JP2006502080A5 - - Google Patents
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- JP2006502080A5 JP2006502080A5 JP2003546932A JP2003546932A JP2006502080A5 JP 2006502080 A5 JP2006502080 A5 JP 2006502080A5 JP 2003546932 A JP2003546932 A JP 2003546932A JP 2003546932 A JP2003546932 A JP 2003546932A JP 2006502080 A5 JP2006502080 A5 JP 2006502080A5
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- Prior art keywords
- pharmaceutical composition
- antagonist
- cancer
- tumor
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- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 40
- 239000005557 antagonist Substances 0.000 claims 20
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 239000000556 agonist Substances 0.000 claims 14
- 210000004443 dendritic cell Anatomy 0.000 claims 11
- 230000002401 inhibitory effect Effects 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 230000003308 immunostimulating effect Effects 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 108010012236 Chemokines Proteins 0.000 claims 4
- 102000019034 Chemokines Human genes 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 150000003384 small molecules Chemical class 0.000 claims 3
- 230000008685 targeting Effects 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 102000004551 Interleukin-10 Receptors Human genes 0.000 claims 2
- 108010017550 Interleukin-10 Receptors Proteins 0.000 claims 2
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 101150016096 17 gene Proteins 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 claims 1
- 102100038238 Aromatic-L-amino-acid decarboxylase Human genes 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102100023702 C-C motif chemokine 13 Human genes 0.000 claims 1
- 102100023700 C-C motif chemokine 16 Human genes 0.000 claims 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
- 102100036848 C-C motif chemokine 20 Human genes 0.000 claims 1
- 102100036846 C-C motif chemokine 21 Human genes 0.000 claims 1
- 102100021933 C-C motif chemokine 25 Human genes 0.000 claims 1
- 102100032367 C-C motif chemokine 5 Human genes 0.000 claims 1
- 102100032366 C-C motif chemokine 7 Human genes 0.000 claims 1
- 102100034871 C-C motif chemokine 8 Human genes 0.000 claims 1
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims 1
- 102100025279 C-X-C motif chemokine 11 Human genes 0.000 claims 1
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims 1
- -1 CCL3 Proteins 0.000 claims 1
- 108010029697 CD40 Ligand Proteins 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100032937 CD40 ligand Human genes 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 101100315624 Caenorhabditis elegans tyr-1 gene Proteins 0.000 claims 1
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 1
- 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 101710190709 Eukaryotic translation initiation factor 4 gamma 2 Proteins 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 101000773083 Homo sapiens 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 claims 1
- 101000978379 Homo sapiens C-C motif chemokine 13 Proteins 0.000 claims 1
- 101000978375 Homo sapiens C-C motif chemokine 16 Proteins 0.000 claims 1
- 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 claims 1
- 101000713099 Homo sapiens C-C motif chemokine 20 Proteins 0.000 claims 1
- 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 claims 1
- 101000897486 Homo sapiens C-C motif chemokine 25 Proteins 0.000 claims 1
- 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 claims 1
- 101000797758 Homo sapiens C-C motif chemokine 7 Proteins 0.000 claims 1
- 101000946794 Homo sapiens C-C motif chemokine 8 Proteins 0.000 claims 1
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims 1
- 101000858060 Homo sapiens C-X-C motif chemokine 11 Proteins 0.000 claims 1
- 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 claims 1
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 1
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 1
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 1
