JP2005528333A5 - - Google Patents
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- JP2005528333A5 JP2005528333A5 JP2003552220A JP2003552220A JP2005528333A5 JP 2005528333 A5 JP2005528333 A5 JP 2005528333A5 JP 2003552220 A JP2003552220 A JP 2003552220A JP 2003552220 A JP2003552220 A JP 2003552220A JP 2005528333 A5 JP2005528333 A5 JP 2005528333A5
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- JP
- Japan
- Prior art keywords
- composition
- vitamin
- antioxidant
- antioxidants
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims description 33
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 8
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 7
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims description 5
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims description 5
- 229930003935 flavonoid Natural products 0.000 claims description 5
- 150000002215 flavonoids Chemical class 0.000 claims description 5
- 235000017173 flavonoids Nutrition 0.000 claims description 5
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims description 5
- 235000005493 rutin Nutrition 0.000 claims description 5
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims description 5
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims description 5
- 229960004555 rutoside Drugs 0.000 claims description 5
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 4
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 4
- 235000005875 quercetin Nutrition 0.000 claims description 4
- 229960001285 quercetin Drugs 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims 16
- 235000006708 antioxidants Nutrition 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 10
- 230000003078 antioxidant effect Effects 0.000 claims 8
- 230000024245 cell differentiation Effects 0.000 claims 6
- 230000004663 cell proliferation Effects 0.000 claims 6
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 3
- 235000003140 Panax quinquefolius Nutrition 0.000 claims 3
- -1 ascorbic acid ester Chemical class 0.000 claims 3
- 235000009508 confectionery Nutrition 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 claims 2
- DDNPCXHBFYJXBJ-UHFFFAOYSA-N 5,7-dihydroxy-2-(4-hydroxyphenyl)-3,6-dimethoxychromen-4-one Chemical compound COC=1C(=O)C2=C(O)C(OC)=C(O)C=C2OC=1C1=CC=C(O)C=C1 DDNPCXHBFYJXBJ-UHFFFAOYSA-N 0.000 claims 2
- MQVRGDZCYDEQML-UHFFFAOYSA-N Astragalin Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(CO)O2)O)C(=O)C2=C(O)C=C(O)C=C2O1 MQVRGDZCYDEQML-UHFFFAOYSA-N 0.000 claims 2
- 241001632410 Eleutherococcus senticosus Species 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 2
- 102000006587 Glutathione peroxidase Human genes 0.000 claims 2
- 108700016172 Glutathione peroxidases Proteins 0.000 claims 2
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 claims 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- 102000004316 Oxidoreductases Human genes 0.000 claims 2
- 108090000854 Oxidoreductases Proteins 0.000 claims 2
- 240000005373 Panax quinquefolius Species 0.000 claims 2
- 229930003427 Vitamin E Natural products 0.000 claims 2
- AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims 2
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 claims 2
