JP2005531486A5 - - Google Patents
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- Publication number
- JP2005531486A5 JP2005531486A5 JP2003519096A JP2003519096A JP2005531486A5 JP 2005531486 A5 JP2005531486 A5 JP 2005531486A5 JP 2003519096 A JP2003519096 A JP 2003519096A JP 2003519096 A JP2003519096 A JP 2003519096A JP 2005531486 A5 JP2005531486 A5 JP 2005531486A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- methyl
- salt
- hydride
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 amino, monosubstituted amino Chemical group 0.000 claims 57
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 51
- 238000000034 method Methods 0.000 claims 34
- 150000003839 salts Chemical class 0.000 claims 34
- 150000001875 compounds Chemical class 0.000 claims 30
- 150000004678 hydrides Chemical class 0.000 claims 30
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 30
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 21
- 125000004442 acylamino group Chemical group 0.000 claims 19
- 125000004112 carboxyamino group Chemical group [H]OC(=O)N([H])[*] 0.000 claims 15
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 11
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 11
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000001589 carboacyl group Chemical group 0.000 claims 7
- 125000000547 substituted alkyl group Chemical group 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 125000001145 hydrido group Chemical group *[H] 0.000 claims 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 230000000850 deacetylating effect Effects 0.000 claims 1
- 230000020176 deacylation Effects 0.000 claims 1
- 238000005947 deacylation reaction Methods 0.000 claims 1
- 0 CNC(C(C*)NC(C(CC(N)=O)NC(C(Cc1c[n]c2ccccc12)O*)=O)=O)=O Chemical compound CNC(C(C*)NC(C(CC(N)=O)NC(C(Cc1c[n]c2ccccc12)O*)=O)=O)=O 0.000 description 7
- YDURMNGSKUCOLY-ZIYOKLDJSA-N NC(CCC(O)=O)[C@H]1OC1N Chemical compound NC(CCC(O)=O)[C@H]1OC1N YDURMNGSKUCOLY-ZIYOKLDJSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31031301P | 2001-08-06 | 2001-08-06 | |
| PCT/US2002/024896 WO2003014147A1 (en) | 2001-08-06 | 2002-08-06 | Novel depsipeptides and process for preparing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005531486A JP2005531486A (ja) | 2005-10-20 |
| JP2005531486A5 true JP2005531486A5 (https=) | 2006-01-05 |
Family
ID=23201948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003519096A Pending JP2005531486A (ja) | 2001-08-06 | 2002-08-06 | 新規のデプシペプチドおよびこれを調製するためのプロセス |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US20030083240A1 (https=) |
| EP (2) | EP1423414A4 (https=) |
| JP (1) | JP2005531486A (https=) |
| KR (1) | KR20040022233A (https=) |
| CN (1) | CN100352836C (https=) |
| AT (1) | ATE430160T1 (https=) |
| AU (1) | AU2002353775A1 (https=) |
| BR (1) | BR0211761A (https=) |
| CA (2) | CA2456323A1 (https=) |
| DE (1) | DE60232158D1 (https=) |
| IL (1) | IL160171A0 (https=) |
| NZ (1) | NZ531493A (https=) |
| RU (1) | RU2348647C2 (https=) |
| WO (2) | WO2003017924A2 (https=) |
| ZA (1) | ZA200400928B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0211761A (pt) * | 2001-08-06 | 2007-01-09 | Cubist Pharm Inc | depsipeptìdeos e processos para preparar os mesmos |
| US6767718B2 (en) * | 2002-05-10 | 2004-07-27 | Biosource Pharm, Inc. | Lipodepsipeptide antibiotics and methods of preparation |
| AU2004246909B2 (en) * | 2003-06-19 | 2010-08-19 | Yeda Research & Development Co. Ltd. | Antimicrobial and anticancer lipopeptides |
