TW200403245A - Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders - Google Patents
Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders Download PDFInfo
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- TW200403245A TW200403245A TW092107144A TW92107144A TW200403245A TW 200403245 A TW200403245 A TW 200403245A TW 092107144 A TW092107144 A TW 092107144A TW 92107144 A TW92107144 A TW 92107144A TW 200403245 A TW200403245 A TW 200403245A
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
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| US36824902P | 2002-03-28 | 2002-03-28 | |
| US40211802P | 2002-08-08 | 2002-08-08 |
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| TW (1) | TW200403245A (enExample) |
| WO (1) | WO2003082208A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI469982B (zh) * | 2009-07-29 | 2015-01-21 | Sanofi Aventis | 環狀(氮雜)吲甲醯胺、其製備及其作為藥劑之用途 |
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| EP0977563B1 (en) * | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| WO2004018478A2 (en) * | 2002-08-23 | 2004-03-04 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| RU2328499C2 (ru) * | 2003-01-09 | 2008-07-10 | Астеллас Фарма Инк. | Производные пирролопиридазина, фармацевтическая композиция, способ профилактики или лечения заболеваний, применение в качестве ингибитора фосфодиэстеразы iv, и/или продуцирования tnf |
| US7030112B2 (en) * | 2003-03-25 | 2006-04-18 | Bristol-Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
| US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
| TW200538453A (en) * | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
| US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| WO2006004191A1 (en) * | 2004-07-05 | 2006-01-12 | Astellas Pharma Inc. | Pyrrolopyridazine derivatives which inhibit pde iv and tnf alfa |
| WO2007035428A1 (en) * | 2005-09-15 | 2007-03-29 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| US7547782B2 (en) | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| EP1953147A1 (en) * | 2005-11-21 | 2008-08-06 | Japan Tobacco, Inc. | Heterocyclic compound and medicinal application thereof |
| US8513276B2 (en) | 2006-12-22 | 2013-08-20 | Astex Therapeutics Limited | Imidazo[1,2-a]pyridine compounds for use in treating cancer |
| HRP20150642T1 (hr) * | 2006-12-22 | 2015-08-14 | Astex Therapeutics Limited | BICIKLIÄŚKE HETEROCIKLIÄŚKE TVARI KAO INHIBITORI FGFR-a |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| AU2009226024B2 (en) | 2008-03-20 | 2012-07-12 | Amgen Inc. | Aurora kinase modulators and method of use |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| WO2010019473A1 (en) | 2008-08-14 | 2010-02-18 | Amgen Inc. | Aurora kinase modulators and methods of use |
| WO2010045095A1 (en) * | 2008-10-14 | 2010-04-22 | Ning Xi | Compounds and methods of use |
| WO2010111063A1 (en) * | 2009-03-21 | 2010-09-30 | Ning Xi | Amino ester derivatives, salts thereof and methods of use |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| NZ807894A (en) | 2009-04-29 | 2025-08-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| JP2013501003A (ja) * | 2009-07-31 | 2013-01-10 | バイオクライスト ファーマシューティカルズ, インコーポレイテッド | ヤヌスキナーゼ阻害剤としてのピロロ[1,2−b]ピリダジン誘導体 |
| JP6386527B2 (ja) * | 2013-03-11 | 2018-09-05 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | カリウムイオンチャネル阻害剤としてのピロロピリダジン |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| EP3692144A1 (en) | 2017-10-05 | 2020-08-12 | Fulcrum Therapeutics, Inc. | Use of p38 inhibitors to reduce expression of dux4 |