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 claims 2
- 235000008714 apigenin Nutrition 0.000 claims 2
- 229940117893 apigenin Drugs 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- 229940099898 chlorophyllin Drugs 0.000 claims 2
- 235000019805 chlorophyllin Nutrition 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 2
- VEVZSMAEJFVWIL-UHFFFAOYSA-O cyanidin cation Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC=C(O)C(O)=C1 VEVZSMAEJFVWIL-UHFFFAOYSA-O 0.000 claims 2
- IBLPTYJTKWQCDX-UHFFFAOYSA-N euvimal-1 Natural products C1CC(C(CCC2C3C2(C)C)(C)O)C3C1(C)C(CC(C)C)C1=C(O)C(C=O)=C(O)C(C=O)=C1O IBLPTYJTKWQCDX-UHFFFAOYSA-N 0.000 claims 2
- XHEFDIBZLJXQHF-UHFFFAOYSA-N fisetin Chemical compound C=1C(O)=CC=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 XHEFDIBZLJXQHF-UHFFFAOYSA-N 0.000 claims 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 2
- 235000020710 ginseng extract Nutrition 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 235000003969 glutathione Nutrition 0.000 claims 2
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 claims 2
- 235000019136 lipoic acid Nutrition 0.000 claims 2
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 claims 2
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 claims 2
- 235000009498 luteolin Nutrition 0.000 claims 2
- IEWHEHWXBLPFER-UHFFFAOYSA-N macrocarpal c Chemical compound C1CC(C(CCC2C3C2(C)C)=C)C3C1(C)C(CC(C)C)C1=C(O)C(C=O)=C(O)C(C=O)=C1O IEWHEHWXBLPFER-UHFFFAOYSA-N 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 claims 2
- DMXHXBGUNHLMQO-UHFFFAOYSA-N pedaliin Natural products C1=C2OC(C=3C=C(O)C(O)=CC=3)=CC(=O)C2=C(O)C(OC)=C1OC1OC(CO)C(O)C(O)C1O DMXHXBGUNHLMQO-UHFFFAOYSA-N 0.000 claims 2
- JVXZRQGOGOXCEC-UHFFFAOYSA-N scutellarein Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C(O)=C(O)C=C2O1 JVXZRQGOGOXCEC-UHFFFAOYSA-N 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 229960002663 thioctic acid Drugs 0.000 claims 2
- 235000019165 vitamin E Nutrition 0.000 claims 2
- 229940046009 vitamin E Drugs 0.000 claims 2
- 239000011709 vitamin E Substances 0.000 claims 2
- GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 claims 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 1
- ALERZNQPBWWLMW-UHFFFAOYSA-N 2''-acetylacteoside Natural products OC1C(O)C(O)C(C)OC1OC1C(OC(C)=O)C(OCCC=2C=C(O)C(O)=CC=2)OC(CO)C1OC(=O)C=CC1=CC=C(O)C(O)=C1 ALERZNQPBWWLMW-UHFFFAOYSA-N 0.000 claims 1
- PHKIHRKCNFFHJP-UHFFFAOYSA-N 2-(3,4-dihydroxyphenyl)-6-hydroxy-5,7,8-trimethoxychromen-4-one Chemical compound COC=1C(OC)=C(O)C(OC)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 PHKIHRKCNFFHJP-UHFFFAOYSA-N 0.000 claims 1
- JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 claims 1
- 239000003872 25-hydroxy-cholecalciferol Substances 0.000 claims 1
- LXEQIOGTMDLLEC-UHFFFAOYSA-N 3,4,3'-Tri-O-methylellagic acid Chemical compound OC1=C(OC)C(OC2=O)=C3C4=C2C=C(OC)C(OC)=C4OC(=O)C3=C1 LXEQIOGTMDLLEC-UHFFFAOYSA-N 0.000 claims 1
- IBLPTYJTKWQCDX-MOTAWSDJSA-N 5-[(1r)-1-[(1ar,4r,4ar,7s,7as,7br)-4-hydroxy-1,1,4,7-tetramethyl-1a,2,3,4a,5,6,7a,7b-octahydrocyclopropa[h]azulen-7-yl]-3-methylbutyl]-2,4,6-trihydroxybenzene-1,3-dicarbaldehyde Chemical compound C1([C@H](CC(C)C)[C@]2(C)[C@@H]3[C@H]([C@](CC[C@@H]4[C@H]3C4(C)C)(C)O)CC2)=C(O)C(C=O)=C(O)C(C=O)=C1O IBLPTYJTKWQCDX-MOTAWSDJSA-N 0.000 claims 1
