JP2005530842A - フルオロシロキサンマトリックス制御拡散薬物送達システム - Google Patents
フルオロシロキサンマトリックス制御拡散薬物送達システム Download PDFInfo
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- JP2005530842A JP2005530842A JP2004515837A JP2004515837A JP2005530842A JP 2005530842 A JP2005530842 A JP 2005530842A JP 2004515837 A JP2004515837 A JP 2004515837A JP 2004515837 A JP2004515837 A JP 2004515837A JP 2005530842 A JP2005530842 A JP 2005530842A
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- 229960005266 polymyxin b Drugs 0.000 description 1
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- 229960000624 procarbazine Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960000611 pyrimethamine Drugs 0.000 description 1
- WKSAUQYGYAYLPV-UHFFFAOYSA-N pyrimethamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1 WKSAUQYGYAYLPV-UHFFFAOYSA-N 0.000 description 1
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- 229930002330 retinoic acid Natural products 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229940009188 silver Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
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- 229940032483 sulfisoxazole diolamine Drugs 0.000 description 1
- FEPTXVIRMZIGFY-UHFFFAOYSA-N sulfisoxazole diolamine Chemical compound OCCNCCO.CC1=NOC(NS(=O)(=O)C=2C=CC(N)=CC=2)=C1C FEPTXVIRMZIGFY-UHFFFAOYSA-N 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 description 1
- 229960003962 trifluridine Drugs 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
- C08G77/24—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen halogen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/14—Polysiloxanes containing silicon bound to oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/20—Polysiloxanes containing silicon bound to unsaturated aliphatic groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/70—Siloxanes defined by use of the MDTQ nomenclature
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/175,716 US20040043067A1 (en) | 2002-06-19 | 2002-06-19 | Fluorosiloxane matrix controlled diffusion drug delivery systems |
| PCT/US2003/019026 WO2004000288A1 (en) | 2002-06-19 | 2003-06-16 | Fluorosiloxane matrix controlled diffusion drug delivery system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005530842A true JP2005530842A (ja) | 2005-10-13 |
| JP2005530842A5 JP2005530842A5 (enExample) | 2006-07-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004515837A Pending JP2005530842A (ja) | 2002-06-19 | 2003-06-16 | フルオロシロキサンマトリックス制御拡散薬物送達システム |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20040043067A1 (enExample) |
| EP (1) | EP1515705B1 (enExample) |
| JP (1) | JP2005530842A (enExample) |
| CN (1) | CN1662227A (enExample) |
| AU (1) | AU2003238247A1 (enExample) |
| BR (1) | BR0311963A (enExample) |
| CA (1) | CA2489987A1 (enExample) |
| CZ (1) | CZ200537A3 (enExample) |
| DE (1) | DE60306379T2 (enExample) |
| ES (1) | ES2261947T3 (enExample) |
| MX (1) | MXPA04012897A (enExample) |
| PL (1) | PL375000A1 (enExample) |
| RU (1) | RU2307667C2 (enExample) |
| TW (1) | TW200404569A (enExample) |
| UA (1) | UA80433C2 (enExample) |
| WO (1) | WO2004000288A1 (enExample) |
| ZA (1) | ZA200409979B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011502182A (ja) * | 2007-10-05 | 2011-01-20 | インターフェース バイオロジクス，インコーポレーテッド | オリゴフッ素化架橋ポリマーおよびそれの使用 |
| JP2012515628A (ja) * | 2009-01-23 | 2012-07-12 | キュー エル ティー インク． | １つまたは複数の薬剤の徐放性送達 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008504938A (ja) | 2004-07-02 | 2008-02-21 | レイザー，エリオット | 治療媒体送出装置およびその送出装置を用いて治療媒体を眼に送り出す方法 |
| US7544371B2 (en) * | 2005-12-20 | 2009-06-09 | Bausch + Lomb Incorporated | Drug delivery systems |
| US20070148244A1 (en) * | 2005-12-22 | 2007-06-28 | Kunzler Jay F | Drug delivery systems |
| US20070218103A1 (en) * | 2006-03-15 | 2007-09-20 | Bausch & Lomb Incorporated | Rate controlled release of a pharmaceutical agent in a biodegradable device |
| US20070218104A1 (en) * | 2006-03-15 | 2007-09-20 | Bausch & Lomb Incorporation | Rate controlled release of a pharmaceutical agent in a biodegradable device |
| ES2717607T3 (es) | 2006-03-31 | 2019-06-24 | Mati Therapeutics Inc | Estructuras de administración de fármacos y composiciones para el sistema nasolagrimal |
| US7579021B2 (en) * | 2006-09-27 | 2009-08-25 | Bausch & Lomb Incorporated | Drug delivery systems based on degradable cationic siloxanyl macromonomers |
| UY30883A1 (es) * | 2007-01-31 | 2008-05-31 | Alcon Res | Tapones punctales y metodos de liberacion de agentes terapeuticos |
| NZ583858A (en) | 2007-09-07 | 2012-08-31 | Quadra Logic Tech Inc | Lacrimal implant detection with detection device |
| CN107669399B (zh) | 2011-08-29 | 2019-11-19 | 麦提疗法有限公司 | 持续释放递送活性剂以治疗青光眼和高眼压 |
