 2020-10-28 | Glaxosmithkline Ip No 2 Ltd | Composés benzoxaborole substitués en position 4 et utilisations associées |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2693190B1 (fr) * | 1992-07-02 | 1994-09-23 | Elf Aquitaine | Procédé d'hydrogénation énantiosélectif de la double liaison C=O OXO. |
| US6476233B1 (en) * | 1998-11-12 | 2002-11-05 | The Penn State Research Foundation | Transition metal-catalyzed reactions based on chiral amine oxazolinyl ligands and related compounds |
| NL1015655C2 (nl) | 2000-07-07 | 2002-01-08 | Dsm Nv | Katalysator voor de asymmetrische hydrogenering. |
| IL154822A0 (en) * | 2000-09-13 | 2003-10-31 | Firmenich & Cie | Catalytic hydrogenation processes |
-
2003
- 2003-11-27 AU AU2003298328A patent/AU2003298328A1/en not_active Abandoned
- 2003-11-27 ES ES03796062T patent/ES2283867T3/es not_active Expired - Lifetime
- 2003-11-27 CN CNB2003801045565A patent/CN100384791C/zh not_active Expired - Lifetime
- 2003-11-27 DE DE60313357T patent/DE60313357T2/de not_active Expired - Lifetime
- 2003-11-27 CA CA002507908A patent/CA2507908A1/en not_active Abandoned
- 2003-11-27 US US10/536,883 patent/US7446236B2/en not_active Expired - Lifetime
- 2003-11-27 WO PCT/EP2003/050902 patent/WO2004050585A1/en not_active Ceased
- 2003-11-27 AT AT03796062T patent/ATE359986T1/de not_active IP Right Cessation
- 2003-11-27 EP EP03796062A patent/EP1567464B1/en not_active Expired - Lifetime
- 2003-11-27 JP JP2004556337A patent/JP2006508161A/ja active Pending
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