- VUKIJLQDSQXHDI-HTBABXNNSA-N 5-[(1r)-1-[(1r,3ar,4r,7r)-7-(2-hydroxypropan-2-yl)-1,4-dimethyl-3,3a,4,5,6,7-hexahydro-2h-azulen-1-yl]-3-methylbutyl]-2,4,6-trihydroxybenzene-1,3-dicarbaldehyde Chemical compound C1([C@H](CC(C)C)[C@]2(C)C3=C[C@@H](CC[C@@H](C)[C@H]3CC2)C(C)(C)O)=C(O)C(C=O)=C(O)C(C=O)=C1O VUKIJLQDSQXHDI-HTBABXNNSA-N 0.000 claims 1
- NTDLXWMIWOECHG-UHFFFAOYSA-N 7-labden-3beta,15-diol Natural products O1CC(O)(CO)C(O)C1OC1C(O)C(O)C(CO)OC1OC(C=1)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C=C1 NTDLXWMIWOECHG-UHFFFAOYSA-N 0.000 claims 1
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- 235000021318 Calcifediol Nutrition 0.000 claims 1
- 108091005960 Citrine Proteins 0.000 claims 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 1
- SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 claims 1
- SBJKKFFYIZUCET-UHFFFAOYSA-N Dehydroascorbic acid Natural products OCC(O)C1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-UHFFFAOYSA-N 0.000 claims 1
- UCTLRSWJYQTBFZ-UHFFFAOYSA-N Dehydrocholesterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCCC(C)C)CCC33)C)C3=CC=C21 UCTLRSWJYQTBFZ-UHFFFAOYSA-N 0.000 claims 1
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 claims 1
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims 1
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- 229920002079 Ellagic acid Polymers 0.000 claims 1
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- IBLPTYJTKWQCDX-NGLILROZSA-N Macrocarpal B Chemical compound C1([C@@H](CC(C)C)[C@]2(C)[C@@H]3[C@H]([C@](CC[C@@H]4[C@H]3C4(C)C)(C)O)CC2)=C(O)C(C=O)=C(O)C(C=O)=C1O IBLPTYJTKWQCDX-NGLILROZSA-N 0.000 claims 1
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- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 claims 1
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- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims 1
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- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 1
- 108010012715 Superoxide dismutase Proteins 0.000 claims 1
- 244000269722 Thea sinensis Species 0.000 claims 1
- ZKEKDTIKFVCKMW-UHFFFAOYSA-N Trifolin Natural products OCC1OC(Oc2cc(O)ccc2C3=CC(=O)c4c(O)cc(O)cc4O3)C(O)C(O)C1O ZKEKDTIKFVCKMW-UHFFFAOYSA-N 0.000 claims 1
- NDXSDWFOYZXARW-UHFFFAOYSA-N Trimethylellagsaeure Natural products COC1=C(OC)C(OC2=O)=C3C4=C2C=C(OC)C(O)=C4OC(=O)C3=C1 NDXSDWFOYZXARW-UHFFFAOYSA-N 0.000 claims 1
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- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
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| US6352713B1 (en) * | 1999-12-01 | 2002-03-05 | Drugtech Corporation | Nutritional composition |
| US7449451B2 (en) * | 2001-08-29 | 2008-11-11 | Premier Micronutrient Corporation | Use of multiple antioxidant micronutrients as systemic biological radioprotective agents against potential ionizing radiation risks |
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| KR101395370B1 (ko) | 2004-01-22 | 2014-05-14 | 유니버시티 오브 마이애미 | 국소용 코-엔자임 큐10 제형 및 그의 사용 방법 |
