JP2009515980A5 - - Google Patents
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- Publication number
- JP2009515980A5 JP2009515980A5 JP2008541300A JP2008541300A JP2009515980A5 JP 2009515980 A5 JP2009515980 A5 JP 2009515980A5 JP 2008541300 A JP2008541300 A JP 2008541300A JP 2008541300 A JP2008541300 A JP 2008541300A JP 2009515980 A5 JP2009515980 A5 JP 2009515980A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- medicament
- manufacture
- compound
- pharmaceutically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000001931 aliphatic group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 230000014399 negative regulation of angiogenesis Effects 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- BFZWDYZNSLLKKO-UHFFFAOYSA-N N#CNN[N+]([O-])=O Chemical compound N#CNN[N+]([O-])=O BFZWDYZNSLLKKO-UHFFFAOYSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73678005P | 2005-11-14 | 2005-11-14 | |
| US60/736,780 | 2005-11-14 | ||
| PCT/US2006/044305 WO2007059195A1 (en) | 2005-11-14 | 2006-11-14 | Integrin-binding small molecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009515980A JP2009515980A (ja) | 2009-04-16 |
| JP2009515980A5 true JP2009515980A5 (enExample) | 2010-01-14 |
| JP5199108B2 JP5199108B2 (ja) | 2013-05-15 |
Family
ID=38048975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541300A Expired - Fee Related JP5199108B2 (ja) | 2005-11-14 | 2006-11-14 | インテグリン結合小分子 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7928113B2 (enExample) |
| EP (2) | EP1959958A4 (enExample) |
| JP (1) | JP5199108B2 (enExample) |
| CA (1) | CA2629815C (enExample) |
| WO (1) | WO2007059195A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7811572B2 (en) | 2005-08-24 | 2010-10-12 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| WO2009051909A1 (en) * | 2007-10-16 | 2009-04-23 | The Regents Of The University Of California | Compounds having activity in correcting mutant-cftr cellular processing and uses thereof |
| US8916149B2 (en) | 2008-11-03 | 2014-12-23 | University Of Rochester | Preventing and treating sepsis |
| US9795442B2 (en) | 2008-11-11 | 2017-10-24 | Shifamed Holdings, Llc | Ablation catheters |
| JP5784592B2 (ja) | 2009-06-03 | 2015-09-24 | イミュノジェン・インコーポレーテッド | 抱合方法 |
| EP2338537A2 (de) * | 2009-12-21 | 2011-06-29 | Biotronik VI Patent AG | Aptamer beschichtetes Implantat, Herstellverfahren und Verwendungen |
| US9005670B2 (en) | 2010-01-05 | 2015-04-14 | The Johns Hopkins University | Use of histone acetyltransferase inhibitors as novel anti-cancer therapies |
| US8686048B2 (en) * | 2010-05-06 | 2014-04-01 | Rhizen Pharmaceuticals Sa | Immunomodulator and anti-inflammatory compounds |
| CA2797130A1 (en) | 2010-05-12 | 2011-11-17 | Shifamed Holdings, Llc | Low profile electrode assembly |
| US9655677B2 (en) | 2010-05-12 | 2017-05-23 | Shifamed Holdings, Llc | Ablation catheters including a balloon and electrodes |
| WO2012007137A1 (en) * | 2010-07-16 | 2012-01-19 | Merck Patent Gmbh | Peptide for use in the treatment of breast cancer and/or bone metastases |
| AU2011346670B2 (en) | 2010-12-23 | 2015-05-07 | Pfizer Inc. | Glucagon receptor modulators |
| PH12013501557A1 (en) | 2011-02-08 | 2019-06-03 | Pfizer | Glucagon receptor modulator |
| EA033468B1 (ru) | 2011-03-29 | 2019-10-31 | Immunogen Inc | Способы получения конъюгата "антитело-майтансиноид" |
| RU2013157388A (ru) | 2011-07-22 | 2015-08-27 | Пфайзер Инк. | Хинолинильные модуляторы глюкагонового рецептора |
| WO2013057183A1 (en) * | 2011-10-20 | 2013-04-25 | Avienne Pharmaceuticals Gmbh | Compositions for controlling vascularization in ophthalmological and dermatological diseases |
| CN104093425A (zh) * | 2011-12-13 | 2014-10-08 | 伊缪诺金公司 | N-羟基琥珀酰亚胺用于改善缀合物的稳定性的用途 |
| CA2820547A1 (en) | 2012-07-02 | 2014-01-02 | University Of South Florida (A Florida Non-Profit Corporation) | Rgd mimetic y-aapeptides and methods of use |
| EP2904089A4 (en) | 2012-10-04 | 2016-05-25 | Immunogen Inc | USE OF A PVDF MEMBRANE FOR PURIFYING CELL BINDING AGENT-CYTOTOXIC AGENT CONJUGATES |
| US10349824B2 (en) | 2013-04-08 | 2019-07-16 | Apama Medical, Inc. | Tissue mapping and visualization systems |
| CN110141177B (zh) | 2013-04-08 | 2021-11-23 | 阿帕玛医疗公司 | 消融导管 |
| US10098694B2 (en) | 2013-04-08 | 2018-10-16 | Apama Medical, Inc. | Tissue ablation and monitoring thereof |
| ITMI20131410A1 (it) * | 2013-08-26 | 2015-02-27 | Univ Degli Studi Modena E Reggio Emilia | Composti e composizioni per l'uso nella inibizione dell' interazione lbc-rhoa |
