JP2005531549A5 - - Google Patents
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- Publication number
- JP2005531549A5 JP2005531549A5 JP2004501408A JP2004501408A JP2005531549A5 JP 2005531549 A5 JP2005531549 A5 JP 2005531549A5 JP 2004501408 A JP2004501408 A JP 2004501408A JP 2004501408 A JP2004501408 A JP 2004501408A JP 2005531549 A5 JP2005531549 A5 JP 2005531549A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorine
- chlorine
- optionally
- substituted
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- -1 optionally Chemical group 0.000 claims 116
- 229910052801 chlorine Inorganic materials 0.000 claims 36
- 239000000460 chlorine Substances 0.000 claims 35
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 34
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 26
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 24
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 21
- 229910052794 bromium Inorganic materials 0.000 claims 21
- CPPKAGUPTKIMNP-UHFFFAOYSA-N cyanogen fluoride Chemical compound FC#N CPPKAGUPTKIMNP-UHFFFAOYSA-N 0.000 claims 21
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 19
- 229910052731 fluorine Inorganic materials 0.000 claims 18
- 239000011737 fluorine Substances 0.000 claims 18
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 18
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 claims 18
- 125000004775 chlorodifluoromethyl group Chemical group FC(F)(Cl)* 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 claims 17
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 17
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 17
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 17
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 16
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 16
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- 125000003652 trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims 9
- 125000004369 butenyl group Chemical group C(=CCC)* 0.000 claims 8
- 125000000480 butynyl group Chemical group [*]C#CC([H])([H])C([H])([H])[H] 0.000 claims 8
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 8
- 125000001153 fluoro group Chemical group F* 0.000 claims 8
- 125000002255 pentenyl group Chemical group C(=CCCC)* 0.000 claims 8
- 125000005981 pentynyl group Chemical group 0.000 claims 8
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims 8
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 claims 8
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000002541 furyl group Chemical group 0.000 claims 6
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 239000003085 diluting agent Substances 0.000 claims 5
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 5
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 125000002603 chloroethyl group Chemical group [H]C([*])([H])C([H])([H])Cl 0.000 claims 4
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 125000006003 dichloroethyl group Chemical group 0.000 claims 4
- 125000006001 difluoroethyl group Chemical group 0.000 claims 4
- 125000006125 ethylsulfonyl group Chemical group 0.000 claims 4
- 125000003784 fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 claims 4
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims 4
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000004434 sulfur atom Chemical group 0.000 claims 4
- 125000006337 tetrafluoro ethyl group Chemical group 0.000 claims 4
- 125000004205 trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 4
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 4
- 241000244206 Nematoda Species 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 3
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 claims 2
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000004606 Fillers/Extenders Substances 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000005998 bromoethyl group Chemical group 0.000 claims 1
- 125000005997 bromomethyl group Chemical group 0.000 claims 1
- XUBDVXOHGQSAHX-UHFFFAOYSA-N chembl188441 Chemical compound C12=NC(C)=NC(O)=C2C=NN1C1=C(Cl)C=C(Cl)C=C1Cl XUBDVXOHGQSAHX-UHFFFAOYSA-N 0.000 claims 1
