JP2006503866A - 癌を処置するための相乗的な方法および組成物 - Google Patents

癌を処置するための相乗的な方法および組成物 Download PDF

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Publication number
JP2006503866A
JP2006503866A JP2004541936A JP2004541936A JP2006503866A JP 2006503866 A JP2006503866 A JP 2006503866A JP 2004541936 A JP2004541936 A JP 2004541936A JP 2004541936 A JP2004541936 A JP 2004541936A JP 2006503866 A JP2006503866 A JP 2006503866A
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Prior art keywords
methyl
hydroxy
ethylamino
phenyl
pyridin
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Japanese (ja)
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JP2006503866A5 (https=
Inventor
ジョーン・エム・カーボニ
ウォーレン・ダブリュー・ハールバート
マルコ・エム・ゴッターディス
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2006503866A publication Critical patent/JP2006503866A/ja
Publication of JP2006503866A5 publication Critical patent/JP2006503866A5/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2004541936A 2002-10-02 2003-10-01 癌を処置するための相乗的な方法および組成物 Withdrawn JP2006503866A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41541602P 2002-10-02 2002-10-02
PCT/US2003/030933 WO2004030625A2 (en) 2002-10-02 2003-10-01 Synergistic methods and compositions for treating cancer

Publications (2)

Publication Number Publication Date
JP2006503866A true JP2006503866A (ja) 2006-02-02
JP2006503866A5 JP2006503866A5 (https=) 2006-11-16

Family

ID=32069854

Family Applications (2)

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JP2004541936A Withdrawn JP2006503866A (ja) 2002-10-02 2003-10-01 癌を処置するための相乗的な方法および組成物
JP2004541997A Withdrawn JP2006503867A (ja) 2002-10-02 2003-10-01 癌を処置するための相乗的な方法および組成物

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JP2004541997A Withdrawn JP2006503867A (ja) 2002-10-02 2003-10-01 癌を処置するための相乗的な方法および組成物

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US (2) US20040106605A1 (https=)
EP (2) EP1556051A2 (https=)
JP (2) JP2006503866A (https=)
AU (2) AU2003275364A1 (https=)
CA (2) CA2500729A1 (https=)
TW (2) TW200501960A (https=)
WO (2) WO2004030627A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
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JP2008501652A (ja) * 2004-06-03 2008-01-24 エフ．ホフマン−ラ　ロシュ　アーゲー ゲムシタビン及びｅｇｆｒインヒビターによる治療
JP2018504418A (ja) * 2015-02-05 2018-02-15 ティルノーヴォ リミテッド 癌を治療するためのｉｒｓ／ｓｔａｔ３二重修飾因子と抗癌剤の組み合わせ
JP2020503376A (ja) * 2016-12-13 2020-01-30 プリンストン ドラッグ ディスカバリー インコーポレイテッド プロテインキナーゼ阻害剤

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US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
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US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008501652A (ja) * 2004-06-03 2008-01-24 エフ．ホフマン−ラ　ロシュ　アーゲー ゲムシタビン及びｅｇｆｒインヒビターによる治療
JP2018504418A (ja) * 2015-02-05 2018-02-15 ティルノーヴォ リミテッド 癌を治療するためのｉｒｓ／ｓｔａｔ３二重修飾因子と抗癌剤の組み合わせ
JP2021073254A (ja) * 2015-02-05 2021-05-13 ティルノーヴォ リミテッド 癌を治療するためのｉｒｓ／ｓｔａｔ３二重修飾因子と抗癌剤の組み合わせ
JP2023062187A (ja) * 2015-02-05 2023-05-02 ティルノーヴォ リミテッド 癌を治療するためのｉｒｓ／ｓｔａｔ３二重修飾因子と抗癌剤の組み合わせ
JP2020503376A (ja) * 2016-12-13 2020-01-30 プリンストン ドラッグ ディスカバリー インコーポレイテッド プロテインキナーゼ阻害剤
JP7077335B2 (ja) 2016-12-13 2022-05-30 プリンストン ドラッグ ディスカバリー インコーポレイテッド プロテインキナーゼ阻害剤

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WO2004030625A3 (en) 2004-06-24
US20040106605A1 (en) 2004-06-03
AU2003275364A1 (en) 2004-04-23
TW200501960A (en) 2005-01-16
AU2003282892A1 (en) 2004-04-23
WO2004030625A2 (en) 2004-04-15
CA2500729A1 (en) 2004-04-15
CA2500714A1 (en) 2004-04-15
EP1556051A2 (en) 2005-07-27
WO2004030627A2 (en) 2004-04-15
WO2004030627A3 (en) 2004-07-01
JP2006503867A (ja) 2006-02-02
TW200410689A (en) 2004-07-01
EP1551411A2 (en) 2005-07-13
US20040072760A1 (en) 2004-04-15

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