- 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 claims 1
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims 1
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims 1
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 1
- 101001133081 Homo sapiens Mucin-2 Proteins 0.000 claims 1
- 101000972284 Homo sapiens Mucin-3A Proteins 0.000 claims 1
- 101000972286 Homo sapiens Mucin-4 Proteins 0.000 claims 1
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 1
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 108010036012 Iodide peroxidase Proteins 0.000 claims 1
- 101710183399 Keratin, type I cytoskeletal 19 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108010010995 MART-1 Antigen Proteins 0.000 claims 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 102100034263 Mucin-2 Human genes 0.000 claims 1
- 102100022497 Mucin-3A Human genes 0.000 claims 1
- 102100022693 Mucin-4 Human genes 0.000 claims 1
- OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102000014128 RANK Ligand Human genes 0.000 claims 1
- 108010025832 RANK Ligand Proteins 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 102100031770 SH2B adapter protein 1 Human genes 0.000 claims 1
- 108050003189 SH2B adapter protein 1 Proteins 0.000 claims 1
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 1
- 101800001271 Surface protein Proteins 0.000 claims 1
- 108010017842 Telomerase Proteins 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 102100027188 Thyroid peroxidase Human genes 0.000 claims 1
- 102100026145 Transitional endoplasmic reticulum ATPase Human genes 0.000 claims 1
- 101710132062 Transitional endoplasmic reticulum ATPase Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 102000003425 Tyrosinase Human genes 0.000 claims 1
- 108060008724 Tyrosinase Proteins 0.000 claims 1
- 108010035075 Tyrosine decarboxylase Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 210000005208 blood dendritic cell Anatomy 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 150000002270 gangliosides Chemical class 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 201000002313 intestinal cancer Diseases 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 230000002601 intratumoral effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 208000011645 metastatic carcinoma Diseases 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 201000008106 ocular cancer Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000002089 prostaglandin antagonist Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33343401P | 2001-11-27 | 2001-11-27 | |
| PCT/US2002/038098 WO2003045431A2 (en) | 2001-11-27 | 2002-11-26 | Methods for treating cancer using a combination of a tumor-derived dendritic cell inhibitory factor antagonist and a toll-like receptor agonist |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005334633A Division JP2006131638A (ja) | 2001-11-27 | 2005-11-18 | 腫瘍由来樹状細胞阻害因子アンタゴニストおよびＴｏｌｌ様レセプターアゴニストの併用を使用する、癌を処置するための方法 |
| JP2009274004A Division JP2010053140A (ja) | 2001-11-27 | 2009-12-01 | 腫瘍由来樹状細胞阻害因子アンタゴニストおよびＴｏｌｌ様レセプターアゴニストの併用を使用する、癌を処置するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006502080A JP2006502080A (ja) | 2006-01-19 |
| JP2006502080A5 true JP2006502080A5 (OSRAM) | 2006-03-02 |
Family
ID=23302758
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003546932A Pending JP2006502080A (ja) | 2001-11-27 | 2002-11-26 | 腫瘍由来樹状細胞阻害因子アンタゴニストおよびＴｏｌｌ様レセプターアゴニストの併用を使用する、癌を処置するための方法 |
| JP2005334633A Pending JP2006131638A (ja) | 2001-11-27 | 2005-11-18 | 腫瘍由来樹状細胞阻害因子アンタゴニストおよびＴｏｌｌ様レセプターアゴニストの併用を使用する、癌を処置するための方法 |
| JP2009274004A Withdrawn JP2010053140A (ja) | 2001-11-27 | 2009-12-01 | 腫瘍由来樹状細胞阻害因子アンタゴニストおよびＴｏｌｌ様レセプターアゴニストの併用を使用する、癌を処置するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005334633A Pending JP2006131638A (ja) | 2001-11-27 | 2005-11-18 | 腫瘍由来樹状細胞阻害因子アンタゴニストおよびＴｏｌｌ様レセプターアゴニストの併用を使用する、癌を処置するための方法 |
| JP2009274004A Withdrawn JP2010053140A (ja) | 2001-11-27 | 2009-12-01 | 腫瘍由来樹状細胞阻害因子アンタゴニストおよびＴｏｌｌ様レセプターアゴニストの併用を使用する、癌を処置するための方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20030138413A1 (OSRAM) |
