JP2006502115A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006502115A5 JP2006502115A5 JP2004521470A JP2004521470A JP2006502115A5 JP 2006502115 A5 JP2006502115 A5 JP 2006502115A5 JP 2004521470 A JP2004521470 A JP 2004521470A JP 2004521470 A JP2004521470 A JP 2004521470A JP 2006502115 A5 JP2006502115 A5 JP 2006502115A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- treatment
- indol
- medicament
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000013078 crystal Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- -1 1-methyl-1H-indol-3-yl Chemical group 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 238000002441 X-ray diffraction Methods 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 2
- 125000006514 pyridin-2-ylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- LFDGRWDETVOGDT-UHFFFAOYSA-N 1h-pyrrole;hydrochloride Chemical compound Cl.C=1C=CNC=1 LFDGRWDETVOGDT-UHFFFAOYSA-N 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39597602P | 2002-07-12 | 2002-07-12 | |
| US60/395,976 | 2002-07-12 | ||
| PCT/US2003/019548 WO2004006928A1 (en) | 2002-07-12 | 2003-07-08 | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011033310A Division JP5242718B2 (ja) | 2002-07-12 | 2011-02-18 | ２，５−ジオン−３−（１−メチル−１ｈ−インドール−３−イル）−４−［１−（ピリジン−２−イルメチル）ピペリジン−４−イル］−１ｈ−インドール−３−イル］−１ｈ−ピロール一塩酸塩の結晶 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006502115A JP2006502115A (ja) | 2006-01-19 |
| JP2006502115A5 true JP2006502115A5 (enExample) | 2006-08-10 |
| JP4771356B2 JP4771356B2 (ja) | 2011-09-14 |
Family
ID=42799191
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004521470A Expired - Fee Related JP4771356B2 (ja) | 2002-07-12 | 2003-07-08 | ２，５−ジオン−３−（１−メチル−１ｈ−インドール−３−イル）−４−［１−（ピリジン−２−イルメチル）ピペリジン−４−イル］−１ｈ−インドール−３−イル］−１ｈ−ピロール一塩酸塩の結晶 |
| JP2011033310A Expired - Fee Related JP5242718B2 (ja) | 2002-07-12 | 2011-02-18 | ２，５−ジオン−３−（１−メチル−１ｈ−インドール−３−イル）−４−［１−（ピリジン−２−イルメチル）ピペリジン−４−イル］−１ｈ−インドール−３−イル］−１ｈ−ピロール一塩酸塩の結晶 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011033310A Expired - Fee Related JP5242718B2 (ja) | 2002-07-12 | 2011-02-18 | ２，５−ジオン−３−（１−メチル−１ｈ−インドール−３−イル）−４−［１−（ピリジン−２−イルメチル）ピペリジン−４−イル］−１ｈ−インドール−３−イル］−１ｈ−ピロール一塩酸塩の結晶 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8114901B2 (enExample) |
| EP (1) | EP1523313B1 (enExample) |
| JP (2) | JP4771356B2 (enExample) |
| KR (1) | KR100687165B1 (enExample) |
| CN (1) | CN100430058C (enExample) |
| AU (1) | AU2003280958B9 (enExample) |
| CA (1) | CA2393720C (enExample) |
| DE (1) | DE60317675T2 (enExample) |
| EA (1) | EA007463B1 (enExample) |
| EC (1) | ECSP055537A (enExample) |
| ES (1) | ES2295605T3 (enExample) |
| HR (1) | HRP20050035B1 (enExample) |
| IL (1) | IL165747A (enExample) |
| NO (1) | NO330254B1 (enExample) |
| NZ (1) | NZ537137A (enExample) |
| PE (1) | PE20040652A1 (enExample) |
| PL (1) | PL373046A1 (enExample) |
| TW (1) | TWI315667B (enExample) |
| UA (1) | UA78801C2 (enExample) |
| WO (1) | WO2004006928A1 (enExample) |
| ZA (1) | ZA200500065B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101345002B1 (ko) | 2005-01-21 | 2013-12-31 | 아스텍스 테라퓨틱스 리미티드 | 제약 화합물 |
| EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| EP2408372B1 (en) | 2009-03-02 | 2019-01-09 | Seventh Sense Biosystems, Inc. | Devices associated with blood sampling |
| US9033898B2 (en) | 2010-06-23 | 2015-05-19 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
| US9295417B2 (en) | 2011-04-29 | 2016-03-29 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
| US9041541B2 (en) | 2010-01-28 | 2015-05-26 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
| ES2561824T3 (es) | 2010-07-16 | 2016-03-01 | Seventh Sense Biosystems, Inc. | Ambiente a baja presión para dispositivos de transferencia de fluidos |
| WO2012044689A1 (en) * | 2010-09-30 | 2012-04-05 | Wisconsin Alumni Research Foundation | (20R,25S)-2-METHYLENE-19,26-DINOR-1α, 25-DIHYDROXYVITAMIN D3 IN CRYSTALLINE FORM |
