JP2006503816A5 - - Google Patents
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- Publication number
- JP2006503816A5 JP2006503816A5 JP2004527508A JP2004527508A JP2006503816A5 JP 2006503816 A5 JP2006503816 A5 JP 2006503816A5 JP 2004527508 A JP2004527508 A JP 2004527508A JP 2004527508 A JP2004527508 A JP 2004527508A JP 2006503816 A5 JP2006503816 A5 JP 2006503816A5
- Authority
- JP
- Japan
- Prior art keywords
- type
- bambatalol
- component
- chiral
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical compound NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 claims 7
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 238000003786 synthesis reaction Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 3
- 229950006768 phenylethanolamine Drugs 0.000 claims 3
- 239000000808 adrenergic beta-agonist Substances 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 230000000414 obstructive effect Effects 0.000 claims 2
- DGSQMAWMWINPRH-UHFFFAOYSA-N 1-bromo-1-phenylethanol Chemical compound CC(O)(Br)C1=CC=CC=C1 DGSQMAWMWINPRH-UHFFFAOYSA-N 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- -1 bromoacetophenone compound Chemical class 0.000 claims 1
- 230000007883 bronchodilation Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- PSEHHVRCDVOTID-UHFFFAOYSA-N chloro-bis(4,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl)borane Chemical compound CC1C(C2(C)C)CC2CC1B(Cl)C(C1C)CC2C(C)(C)C1C2 PSEHHVRCDVOTID-UHFFFAOYSA-N 0.000 claims 1
- PSEHHVRCDVOTID-YYNWCRCSSA-N chloro-bis[(1r,3s,4r,5r)-4,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]borane Chemical compound C([C@@H]([C@H]1C)B(Cl)[C@H]2C[C@@H]3C[C@@H](C3(C)C)[C@@H]2C)[C@H]2C(C)(C)[C@@H]1C2 PSEHHVRCDVOTID-YYNWCRCSSA-N 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- LIGACIXOYTUXAW-UHFFFAOYSA-N phenacyl bromide Chemical compound BrCC(=O)C1=CC=CC=C1 LIGACIXOYTUXAW-UHFFFAOYSA-N 0.000 claims 1
- 150000003141 primary amines Chemical class 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2002/025225 WO2004014290A2 (en) | 2002-08-08 | 2002-08-08 | R-bambuterol, its preparation and therapeutic uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006503816A JP2006503816A (ja) | 2006-02-02 |
| JP2006503816A5 true JP2006503816A5 (enExample) | 2006-03-16 |
| JP4979889B2 JP4979889B2 (ja) | 2012-07-18 |
Family
ID=31713793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004527508A Expired - Fee Related JP4979889B2 (ja) | 2002-08-08 | 2002-08-08 | Ｒ型バンブテロール又はその薬学的に許容される塩の製造方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP2002831A1 (enExample) |
| JP (1) | JP4979889B2 (enExample) |
| CN (1) | CN100356913C (enExample) |
| AT (1) | ATE406887T1 (enExample) |
| AU (1) | AU2002332488A1 (enExample) |
| DE (1) | DE60228764D1 (enExample) |
| ES (1) | ES2312669T3 (enExample) |
| WO (1) | WO2004014290A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100803291B1 (ko) | 2006-09-08 | 2008-02-13 | (주)팜스웰 | 밤부테롤 염산염의 개선된 제조방법 |
| AU2010260513A1 (en) * | 2009-06-16 | 2012-02-02 | Wen Tan | Use of R-Bambuterol as inhaled medicament and combination therapies for treatment of respiratory disorders |
| CN102617404A (zh) * | 2012-04-06 | 2012-08-01 | 张长利 | 盐酸班布特罗及其中间体的制备工艺 |
| CN103288670B (zh) * | 2013-05-16 | 2014-11-05 | 南京医科大学第一附属医院 | 多羟基二苯甲酮衍生物及其应用 |
| CN104478740B (zh) * | 2014-11-19 | 2017-01-25 | 上海化工研究院 | 一种稳定同位素标记β受体激动剂类化合物的合成方法 |
| CN104557614B (zh) * | 2014-12-15 | 2017-01-04 | 广东东阳光药业有限公司 | 一种胺的还原方法 |
| CN105254512B (zh) * | 2015-11-10 | 2017-03-22 | 山东达因海洋生物制药股份有限公司 | 一种硫酸特布他林的制备方法 |
| CN106831452A (zh) * | 2017-02-15 | 2017-06-13 | 杭州百诚医药科技股份有限公司 | 一种硫酸特布他林的制备方法 |
| CN107445867A (zh) * | 2017-07-13 | 2017-12-08 | 上海昕盛医药科技有限公司 | 一种盐酸班布特罗杂质b的合成方法 |
| CN107445866A (zh) * | 2017-07-13 | 2017-12-08 | 上海昕盛医药科技有限公司 | 一种盐酸班布特罗杂质d的合成方法 |
| WO2020028124A1 (en) * | 2018-07-31 | 2020-02-06 | Wen Tan | NEW USE OF CARBAMATE β PHENYLETHANOLAMINE ANALOGUES FOR ENHANCING INTRACELLULAR CLEARANCE OF LDL CHOLESTEROL AND FOR COMBINING THERAPY WITH STATINS TO ENHANCE THE EFFICACY AND REDUCE ADVERSE EFFECTS |
| CN109942462B (zh) * | 2019-03-06 | 2022-01-14 | 宏冠生物药业有限公司 | 一种盐酸班布特罗的合成工艺 |
| WO2020247136A2 (en) * | 2019-05-07 | 2020-12-10 | Wen Tan | USE OF R-ENANTIOMER β2-AGONISTS FOR PREVENT AND TREATMENT OF PULMONARY INFLAMMATION AND INFLAMMATORY REMODELING FOR REDUCED ADVERSE EFFECTS |
| CN115531368A (zh) * | 2021-06-14 | 2022-12-30 | 谭文 | R-氨基甲酸酯-β-苯乙醇胺类化合物治疗学习和记忆缺陷以及神经退行性疾病的应用 |
| CN117586152A (zh) * | 2023-11-23 | 2024-02-23 | 黑龙江乌苏里江制药有限公司 | 一种盐酸班布特罗的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3163871D1 (en) * | 1980-07-09 | 1984-07-05 | Draco Ab | 1-(dihydroxyphenyl)-2-amino-ethanol derivatives; preparation, compositions and intermediates |
| SE9000948D0 (sv) * | 1990-03-16 | 1990-03-16 | Draco Ab | New use |
| GB9107196D0 (en) * | 1991-04-05 | 1991-05-22 | Sandoz Ag | Improvements in or relating to organic compounds |
-
2002
- 2002-08-08 DE DE60228764T patent/DE60228764D1/de not_active Expired - Lifetime
- 2002-08-08 CN CNB028293975A patent/CN100356913C/zh not_active Expired - Lifetime
- 2002-08-08 AU AU2002332488A patent/AU2002332488A1/en not_active Abandoned
- 2002-08-08 JP JP2004527508A patent/JP4979889B2/ja not_active Expired - Fee Related
- 2002-08-08 ES ES02807678T patent/ES2312669T3/es not_active Expired - Lifetime
- 2002-08-08 WO PCT/US2002/025225 patent/WO2004014290A2/en not_active Ceased
- 2002-08-08 AT AT02807678T patent/ATE406887T1/de not_active IP Right Cessation
- 2002-08-08 EP EP08015488A patent/EP2002831A1/en not_active Ceased
- 2002-08-08 EP EP02807678A patent/EP1542672B1/en not_active Expired - Lifetime
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