JP2006503816A5 - - Google Patents
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- Publication number
- JP2006503816A5 JP2006503816A5 JP2004527508A JP2004527508A JP2006503816A5 JP 2006503816 A5 JP2006503816 A5 JP 2006503816A5 JP 2004527508 A JP2004527508 A JP 2004527508A JP 2004527508 A JP2004527508 A JP 2004527508A JP 2006503816 A5 JP2006503816 A5 JP 2006503816A5
- Authority
- JP
- Japan
- Prior art keywords
- type
- bambatalol
- component
- chiral
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical compound NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 claims 7
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 238000003786 synthesis reaction Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 3
- 229950006768 phenylethanolamine Drugs 0.000 claims 3
- 239000000808 adrenergic beta-agonist Substances 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 230000000414 obstructive effect Effects 0.000 claims 2
- DGSQMAWMWINPRH-UHFFFAOYSA-N 1-bromo-1-phenylethanol Chemical compound CC(O)(Br)C1=CC=CC=C1 DGSQMAWMWINPRH-UHFFFAOYSA-N 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- -1 bromoacetophenone compound Chemical class 0.000 claims 1
- 230000007883 bronchodilation Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- PSEHHVRCDVOTID-UHFFFAOYSA-N chloro-bis(4,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl)borane Chemical compound CC1C(C2(C)C)CC2CC1B(Cl)C(C1C)CC2C(C)(C)C1C2 PSEHHVRCDVOTID-UHFFFAOYSA-N 0.000 claims 1
- PSEHHVRCDVOTID-YYNWCRCSSA-N chloro-bis[(1r,3s,4r,5r)-4,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]borane Chemical compound C([C@@H]([C@H]1C)B(Cl)[C@H]2C[C@@H]3C[C@@H](C3(C)C)[C@@H]2C)[C@H]2C(C)(C)[C@@H]1C2 PSEHHVRCDVOTID-YYNWCRCSSA-N 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- LIGACIXOYTUXAW-UHFFFAOYSA-N phenacyl bromide Chemical compound BrCC(=O)C1=CC=CC=C1 LIGACIXOYTUXAW-UHFFFAOYSA-N 0.000 claims 1
- 150000003141 primary amines Chemical class 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2002/025225 WO2004014290A2 (en) | 2002-08-08 | 2002-08-08 | R-bambuterol, its preparation and therapeutic uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006503816A JP2006503816A (ja) | 2006-02-02 |
| JP2006503816A5 true JP2006503816A5 (enExample) | 2006-03-16 |
| JP4979889B2 JP4979889B2 (ja) | 2012-07-18 |
Family
ID=31713793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004527508A Expired - Fee Related JP4979889B2 (ja) | 2002-08-08 | 2002-08-08 | Ｒ型バンブテロール又はその薬学的に許容される塩の製造方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1542672B1 (enExample) |
| JP (1) | JP4979889B2 (enExample) |
| CN (1) | CN100356913C (enExample) |
| AT (1) | ATE406887T1 (enExample) |
| AU (1) | AU2002332488A1 (enExample) |
| DE (1) | DE60228764D1 (enExample) |
| ES (1) | ES2312669T3 (enExample) |
| WO (1) | WO2004014290A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100803291B1 (ko) | 2006-09-08 | 2008-02-13 | (주)팜스웰 | 밤부테롤 염산염의 개선된 제조방법 |
| CN102448309A (zh) * | 2009-06-16 | 2012-05-09 | 谭文 | 左旋(r)班布特罗在制备治疗呼吸性疾病的吸入性药物制剂和药物组合中的应用 |
| CN102617404A (zh) * | 2012-04-06 | 2012-08-01 | 张长利 | 盐酸班布特罗及其中间体的制备工艺 |
| CN103288670B (zh) * | 2013-05-16 | 2014-11-05 | 南京医科大学第一附属医院 | 多羟基二苯甲酮衍生物及其应用 |
| CN104478740B (zh) * | 2014-11-19 | 2017-01-25 | 上海化工研究院 | 一种稳定同位素标记β受体激动剂类化合物的合成方法 |
| CN104557614B (zh) * | 2014-12-15 | 2017-01-04 | 广东东阳光药业有限公司 | 一种胺的还原方法 |
| CN105254512B (zh) * | 2015-11-10 | 2017-03-22 | 山东达因海洋生物制药股份有限公司 | 一种硫酸特布他林的制备方法 |
| CN106831452A (zh) * | 2017-02-15 | 2017-06-13 | 杭州百诚医药科技股份有限公司 | 一种硫酸特布他林的制备方法 |
| CN107445866A (zh) * | 2017-07-13 | 2017-12-08 | 上海昕盛医药科技有限公司 | 一种盐酸班布特罗杂质d的合成方法 |
| CN107445867A (zh) * | 2017-07-13 | 2017-12-08 | 上海昕盛医药科技有限公司 | 一种盐酸班布特罗杂质b的合成方法 |
| WO2020028124A1 (en) * | 2018-07-31 | 2020-02-06 | Wen Tan | NEW USE OF CARBAMATE β PHENYLETHANOLAMINE ANALOGUES FOR ENHANCING INTRACELLULAR CLEARANCE OF LDL CHOLESTEROL AND FOR COMBINING THERAPY WITH STATINS TO ENHANCE THE EFFICACY AND REDUCE ADVERSE EFFECTS |
| CN109942462B (zh) * | 2019-03-06 | 2022-01-14 | 宏冠生物药业有限公司 | 一种盐酸班布特罗的合成工艺 |
| WO2020247136A2 (en) * | 2019-05-07 | 2020-12-10 | Wen Tan | USE OF R-ENANTIOMER β2-AGONISTS FOR PREVENT AND TREATMENT OF PULMONARY INFLAMMATION AND INFLAMMATORY REMODELING FOR REDUCED ADVERSE EFFECTS |
| CN115531368A (zh) * | 2021-06-14 | 2022-12-30 | 谭文 | R-氨基甲酸酯-β-苯乙醇胺类化合物治疗学习和记忆缺陷以及神经退行性疾病的应用 |
| CN117586152B (zh) * | 2023-11-23 | 2026-04-03 | 黑龙江乌苏里江制药有限公司 | 一种盐酸班布特罗的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3163871D1 (en) * | 1980-07-09 | 1984-07-05 | Draco Ab | 1-(dihydroxyphenyl)-2-amino-ethanol derivatives; preparation, compositions and intermediates |
| SE9000948D0 (sv) * | 1990-03-16 | 1990-03-16 | Draco Ab | New use |
| GB9107196D0 (en) * | 1991-04-05 | 1991-05-22 | Sandoz Ag | Improvements in or relating to organic compounds |
-
2002
- 2002-08-08 EP EP02807678A patent/EP1542672B1/en not_active Expired - Lifetime
- 2002-08-08 CN CNB028293975A patent/CN100356913C/zh not_active Expired - Lifetime
- 2002-08-08 WO PCT/US2002/025225 patent/WO2004014290A2/en not_active Ceased
- 2002-08-08 DE DE60228764T patent/DE60228764D1/de not_active Expired - Lifetime
- 2002-08-08 EP EP08015488A patent/EP2002831A1/en not_active Ceased
- 2002-08-08 ES ES02807678T patent/ES2312669T3/es not_active Expired - Lifetime
- 2002-08-08 JP JP2004527508A patent/JP4979889B2/ja not_active Expired - Fee Related
- 2002-08-08 AU AU2002332488A patent/AU2002332488A1/en not_active Abandoned
- 2002-08-08 AT AT02807678T patent/ATE406887T1/de not_active IP Right Cessation
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