JP2005531486A - 新規のデプシペプチドおよびこれを調製するためのプロセス - Google Patents

新規のデプシペプチドおよびこれを調製するためのプロセス Download PDF

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Publication number
JP2005531486A
JP2005531486A JP2003519096A JP2003519096A JP2005531486A JP 2005531486 A JP2005531486 A JP 2005531486A JP 2003519096 A JP2003519096 A JP 2003519096A JP 2003519096 A JP2003519096 A JP 2003519096A JP 2005531486 A JP2005531486 A JP 2005531486A
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JP
Japan
Prior art keywords
compound
amino
methyl
salt
formula
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2003519096A
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English (en)
Japanese (ja)
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JP2005531486A5 (https=
Inventor
ジョン フィン，
マイケル モリトコ，
イアン バリー パー，
マイケル ユング，
Original Assignee
キュービスト ファーマシューティカルズ， インコーポレイテッド
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Application filed by キュービスト ファーマシューティカルズ， インコーポレイテッド filed Critical キュービスト ファーマシューティカルズ， インコーポレイテッド
Publication of JP2005531486A publication Critical patent/JP2005531486A/ja
Publication of JP2005531486A5 publication Critical patent/JP2005531486A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2003519096A 2001-08-06 2002-08-06 新規のデプシペプチドおよびこれを調製するためのプロセス Pending JP2005531486A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31031301P 2001-08-06 2001-08-06
PCT/US2002/024896 WO2003014147A1 (en) 2001-08-06 2002-08-06 Novel depsipeptides and process for preparing same

Publications (2)

Publication Number Publication Date
JP2005531486A true JP2005531486A (ja) 2005-10-20
JP2005531486A5 JP2005531486A5 (https=) 2006-01-05

Family

ID=23201948

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003519096A Pending JP2005531486A (ja) 2001-08-06 2002-08-06 新規のデプシペプチドおよびこれを調製するためのプロセス

Country Status (15)

Country Link
US (5) US20030083240A1 (https=)
EP (2) EP1423414A4 (https=)
JP (1) JP2005531486A (https=)
KR (1) KR20040022233A (https=)
CN (1) CN100352836C (https=)
AT (1) ATE430160T1 (https=)
AU (1) AU2002353775A1 (https=)
BR (1) BR0211761A (https=)
CA (2) CA2456323A1 (https=)
DE (1) DE60232158D1 (https=)
IL (1) IL160171A0 (https=)
NZ (1) NZ531493A (https=)
RU (1) RU2348647C2 (https=)
WO (2) WO2003017924A2 (https=)
ZA (1) ZA200400928B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012126753A (ja) * 2008-04-21 2012-07-05 Signum Biosciences Inc 化合物、組成物およびそれらを作製する方法
JP2014217322A (ja) * 2013-05-08 2014-11-20 株式会社ゲノム創薬研究所 固相レジンを用いた環状ペプチド化合物の製造方法

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BR0211761A (pt) * 2001-08-06 2007-01-09 Cubist Pharm Inc depsipeptìdeos e processos para preparar os mesmos
US6767718B2 (en) * 2002-05-10 2004-07-27 Biosource Pharm, Inc. Lipodepsipeptide antibiotics and methods of preparation
AU2004246909B2 (en) * 2003-06-19 2010-08-19 Yeda Research & Development Co. Ltd. Antimicrobial and anticancer lipopeptides
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
CA2587848A1 (en) * 2004-11-12 2006-10-19 Cubist Pharmaceuticals, Inc. Antiinfective lipopeptides
WO2006063132A2 (en) * 2004-12-06 2006-06-15 The Regents Of The University Of California Methods for improving the structure and function of arterioles
EP1877041A2 (en) * 2005-04-29 2008-01-16 Cubist Pharmaceuticals, Inc. Therapeutic compositions
PL2379580T3 (pl) 2008-12-22 2014-05-30 Merck Sharp & Dohme Nowe środki przeciwbakteryjne do leczenia zakażeń wywołanych bakteriami Gram-dodatnimi
CA2747995A1 (en) 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
CN101899094B (zh) * 2009-06-01 2012-11-21 安徽丰原发酵技术工程研究有限公司 一种高纯达托霉素的制备方法
KR101013755B1 (ko) * 2010-02-02 2011-02-14 주식회사 삼광산전 정출력용 엘이디모듈 전원공급 컨버터
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
CN102351775B (zh) * 2011-09-14 2013-10-09 佛山普正医药科技有限公司 一种左旋5-羟基色氨酸的制备方法
WO2013059610A1 (en) 2011-10-20 2013-04-25 Trius Therapeutics, Inc. Therapeutic combination of daptomycin and protein synthesis inhibitor antibiotic, and methods of use
TW202244057A (zh) * 2012-12-03 2022-11-16 美商諾維生物製藥有限公司 新穎縮肽及其用途
WO2015172047A1 (en) * 2014-05-08 2015-11-12 Merck Sharp & Dohme Corp. Cyclic peptide compounds and related methods, salts and compositions
KR101671325B1 (ko) * 2015-01-09 2016-11-02 한국생명공학연구원 신규한 고리형 뎁시펩타이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 항균용 약학적 조성물
US11667674B2 (en) * 2016-04-08 2023-06-06 Versitech Limited Antibacterial cyclic lipopeptides
US10072045B1 (en) 2017-06-26 2018-09-11 Ramapo Pharmaceuticals, Inc. Antibacterial lipopeptides and methods for their preparation and use
US11643438B2 (en) 2018-07-20 2023-05-09 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use

