JP2006501149A5 - - Google Patents
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- JP2006501149A5 JP2006501149A5 JP2004500925A JP2004500925A JP2006501149A5 JP 2006501149 A5 JP2006501149 A5 JP 2006501149A5 JP 2004500925 A JP2004500925 A JP 2004500925A JP 2004500925 A JP2004500925 A JP 2004500925A JP 2006501149 A5 JP2006501149 A5 JP 2006501149A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- vitamin
- receptor
- derivative
- binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 27
- 102000035029 vitamin receptors Human genes 0.000 claims 15
- 108091005463 vitamin receptors Proteins 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 11
- 229940088594 vitamin Drugs 0.000 claims 10
- 229930003231 vitamin Natural products 0.000 claims 10
- 235000013343 vitamin Nutrition 0.000 claims 10
- 239000011782 vitamin Substances 0.000 claims 10
- 150000003722 vitamin derivatives Chemical class 0.000 claims 10
- 241001465754 Metazoa Species 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 150000001768 cations Chemical class 0.000 claims 8
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 6
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical group OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 6
- 229940014144 folate Drugs 0.000 claims 6
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical group C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 6
- 235000019152 folic acid Nutrition 0.000 claims 6
- 239000011724 folic acid Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 229910052713 technetium Inorganic materials 0.000 claims 6
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 claims 6
- 238000002059 diagnostic imaging Methods 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 238000003384 imaging method Methods 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 230000032895 transmembrane transport Effects 0.000 claims 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 3
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Chemical group OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims 3
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims 3
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Chemical group CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims 3
- 229960002685 biotin Drugs 0.000 claims 3
- 235000020958 biotin Nutrition 0.000 claims 3
- 239000011616 biotin Substances 0.000 claims 3
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical group [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 claims 3
- 229910052802 copper Inorganic materials 0.000 claims 3
- 239000010949 copper Substances 0.000 claims 3
- 102000006815 folate receptor Human genes 0.000 claims 3
- 108020005243 folate receptor Proteins 0.000 claims 3
- 229910052733 gallium Inorganic materials 0.000 claims 3
- 229910052738 indium Inorganic materials 0.000 claims 3
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims 3
- 229910052702 rhenium Inorganic materials 0.000 claims 3
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 claims 3
- 229960002477 riboflavin Drugs 0.000 claims 3
- 235000019192 riboflavin Nutrition 0.000 claims 3
- 239000002151 riboflavin Chemical group 0.000 claims 3
- 235000019157 thiamine Nutrition 0.000 claims 3
- 239000011721 thiamine Chemical group 0.000 claims 3
- 229960003495 thiamine Drugs 0.000 claims 3
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical group CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims 3
- 238000012544 monitoring process Methods 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37857102P | 2002-05-06 | 2002-05-06 | |
| US60/378,571 | 2002-05-06 | ||
| PCT/US2003/014379 WO2003092742A1 (en) | 2002-05-06 | 2003-05-06 | Vitamin-targeted imaging agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010161087A Division JP4801786B6 (ja) | 2002-05-06 | 2010-07-15 | ビタミンを標的とした造影剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006501149A JP2006501149A (ja) | 2006-01-12 |
| JP2006501149A5 true JP2006501149A5 (https=) | 2006-06-15 |
| JP4801348B2 JP4801348B2 (ja) | 2011-10-26 |
Family
ID=29401611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004500925A Expired - Fee Related JP4801348B2 (ja) | 2002-05-06 | 2003-05-06 | ビタミンを標的とした造影剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US7128893B2 (https=) |
| EP (4) | EP2258401B1 (https=) |
| JP (1) | JP4801348B2 (https=) |
| KR (1) | KR100978418B1 (https=) |