| US9974685B2 (en) | 2011-08-29 | 2018-05-22 | Mati Therapeutics | Drug delivery system and methods of treating open angle glaucoma and ocular hypertension |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62103028A (ja) * | 1985-08-16 | 1987-05-13 | ボーシュ アンド ローム インコーポレイテイド | 疎水性ポリマ−系を含む持効性製剤 |
| JPH08506841A (ja) * | 1993-02-12 | 1996-07-23 | ボシュ アンド ロム インコーポレイテッド | フルオロシリコーンヒドロゲル |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4327725A (en) * | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| IL91398A (en) * | 1988-08-30 | 1994-05-30 | Pfizer | Pharmaceutical delivery device comprising active substance surrounded by asymmetric membrane |
| US4882377A (en) * | 1988-09-21 | 1989-11-21 | Dow Corning Corporation | Low-viscosity pressure-adherent silicone elastomer compositions |
| US5463010A (en) * | 1993-11-12 | 1995-10-31 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Hydrocyclosiloxane membrane prepared by plasma polymerization process |
| US6322815B1 (en) * | 1994-07-22 | 2001-11-27 | W. Mark Saltzman | Multipart drug delivery system |
| US5714557A (en) * | 1995-12-07 | 1998-02-03 | Bausch & Lomb Incorporated | Monomeric units useful for reducing the modulus of low water polymeric silicone compositions |
| CN1084335C (zh) * | 1995-12-07 | 2002-05-08 | 博士伦公司 | 用于降低硅氧烷水凝胶的模量的单体单元 |
| US6296873B1 (en) * | 1997-01-23 | 2001-10-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Zero-order sustained release delivery system for carbamazephine derivatives |
| NZ500649A (en) * | 1997-04-03 | 2001-05-25 | Guilford Pharm Inc | Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, articles, and methods for making a biosorbable suture, an orthopedic appliance or bone cement for repairing injuries to bone or connective tissue |
| US5908996A (en) * | 1997-10-24 | 1999-06-01 | Timewarp Technologies Ltd | Device for controlling a musical performance |
| US6312728B1 (en) * | 1998-07-07 | 2001-11-06 | Cascade Development, Inc. | Sustained release pharmaceutical preparation |
| TW200800298A (en) * | 2000-01-27 | 2008-01-01 | Zentaris Ag | Compressed microparticles for dry injection |
-
2002
- 2002-06-19 US US10/175,716 patent/US20040043067A1/en not_active Abandoned
-
2003
- 2003-06-16 MX MXPA04012897A patent/MXPA04012897A/es active IP Right Grant
- 2003-06-16 ES ES03737141T patent/ES2261947T3/es not_active Expired - Lifetime
- 2003-06-16 EP EP03737141A patent/EP1515705B1/en not_active Expired - Lifetime
- 2003-06-16 DE DE60306379T patent/DE60306379T2/de not_active Expired - Fee Related
- 2003-06-16 JP JP2004515837A patent/JP2005530842A/ja active Pending
- 2003-06-16 AU AU2003238247A patent/AU2003238247A1/en not_active Abandoned
- 2003-06-16 RU RU2005100840/04A patent/RU2307667C2/ru not_active IP Right Cessation
- 2003-06-16 CZ CZ20050037A patent/CZ200537A3/cs unknown
- 2003-06-16 CA CA002489987A patent/CA2489987A1/en not_active Abandoned
- 2003-06-16 WO PCT/US2003/019026 patent/WO2004000288A1/en not_active Ceased
- 2003-06-16 PL PL03375000A patent/PL375000A1/xx not_active Application Discontinuation
- 2003-06-16 BR BR0311963-7A patent/BR0311963A/pt not_active IP Right Cessation
- 2003-06-16 CN CN038144662A patent/CN1662227A/zh active Pending
- 2003-06-16 UA UAA200500490A patent/UA80433C2/uk unknown
- 2003-06-18 TW TW092116547A patent/TW200404569A/zh unknown
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2004
- 2004-12-09 ZA ZA200409979A patent/ZA200409979B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62103028A (ja) * | 1985-08-16 | 1987-05-13 | ボーシュ アンド ローム インコーポレイテイド | 疎水性ポリマ−系を含む持効性製剤 |
| JPH08506841A (ja) * | 1993-02-12 | 1996-07-23 | ボシュ アンド ロム インコーポレイテッド | フルオロシリコーンヒドロゲル |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011502182A (ja) * | 2007-10-05 | 2011-01-20 | インターフェース バイオロジクス，インコーポレーテッド | オリゴフッ素化架橋ポリマーおよびそれの使用 |
| US10039864B2 (en) | 2007-10-05 | 2018-08-07 | Interface Biologics, Inc. | Oligofluorinated cross-linked polymers and uses thereof |
| JP2012515628A (ja) * | 2009-01-23 | 2012-07-12 | キュー エル ティー インク． | １つまたは複数の薬剤の徐放性送達 |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200409979B (en) | 2006-07-26 |
| MXPA04012897A (es) | 2005-03-31 |
| UA80433C2 (en) | 2007-09-25 |
| TW200404569A (en) | 2004-04-01 |
| HK1070826A1 (en) | 2005-06-30 |
| CZ200537A3 (cs) | 2006-04-12 |
| BR0311963A (pt) | 2005-03-29 |
| US20040043067A1 (en) | 2004-03-04 |
| CA2489987A1 (en) | 2003-12-31 |
| PL375000A1 (en) | 2005-11-14 |
| EP1515705A1 (en) | 2005-03-23 |
| EP1515705B1 (en) | 2006-06-21 |
| CN1662227A (zh) | 2005-08-31 |
| ES2261947T3 (es) | 2006-11-16 |
| RU2307667C2 (ru) | 2007-10-10 |
| DE60306379T2 (de) | 2007-06-14 |
| WO2004000288A1 (en) | 2003-12-31 |
| AU2003238247A1 (en) | 2004-01-06 |
| DE60306379D1 (de) | 2006-08-03 |
| RU2005100840A (ru) | 2005-07-10 |
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