JP2006507235A5 - - Google Patents
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- Publication number
- JP2006507235A5 JP2006507235A5 JP2004526388A JP2004526388A JP2006507235A5 JP 2006507235 A5 JP2006507235 A5 JP 2006507235A5 JP 2004526388 A JP2004526388 A JP 2004526388A JP 2004526388 A JP2004526388 A JP 2004526388A JP 2006507235 A5 JP2006507235 A5 JP 2006507235A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- independently hydrogen
- hydrogen
- aryl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 154
- 229910052739 hydrogen Inorganic materials 0.000 claims 154
- 239000001257 hydrogen Substances 0.000 claims 154
- 150000002431 hydrogen Chemical class 0.000 claims 116
- 125000003342 alkenyl group Chemical group 0.000 claims 59
- 125000003118 aryl group Chemical group 0.000 claims 59
- 229910052794 bromium Inorganic materials 0.000 claims 57
- 229910052801 chlorine Inorganic materials 0.000 claims 57
- 229910052731 fluorine Inorganic materials 0.000 claims 57
- 229910052736 halogen Inorganic materials 0.000 claims 57
- 150000002367 halogens Chemical class 0.000 claims 57
- 229910052740 iodine Inorganic materials 0.000 claims 57
- 125000003710 aryl alkyl group Chemical group 0.000 claims 50
- 125000000539 amino acid group Chemical group 0.000 claims 47
- 125000002947 alkylene group Chemical group 0.000 claims 40
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 38
- 125000003545 alkoxy group Chemical group 0.000 claims 38
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 38
- 125000002577 pseudohalo group Chemical group 0.000 claims 38
- 125000001072 heteroaryl group Chemical group 0.000 claims 31
- 125000000623 heterocyclic group Chemical group 0.000 claims 31
- 150000001875 compounds Chemical class 0.000 claims 30
- 229910052760 oxygen Inorganic materials 0.000 claims 28
- 150000003839 salts Chemical class 0.000 claims 28
- 229910052717 sulfur Inorganic materials 0.000 claims 25
- 239000003937 drug carrier Substances 0.000 claims 24
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 125000002252 acyl group Chemical group 0.000 claims 19
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims 19
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 19
- 208000015181 infectious disease Diseases 0.000 claims 18
- 229910052711 selenium Inorganic materials 0.000 claims 16
- -1 carbocycle Chemical group 0.000 claims 15
- 108010050904 Interferons Proteins 0.000 claims 12
- 102000014150 Interferons Human genes 0.000 claims 12
- 125000004103 aminoalkyl group Chemical group 0.000 claims 12
- 125000005001 aminoaryl group Chemical group 0.000 claims 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 12
- 229940079322 interferon Drugs 0.000 claims 12
- 239000001301 oxygen Substances 0.000 claims 12
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- 239000011593 sulfur Substances 0.000 claims 9
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 229940124597 therapeutic agent Drugs 0.000 claims 8
- SCVHJVCATBPIHN-SJCJKPOMSA-N (3s)-3-[[(2s)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid Chemical compound N([C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)COC=1C(=C(F)C=C(F)C=1F)F)C(=O)C(=O)NC1=CC=CC=C1C(C)(C)C SCVHJVCATBPIHN-SJCJKPOMSA-N 0.000 claims 6
- 108010005716 Interferon beta-1a Proteins 0.000 claims 6
- 108010078233 Thymalfasin Proteins 0.000 claims 6
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 6
- 239000003443 antiviral agent Substances 0.000 claims 6
- 229950000234 emricasan Drugs 0.000 claims 6
- PPZMYIBUHIPZOS-UHFFFAOYSA-N histamine dihydrochloride Chemical compound Cl.Cl.NCCC1=CN=CN1 PPZMYIBUHIPZOS-UHFFFAOYSA-N 0.000 claims 6
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 claims 6
- 229960004231 thymalfasin Drugs 0.000 claims 6
- 229960004295 valine Drugs 0.000 claims 6
- 108010010648 interferon alfacon-1 Proteins 0.000 claims 4
- IWUCXVSUMQZMFG-RGDLXGNYSA-N 1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide Chemical compound N1=C(C(=O)N)N=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 IWUCXVSUMQZMFG-RGDLXGNYSA-N 0.000 claims 3