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| CA2587848A1 (en) * | 2004-11-12 | 2006-10-19 | Cubist Pharmaceuticals, Inc. | Antiinfective lipopeptides |
| WO2006063132A2 (en) * | 2004-12-06 | 2006-06-15 | The Regents Of The University Of California | Methods for improving the structure and function of arterioles |
| EP1877041A2 (en) * | 2005-04-29 | 2008-01-16 | Cubist Pharmaceuticals, Inc. | Therapeutic compositions |
| JP5607025B2 (ja) * | 2008-04-21 | 2014-10-15 | シグナム バイオサイエンシーズ， インコーポレイテッド | 化合物、組成物およびそれらを作製する方法 |
| PL2379580T3 (pl) | 2008-12-22 | 2014-05-30 | Merck Sharp & Dohme | Nowe środki przeciwbakteryjne do leczenia zakażeń wywołanych bakteriami Gram-dodatnimi |
| CA2747995A1 (en) | 2008-12-23 | 2010-07-01 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| CN101899094B (zh) * | 2009-06-01 | 2012-11-21 | 安徽丰原发酵技术工程研究有限公司 | 一种高纯达托霉素的制备方法 |
| KR101013755B1 (ko) * | 2010-02-02 | 2011-02-14 | 주식회사 삼광산전 | 정출력용 엘이디모듈 전원공급 컨버터 |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| CN102351775B (zh) * | 2011-09-14 | 2013-10-09 | 佛山普正医药科技有限公司 | 一种左旋5-羟基色氨酸的制备方法 |
| WO2013059610A1 (en) | 2011-10-20 | 2013-04-25 | Trius Therapeutics, Inc. | Therapeutic combination of daptomycin and protein synthesis inhibitor antibiotic, and methods of use |
| TW202244057A (zh) * | 2012-12-03 | 2022-11-16 | 美商諾維生物製藥有限公司 | 新穎縮肽及其用途 |
| JP6634197B2 (ja) * | 2013-05-08 | 2020-01-22 | 株式会社ゲノム創薬研究所 | 固相レジンを用いた環状ペプチド化合物の製造方法 |
| WO2015172047A1 (en) * | 2014-05-08 | 2015-11-12 | Merck Sharp & Dohme Corp. | Cyclic peptide compounds and related methods, salts and compositions |
| KR101671325B1 (ko) * | 2015-01-09 | 2016-11-02 | 한국생명공학연구원 | 신규한 고리형 뎁시펩타이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 항균용 약학적 조성물 |
| US11667674B2 (en) * | 2016-04-08 | 2023-06-06 | Versitech Limited | Antibacterial cyclic lipopeptides |
| US10072045B1 (en) | 2017-06-26 | 2018-09-11 | Ramapo Pharmaceuticals, Inc. | Antibacterial lipopeptides and methods for their preparation and use |
| US11643438B2 (en) | 2018-07-20 | 2023-05-09 | The Board Of Regents Of The University Of Oklahoma | Antimicrobial peptides and methods of use |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE32333E (en) | 1978-10-16 | 1987-01-20 | Eli Lilly And Company | A-21978 Antibiotics and process for their production |
| USRE32455E (en) | 1978-10-16 | 1987-07-07 | Eli Lilly And Company | A-21978 antibiotics and process for their production |
| US4524135A (en) | 1982-05-21 | 1985-06-18 | Eli Lilly And Company | A-21978C cyclic peptides |
| USRE32310E (en) * | 1982-05-21 | 1986-12-16 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
| US4482487A (en) | 1982-05-21 | 1984-11-13 | Eli Lilly And Company | A-21978C cyclic peptides |
| USRE32311E (en) * | 1982-05-21 | 1986-12-16 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
| US4537717A (en) | 1982-05-21 | 1985-08-27 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
| US4399067A (en) * | 1982-05-21 | 1983-08-16 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
| US4885243A (en) | 1984-10-09 | 1989-12-05 | Eli Lilly And Company | Process for producing A-21978C derivatives |
| US4800157A (en) * | 1985-09-09 | 1989-01-24 | Eli Lilly And Company | Process for producing the A-21978C antibiotics |
| CA1315229C (en) * | 1987-06-10 | 1993-03-30 | Eli Lilly And Company | Chromatographic purification process |
| US4874843A (en) * | 1987-12-03 | 1989-10-17 | Eli Lilly And Company | Chromatographic purification process |
| US5039789A (en) * | 1988-04-11 | 1991-08-13 | Eli Lilly And Company | A54145 cyclic peptides |