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USRE32333E (en) 1978-10-16 1987-01-20 Eli Lilly And Company A-21978 Antibiotics and process for their production
USRE32455E (en) 1978-10-16 1987-07-07 Eli Lilly And Company A-21978 antibiotics and process for their production
US4524135A (en) 1982-05-21 1985-06-18 Eli Lilly And Company A-21978C cyclic peptides
USRE32310E (en) * 1982-05-21 1986-12-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4482487A (en) 1982-05-21 1984-11-13 Eli Lilly And Company A-21978C cyclic peptides
USRE32311E (en) * 1982-05-21 1986-12-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4537717A (en) 1982-05-21 1985-08-27 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4399067A (en) * 1982-05-21 1983-08-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4885243A (en) 1984-10-09 1989-12-05 Eli Lilly And Company Process for producing A-21978C derivatives
US4800157A (en) * 1985-09-09 1989-01-24 Eli Lilly And Company Process for producing the A-21978C antibiotics
CA1315229C (en) * 1987-06-10 1993-03-30 Eli Lilly And Company Chromatographic purification process
US4874843A (en) * 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
US5039789A (en) * 1988-04-11 1991-08-13 Eli Lilly And Company A54145 cyclic peptides
US4977083A (en) * 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
US4994270A (en) * 1988-04-11 1991-02-19 Eli Lilly And Company A54145 antibiotics and process for their production
US5028590A (en) * 1988-04-11 1991-07-02 Eli Lilly And Company Derivatives of A54145 cyclic peptides
IL98349A (en) * 1990-06-07 1995-05-26 Lilly Co Eli Diphylase lipopeptide
CA2131389A1 (en) * 1992-03-02 1993-09-16 John M. Maraganore Thrombin receptor antagonists
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
DE4411025A1 (de) * 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
JP3123078B2 (ja) 1996-03-08 2001-01-09 藤沢薬品工業株式会社 環状リポペプチド物質の脱アシル化法
US5958728A (en) * 1996-11-18 1999-09-28 Novo Nordiskbiotech, Inc. Methods for producing polypeptides in mutants of bacillus cells
US20010041346A1 (en) 1999-07-14 2001-11-15 Michael E. Mendelsohn Method for assaying compounds affecting smooth muscle contractile state
AU784812B2 (en) 1999-12-15 2006-06-29 Merck Sharp & Dohme Corp. Lipopeptides as antibacterial agents
CA2394313A1 (en) * 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Novel lipopeptides as antibacterial agents
MXPA02006029A (es) 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos novedosos como agentes antibacterianos.
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US6750199B2 (en) * 2000-07-17 2004-06-15 Micrologix Biotech Inc. Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
BR0211761A (pt) 2001-08-06 2007-01-09 Cubist Pharm Inc depsipeptìdeos e processos para preparar os mesmos

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012126753A (ja) * 2008-04-21 2012-07-05 Signum Biosciences Inc 化合物、組成物およびそれらを作製する方法
JP2014217322A (ja) * 2013-05-08 2014-11-20 株式会社ゲノム創薬研究所 固相レジンを用いた環状ペプチド化合物の製造方法

Also Published As

Publication number Publication date
WO2003017924A2 (en) 2003-03-06
EP1423137B1 (en) 2009-04-29
AU2002353775A1 (en) 2003-03-10
US20080119395A1 (en) 2008-05-22
CN100352836C (zh) 2007-12-05
BR0211761A (pt) 2007-01-09
KR20040022233A (ko) 2004-03-11
EP1423414A1 (en) 2004-06-02
US7335726B2 (en) 2008-02-26
US20030083240A1 (en) 2003-05-01
US20060223983A1 (en) 2006-10-05
WO2003017924A3 (en) 2004-03-04
US7262268B2 (en) 2007-08-28
CN1551887A (zh) 2004-12-01
EP1423137A2 (en) 2004-06-02
US20030096948A1 (en) 2003-05-22
WO2003014147A1 (en) 2003-02-20
ZA200400928B (en) 2005-05-04
RU2348647C2 (ru) 2009-03-10
IL160171A0 (en) 2004-07-25
US20060194714A1 (en) 2006-08-31
ATE430160T1 (de) 2009-05-15
EP1423414A4 (en) 2005-11-30
CA2456323A1 (en) 2003-03-06
NZ531493A (en) 2006-03-31
EP1423137A4 (en) 2005-11-30
DE60232158D1 (de) 2009-06-10
RU2004106630A (ru) 2005-06-27
CA2456761A1 (en) 2003-02-20

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