RU2307667C2 - Фторсилоксановые матриксные системы доставки лекарств с регулируемой диффузией и способ ее получения - Google Patents
Фторсилоксановые матриксные системы доставки лекарств с регулируемой диффузией и способ ее получения Download PDFInfo
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- RU2307667C2 RU2307667C2 RU2005100840/04A RU2005100840A RU2307667C2 RU 2307667 C2 RU2307667 C2 RU 2307667C2 RU 2005100840/04 A RU2005100840/04 A RU 2005100840/04A RU 2005100840 A RU2005100840 A RU 2005100840A RU 2307667 C2 RU2307667 C2 RU 2307667C2
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- methacrylate
- agents
- drug delivery
- pharmaceutically active
- active agent
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- RMLUKZWYIKEASN-UHFFFAOYSA-M sodium;2-amino-9-(2-hydroxyethoxymethyl)purin-6-olate Chemical compound [Na+].O=C1[N-]C(N)=NC2=C1N=CN2COCCO RMLUKZWYIKEASN-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
- C08G77/24—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen halogen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/14—Polysiloxanes containing silicon bound to oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/20—Polysiloxanes containing silicon bound to unsaturated aliphatic groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/70—Siloxanes defined by use of the MDTQ nomenclature
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/175,716 US20040043067A1 (en) | 2002-06-19 | 2002-06-19 | Fluorosiloxane matrix controlled diffusion drug delivery systems |
| US10/175,716 | 2002-06-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005100840A RU2005100840A (ru) | 2005-07-10 |
| RU2307667C2 true RU2307667C2 (ru) | 2007-10-10 |
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|---|---|
| US (1) | US20040043067A1 (enExample) |
| EP (1) | EP1515705B1 (enExample) |
| JP (1) | JP2005530842A (enExample) |
| CN (1) | CN1662227A (enExample) |
| AU (1) | AU2003238247A1 (enExample) |
| BR (1) | BR0311963A (enExample) |
| CA (1) | CA2489987A1 (enExample) |
| CZ (1) | CZ200537A3 (enExample) |
| DE (1) | DE60306379T2 (enExample) |
| ES (1) | ES2261947T3 (enExample) |
| MX (1) | MXPA04012897A (enExample) |
| PL (1) | PL375000A1 (enExample) |
| RU (1) | RU2307667C2 (enExample) |
| TW (1) | TW200404569A (enExample) |
| UA (1) | UA80433C2 (enExample) |
| WO (1) | WO2004000288A1 (enExample) |
| ZA (1) | ZA200409979B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2008504938A (ja) | 2004-07-02 | 2008-02-21 | レイザー，エリオット | 治療媒体送出装置およびその送出装置を用いて治療媒体を眼に送り出す方法 |
| US7544371B2 (en) * | 2005-12-20 | 2009-06-09 | Bausch + Lomb Incorporated | Drug delivery systems |
| US20070148244A1 (en) * | 2005-12-22 | 2007-06-28 | Kunzler Jay F | Drug delivery systems |
| US20070218103A1 (en) * | 2006-03-15 | 2007-09-20 | Bausch & Lomb Incorporated | Rate controlled release of a pharmaceutical agent in a biodegradable device |
| US20070218104A1 (en) * | 2006-03-15 | 2007-09-20 | Bausch & Lomb Incorporation | Rate controlled release of a pharmaceutical agent in a biodegradable device |
| ES2717607T3 (es) | 2006-03-31 | 2019-06-24 | Mati Therapeutics Inc | Estructuras de administración de fármacos y composiciones para el sistema nasolagrimal |
| US7579021B2 (en) * | 2006-09-27 | 2009-08-25 | Bausch & Lomb Incorporated | Drug delivery systems based on degradable cationic siloxanyl macromonomers |
| UY30883A1 (es) * | 2007-01-31 | 2008-05-31 | Alcon Res | Tapones punctales y metodos de liberacion de agentes terapeuticos |
| NZ583858A (en) | 2007-09-07 | 2012-08-31 | Quadra Logic Tech Inc | Lacrimal implant detection with detection device |
| WO2009043174A1 (en) * | 2007-10-05 | 2009-04-09 | Interface Biologics Inc. | Oligofluorinated cross-linked polymers and uses thereof |
| WO2010085696A2 (en) * | 2009-01-23 | 2010-07-29 | Qlt Plug Delivery Inc. | Sustained released delivery of one or more agents |
| CN107669399B (zh) | 2011-08-29 | 2019-11-19 | 麦提疗法有限公司 | 持续释放递送活性剂以治疗青光眼和高眼压 |
| US9974685B2 (en) | 2011-08-29 | 2018-05-22 | Mati Therapeutics | Drug delivery system and methods of treating open angle glaucoma and ocular hypertension |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5321108A (en) * | 1993-02-12 | 1994-06-14 | Bausch & Lomb Incorporated | Fluorosilicone hydrogels |
| WO1997020851A1 (en) * | 1995-12-07 | 1997-06-12 | Bausch & Lomb Incorporated | Monomeric units useful for reducing the modulus of low water polymeric silicone compositions |
| RU2093147C1 (ru) * | 1988-08-30 | 1997-10-20 | Пфайзер Инк. | Изделия для пролонгированного выделения одного или нескольких фармацевтически активных веществ |