| JPWO2005085223A1 (ja) * | 2004-03-04 | 2007-12-13 | 和夫 永井 | 骨疾患の予防及び／又は治療用組成物、その組成物を含有する機能性食品もしくは健康食品、並びにその組成物を有効成分とする医薬製剤 |
| KR100868905B1 (ko) * | 2004-03-26 | 2008-11-14 | (주)아모레퍼시픽 | 진세노사이드 ｆ1과 ｅｇｃｇ을 함유한 자외선 조사로유도되는 피부손상 방지용 조성물 |
| US7947645B2 (en) | 2004-09-02 | 2011-05-24 | Cognosci, Inc. | APO E analogs and methods for their use |
| JP4864302B2 (ja) * | 2004-09-06 | 2012-02-01 | 株式会社武蔵野免疫研究所 | 細胞増殖促進組成物 |
| JP5040060B2 (ja) * | 2004-10-14 | 2012-10-03 | 大正製薬株式会社 | メチオニン配合内服液剤 |
| US8647660B2 (en) | 2004-12-29 | 2014-02-11 | Hill's Pet Nutrition, Inc. | Combination of limited nutrients and enhanced dietary antioxidants to impart improved kidney health |
| WO2006089211A2 (en) * | 2005-02-17 | 2006-08-24 | Premier Micronutrient Corporation | Combat/training antioxidant micronutrient formulation and method of administration |
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| JP2006298808A (ja) * | 2005-04-19 | 2006-11-02 | Hayashibara Biochem Lab Inc | 痛覚刺激緩和剤 |
| AU2006236345B2 (en) * | 2005-04-19 | 2011-03-31 | Hill's Pet Nutrition, Inc. | Methods and compositions for the prevention and treatment of kidney disease |
| CA2654446C (en) | 2005-06-07 | 2014-02-25 | The Regents Of The University Of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of graft rejection and promotion of graft survival |
| US9457070B2 (en) | 2005-06-07 | 2016-10-04 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses of alpha 1-antitrypsin for early intervention in bone marrow transplantation and treatment of graft versus host disease |
| EP2368442B1 (en) | 2005-07-27 | 2014-12-17 | Symrise AG | Use of hesperetin for enhancing the sweet taste |
| JP2007091737A (ja) * | 2005-09-01 | 2007-04-12 | Chieko Tanaka | 口腔用組成物 |
| JP2007223965A (ja) * | 2006-02-24 | 2007-09-06 | National Institute Of Advanced Industrial & Technology | 表皮角化細胞エンドセリン−１産生抑制剤 |
| US20090068166A1 (en) * | 2006-03-17 | 2009-03-12 | Ning Man Cheng | Method and composition for protection against radiation |
| EP3173068B1 (en) * | 2006-05-02 | 2020-09-09 | University of Miami | Topical co-enzyme q10 formulations and treatment of wounds |
| GB0614353D0 (en) | 2006-07-20 | 2006-08-30 | Oraldent Ltd | Oral compositions, their preparation and use |
| EP1882473A1 (en) * | 2006-07-28 | 2008-01-30 | Indena S.P.A. | Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs |
| JP4790561B2 (ja) * | 2006-10-12 | 2011-10-12 | 東洋精糖株式会社 | フラボノイド組成物、その製造方法および用途 |
| WO2009002425A2 (en) * | 2007-06-22 | 2008-12-31 | Scidose Llc | Solubilized formulation of docetaxel without tween 80 |
| WO2009080842A1 (es) * | 2007-12-21 | 2009-07-02 | Asac Compañía De Biotecnología E Investigación Sa | Composiciones fotoprotectoras |
| RU2491084C2 (ru) | 2007-12-21 | 2013-08-27 | Асак Компанья Де Биотекнолохия Э Инвестигасион, С.А. | Способ улучшения терапевтической эффективности куркуминоидов и их аналогов |
| MX2010011032A (es) | 2008-04-11 | 2011-03-01 | Cytotech Labs Llc Star | Metodos y uso de induccion de apoptosis en celulas cancerigenas. |
| CA2744388A1 (en) * | 2008-11-21 | 2010-05-27 | The Johns Hopkins University | Compositions and methods for treating or preventing radiation injury |
| IT1398507B1 (it) * | 2009-01-13 | 2013-03-01 | Giellepi Chemicals S P A | Composizione per il trattamento di neuropatie |