| ES2565805T3 (es) | 2010-11-09 | 2016-04-07 | Seventh Sense Biosystems, Inc. | Sistemas e interfaces para el muestreo de sangre |
| KR102237667B1 (ko) | 2011-04-29 | 2021-04-12 | 세븐쓰 센스 바이오시스템즈, 인크. | 유체들의 전달 및/또는 수용 |
| KR20190086655A (ko) | 2016-06-17 | 2019-07-23 | 유니버시다드 데 로스 안데스 | 저온-적응된 해양생물종의 천연 공급원으로부터 유래된 젤라틴 중합체 및 그것의 용도 |
| TWI855386B (zh) | 2016-08-10 | 2024-09-11 | 瑞士商赫孚孟拉羅股份公司 | 包含Ａｋｔ蛋白質激酶抑制劑之醫藥組合物 |
| JOP20190025A1 (ar) | 2016-09-01 | 2019-02-19 | Denovo Biopharma Llc | طرق وتركيبة لتوقع نشاط إنزاستورين |
| CN116199590B (zh) * | 2022-12-26 | 2024-12-24 | 湖北美林药业有限公司 | 一种盐酸多巴酚丁胺及其注射剂 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3625738A1 (de) | 1986-07-30 | 1988-02-11 | Goedecke Ag | 2-acyloxypropylamin-derivate, verfahren zu deren herstellung und deren verwendung |
| US4785085A (en) | 1986-11-21 | 1988-11-15 | Bristol-Myers Company | Rebeccamycin analogs |
| US4808613A (en) | 1986-11-21 | 1989-02-28 | Bristol-Myers Company | Rebeccamycin derivative containing pharmaceutical composition |
| DE3752123T2 (de) | 1987-03-09 | 1998-05-14 | Kyowa Hakko Kogyo Kk | Derivate des physiologisch aktiven mittels k-252 |
| DE3803620A1 (de) | 1988-02-06 | 1989-08-17 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| CZ280738B6 (cs) | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
| GB8904161D0 (en) | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
| CA2015996C (en) | 1989-05-05 | 2001-08-28 | Hartmut Osswald | Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals |
| US5380746A (en) | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| US5489608A (en) | 1989-12-21 | 1996-02-06 | Goedecke Aktiengesellschaft | Indolocarbazole derivatives and the use thereof |
| DE4005969A1 (de) | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| DE4005970A1 (de) | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| CA2046801C (en) | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
| US5292747A (en) | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
| GB9123396D0 (en) | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| US5461146A (en) | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| DE4243321A1 (de) | 1992-12-21 | 1994-06-23 | Goedecke Ag | Aminosäurederivate von Heterocyclen als PKC-Inhibitoren |
| US5484926A (en) | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| AU678435B2 (en) | 1993-05-10 | 1997-05-29 | F. Hoffmann-La Roche Ag | Substituted pyrroles |
| SE501711C2 (sv) * | 1993-09-08 | 1995-05-02 | Jimek Int Ab | Sprayrör för en duktvättanordning vid en tryckpress |
| US5624949A (en) | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| ATE456367T1 (de) * | 1993-12-23 | 2010-02-15 | Lilly Co Eli | Proteinkinase c inhibitoren |
| US5545636A (en) * | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5481003A (en) | 1994-06-22 | 1996-01-02 | Eli Lilly And Company | Protein kinase C inhibitors |
| PE91598A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
| GB9620390D0 (en) | 1996-09-30 | 1996-11-13 | Eisai London Res Lab Ltd | Substances and their uses |
| WO2001009116A2 (en) * | 1999-07-29 | 2001-02-08 | Eli Lilly And Company | A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3- (4-[2-(PIPERIDIN-1-YL) ETHOXY]PHENOXY)- 2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE |
| AU1189201A (en) * | 1999-10-22 | 2001-05-08 | Eli Lilly And Company | Therapeutic compositions including protein kinase c inhibitors |
| AU2001271261A1 (en) * | 2000-06-29 | 2002-01-14 | Eli Lilly And Company | Therapeutic treatment of cancer with a protein kinase c inhibitor |
| WO2002002094A2 (en) * | 2000-06-29 | 2002-01-10 | Eli Lilly And Company | Use of a protein kinase c inhibitor to enhance the clinical efficacy of anti-neoplastic chemotherapeutic agents and radiation therapy |
| RU2004135382A (ru) * | 2002-06-05 | 2005-06-27 | Янссен Фармацевтика Н.В. (Be) | Замещенные пирролины в качестве ингибиторов киназы |