- ABEXEQSGABRUHS-UHFFFAOYSA-N 16-methylheptadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C ABEXEQSGABRUHS-UHFFFAOYSA-N 0.000 claims 3
- 108010078049 Interferon alpha-2 Proteins 0.000 claims 3
- 108010047761 Interferon-alpha Proteins 0.000 claims 3
- 102000006992 Interferon-alpha Human genes 0.000 claims 3
- 102000003814 Interleukin-10 Human genes 0.000 claims 3
- 108090000174 Interleukin-10 Proteins 0.000 claims 3
- 241000764238 Isis Species 0.000 claims 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-Valine Natural products CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 3
- 125000003580 L-valyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(C([H])([H])[H])(C([H])([H])[H])[H] 0.000 claims 3
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical group N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 3
- 102400000800 Thymosin alpha-1 Human genes 0.000 claims 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 3
- 229960003805 amantadine Drugs 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 229960001340 histamine Drugs 0.000 claims 3
- 229960004931 histamine dihydrochloride Drugs 0.000 claims 3
- 102000011749 human hepatitis C immune globulin Human genes 0.000 claims 3
- 108010062138 human hepatitis C immune globulin Proteins 0.000 claims 3
- 238000005417 image-selected in vivo spectroscopy Methods 0.000 claims 3
- 238000012739 integrated shape imaging system Methods 0.000 claims 3
- 229960003521 interferon alfa-2a Drugs 0.000 claims 3
- 229960003358 interferon alfacon-1 Drugs 0.000 claims 3
- 229960004461 interferon beta-1a Drugs 0.000 claims 3
- 229940076144 interleukin-10 Drugs 0.000 claims 3
- 229940002988 pegasys Drugs 0.000 claims 3
- 108010092853 peginterferon alfa-2a Proteins 0.000 claims 3
- 229940038850 rebif Drugs 0.000 claims 3
- 229960000329 ribavirin Drugs 0.000 claims 3
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 3
- NHKZSTHOYNWEEZ-AFCXAGJDSA-N taribavirin Chemical compound N1=C(C(=N)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NHKZSTHOYNWEEZ-AFCXAGJDSA-N 0.000 claims 3
- 229950006081 taribavirin Drugs 0.000 claims 3
- 239000004474 valine Substances 0.000 claims 3
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 229940090438 infergen Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 0 C[C@@](C([C@@](*)(C1)O2)OC2=S)OCC1[n]1nnc(C(N2)=O)c1NC2=O Chemical compound C[C@@](C([C@@](*)(C1)O2)OC2=S)OCC1[n]1nnc(C(N2)=O)c1NC2=O 0.000 description 5
- VQJNXQICGCPJNJ-YUMJJMQISA-N CC(C)(CC12)OC1C(C[n]1n[n-]c(C(N3)=S)c11)O[C@H]2N1C3=O Chemical compound CC(C)(CC12)OC1C(C[n]1n[n-]c(C(N3)=S)c11)O[C@H]2N1C3=O VQJNXQICGCPJNJ-YUMJJMQISA-N 0.000 description 1
- KQRSVWIORINOKB-ACJOCUEISA-N CN(C(c(nn[n]1C2)c1N1[C@@H](C3O)O[C@H]2[C@@H]3O)=O)C1=O Chemical compound CN(C(c(nn[n]1C2)c1N1[C@@H](C3O)O[C@H]2[C@@H]3O)=O)C1=O KQRSVWIORINOKB-ACJOCUEISA-N 0.000 description 1
- WLJKCZVHEMOUFK-CSWMIUAYSA-N CN(C)C(C([N-][NH+](N1C[C@@H](C2)[C@@H]3O)/[O]=C(\C=C4)/N5c6c4nn[n]6C[C@H]4O[C@@H]5CC4=O)=C1N1[C@H]2C3O)=NC1=O Chemical compound CN(C)C(C([N-][NH+](N1C[C@@H](C2)[C@@H]3O)/[O]=C(\C=C4)/N5c6c4nn[n]6C[C@H]4O[C@@H]5CC4=O)=C1N1[C@H]2C3O)=NC1=O WLJKCZVHEMOUFK-CSWMIUAYSA-N 0.000 description 1
- YRGGJVPXWDISKE-RKBOWSCOSA-N O=C(C=C1)N2c3c1nn[n]3C[C@H]([C@@H]1O3)O[C@@H]2[C@H]1OC3=S Chemical compound O=C(C=C1)N2c3c1nn[n]3C[C@H]([C@@H]1O3)O[C@@H]2[C@H]1OC3=S YRGGJVPXWDISKE-RKBOWSCOSA-N 0.000 description 1
- XWHZXQKXLMRJDA-UKPFUCPKSA-N OC([C@@H](C[n]1nnc(C(N2)=S)c11)O[C@H]3N1C2=O)[C@@H]3O Chemical compound OC([C@@H](C[n]1nnc(C(N2)=S)c11)O[C@H]3N1C2=O)[C@@H]3O XWHZXQKXLMRJDA-UKPFUCPKSA-N 0.000 description 1
- BQGPSQMCORFWQS-ACJOCUEISA-N O[C@@H]([C@@H](C[n]1c2c(C(N3)=O)nc1)O[C@H]1N2C3=O)C1O Chemical compound O[C@@H]([C@@H](C[n]1c2c(C(N3)=O)nc1)O[C@H]1N2C3=O)C1O BQGPSQMCORFWQS-ACJOCUEISA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45371602P | 2002-08-01 | 2002-08-01 | |
| US60/453,716 | 2002-08-01 | ||