| CA2751511C (en) | 2009-02-23 | 2017-04-11 | Unilever Plc | Edible composition for treating cutaneous signs of ageing |
| CN101524341B (zh) * | 2009-03-20 | 2011-04-20 | 中国科学院近代物理研究所 | 异甘草素在制备肿瘤放射治疗辅助治疗药物中的应用 |
| CN102481271A (zh) | 2009-05-11 | 2012-05-30 | 博格生物系统有限责任公司 | 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法 |
| US20120219511A1 (en) * | 2009-09-29 | 2012-08-30 | Igor Arturovich Petropavlov | Oral care compositions containing human recombinant interleukin-1 |
| KR101791277B1 (ko) * | 2009-10-20 | 2017-10-27 | 디스커버리 파트너스, 엘엘씨 | 피부과학 및 미용학적 조성물 |
| CN101953506B (zh) * | 2010-05-28 | 2012-12-05 | 西南大学 | β-葡聚糖-茶多酚复合物及其应用 |
| KR101021835B1 (ko) | 2010-09-06 | 2011-03-17 | 충남대학교산학협력단 | 크리소스플레놀 시를 함유하는 심장 질환의 예방 및 치료용 조성물 |
| CN102078312A (zh) * | 2010-12-24 | 2011-06-01 | 中国药科大学 | 一种姜黄素类化合物干粉吸入剂及其制备方法和用途 |
| US20120183587A1 (en) * | 2011-01-18 | 2012-07-19 | Mitsunori Ono | Flavonol compositions |
| US8980574B2 (en) | 2011-03-11 | 2015-03-17 | James D. Crapo | Method for ameliorating radiation exposure effects with alpha-1 antitrypsin |
| CA2832324C (en) | 2011-04-04 | 2022-03-15 | Berg Llc | Methods of treating central nervous system tumors |
| JP5985637B2 (ja) * | 2011-08-11 | 2016-09-06 | スティーフェル リサーチ オーストラリア ピーティーワイ リミテッド | 抗酸化剤局所用組成物 |
| KR101950661B1 (ko) * | 2011-09-28 | 2019-02-20 | 라이온 가부시키가이샤 | 구강용 조성물 |
| US20130164228A1 (en) * | 2011-12-21 | 2013-06-27 | Colgate-Palmolive Company | Compositions comprising gallates and gallamides |
| EP2700413B1 (en) | 2012-08-20 | 2015-10-14 | Bionoox Suisse SA | Composition comprising dihydroquercetin, alpha-tocopherol and bisabolol |
| CZ306439B6 (cs) * | 2012-12-20 | 2017-01-25 | Navrátil Jiří | Potravinový doplněk kompenzující nepříznivé účinky očkování |
| WO2014113635A1 (en) * | 2013-01-18 | 2014-07-24 | Sloan-Kettering Institute For Cancer Research | Reduction of toxicities by synthetic panaxytriol analogs |
| US20140274965A1 (en) * | 2013-03-14 | 2014-09-18 | Hygia Pharmaceuticals, Llc | Drink Product and Use Thereof |
| US20140274966A1 (en) * | 2013-03-14 | 2014-09-18 | Hygia Pharmaceuticals, Llc | Drink Product Containing Genistein and Use Thereof |
| NZ713868A (en) | 2013-04-08 | 2021-12-24 | Berg Llc | Treatment of cancer using coenzyme q10 combination therapies |
| KR102370843B1 (ko) | 2013-09-04 | 2022-03-04 | 버그 엘엘씨 | 코엔자임 q10의 연속주입에 의한 암치료 방법 |
| JP6175048B2 (ja) * | 2013-12-27 | 2017-08-02 | 花王株式会社 | 容器詰飲料 |
| EP2907513A1 (en) | 2014-02-18 | 2015-08-19 | Bionoox Suisse SA | Compositions comprising dihydroquercetin for use in methods for alleviating the effects associated with skin inflammatory disorders |
| EP2952104A1 (en) * | 2014-06-05 | 2015-12-09 | Böhm, Kirsten | Composition and method for preventing damage of human cells by ionising radiation |
| US10499682B2 (en) | 2014-08-25 | 2019-12-10 | New Age Beverage Corporation | Micronutrient formulation in electronic cigarettes |
| CN104522646A (zh) * | 2014-12-18 | 2015-04-22 | 无限极（中国）有限公司 | 一种具有增强免疫力、缓解体力疲劳功能的组合物及其应用 |
| JP2018507895A (ja) | 2015-03-18 | 2018-03-22 | バイオヌークス スイス エスエー | ヘルペスを処置するための方法において使用するためのジヒドロケルセチンを含む組成物 |
| TWI555537B (zh) * | 2015-05-21 | 2016-11-01 | 張德生 | 3’-羥基染料木黃酮用於製備抑制黑色素生成之組合物的用途 |
