JP2005535586A - p38キナーゼ阻害剤としてのヘテロアリール置換ビフェニル誘導体 - Google Patents
p38キナーゼ阻害剤としてのヘテロアリール置換ビフェニル誘導体 Download PDFInfo
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- JP2005535586A JP2005535586A JP2004501387A JP2004501387A JP2005535586A JP 2005535586 A JP2005535586 A JP 2005535586A JP 2004501387 A JP2004501387 A JP 2004501387A JP 2004501387 A JP2004501387 A JP 2004501387A JP 2005535586 A JP2005535586 A JP 2005535586A
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- Prior art keywords
- methyl
- biphenyl
- cyclopropyl
- oxadiazol
- alkyl
- Prior art date
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- DTZUTWTZMJJZRG-UHFFFAOYSA-N CC(C)(C)CC(NCC(OC(c(cc1)ccc1-c1cc(C(NC2CC2)=O)ccc1C)=C1)=CC1=C)=O Chemical compound CC(C)(C)CC(NCC(OC(c(cc1)ccc1-c1cc(C(NC2CC2)=O)ccc1C)=C1)=CC1=C)=O DTZUTWTZMJJZRG-UHFFFAOYSA-N 0.000 description 1
- 0 Cc(c(-c(cc1)ccc1-c1c(*)cc[n]1)c1)ccc1C(Nc1cc(*2CCOCC2)ccc1)=O Chemical compound Cc(c(-c(cc1)ccc1-c1c(*)cc[n]1)c1)ccc1C(Nc1cc(*2CCOCC2)ccc1)=O 0.000 description 1
- QFZDAAWKUJFDSN-UHFFFAOYSA-N Cc(c(-c(cc1)ccc1-c1c[s]c(N)n1)c1)ccc1C(NC1CC1)=O Chemical compound Cc(c(-c(cc1)ccc1-c1c[s]c(N)n1)c1)ccc1C(NC1CC1)=O QFZDAAWKUJFDSN-UHFFFAOYSA-N 0.000 description 1
- HOHZBOGLXKHQJH-UHFFFAOYSA-N Cc(c(-c(cc1)ccc1-c1nnc(CN2CCSCC2)[o]1)c1)ccc1C(NC1CC1)=O Chemical compound Cc(c(-c(cc1)ccc1-c1nnc(CN2CCSCC2)[o]1)c1)ccc1C(NC1CC1)=O HOHZBOGLXKHQJH-UHFFFAOYSA-N 0.000 description 1
- RLEXMZRTAZFDPR-UHFFFAOYSA-N Cc(c(-c(cc1)ccc1C1=[N]=C(CN2CCCCC2)O1)c1)ccc1C(NC1CC1)=O Chemical compound Cc(c(-c(cc1)ccc1C1=[N]=C(CN2CCCCC2)O1)c1)ccc1C(NC1CC1)=O RLEXMZRTAZFDPR-UHFFFAOYSA-N 0.000 description 1
- VORMBGBVWWVMOA-UHFFFAOYSA-N Cc(ccc(NC(c1c[s]cc1)=O)c1)c1-c(c(C)c1)ccc1C1=NCC=C(C)O1 Chemical compound Cc(ccc(NC(c1c[s]cc1)=O)c1)c1-c(c(C)c1)ccc1C1=NCC=C(C)O1 VORMBGBVWWVMOA-UHFFFAOYSA-N 0.000 description 1
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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Applications Claiming Priority (2)
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GBGB0209891.1A GB0209891D0 (en) | 2002-04-30 | 2002-04-30 | Novel compounds |
PCT/GB2003/001834 WO2003093248A1 (en) | 2002-04-30 | 2003-04-29 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors |
Publications (2)
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JP2005535586A true JP2005535586A (ja) | 2005-11-24 |
JP2005535586A5 JP2005535586A5 (US07132539-20061107-C00040.png) | 2006-06-08 |
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JP2004501387A Pending JP2005535586A (ja) | 2002-04-30 | 2003-04-29 | p38キナーゼ阻害剤としてのヘテロアリール置換ビフェニル誘導体 |
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Cited By (1)
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JP2011500689A (ja) * | 2007-10-20 | 2011-01-06 | キネックス ファーマシューティカルズ, エルエルシー | キナーゼカスケードをモジュレートするための医薬組成物およびその使用の方法 |
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GB0124934D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
US7125898B2 (en) * | 2002-02-12 | 2006-10-24 | Smithkline Beecham Corporation | Nicotinamide derivatives useful as p38 inhibitors. |
GB0209891D0 (en) | 2002-04-30 | 2002-06-05 | Glaxo Group Ltd | Novel compounds |
GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
GB0308186D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0308201D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0308185D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
MXPA06000915A (es) | 2003-07-25 | 2006-03-30 | Novartis Ag | Inhibidores de quinasa p-38. |
GB0318814D0 (en) | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
GB0402143D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
GB0402138D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
GB0402140D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
GB0402137D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
US7683097B2 (en) * | 2004-05-27 | 2010-03-23 | Propharmacon Inc. | Topoisomerase inhibitors |
US20080051416A1 (en) * | 2004-10-05 | 2008-02-28 | Smithkline Beecham Corporation | Novel Compounds |
EP1802606B1 (en) * | 2004-10-19 | 2011-03-16 | Compass Pharmaceuticals LLC | Arylcarboxamides and their use as anti-tumor agents |
US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
US7300931B2 (en) | 2004-12-28 | 2007-11-27 | Kinex Pharmaceuticals, Llc | Compositions for treating cell proliferation disorders |
GB0512429D0 (en) * | 2005-06-17 | 2005-07-27 | Smithkline Beecham Corp | Novel compound |
SI1940786T1 (sl) * | 2005-09-16 | 2010-11-30 | Arrow Therapeutics Ltd | Bifenilni derivati in njihova uporaba pri zdravljenju hepatitisa C |