| CN (2) | CN101648028B (https=) |
| AT (1) | ATE448799T1 (https=) |
| AU (1) | AU2003239383C1 (https=) |
| CA (1) | CA2484345C (https=) |
| CY (1) | CY1114733T1 (https=) |
| DE (1) | DE60330135D1 (https=) |
| DK (3) | DK2260875T3 (https=) |
| ES (4) | ES2472423T3 (https=) |
| IL (1) | IL164811A (https=) |
| NZ (1) | NZ536467A (https=) |
| PT (2) | PT2151250E (https=) |
| SI (2) | SI2151250T1 (https=) |
| WO (1) | WO2003092742A1 (https=) |
| ZA (1) | ZA200408664B (https=) |
Families Citing this family (103)
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| US2816110A (en) | 1956-11-23 | 1957-12-10 | Merck & Co Inc | Methods for the production of substituted pteridines |
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| US5242679A (en) * | 1985-01-14 | 1993-09-07 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5175343A (en) * | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| NZ217821A (en) | 1985-10-10 | 1989-07-27 | Biotech Australia Pty Ltd | Oral delivery system; complex of active agent and vitamin b12 or analogue thereof |
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| EP0273085A1 (en) | 1986-12-29 | 1988-07-06 | IntraCel Corporation | A method for internalizing nucleic acids into eukaryotic cells |
| US5053493A (en) * | 1987-04-02 | 1991-10-01 | Centocor Cardiovascular Imaging Partners, L.P. | Method for labeling antibodies with a metal ion |
| US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
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| US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
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| US5159079A (en) | 1991-12-20 | 1992-10-27 | Eli Lilly And Company | 2-piperidones as intermediates for 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids |
| US6022966A (en) | 1993-11-22 | 2000-02-08 | Neorx Corporation | Pretargeting methods and compounds |
| DE4310999C2 (de) * | 1993-03-31 | 1996-07-18 | Diagnostikforschung Inst | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ XN¶1¶S¶1¶X' für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
| DE4311022C2 (de) * | 1993-03-31 | 1996-07-11 | Diagnostikforschung Inst | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ S¶3¶N¶2¶ für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
| DE4311021A1 (de) * | 1993-03-31 | 1994-10-27 | Diagnostikforschung Inst | Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel |
| DE4311023C2 (de) * | 1993-03-31 | 1996-05-02 | Diagnostikforschung Inst | Bifunktionelle chalkogenatom-unterbrochene Chelatbildner von Typ XN¶1¶S¶1¶O¶1¶ für radioaktive Isotope, deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel |
| DE4425781A1 (de) * | 1994-07-14 | 1996-01-18 | Schering Ag | Technetium-Sulfonamid-Komplexe, deren Verwendung, diese enthaltende pharmazeutische Mittel, sowie Verfahren zur Herstellung der Komplexe und Mittel |
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| ES2518926T3 (es) * | 2000-06-02 | 2014-11-05 | Board Of Regents, The University Of Texas System | Conjugados de etilendicisteína y un análogo de glucosa |
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2003
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- 2003-05-06 ES ES03733967T patent/ES2336780T3/es not_active Expired - Lifetime
- 2003-05-06 WO PCT/US2003/014379 patent/WO2003092742A1/en not_active Ceased
- 2003-05-06 AU AU2003239383A patent/AU2003239383C1/en not_active Ceased
- 2003-05-06 PT PT91715037T patent/PT2151250E/pt unknown
- 2003-05-06 DK DK09171503.7T patent/DK2151250T3/da active
- 2003-05-06 SI SI200332331T patent/SI2151250T1/sl unknown
- 2003-05-06 EP EP10179448.5A patent/EP2258401B1/en not_active Expired - Lifetime
- 2003-05-06 JP JP2004500925A patent/JP4801348B2/ja not_active Expired - Fee Related
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- 2003-05-06 CN CN200910151274XA patent/CN101648028B/zh not_active Expired - Fee Related
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- 2003-05-06 CA CA2484345A patent/CA2484345C/en not_active Expired - Fee Related
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- 2003-05-06 DK DK10179448.5T patent/DK2258401T3/da active
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- 2003-05-06 CN CNB038146835A patent/CN100528241C/zh not_active Expired - Fee Related
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2009
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