-
2002
- 2002-07-16 CA CA2393720A patent/CA2393720C/en not_active Expired - Fee Related
-
2003
- 2003-07-08 NZ NZ537137A patent/NZ537137A/en not_active IP Right Cessation
- 2003-07-08 WO PCT/US2003/019548 patent/WO2004006928A1/en not_active Ceased
- 2003-07-08 AU AU2003280958A patent/AU2003280958B9/en not_active Ceased
- 2003-07-08 DE DE60317675T patent/DE60317675T2/de not_active Expired - Lifetime
- 2003-07-08 ES ES03742111T patent/ES2295605T3/es not_active Expired - Lifetime
- 2003-07-08 KR KR1020057000501A patent/KR100687165B1/ko not_active Expired - Fee Related
- 2003-07-08 CN CNB038166216A patent/CN100430058C/zh not_active Expired - Lifetime
- 2003-07-08 EA EA200500191A patent/EA007463B1/ru not_active IP Right Cessation
- 2003-07-08 JP JP2004521470A patent/JP4771356B2/ja not_active Expired - Fee Related
- 2003-07-08 PL PL03373046A patent/PL373046A1/xx unknown
- 2003-07-08 US US10/520,360 patent/US8114901B2/en not_active Expired - Fee Related
- 2003-07-08 HR HRP20050035AA patent/HRP20050035B1/hr not_active IP Right Cessation
- 2003-07-08 EP EP03742111A patent/EP1523313B1/en not_active Expired - Lifetime
- 2003-07-09 TW TW092118725A patent/TWI315667B/zh not_active IP Right Cessation
- 2003-07-09 PE PE2003000687A patent/PE20040652A1/es not_active Application Discontinuation
- 2003-08-07 UA UA20041210897A patent/UA78801C2/uk unknown
-
2004
- 2004-12-14 IL IL165747A patent/IL165747A/en active IP Right Grant
-
2005
- 2005-01-12 EC EC2005005537A patent/ECSP055537A/es unknown
- 2005-02-09 NO NO20050676A patent/NO330254B1/no not_active IP Right Cessation
-
2006
- 2006-01-04 ZA ZA200500065A patent/ZA200500065B/xx unknown
-
2007
- 2007-07-11 US US11/776,245 patent/US20070270465A1/en not_active Abandoned
-
2011
- 2011-02-18 JP JP2011033310A patent/JP5242718B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006502115A5 (enExample) | ||
| IL191832A (en) | Pyridiazinone compounds and their use in the preparation of drugs for the treatment of tumors | |
| MY150797A (en) | Combination therapies comprising quinaxoline inhibitors of pi3k-alpha for use in the treatment of cancer | |
| IL189194A (en) | Benzimidazoles are conserved as kinase inhibitors and their use in the preparation of cancer drugs | |
| UA84712C2 (en) | N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors | |
| MXPA03012004A (es) | Derivados de aminonicotinato como moduladores de glucocinasa (glk). | |
| IS8132A (is) | Pýrósóló-kínasólín afleiður, aðferð við framleiðslu þeirra og notkun sem kínasa hindrar | |
| TW200512200A (en) | Carbonyl compounds | |
| MXPA05010712A (es) | Derivados de quinolin-2-ona para el tratamiento de enfermedades de las vias respiratorias. | |
| EA200970932A1 (ru) | Способы лечения с применением пиридопиримидиноновых ингибиторов pi3k альфа | |
| JP2007510667A5 (enExample) | ||
| UA92000C2 (en) | 1-benzylindole-2-carboxamide derivatives | |
| TW200722083A (en) | Combinations and methods of using an indolinone compound | |
| MX272108B (es) | Heterociclos sustituidos. | |
| TW200504012A (en) | Ethynylproline derivatives | |
| TNSN08020A1 (en) | 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them | |
| MX2007003104A (es) | Nuevos derivados de ftalazinona, como inhibidores de cinasa aurora-a. | |
| TW200633704A (en) | N-substituted benzimidazolyl c-kit inhibitors and combinatorial benzimidazole library | |
| BRPI0416690A (pt) | derivados de pirrol | |
| NO20074360L (no) | Behandling av metastaterte tumorer | |
| NO20050428L (no) | Arylkarbonylpiperaziner og heteroarylkarbonylpiperaziner og anvendelse derav for behandling av godartede og ondartede tumorsykdommer | |
| CA2393720A1 (en) | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride | |
| JP2008524329A5 (enExample) | ||
| WO2006084197A3 (en) | Nitroxides for use in treating or preventing neoplastic disease | |
| UA85676C2 (en) | Carbonyl compounds |