| US5908906A (en) * | 1995-12-07 | 1999-06-01 | Bausch & Lomb Incorporated | Monomeric units useful for reducing the modulus of silicone hydrogels |
| RU2272617C2 (ru) * | 2000-01-27 | 2006-03-27 | Ардана Биосайенс Лимитед | Фармацевтический имплантат, способ его получения (варианты) и способ регулируемого высвобождения лекарства |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4327725A (en) * | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
| CA1295941C (en) * | 1985-08-16 | 1992-02-18 | Rajan Bawa | Sustained-release formulation comprising a hydrophobic polymer system |
| US4882377A (en) * | 1988-09-21 | 1989-11-21 | Dow Corning Corporation | Low-viscosity pressure-adherent silicone elastomer compositions |
| US5463010A (en) * | 1993-11-12 | 1995-10-31 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Hydrocyclosiloxane membrane prepared by plasma polymerization process |
| US6322815B1 (en) * | 1994-07-22 | 2001-11-27 | W. Mark Saltzman | Multipart drug delivery system |
| US6296873B1 (en) * | 1997-01-23 | 2001-10-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Zero-order sustained release delivery system for carbamazephine derivatives |
| NZ500649A (en) * | 1997-04-03 | 2001-05-25 | Guilford Pharm Inc | Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, articles, and methods for making a biosorbable suture, an orthopedic appliance or bone cement for repairing injuries to bone or connective tissue |
| US5908996A (en) * | 1997-10-24 | 1999-06-01 | Timewarp Technologies Ltd | Device for controlling a musical performance |
| US6312728B1 (en) * | 1998-07-07 | 2001-11-06 | Cascade Development, Inc. | Sustained release pharmaceutical preparation |
-
2002
- 2002-06-19 US US10/175,716 patent/US20040043067A1/en not_active Abandoned
-
2003
- 2003-06-16 MX MXPA04012897A patent/MXPA04012897A/es active IP Right Grant
- 2003-06-16 ES ES03737141T patent/ES2261947T3/es not_active Expired - Lifetime
- 2003-06-16 EP EP03737141A patent/EP1515705B1/en not_active Expired - Lifetime
- 2003-06-16 DE DE60306379T patent/DE60306379T2/de not_active Expired - Fee Related
- 2003-06-16 JP JP2004515837A patent/JP2005530842A/ja active Pending
- 2003-06-16 AU AU2003238247A patent/AU2003238247A1/en not_active Abandoned
- 2003-06-16 RU RU2005100840/04A patent/RU2307667C2/ru not_active IP Right Cessation
- 2003-06-16 CZ CZ20050037A patent/CZ200537A3/cs unknown
- 2003-06-16 CA CA002489987A patent/CA2489987A1/en not_active Abandoned
- 2003-06-16 WO PCT/US2003/019026 patent/WO2004000288A1/en not_active Ceased
- 2003-06-16 PL PL03375000A patent/PL375000A1/xx not_active Application Discontinuation
- 2003-06-16 BR BR0311963-7A patent/BR0311963A/pt not_active IP Right Cessation
- 2003-06-16 CN CN038144662A patent/CN1662227A/zh active Pending
- 2003-06-16 UA UAA200500490A patent/UA80433C2/uk unknown
- 2003-06-18 TW TW092116547A patent/TW200404569A/zh unknown
-
2004
- 2004-12-09 ZA ZA200409979A patent/ZA200409979B/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2093147C1 (ru) * | 1988-08-30 | 1997-10-20 | Пфайзер Инк. | Изделия для пролонгированного выделения одного или нескольких фармацевтически активных веществ |
| US5321108A (en) * | 1993-02-12 | 1994-06-14 | Bausch & Lomb Incorporated | Fluorosilicone hydrogels |
| WO1997020851A1 (en) * | 1995-12-07 | 1997-06-12 | Bausch & Lomb Incorporated | Monomeric units useful for reducing the modulus of low water polymeric silicone compositions |
| US5908906A (en) * | 1995-12-07 | 1999-06-01 | Bausch & Lomb Incorporated | Monomeric units useful for reducing the modulus of silicone hydrogels |
| RU2272617C2 (ru) * | 2000-01-27 | 2006-03-27 | Ардана Биосайенс Лимитед | Фармацевтический имплантат, способ его получения (варианты) и способ регулируемого высвобождения лекарства |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200409979B (en) | 2006-07-26 |
| MXPA04012897A (es) | 2005-03-31 |
| UA80433C2 (en) | 2007-09-25 |
| TW200404569A (en) | 2004-04-01 |
| HK1070826A1 (en) | 2005-06-30 |
| CZ200537A3 (cs) | 2006-04-12 |
| JP2005530842A (ja) | 2005-10-13 |
| BR0311963A (pt) | 2005-03-29 |
| US20040043067A1 (en) | 2004-03-04 |
| CA2489987A1 (en) | 2003-12-31 |
| PL375000A1 (en) | 2005-11-14 |
| EP1515705A1 (en) | 2005-03-23 |
| EP1515705B1 (en) | 2006-06-21 |
| CN1662227A (zh) | 2005-08-31 |
| ES2261947T3 (es) | 2006-11-16 |
| DE60306379T2 (de) | 2007-06-14 |
| WO2004000288A1 (en) | 2003-12-31 |
| AU2003238247A1 (en) | 2004-01-06 |
| DE60306379D1 (de) | 2006-08-03 |
| RU2005100840A (ru) | 2005-07-10 |
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