- 125000004789 chlorodifluoromethoxy group Chemical group ClC(O*)(F)F 0.000 claims 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 claims 1
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004289 pyrazol-3-yl group Chemical group [H]N1N=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 125000006000 trichloroethyl group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 0 *[n]1ncc(C(N)=O)c1N Chemical compound *[n]1ncc(C(N)=O)c1N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10219435A DE10219435A1 (de) | 2002-05-02 | 2002-05-02 | Substituierte Pyrazolo-pyrimidin-4-one |
| PCT/EP2003/004137 WO2003093269A2 (de) | 2002-05-02 | 2003-04-22 | Substituierte pyrazolo-pyrimidin-4-one |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005531549A JP2005531549A (ja) | 2005-10-20 |
| JP2005531549A5 true JP2005531549A5 (https=) | 2006-06-08 |
Family
ID=29224943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004501408A Withdrawn JP2005531549A (ja) | 2002-05-02 | 2003-04-22 | 置換ピラゾロ−ピリミジン−４−オン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050209251A1 (https=) |
| EP (1) | EP1504005A2 (https=) |
| JP (1) | JP2005531549A (https=) |
| AR (1) | AR039468A1 (https=) |
| AU (1) | AU2003224111A1 (https=) |
| BR (1) | BR0309873A (https=) |
| CA (1) | CA2484997A1 (https=) |
| DE (1) | DE10219435A1 (https=) |
| WO (1) | WO2003093269A2 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2773482B1 (fr) † | 1998-01-13 | 2001-04-20 | Oreal | Composition de teinture d'oxydation des fibres keratiniques et procede de teinture mettant en oeuvre cette composition |
| DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
| DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
| DE10238723A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
| MXPA05007485A (es) | 2003-01-14 | 2006-01-30 | Arena Pharm Inc | Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia. |
| CA2524900C (en) * | 2003-05-09 | 2012-03-20 | Bayer Healthcare Ag | 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines |
| DE102004004142A1 (de) * | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine |
| US8044060B2 (en) | 2003-05-09 | 2011-10-25 | Boehringer Ingelheim International Gmbh | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory |
| DE10320785A1 (de) | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Arylmethyl-substituierte Pyrazolopyrimidine |
| DE10328479A1 (de) | 2003-06-25 | 2005-01-13 | Bayer Ag | 6-Arylamino-5-cyano-4-pyrimidinone |
| DE102004001873A1 (de) | 2004-01-14 | 2005-09-29 | Bayer Healthcare Ag | Cyanopyrimidinone |
| DOP2006000009A (es) * | 2005-01-13 | 2006-08-15 | Arena Pharm Inc | Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina |
| WO2006134459A1 (en) * | 2005-06-15 | 2006-12-21 | Pfizer Limited | Substituted arylpyrazoles |
| US8097712B2 (en) | 2007-11-07 | 2012-01-17 | Beelogics Inc. | Compositions for conferring tolerance to viral disease in social insects, and the use thereof |
| JP5498392B2 (ja) * | 2007-11-30 | 2014-05-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用 |
| UA105362C2 (en) * | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| JP5453431B2 (ja) | 2008-09-08 | 2014-03-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピラゾロピリミジン及びｃｎｓ障害の治療のためのそれらの使用 |
| PE20120505A1 (es) | 2009-03-31 | 2012-05-09 | Boehringer Ingelheim Int | Derivados de 1-heterociclil-1,5-dihidro-pirazolo[3,4-d]pirimidin-4-ona como moduladores de pde9a |
| AR077859A1 (es) * | 2009-08-12 | 2011-09-28 | Boehringer Ingelheim Int | Compuestos para el tratamiento de trastornos del snc |
| US8962584B2 (en) | 2009-10-14 | 2015-02-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Compositions for controlling Varroa mites in bees |
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| PH12013500547A1 (en) | 2010-09-22 | 2013-06-10 | Arena Pharm Inc | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US8809345B2 (en) | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
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| UY35252A (es) | 2013-01-01 | 2014-07-31 | Seeds Ltd Ab | MÉTODOS PARA INTRODUCIR dsRNA EN SEMILLAS DE PLANTAS PARA MODULAR LA EXPRESIÓN GENÉTICA |