| PCT/US2003/024324 WO2004013300A2 (en) | 2002-08-01 | 2003-08-01 | Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006507235A JP2006507235A (ja) | 2006-03-02 |
| JP2006507235A5 true JP2006507235A5 (enExample) | 2006-09-28 |
Family
ID=31496098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004526388A Pending JP2006507235A (ja) | 2002-08-01 | 2003-08-01 | フラビウイルス科ウイルス感染治療のためのビシクロ［４．２．１］ノナン系を有する化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8093380B2 (enExample) |
| EP (1) | EP1545545A4 (enExample) |
| JP (1) | JP2006507235A (enExample) |
| KR (1) | KR20050040912A (enExample) |
| AU (1) | AU2003257157C1 (enExample) |
| BR (1) | BR0313164A (enExample) |
| CA (1) | CA2494340C (enExample) |
| IL (1) | IL166640A0 (enExample) |
| MX (1) | MXPA05001298A (enExample) |
| SG (1) | SG174624A1 (enExample) |
| WO (1) | WO2004013300A2 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ298749B6 (cs) | 1996-10-18 | 2008-01-16 | Vertex Pharmaceuticals Incorporated | Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| WO2004084796A2 (en) * | 2003-03-28 | 2004-10-07 | Pharmasset Ltd. | Compounds for the treatment of flaviviridae infections |
| BRPI0419345B8 (pt) | 2003-05-30 | 2021-05-25 | Gilead Pharmasset Llc | uso do (2r)-2-desoxi-2-flúor-2-c-metil nucleosídeo e de uma composição farmacêutica que o compreende |
| DK1658302T3 (da) | 2003-07-25 | 2010-11-22 | Idenix Pharmaceuticals Inc | Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis C |
| WO2005018330A1 (en) * | 2003-08-18 | 2005-03-03 | Pharmasset, Inc. | Dosing regimen for flaviviridae therapy |
| PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
| US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
| US7534767B2 (en) | 2004-06-15 | 2009-05-19 | Merck & Co., Inc. | C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase |
| WO2006000922A2 (en) * | 2004-06-23 | 2006-01-05 | Idenix (Cayman) Limited | 5-aza-7-deazapurine derivatives for treating infections with flaviviridae |
| CA2571079A1 (en) | 2004-06-24 | 2006-02-02 | Merck & Co., Inc. | Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection |
| CA2583472A1 (en) * | 2004-10-01 | 2006-04-13 | Chao Lin | Hcv ns3-ns4a protease inhibition |
| MY141025A (en) | 2004-10-29 | 2010-02-25 | Vertex Pharma | Dose forms |
| WO2006119061A2 (en) | 2005-05-02 | 2006-11-09 | Merck & Co., Inc. | Hcv ns3 protease inhibitors |
| US20070004635A1 (en) * | 2005-06-02 | 2007-01-04 | Schering Corporation | Method of treating interferon non-responders using HCV protease inhibitor |
| TWI387603B (zh) | 2005-07-20 | 2013-03-01 | Merck Sharp & Dohme | Ｈｃｖ ｎｓ３蛋白酶抑制劑 |
| KR20080036598A (ko) | 2005-08-01 | 2008-04-28 | 머크 앤드 캄파니 인코포레이티드 | Ｈｃｖ ｎｓ３ 프로테아제 억제제로서의 마크로사이클릭펩티드 |
| CA2617679A1 (en) * | 2005-08-02 | 2007-02-08 | Steve Lyons | Inhibitors of serine proteases |
| AR055395A1 (es) * | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| US7964624B1 (en) * | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| US20100087388A1 (en) | 2005-10-03 | 2010-04-08 | Kotra Lakshmi P | Odcase inhibitors as anti-virals and antibiotics |
| CA2643688A1 (en) | 2006-02-27 | 2007-08-30 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| WO2007109080A2 (en) | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis c protease inhibitors |
| GB0609492D0 (en) | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| GB0612423D0 (en) | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| AU2007309488B2 (en) | 2006-10-24 | 2012-10-11 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
| AU2007309546A1 (en) | 2006-10-24 | 2008-05-02 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | HCV NS3 protease inhibitors |
| EP2079479B1 (en) | 2006-10-24 | 2014-11-26 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
| CA2667031C (en) | 2006-10-27 | 2013-01-22 | Merck & Co., Inc. | Hcv ns3 protease inhibitors |
| CN101568346B (zh) | 2006-10-27 | 2015-11-25 | 默沙东公司 | Hcv ns3蛋白酶抑制剂 |
| JP2010512365A (ja) * | 2006-12-11 | 2010-04-22 | エフ．ホフマン−ラ ロシュ アーゲー | ４’−アジドシチジン誘導体の製造方法 |