| WO2017030167A1 (ja) * | 2015-08-18 | 2017-02-23 | レジリオ株式会社 | 神経回路網の再構築・賦活剤 |
| WO2017087576A1 (en) | 2015-11-16 | 2017-05-26 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| CN105497006A (zh) * | 2015-12-15 | 2016-04-20 | 武汉华纳联合药业有限公司 | 黄酮醇、黄烷醇类化合物的用途 |
| US10183026B2 (en) * | 2016-04-08 | 2019-01-22 | The Secretary, Department Of Atomic Energy | Method of adjuvant treatment with chlorophyllin containing therapeutic preparation including for radioprotection of normal tissues during radiation therapy and kit therefor |
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| CN108434017A (zh) * | 2018-06-13 | 2018-08-24 | 长沙小如信息科技有限公司 | 一种牙齿美白液及其制备方法 |
| WO2021081634A1 (en) * | 2019-10-28 | 2021-05-06 | Kieran Murphy | Formulation to reduce or prevent oxidative stress damage |
| CN113367337B (zh) * | 2020-03-10 | 2023-02-24 | 晨光生物科技集团股份有限公司 | 一种包含槲皮万寿菊素的组合物 |
| CN111700888A (zh) * | 2020-06-18 | 2020-09-25 | 中国医学科学院放射医学研究所 | 一种漆黄素及其盐在制备抗辐射损伤药物中的应用 |
| CN111728966A (zh) * | 2020-07-07 | 2020-10-02 | 苏州大学 | Egcg在制备电离辐射致肠道损伤的防护药物中的应用 |
| CN112716854B (zh) * | 2021-01-27 | 2022-12-13 | 新乡博凯生物技术有限公司 | 一种中药牙膏及其制备方法 |
| ES2956376A1 (es) * | 2022-05-13 | 2023-12-20 | Espada Regalado Jesus | Uso de un procedimiento de transferencia fotonica secuencial para fomentar la fotoproteccion y regeneracion cutanea |
| CN115364016B (zh) * | 2022-09-27 | 2023-07-25 | 云南八凯生物科技有限公司 | 一种具有改善牙周病功效的牙膏及其制备方法 |
| CN116492320B (zh) * | 2023-06-27 | 2023-09-29 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 大果桉醛i在制备肿瘤免疫治疗增效剂中的应用 |
| KR102915228B1 (ko) | 2023-09-04 | 2026-01-22 | 한국원자력연구원 | 방사선 에너지 강하용 조성물 및 이를 이용한 코팅층을 갖는 태양전지 |
| CN119970694A (zh) * | 2025-03-12 | 2025-05-13 | 中国科学院近代物理研究所 | 姜黄素在制备预防和/或治疗Ra-223引起的骨组织辐射损伤的药物中的应用 |
| CN120131626B (zh) * | 2025-05-16 | 2025-07-22 | 台州恩泽医疗中心(集团) | 金合欢素和辅酶q10组合物在防治阿霉素诱导心肌毒性的药物中的应用 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4147795A (en) * | 1977-02-11 | 1979-04-03 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4250097A (en) * | 1978-03-08 | 1981-02-10 | Syntex (U.S.A.) Inc. | Compositions for and a method of preventing diabetic complications |
| US4232040A (en) * | 1978-03-08 | 1980-11-04 | Syntex (U.S.A.) Inc. | Compositions for and a method of preventing diabetic complications |
| US4210667A (en) * | 1979-04-19 | 1980-07-01 | Pfizer Inc. | Pharmaceutical preparations containing coumarin carboxylic acid derivatives |
| JPS60100517A (ja) * | 1983-11-08 | 1985-06-04 | Eisai Co Ltd | 放射線潰瘍治療剤および方法 |
| US4627973A (en) * | 1984-12-14 | 1986-12-09 | Charles Of The Ritz Group Ltd. | Skin mousse |
| WO1993013092A1 (en) * | 1986-11-24 | 1993-07-08 | Reinhard Sarges | Imidazolidinedione derivatives |
| US4822816A (en) * | 1987-04-10 | 1989-04-18 | Oxycal Laboratories, Inc. | Compositions and methods for administering vitamin C |
| US5070085A (en) * | 1987-04-10 | 1991-12-03 | Oxycal Laboratories, Inc. | Compositions and methods for administering therapeutically active compounds |
| FR2675996B1 (fr) * | 1991-04-30 | 1993-10-15 | Georges Baritiu | Compositions sanogenes dietetiques complexes. |
| KR930008763B1 (ko) * | 1991-05-27 | 1993-09-15 | 주식회사 태평양화학 | 화장료 조성물 |