| JP7093410B2 (ja) * | 2017-11-17 | 2022-06-29 | アカデミア シニカ | ビス(ヒドロキシメチル)ピロロフタラジン混成物、調製方法及びその用途 |
| WO2020014068A1 (en) | 2018-07-09 | 2020-01-16 | Boehringer Ingelheim Animal Health USA Inc. | Anthelminthic heterocyclic compounds |
| TWI842978B (zh) | 2018-07-13 | 2024-05-21 | 美商基利科學股份有限公司 | 衍生物 |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| AU2021278889A1 (en) | 2020-05-29 | 2023-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelmintic heterocyclic compounds |
| UY39995A (es) | 2021-11-01 | 2023-05-15 | Boehringer Ingelheim Vetmedica GmbH | Compuestos de pirrolopiridazina como antihelmínticos |
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| US6472389B1 (en) * | 1998-05-21 | 2002-10-29 | Shionogi & Co., Ltd. | Pyrrolo[1,2-b] pyridazine derivatives having sPLA2 inhibitory effect |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| WO2000012074A2 (en) | 1998-08-28 | 2000-03-09 | Scios Inc. | Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase |
| GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
| KR100666514B1 (ko) | 1999-05-21 | 2007-02-28 | 브리스톨-마이어즈 스퀴브 컴페니 | 키나제의 피롤로트리아진 저해제 |
| US6982265B1 (en) | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| JPWO2002000621A1 (ja) * | 2000-06-29 | 2004-04-22 | 塩野義製薬株式会社 | X型sPLA2阻害作用を有する化合物 |
| NZ525334A (en) | 2000-11-17 | 2005-07-29 | Bristol Myers Squibb Co | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
| US6670357B2 (en) | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
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2003
- 2003-03-25 US US10/396,197 patent/US6900208B2/en not_active Expired - Lifetime
- 2003-03-26 AU AU2003223380A patent/AU2003223380A1/en not_active Abandoned
- 2003-03-26 WO PCT/US2003/009550 patent/WO2003082208A2/en not_active Ceased
- 2003-03-26 AT AT03719500T patent/ATE490964T1/de not_active IP Right Cessation
- 2003-03-26 DE DE60335293T patent/DE60335293D1/de not_active Expired - Lifetime
- 2003-03-26 PL PL03374759A patent/PL374759A1/xx not_active Application Discontinuation
- 2003-03-26 EP EP03719500A patent/EP1578351B1/en not_active Expired - Lifetime
- 2003-03-26 JP JP2003579751A patent/JP4589005B2/ja not_active Expired - Fee Related
- 2003-03-28 TW TW092107144A patent/TW200403245A/zh unknown
- 2003-03-28 AR ARP030101102A patent/AR039189A1/es not_active Application Discontinuation
- 2003-03-28 PE PE2003000316A patent/PE20040168A1/es not_active Application Discontinuation
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2005
- 2005-01-05 US US11/029,547 patent/US20050159420A1/en not_active Abandoned
-
2008
- 2008-11-14 CL CL2008003391A patent/CL2008003391A1/es unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI469982B (zh) * | 2009-07-29 | 2015-01-21 | Sanofi Aventis | 環狀(氮雜)吲甲醯胺、其製備及其作為藥劑之用途 |
Also Published As
| Publication number | Publication date |
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| CL2008003391A1 (es) | 2009-03-06 |
| EP1578351A4 (en) | 2006-06-14 |
| US20040063712A1 (en) | 2004-04-01 |
| JP4589005B2 (ja) | 2010-12-01 |
| US20050159420A1 (en) | 2005-07-21 |
| AU2003223380A1 (en) | 2003-10-13 |
| AU2003223380A8 (en) | 2003-10-13 |
| EP1578351B1 (en) | 2010-12-08 |
| WO2003082208A3 (en) | 2006-03-02 |
| JP2006504624A (ja) | 2006-02-09 |
| PE20040168A1 (es) | 2004-03-27 |
| DE60335293D1 (de) | 2011-01-20 |
| US6900208B2 (en) | 2005-05-31 |
| EP1578351A2 (en) | 2005-09-28 |
| AR039189A1 (es) | 2005-02-09 |
| WO2003082208A8 (en) | 2005-03-24 |
| PL374759A1 (en) | 2005-10-31 |
| WO2003082208A2 (en) | 2003-10-09 |
| ATE490964T1 (de) | 2010-12-15 |
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