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| AU2014261585B2 (en) | 2013-05-02 | 2018-03-08 | F. Hoffmann-La Roche Ag | Purine derivatives as CB2 receptor agonists |
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| AU2014341879B2 (en) | 2013-11-04 | 2020-07-23 | Greenlight Biosciences, Inc. | Compositions and methods for controlling arthropod parasite and pest infestations |
| UA119253C2 (uk) | 2013-12-10 | 2019-05-27 | Біолоджикс, Інк. | Спосіб боротьби із вірусом у кліща varroa та у бджіл |
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| CN106604993A (zh) | 2014-07-29 | 2017-04-26 | 孟山都技术公司 | 用于控制昆虫害虫的组合物和方法 |
| MX386419B (es) | 2015-01-06 | 2025-03-18 | Arena Pharm Inc | Metodos de condiciones de tratamiento relacionadas con el receptor s1p1. |
| CN108064288B (zh) | 2015-01-22 | 2021-11-26 | 孟山都技术公司 | 用于控制叶甲属的组合物和方法 |
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| WO2016196782A1 (en) | 2015-06-03 | 2016-12-08 | Monsanto Technology Llc | Methods and compositions for introducing nucleic acids into plants |
| EP3939965A1 (en) | 2015-06-22 | 2022-01-19 | Arena Pharmaceuticals, Inc. | Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid for use in sipi receptor-associated disorders |
| MA47504A (fr) | 2017-02-16 | 2019-12-25 | Arena Pharm Inc | Composés et méthodes de traitement de l'angiocholite biliaire primitive |
| ES2987794T3 (es) | 2018-06-06 | 2024-11-18 | Arena Pharm Inc | Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1 |
| CN110317204B (zh) * | 2019-08-02 | 2022-02-08 | 安徽农业大学 | 吡唑并嘧啶酮类衍生物及其制备方法和应用 |
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| US2925418A (en) * | 1960-02-16 | Certificate of correction | ||
| GB1406412A (en) * | 1974-03-04 | 1975-09-17 | Pfizer | Pyrimidinones and process for preparing them |
| US4496390A (en) * | 1980-02-26 | 1985-01-29 | May & Baker Limited | N-Phenylpyrazole derivatives |
| JPS57167902A (en) * | 1981-04-08 | 1982-10-16 | Otsuka Chem Co Ltd | Herbicidal composition |
| MA19539A1 (fr) * | 1981-07-17 | 1983-04-01 | May & Baker Ltd | N Acylaminophenylpyrazoles |
| DE3420985A1 (de) * | 1983-10-15 | 1985-04-25 | Bayer Ag, 5090 Leverkusen | Substituierte 5-acylamino-1-phenylpyrazole |
| DE3520331A1 (de) * | 1985-06-07 | 1986-12-11 | Bayer Ag, 5090 Leverkusen | 1-aryl-5-alkoximinoalkylamino-pyrazole |
| DE3625686A1 (de) * | 1986-07-30 | 1988-02-04 | Bayer Ag | 4-cyano(nitro)-5-oxy(thio)-pyrazol-derivate |
| US5167691A (en) * | 1991-10-03 | 1992-12-01 | Fmc Corporation | Herbicidal 5-amino-1-phenyl pyrazole compounds |
| IL103678A (en) * | 1991-11-13 | 1996-09-12 | Schering Ag | History of pyrazolylpyrazole, processes for their preparation and herbicidal preparations containing them |
| US5198014A (en) * | 1991-11-20 | 1993-03-30 | Fmc Corporation | Herbicidal beta-pyrazolylacrylic acid compound |
| US5250504A (en) * | 1991-11-20 | 1993-10-05 | Fmc Corporation | Herbicidal β-pyrazolylacrylic acids |
| DK0663913T3 (da) * | 1992-10-12 | 1999-05-03 | Hoechst Schering Agrevo Gmbh | Nye substituerede pyrazolderivater, fremgangsmåder til deres fremstilling samt deres anvendelse som herbicider |
| TW370529B (en) * | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
| DE19530606A1 (de) * | 1995-08-21 | 1997-02-27 | Basf Ag | 1-(Pyridyl)-pyrazole |
| DE19623892A1 (de) * | 1996-06-06 | 1997-12-11 | Hoechst Schering Agrevo Gmbh | Substituierte Pyrazolyl-pyrazolderivate |
-
2002
- 2002-05-02 DE DE10219435A patent/DE10219435A1/de not_active Withdrawn
-
2003
- 2003-04-22 CA CA002484997A patent/CA2484997A1/en not_active Abandoned
- 2003-04-22 WO PCT/EP2003/004137 patent/WO2003093269A2/de not_active Ceased
- 2003-04-22 BR BR0309873-7A patent/BR0309873A/pt not_active IP Right Cessation
- 2003-04-22 JP JP2004501408A patent/JP2005531549A/ja not_active Withdrawn
- 2003-04-22 US US10/512,834 patent/US20050209251A1/en not_active Abandoned
- 2003-04-22 EP EP03720510A patent/EP1504005A2/de not_active Withdrawn
- 2003-04-22 AU AU2003224111A patent/AU2003224111A1/en not_active Abandoned
- 2003-04-28 AR ARP030101462A patent/AR039468A1/es not_active Application Discontinuation
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