| US5561110A (en) * | 1991-09-09 | 1996-10-01 | Peptide Technology Limited | Method for the treatment of the complications and pathology of diabetes |
| IT1254045B (it) * | 1991-12-31 | 1995-09-06 | Lifegroup Spa | Derivati idrosolubili della biotina e relative composizioni terapeutiche |
| GB9206648D0 (en) * | 1992-03-26 | 1992-05-06 | Leo Pharm Prod Ltd | Chemical compounds |
| US5728704A (en) * | 1992-09-28 | 1998-03-17 | Pfizer Inc. | Substituted pyridmidines for control of diabetic complications |
| US5298525A (en) * | 1992-11-23 | 1994-03-29 | University Technologies International, Inc. | Diabetes prevention and treatment |
| FR2699818B1 (fr) * | 1992-12-24 | 1995-02-03 | Oreal | Composition cosmétique ou pharmaceutique contenant en association un polyphénol et un extrait de gingko. |
| US5665360A (en) * | 1993-05-14 | 1997-09-09 | Mann; Richard H. | Method of treating peripheral neuropathies of the feet and legs |
| GB9315253D0 (en) * | 1993-07-23 | 1993-09-08 | Res Inst Medicine Chem | Chemical compounds |
| JP2790163B2 (ja) * | 1993-07-29 | 1998-08-27 | 富士通株式会社 | シリコン酸化膜の形成方法、半導体装置の製造方法及びフラットディスプレイ装置の製造方法 |
| CZ267396A3 (en) * | 1994-03-11 | 1997-03-12 | Procter & Gamble | HYDROLYTIC STABLE COSMETIC, PREPARATION WITH LOW pH VALUE CONTAINING ACID ACTIVE SUBSTANCES |
| US5595982A (en) * | 1994-03-31 | 1997-01-21 | Harlmen Inc. | Equine nutritional supplement |
| AU711482B2 (en) * | 1994-06-28 | 1999-10-14 | Scotia Holdings Plc | Compositions for treatment of diabetic complications |
| ATE223202T1 (de) * | 1994-09-30 | 2002-09-15 | Mika Pharma Ges Fuer Die Entwi | Pharmazeutische zusammensetzung |
| US5571441A (en) * | 1994-11-01 | 1996-11-05 | The Procter & Gamble Company | Nutrient supplement compositions providing physiologic feedback |
| US5648083A (en) * | 1995-02-10 | 1997-07-15 | The Procter & Gamble Company | Personal care compositions and wipe products containing the compositions |
| US5614224A (en) * | 1995-04-20 | 1997-03-25 | Womack; Rick W. | Nutritional supplement for diabetics |
| CA2244535A1 (en) * | 1995-05-15 | 2000-01-30 | Avon Products, Inc. | Novel uses for ascorbyl-phosphoryl-cholesterol in topical compositions |
| KR100192678B1 (ko) * | 1995-06-07 | 1999-06-15 | 손경식 | 약효가 증강된 가공인삼 제품 |
| US5709868A (en) * | 1995-09-20 | 1998-01-20 | Perricone; Nicholas V. | Lipoic acid in topical compositions |
| US6162801A (en) * | 1995-11-20 | 2000-12-19 | Kita; Kiyoshi | External ophthalmic preparation containing vitamin D |
| US5948443A (en) * | 1996-02-23 | 1999-09-07 | Medical Doctor's Research Institute, Inc. | Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease |
| US5998393A (en) * | 1996-04-05 | 1999-12-07 | Kang; Sewon | Methods for assessing 1,25(OH)2 D3 activity in skin and for enhancing the therapeutic use of 1,25(OH)2 D3 |
| DE19615577A1 (de) * | 1996-04-19 | 1997-10-23 | Beiersdorf Ag | Verwendung von Salicin als antiirritativer Wirkstoff in kosmetischen und topischen dermatologischen Zubereitungen |
| US5895652A (en) * | 1996-07-29 | 1999-04-20 | Longevity Institute International | Method of metabolic adjuvanation and cellular repair |
