JP2006504624A5 - - Google Patents
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- Publication number
- JP2006504624A5 JP2006504624A5 JP2003579751A JP2003579751A JP2006504624A5 JP 2006504624 A5 JP2006504624 A5 JP 2006504624A5 JP 2003579751 A JP2003579751 A JP 2003579751A JP 2003579751 A JP2003579751 A JP 2003579751A JP 2006504624 A5 JP2006504624 A5 JP 2006504624A5
- Authority
- JP
- Japan
- Prior art keywords
- heterocyclo
- group
- alkyl
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36824902P | 2002-03-28 | 2002-03-28 | |
| US40211802P | 2002-08-08 | 2002-08-08 | |
| PCT/US2003/009550 WO2003082208A2 (en) | 2002-03-28 | 2003-03-26 | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006504624A JP2006504624A (ja) | 2006-02-09 |
| JP2006504624A5 true JP2006504624A5 (enExample) | 2006-04-20 |
| JP4589005B2 JP4589005B2 (ja) | 2010-12-01 |
Family
ID=28678223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003579751A Expired - Fee Related JP4589005B2 (ja) | 2002-03-28 | 2003-03-26 | ピロロピリダジン化合物および増殖性疾患治療におけるその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6900208B2 (enExample) |
| EP (1) | EP1578351B1 (enExample) |
| JP (1) | JP4589005B2 (enExample) |
| AR (1) | AR039189A1 (enExample) |
| AT (1) | ATE490964T1 (enExample) |
| AU (1) | AU2003223380A1 (enExample) |
| CL (1) | CL2008003391A1 (enExample) |
| DE (1) | DE60335293D1 (enExample) |
| PE (1) | PE20040168A1 (enExample) |
| PL (1) | PL374759A1 (enExample) |
| TW (1) | TW200403245A (enExample) |
| WO (1) | WO2003082208A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242469B1 (en) * | 1996-12-03 | 2001-06-05 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| EP2186811A1 (en) * | 2002-08-23 | 2010-05-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| EP1581535B3 (en) | 2003-01-09 | 2009-09-02 | Astellas Pharma Inc. | Pyrrolopyridazine derivatives |
| US7030112B2 (en) * | 2003-03-25 | 2006-04-18 | Bristol-Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
| US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
| TW200538453A (en) * | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
| US20050288290A1 (en) | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
| WO2006004191A1 (en) * | 2004-07-05 | 2006-01-12 | Astellas Pharma Inc. | Pyrrolopyridazine derivatives which inhibit pde iv and tnf alfa |
| WO2007035428A1 (en) * | 2005-09-15 | 2007-03-29 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| US7547782B2 (en) | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| WO2007058392A1 (ja) * | 2005-11-21 | 2007-05-24 | Japan Tobacco Inc. | ヘテロ環化合物およびその医薬用途 |
| HRP20151398T1 (hr) | 2006-12-22 | 2016-02-12 | Astex Therapeutics Limited | Tricikliäśni derivati amina kao inhibitori protein tirozin kinaze |
| CN101679408B (zh) * | 2006-12-22 | 2016-04-27 | Astex治疗学有限公司 | 作为fgfr抑制剂的双环杂环化合物 |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| MX2010010151A (es) | 2008-03-20 | 2010-10-25 | Amgen Inc | Moduladores de cinasa aurora y metodo de uso. |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| US9126935B2 (en) | 2008-08-14 | 2015-09-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
| US8293897B2 (en) | 2008-10-14 | 2012-10-23 | Ning Xi | Compounds comprising a spiro-ring and methods of use |
| RU2011142597A (ru) * | 2009-03-21 | 2013-04-27 | Саншайн Лейк Фарма Ко., Лтд. | Производные сложных эфиров аминокислот, их соли и способы применения |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| MX2011011517A (es) | 2009-04-29 | 2012-06-19 | Amarin Corp Plc | Composiciones farmaceuticas que comprenden epa y un agente cardiovascular y metodos para utilizar el mismo. |
| AR077428A1 (es) * | 2009-07-29 | 2011-08-24 | Sanofi Aventis | (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos |
| AR077346A1 (es) * | 2009-07-31 | 2011-08-17 | Biocryst Pharm Inc | Compuestos heterociclicos como inhibidores de janus quinasa |
| ES2616026T3 (es) * | 2013-03-11 | 2017-06-09 | Bristol-Myers Squibb Company | Pirrolopiridazinas como inhibidores de canales de iones potasio |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| PT3691620T (pt) | 2017-10-05 | 2022-10-06 | Fulcrum Therapeutics Inc | Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd |
| EP3710005B8 (en) * | 2017-11-17 | 2023-06-14 | Academia Sinica | SUBSTITUTED PYRROLO[2,1,-ALPHA]PHTHALAZINES AND BENZO[g]PYRROL[2,1,-ALPHA]PHTHALAZINES AND THEIR USES IN THE TREATMENT OF CANCER |
| IL279977B2 (en) | 2018-07-09 | 2024-06-01 | Boehringer Ingelheim Animal Health Usa Inc | Heterocyclic anthelmintic compounds |
| TWI842978B (zh) | 2018-07-13 | 2024-05-21 | 美商基利科學股份有限公司 | 衍生物 |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| MX2022015038A (es) | 2020-05-29 | 2023-01-04 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos como anthelminticos. |
| IL312412A (en) | 2021-11-01 | 2024-06-01 | Boehringer Ingelheim Vetmedica Gmbh | Pyrrolopyridazine compounds against worms |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999059999A1 (en) * | 1998-05-21 | 1999-11-25 | Shionogi & Co., Ltd. | PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES HAVING sPLA2 INHIBITORY EFFECT |
| BR9913654A (pt) | 1998-08-28 | 2001-11-27 | Scios Inc | Inibidores de p-38alfa quinase |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
| WO2000071129A1 (en) | 1999-05-21 | 2000-11-30 | Bristol-Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| US6982265B1 (en) | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| WO2002000621A1 (en) * | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Compounds exhibiting x-type spla2 inhibiting effect |
| GEP20063915B (en) | 2000-11-17 | 2006-09-11 | Bristol Myers Squibb Co | PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS AND USE THEREOF FOR TREATING p38 KINASE-ASSOCIATED CONDITIONS |
| US6670357B2 (en) | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
-
2003
- 2003-03-25 US US10/396,197 patent/US6900208B2/en not_active Expired - Lifetime
- 2003-03-26 AT AT03719500T patent/ATE490964T1/de not_active IP Right Cessation
- 2003-03-26 EP EP03719500A patent/EP1578351B1/en not_active Expired - Lifetime
- 2003-03-26 DE DE60335293T patent/DE60335293D1/de not_active Expired - Lifetime
- 2003-03-26 WO PCT/US2003/009550 patent/WO2003082208A2/en not_active Ceased
- 2003-03-26 PL PL03374759A patent/PL374759A1/xx not_active Application Discontinuation
- 2003-03-26 AU AU2003223380A patent/AU2003223380A1/en not_active Abandoned
- 2003-03-26 JP JP2003579751A patent/JP4589005B2/ja not_active Expired - Fee Related
- 2003-03-28 TW TW092107144A patent/TW200403245A/zh unknown
- 2003-03-28 PE PE2003000316A patent/PE20040168A1/es not_active Application Discontinuation
- 2003-03-28 AR ARP030101102A patent/AR039189A1/es not_active Application Discontinuation
-
2005
- 2005-01-05 US US11/029,547 patent/US20050159420A1/en not_active Abandoned
-
2008
- 2008-11-14 CL CL2008003391A patent/CL2008003391A1/es unknown
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