| US4977083A (en) * | 1988-04-11 | 1990-12-11 | Eli Lilly And Company | Processes for preparing A54145 compounds |
| US4994270A (en) * | 1988-04-11 | 1991-02-19 | Eli Lilly And Company | A54145 antibiotics and process for their production |
| US5028590A (en) * | 1988-04-11 | 1991-07-02 | Eli Lilly And Company | Derivatives of A54145 cyclic peptides |
| IL98349A (en) * | 1990-06-07 | 1995-05-26 | Lilly Co Eli | Diphylase lipopeptide |
| CA2131389A1 (en) * | 1992-03-02 | 1993-09-16 | John M. Maraganore | Thrombin receptor antagonists |
| US5378804A (en) * | 1993-03-16 | 1995-01-03 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| DE4411025A1 (de) * | 1994-03-30 | 1995-10-05 | Hoechst Ag | Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
| JP3123078B2 (ja) | 1996-03-08 | 2001-01-09 | 藤沢薬品工業株式会社 | 環状リポペプチド物質の脱アシル化法 |
| US5958728A (en) * | 1996-11-18 | 1999-09-28 | Novo Nordiskbiotech, Inc. | Methods for producing polypeptides in mutants of bacillus cells |
| US20010041346A1 (en) | 1999-07-14 | 2001-11-15 | Michael E. Mendelsohn | Method for assaying compounds affecting smooth muscle contractile state |
| AU784812B2 (en) | 1999-12-15 | 2006-06-29 | Merck Sharp & Dohme Corp. | Lipopeptides as antibacterial agents |
| CA2394313A1 (en) * | 1999-12-15 | 2001-06-21 | Cubist Pharmaceuticals, Inc. | Novel lipopeptides as antibacterial agents |
| MXPA02006029A (es) | 1999-12-15 | 2004-08-23 | Cubist Pharm Inc | Lipopeptidos novedosos como agentes antibacterianos. |
| US6696412B1 (en) | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
| US6750199B2 (en) * | 2000-07-17 | 2004-06-15 | Micrologix Biotech Inc. | Antimicrobial sulfonamide derivatives of lipopeptide antibiotics |
| BR0211761A (pt) | 2001-08-06 | 2007-01-09 | Cubist Pharm Inc | depsipeptìdeos e processos para preparar os mesmos |
-
2002
- 2002-08-06 BR BRPI0211761-4A patent/BR0211761A/pt not_active IP Right Cessation
- 2002-08-06 JP JP2003519096A patent/JP2005531486A/ja active Pending
- 2002-08-06 DE DE60232158T patent/DE60232158D1/de not_active Expired - Fee Related
- 2002-08-06 CA CA002456323A patent/CA2456323A1/en not_active Abandoned
- 2002-08-06 CN CNB028174658A patent/CN100352836C/zh not_active Expired - Fee Related
- 2002-08-06 EP EP02761255A patent/EP1423414A4/en not_active Withdrawn
- 2002-08-06 US US10/213,389 patent/US20030083240A1/en not_active Abandoned
- 2002-08-06 RU RU2004106630/04A patent/RU2348647C2/ru not_active IP Right Cessation
- 2002-08-06 AU AU2002353775A patent/AU2002353775A1/en not_active Abandoned
- 2002-08-06 WO PCT/US2002/025106 patent/WO2003017924A2/en not_active Ceased
- 2002-08-06 EP EP02789158A patent/EP1423137B1/en not_active Expired - Lifetime
- 2002-08-06 NZ NZ531493A patent/NZ531493A/xx not_active IP Right Cessation
- 2002-08-06 KR KR10-2004-7001758A patent/KR20040022233A/ko not_active Ceased
- 2002-08-06 IL IL16017102A patent/IL160171A0/xx unknown
- 2002-08-06 AT AT02789158T patent/ATE430160T1/de not_active IP Right Cessation
- 2002-08-06 WO PCT/US2002/024896 patent/WO2003014147A1/en not_active Ceased
- 2002-08-06 CA CA002456761A patent/CA2456761A1/en not_active Abandoned
- 2002-08-06 US US10/213,218 patent/US7262268B2/en not_active Expired - Fee Related
-
2004
- 2004-02-04 ZA ZA200400928A patent/ZA200400928B/en unknown
-
2006
- 2006-04-28 US US11/414,762 patent/US20060194714A1/en not_active Abandoned
- 2006-06-06 US US11/448,066 patent/US7335726B2/en not_active Expired - Fee Related
-
2008
- 2008-01-30 US US12/022,470 patent/US20080119395A1/en not_active Abandoned
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