GB0612026D0 (en) | 2006-06-16 | 2006-07-26 | Smithkline Beecham Corp | New use |
AU2007265373B2 (en) | 2006-06-29 | 2013-02-21 | Atnx Spv, Llc | Biaryl compositions and methods for modulating a kinase cascade |
EP2054444B1 (en) | 2006-08-04 | 2016-11-02 | MedImmune Limited | Antibodies to erbb2 |
US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
US7939529B2 (en) | 2007-05-17 | 2011-05-10 | Kinex Pharmaceuticals, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
US8124605B2 (en) | 2007-07-06 | 2012-02-28 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
TWI490214B (zh) | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | 苯或噻吩衍生物及該等作為vap-1抑制劑之用途 |
CA2728769A1 (en) * | 2008-07-04 | 2010-01-07 | Bruno Villoutreix | Nitrogen heterocycle derivatives as proteasome modulators |
CA2796419C (en) | 2010-04-16 | 2018-11-06 | Kinex Pharmaceuticals, Llc | Compositions and methods for the prevention and treatment of cancer |
KR101530141B1 (ko) | 2010-12-17 | 2015-06-18 | 미쓰비시 타나베 파마 코퍼레이션 | 연속 아리시클릭 화합물 |
ES2690315T3 (es) | 2012-06-15 | 2018-11-20 | Mitsubishi Tanabe Pharma Corporation | Compuestos de imidazol y triazol como inhibidores de DGAT-1 |
SI2890680T1 (en) | 2012-08-30 | 2018-08-31 | Athenex, Inc. Conventus Building | N- (3-FLUOROBENZYL) -2- (5- (4-MORFOLINOPHENYL) PIRIDIN-2-IL) ACETAMIDE AS PROTEIN TIROZINE KINASE PROTECTORS |
TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
EP3495359A1 (en) * | 2013-02-04 | 2019-06-12 | Janssen Pharmaceutica NV | Flap modulators |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
WO2019071144A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | USE OF P38 INHIBITORS TO REDUCE DUX4 EXPRESSION |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
WO2019191032A1 (en) | 2018-03-26 | 2019-10-03 | Clear Creek Bio, Inc. | Compositions and methods for inhibiting dihydroorotate dehydrogenase |
US20210315880A1 (en) | 2020-03-20 | 2021-10-14 | Clear Creek Bio, Inc. | Methods of treating viral infections using inhibitors of nucleotide synthesis pathways |
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TW240217B (US07132539-20061107-C00040.png) * | 1992-12-30 | 1995-02-11 | Glaxo Group Ltd | |
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GB0124934D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124932D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124933D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124939D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124928D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124931D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
US7125898B2 (en) | 2002-02-12 | 2006-10-24 | Smithkline Beecham Corporation | Nicotinamide derivatives useful as p38 inhibitors. |
GB0209891D0 (en) | 2002-04-30 | 2002-06-05 | Glaxo Group Ltd | Novel compounds |
GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
-
2002
- 2002-04-30 GB GBGB0209891.1A patent/GB0209891D0/en not_active Ceased
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2003
- 2003-04-29 EP EP03747504A patent/EP1499600B1/en not_active Expired - Lifetime
- 2003-04-29 US US10/513,095 patent/US7425555B2/en not_active Expired - Fee Related
- 2003-04-29 DE DE60315146T patent/DE60315146T2/de not_active Expired - Lifetime
- 2003-04-29 JP JP2004501387A patent/JP2005535586A/ja active Pending
- 2003-04-29 AU AU2003226572A patent/AU2003226572A1/en not_active Abandoned
- 2003-04-29 AT AT03747504T patent/ATE368034T1/de not_active IP Right Cessation
- 2003-04-29 WO PCT/GB2003/001834 patent/WO2003093248A1/en active IP Right Grant
- 2003-04-29 ES ES03747504T patent/ES2290486T3/es not_active Expired - Lifetime
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JPH09506101A (ja) * | 1993-12-07 | 1997-06-17 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 5ht1d拮抗薬として有用な複素環式ビフェニリルアミド類 |
JPH10158240A (ja) * | 1996-11-04 | 1998-06-16 | Rhone Poulenc Agrochim | 殺有害生物性1−ポリアリールピラゾール類 |
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JP2011500689A (ja) * | 2007-10-20 | 2011-01-06 | キネックス ファーマシューティカルズ, エルエルシー | キナーゼカスケードをモジュレートするための医薬組成物およびその使用の方法 |
Also Published As
Publication number | Publication date |
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WO2003093248A1 (en) | 2003-11-13 |
EP1499600B1 (en) | 2007-07-25 |
US7425555B2 (en) | 2008-09-16 |
US20060089393A1 (en) | 2006-04-27 |
DE60315146T2 (de) | 2008-04-17 |
ATE368034T1 (de) | 2007-08-15 |
AU2003226572A1 (en) | 2003-11-17 |
GB0209891D0 (en) | 2002-06-05 |
ES2290486T3 (es) | 2008-02-16 |
DE60315146D1 (de) | 2007-09-06 |
EP1499600A1 (en) | 2005-01-26 |
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