| WO2015031084A1 (en) | 2013-08-28 | 2015-03-05 | Jianfeng Cai | Methods of synthesizing y-aapeptides, y-aapeptide building blocks, y-aapeptide libraries, and y-aapeptide inhibitors of ab40 aggregates |
| EP3054996B1 (en) | 2013-10-07 | 2023-06-21 | IGL Pharma, Inc. | Process for preparing high purity therapeutic bone agents |
| US10155754B2 (en) | 2014-05-28 | 2018-12-18 | Universitat Bern | Substituted 2-imino-1,3-thiazolidin-4-ones as N-arachidonoylethanolamine cellular uptake inhibitors |
| EP2952188A1 (en) * | 2014-06-03 | 2015-12-09 | Universität Bern | Thiazolidinones as cellular anandamide uptake inhibitors and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation |
| US10300048B2 (en) | 2014-05-28 | 2019-05-28 | Universitat Bern | Thiazolidinones as cellular anandamide uptake inhibitors and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation |
| EP2987533B1 (en) * | 2014-08-21 | 2018-07-11 | King Saud University | 7-substituted piperazin-1-yl fluoroquinolone compounds, their use in the treatment of cancer, pharmaceutical compositions and a method for preparation |
| CN108348146A (zh) | 2015-11-16 | 2018-07-31 | 阿帕玛医疗公司 | 能量传递装置 |
| EP3207937A1 (en) | 2016-02-17 | 2017-08-23 | Royal College of Surgeons in Ireland | A method of treating or preventing sepsis |
| CA3045944A1 (en) | 2016-12-07 | 2018-06-14 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CN116712540A (zh) | 2016-12-14 | 2023-09-08 | 比奥拉治疗股份有限公司 | 使用整联蛋白抑制剂治疗胃肠道疾病 |
| US20200109205A1 (en) * | 2017-03-31 | 2020-04-09 | The Regents Of The University Of California | Compositions and methods for targeting and killing alpha-v beta-3-positive cancer stem cells (cscs) and treating drug resistant cancers |
| JOP20180092A1 (ar) | 2017-10-13 | 2019-04-13 | Gilead Sciences Inc | مثبطات hiv بروتياز |
| EP3810085A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| CN113348011B (zh) | 2018-11-19 | 2023-04-18 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| TW202104210A (zh) | 2019-04-17 | 2021-02-01 | 美商基利科學股份有限公司 | Hiv蛋白酶抑制劑 |
| CN121197633A (zh) | 2019-12-13 | 2025-12-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| CN112028833B (zh) * | 2020-09-25 | 2022-07-05 | 西南大学 | 对氨基水杨酸唑类衍生物及其制备方法和应用 |
| JP2024512824A (ja) | 2021-01-22 | 2024-03-19 | ロイヤル カレッジ オブ サージャンズ イン アイルランド | コロナウイルスの治療 |
| CN116730925A (zh) * | 2023-08-08 | 2023-09-12 | 中国药科大学 | 一种杂环类免疫抑制剂及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL52895A (en) * | 1976-09-07 | 1981-01-30 | Sparamedica Ag | 5-(indol-3-ylmethylene)-1,3-dimethyl-2-methylimino-4-imidazolidinone derivatives,their preparation and pharmaceutica compositions containing them |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| DE4126277A1 (de) * | 1991-08-08 | 1993-02-11 | Cassella Ag | Hydantoinderivate |
| JP2879395B2 (ja) * | 1992-10-26 | 1999-04-05 | 富士写真フイルム株式会社 | ロダシアニン化合物及びシクロデキストリンを含有する抗癌性組成物 |
| JPH06220053A (ja) * | 1992-11-17 | 1994-08-09 | Fuji Photo Film Co Ltd | 水溶性メチン化合物 |
| US5618831A (en) * | 1992-11-17 | 1997-04-08 | Fuji Photo Film Co., Ltd. | Composition and method for treating cancer |
| DE69829891T2 (de) * | 1997-04-07 | 2005-10-06 | Genentech, Inc., South San Francisco | Anti-VEGF Antikörper |
| WO1998053790A2 (en) * | 1997-05-30 | 1998-12-03 | Texas Biotechnology Corporation | Compounds that inhibit the binding of vascular endothelial growth factor to its receptors |
| US6756196B2 (en) | 1999-06-28 | 2004-06-29 | Millennium Pharmaceuticals, Inc. | Molecules of the card-related protein family and uses thereof |
| JP4258167B2 (ja) * | 2002-04-11 | 2009-04-30 | 大正製薬株式会社 | ベンジリデン誘導体 |
| BR0203747A (pt) * | 2002-09-10 | 2004-05-25 | Conselho Nacional Cnpq | Moléculas com atividade antitumoral e processo para a sua obtenção |
| BRPI0416752B8 (pt) * | 2003-11-21 | 2021-05-25 | Actelion Pharmaceuticals Ltd | composição farmacêutica, uso de um ou mais compostos, e, compostos |
-
2006
- 2006-11-14 WO PCT/US2006/044305 patent/WO2007059195A1/en not_active Ceased
- 2006-11-14 EP EP06837643A patent/EP1959958A4/en not_active Withdrawn
- 2006-11-14 US US11/559,857 patent/US7928113B2/en not_active Expired - Fee Related
- 2006-11-14 JP JP2008541300A patent/JP5199108B2/ja not_active Expired - Fee Related
- 2006-11-14 EP EP11150187A patent/EP2298308B1/en not_active Not-in-force
- 2006-11-14 CA CA2629815A patent/CA2629815C/en not_active Expired - Fee Related
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