| EP (1) | EP1450858A2 (OSRAM) |
| JP (3) | JP2006502080A (OSRAM) |
| CN (1) | CN1617742B (OSRAM) |
| AU (1) | AU2002359516B2 (OSRAM) |
| BR (1) | BR0214457A (OSRAM) |
| CA (1) | CA2468320A1 (OSRAM) |
| HU (1) | HUP0500999A2 (OSRAM) |
| MX (1) | MXPA04004998A (OSRAM) |
| NO (1) | NO20042697L (OSRAM) |
| NZ (1) | NZ565420A (OSRAM) |
| TW (1) | TW200303759A (OSRAM) |
| WO (1) | WO2003045431A2 (OSRAM) |
| ZA (1) | ZA200404113B (OSRAM) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| DK1733735T3 (en) | 1998-05-22 | 2017-06-19 | Ottawa Hospital Res Inst | Methods and products for the induction of mucosal immunity |
| US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| EP1322655B1 (en) | 2000-01-14 | 2007-11-14 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| US20010044416A1 (en) * | 2000-01-20 | 2001-11-22 | Mccluskie Michael J. | Immunostimulatory nucleic acids for inducing a Th2 immune response |
| US20040175355A1 (en) * | 2001-04-18 | 2004-09-09 | The Regents Of The University Of California | Methods of using secondary lymphoid organ chemokine to modulate physiological processes in mammals |
| US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
| WO2003020884A2 (en) * | 2001-08-14 | 2003-03-13 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Method for rapid generation of mature dendritic cells |
| EP1450856B1 (en) | 2001-09-14 | 2009-11-11 | Cytos Biotechnology AG | Packaging of immunostimulatory cpg into virus-like particles: method of preparation and use |
| US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
| AU2002366710A1 (en) | 2001-12-20 | 2003-07-09 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS |
| US8263091B2 (en) * | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
| JP2006512927A (ja) | 2002-12-11 | 2006-04-20 | コーリー ファーマシューティカル グループ，インコーポレイテッド | ５’ｃｐｇ核酸およびその使用方法 |
| EP2572714A1 (en) * | 2002-12-30 | 2013-03-27 | 3M Innovative Properties Company | Immunostimulatory Combinations |
| WO2004074437A2 (en) * | 2003-02-14 | 2004-09-02 | University Of Southern California | Compositions and methods for cancer immunotherapy |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| RU2351362C2 (ru) | 2003-03-26 | 2009-04-10 | Цитос Байотекнолоджи Аг | КОНЪЮГАТЫ ПЕПТИДА Melan-A, АНАЛОГА ВИРУСОПОДОБНОЙ ЧАСТИЦЫ |
| CA2544240A1 (en) * | 2003-07-22 | 2005-02-17 | Cytos Biotechnology Ag | Cpg-packaged liposomes |
| AU2005205533B2 (en) | 2004-01-07 | 2012-03-22 | Novartis Vaccines And Diagnostics, Inc. | M-CSF-specific monoclonal antibody and uses thereof |
| EP1720568A2 (en) * | 2004-02-19 | 2006-11-15 | Coley Pharmaceutical Group, Inc. | Immunostimulatory viral rna oligonucleotides |
| WO2006112869A2 (en) * | 2004-07-19 | 2006-10-26 | Baylor College Of Medicine | Modulation of cytokine signaling regulators and applications for immunotherapy |
| WO2006014653A1 (en) * | 2004-07-20 | 2006-02-09 | Schering Corporation | Induction of apoptosis in toll-like receptor expressing tumor cells |
| US20080274140A1 (en) | 2004-11-19 | 2008-11-06 | David B Weiner | Vaccines and Methods for Using the Same |
| JPWO2006077724A1 (ja) * | 2004-12-28 | 2008-06-19 | 株式会社イミュノフロンティア | がんワクチン製剤 |
| EP1712241A1 (en) | 2005-04-15 | 2006-10-18 | Centre National De La Recherche Scientifique (Cnrs) | Composition for treating cancer adapted for intra-tumoral administration and uses thereof |
| US20100143899A1 (en) * | 2005-05-17 | 2010-06-10 | University Of Vermont And State Agricultural College | Methods and products for diagnosing cancer |
| US7868159B2 (en) * | 2005-06-23 | 2011-01-11 | Baylor College Of Medicine | Modulation of negative immune regulators and applications for immunotherapy |
| BRPI0613515A2 (pt) * | 2005-07-11 | 2011-01-11 | Cbio Ltd | imunomodulação induzida por chaperonina 10 |
| NZ569086A (en) * | 2005-12-01 | 2011-07-29 | Trinity College Dublin | Compositions comprising a Toll-like receptor (TLR) agonist and an immune modulator for treating Th1-mediated conditions, such as cancer and infectious diseases |