| GB0625345D0 (en) | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| CA2672250C (en) | 2006-12-20 | 2013-04-30 | Ian Stansfield | Antiviral indoles |
| GB0625349D0 (en) | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| US8071568B2 (en) | 2007-01-05 | 2011-12-06 | Merck Sharp & Dohme Corp. | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection |
| GEP20125645B (en) * | 2007-02-27 | 2012-09-25 | Vertex Pharma | Co-crystals and pharmaceutical compositions comprising the same |
| WO2008106058A2 (en) * | 2007-02-27 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| JP2010533699A (ja) | 2007-07-17 | 2010-10-28 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | Ｃ型肝炎感染症の治療のための大環状インドール誘導体 |
| AU2008277377B2 (en) | 2007-07-19 | 2013-08-01 | Msd Italia S.R.L. | Macrocyclic compounds as antiviral agents |
| WO2009032198A1 (en) * | 2007-08-30 | 2009-03-12 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| EP2271345B1 (en) | 2008-04-28 | 2015-05-20 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
| ME02024B (me) | 2008-07-22 | 2015-05-20 | Merck Sharp & Dohme | Makrociklična jedinjenja hinoksalina kao inhibitori hcv ns3 proteaze |
| WO2010082050A1 (en) | 2009-01-16 | 2010-07-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections |
| GB0900914D0 (en) | 2009-01-20 | 2009-03-04 | Angeletti P Ist Richerche Bio | Antiviral agents |
| EP2396028A2 (en) | 2009-02-12 | 2011-12-21 | Vertex Pharmceuticals Incorporated | Hcv combination therapies comprising pegylated interferon, ribavirin and telaprevir |
| WO2011014487A1 (en) | 2009-07-30 | 2011-02-03 | Merck Sharp & Dohme Corp. | Hepatitis c virus ns3 protease inhibitors |
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| CN102844030A (zh) | 2010-01-29 | 2012-12-26 | 沃泰克斯药物股份有限公司 | 用于治疗丙型肝炎病毒感染的疗法 |
| WO2011156545A1 (en) | 2010-06-09 | 2011-12-15 | Vertex Pharmaceuticals Incorporated | Viral dynamic model for hcv combination therapy |
| EP2593105A1 (en) | 2010-07-14 | 2013-05-22 | Vertex Pharmaceuticals Incorporated | Palatable pharmaceutical composition comprising vx-950 |
| WO2012109646A1 (en) | 2011-02-11 | 2012-08-16 | Vertex Pharmaceuticals Incorporated | Treatment of hcv in hiv infection patients |
| WO2013074386A2 (en) | 2011-11-15 | 2013-05-23 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
| US20130195797A1 (en) | 2012-01-31 | 2013-08-01 | Vertex Pharmaceuticals Incorporated | High potency formulations of vx-950 |
| AU2013221571A1 (en) | 2012-02-14 | 2014-08-28 | University Of Georgia Research Foundation, Inc. | Spiro [2.4] heptanes for treatment of Flaviviridae infections |
| WO2014121418A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
| WO2014121417A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
| GEP20217282B (en) | 2015-03-06 | 2021-08-10 | Atea Pharmaceuticals Inc | β-D-2'-DEOXY-2'α-FLUORO-2'-β-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT |
| WO2018013937A1 (en) | 2016-07-14 | 2018-01-18 | Atea Pharmaceuticals, Inc. | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| PT3512863T (pt) | 2016-09-07 | 2022-03-09 | Atea Pharmaceuticals Inc | Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna |
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- 2003-08-01 JP JP2004526388A patent/JP2006507235A/ja active Pending
- 2003-08-01 MX MXPA05001298A patent/MXPA05001298A/es active IP Right Grant
- 2003-08-01 AU AU2003257157A patent/AU2003257157C1/en not_active Ceased
- 2003-08-01 CA CA2494340A patent/CA2494340C/en not_active Expired - Fee Related
- 2003-08-01 BR BRPI0313164-5A patent/BR0313164A/pt not_active IP Right Cessation
- 2003-08-01 EP EP03767138A patent/EP1545545A4/en not_active Withdrawn
- 2003-08-01 WO PCT/US2003/024324 patent/WO2004013300A2/en not_active Ceased
- 2003-08-01 KR KR1020057001868A patent/KR20050040912A/ko not_active Ceased
- 2003-08-01 US US10/632,997 patent/US8093380B2/en not_active Expired - Fee Related
- 2003-08-01 IL IL16664003A patent/IL166640A0/xx unknown
- 2003-08-01 SG SG2007015332A patent/SG174624A1/en unknown
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