| WO2007068747A1 (en) | 2005-12-14 | 2007-06-21 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| JP5437797B2 (ja) | 2006-06-12 | 2014-03-12 | サイトス バイオテクノロジー アーゲー | Ｒｎａバクテリオファージのウイルス様粒子にオリゴヌクレオチドをパッケージ化するための方法 |
| DE102006035618A1 (de) * | 2006-07-31 | 2008-02-07 | Curevac Gmbh | Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz |
| US20080124366A1 (en) * | 2006-08-06 | 2008-05-29 | Ohlfest John R | Methods and Compositions for Treating Tumors |
| US20090074711A1 (en) * | 2006-09-07 | 2009-03-19 | University Of Southhampton | Human therapies using chimeric agonistic anti-human cd40 antibody |
| AU2007333146A1 (en) * | 2006-12-12 | 2008-06-19 | Idera Pharmaceuticals, Inc. | Synthetic agonists of TLR9 |
| US8445442B2 (en) * | 2007-04-26 | 2013-05-21 | University Of Vermont And State Agricultural College | CCL18 and CCL3 methods and compositions for detecting and treating cancer |
| US8324369B2 (en) * | 2007-11-30 | 2012-12-04 | Baylor College Of Medicine | Dendritic cell vaccine compositions and uses of same |
| RU2011135993A (ru) * | 2009-01-30 | 2013-03-10 | Идера Фармасьютикалз, Инк. | Новые синтетические агонисты tlr9 |
| CA2781311C (en) | 2009-12-07 | 2019-03-12 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for enhancing anti-tumor antibody therapy |
| WO2011097384A2 (en) * | 2010-02-04 | 2011-08-11 | Board Of Regents, The University Of Texas System | Tumor targeted delivery of immunomodulators by nanoplymers |
| EP2531207B1 (en) | 2010-02-05 | 2019-10-30 | Cornell University | Methods and compositions for cancer immunotherapy using flagellin-tumor associated antigen fusion protein expressing tumor cells |
| JP2013538558A (ja) | 2010-07-19 | 2013-10-17 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | Ｔｌｒ媒介疾患を治療するためのｔｏｌｌ様受容体（ｔｌｒ）の膜貫通型ドメインに基づくペプチド |
| RU2013110889A (ru) * | 2010-08-13 | 2014-09-20 | Бейлор Рисёч Инститьют | Новые вакцинные адъюванты на основе адъювантов-антител, нацеливающих непосредственно на антигенпрезентирующие клетки |
| NZ702392A (en) * | 2012-06-08 | 2017-03-31 | Aduro Biotech | Compositions and methods for cancer immunotherapy |
| GB2534478A (en) * | 2012-06-27 | 2016-07-27 | Hasumi Int Res Found | Therapy and method for intratumorally introducing cytotoxic T lymphocyte and/or NKT cell with anti-TNF and/or anti-IL-10 |
| KR102130864B1 (ko) | 2012-09-05 | 2020-07-08 | 추가이 세이야쿠 가부시키가이샤 | 아미노산 및 스테릴기가 도입된 히알루론산 유도체 |
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2002
- 2002-11-25 TW TW091134176A patent/TW200303759A/zh unknown
- 2002-11-26 US US10/304,616 patent/US20030138413A1/en not_active Abandoned
- 2002-11-26 WO PCT/US2002/038098 patent/WO2003045431A2/en not_active Ceased
- 2002-11-26 EP EP02794058A patent/EP1450858A2/en not_active Withdrawn
- 2002-11-26 JP JP2003546932A patent/JP2006502080A/ja active Pending
- 2002-11-26 AU AU2002359516A patent/AU2002359516B2/en not_active Ceased
- 2002-11-26 NZ NZ565420A patent/NZ565420A/en not_active IP Right Cessation
- 2002-11-26 CA CA002468320A patent/CA2468320A1/en not_active Abandoned
- 2002-11-26 CN CN028275985A patent/CN1617742B/zh not_active Expired - Fee Related
- 2002-11-26 MX MXPA04004998A patent/MXPA04004998A/es unknown
- 2002-11-26 BR BRPI0214457-3A patent/BR0214457A/pt not_active IP Right Cessation
- 2002-11-26 HU HU0500999A patent/HUP0500999A2/hu unknown
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2004
- 2004-05-26 ZA ZA200404113A patent/ZA200404113B/xx unknown
- 2004-06-25 NO NO20042697A patent/NO20042697L/no not_active Application Discontinuation
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2005
- 2005-11-18 JP JP2005334633A patent/JP2006131638A/ja active Pending
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2008
- 2008-09-19 US US12/234,361 patent/US20090087440A1/en not_active Abandoned
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2009
- 2009-12-01 JP JP2009274004A patent/JP2010053140A/ja not_active Withdrawn
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