| US5840736A (en) * | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5804594A (en) * | 1997-01-22 | 1998-09-08 | Murad; Howard | Pharmaceutical compositions and methods for improving wrinkles and other skin conditions |
| US5804168A (en) * | 1997-01-29 | 1998-09-08 | Murad; Howard | Pharmaceutical compositions and methods for protecting and treating sun damaged skin |
| US5976568A (en) * | 1997-02-21 | 1999-11-02 | Medical Doctors' Research Institute, Inc. | Modular system of dietary supplement compositions for optimizing health benefits and methods |
| US5962030A (en) * | 1997-03-07 | 1999-10-05 | Akesis Pharmaceuticals, Inc. | Dietary supplement and method of treatment for diabetic control |
| JPH10251146A (ja) * | 1997-03-11 | 1998-09-22 | Toray Ind Inc | 糖尿病性神経障害の治療方法 |
| US5883086A (en) * | 1997-05-02 | 1999-03-16 | Craft; John C. | DHEA-containing nutritional supplement |
| US6207656B1 (en) * | 1997-05-22 | 2001-03-27 | Cephalon, Inc. | Vitamin D analogues and their neuronal effects |
| US5972359A (en) * | 1997-05-23 | 1999-10-26 | The Procter & Gamble Company | Skin care compositions and method of improving skin appearance |
| US5976579A (en) * | 1997-07-03 | 1999-11-02 | Mclean; Linsey | Nutritional supplement for the prevention and treatment of excessive intestinal permeability |
| US6054128A (en) * | 1997-09-29 | 2000-04-25 | Wakat; Diane | Dietary supplements for the cardiovascular system |
| DE19755504A1 (de) * | 1997-12-13 | 1999-06-17 | Beiersdorf Ag | Verwendung von Flavonen und Flavonoiden gegen die UV-induzierte Zersetzung von Dibenzoylmethan und dessen Derivaten |
| BR9908870A (pt) * | 1998-03-16 | 2000-11-21 | Procter & Gamble | Processos para regularizarem a aparência da pele |
| JP2002519312A (ja) * | 1998-06-30 | 2002-07-02 | エイボン プロダクツ インコーポレーテッド | 皮膚美白組成物 |
| US6048886A (en) * | 1998-10-05 | 2000-04-11 | Neigut; Stanley | Compositions and delivery systems for the topical treatment of psoriasis and other conditions of the skin |
| US6296861B1 (en) * | 1999-05-03 | 2001-10-02 | Nicholas V. Perricone | Treatment of skin damage using conjugated linoleic acid and ascorbyl fatty acid esters |
| HK1050840A1 (zh) * | 1999-11-24 | 2003-07-11 | Access Business Group International Llc | 局部使用皮肤组合物 |
| US6299896B1 (en) * | 2000-04-13 | 2001-10-09 | Cooper Concepts, Inc. | Multi-vitamin and mineral supplement |
| US6555573B2 (en) * | 2000-12-21 | 2003-04-29 | The Quigley Corporation | Method and composition for the topical treatment of diabetic neuropathy |
| NZ526041A (en) * | 2000-12-21 | 2005-01-28 | The Quigley Corp | Method and composition for the treatment of diabetic neuropathy |
| US6592896B2 (en) * | 2001-08-06 | 2003-07-15 | The Quigley Corporation | Medicinal composition and method of using it |
| US6596313B2 (en) * | 2001-08-06 | 2003-07-22 | The Quigley Corporation | Nutritional supplement and methods of using it |
-
2002
- 2002-04-25 US US10/132,642 patent/US20030105027A1/en not_active Abandoned
- 2002-05-01 CN CNA028220579A patent/CN1630521A/zh active Pending
- 2002-05-01 JP JP2003541744A patent/JP2005510509A/ja active Pending
- 2002-05-01 WO PCT/US2002/013526 patent/WO2003039452A2/en not_active Ceased
- 2002-05-01 MX MXPA04004376A patent/MXPA04004376A/es active IP Right Grant
- 2002-05-01 EP EP02736624A patent/EP1505984A4/en not_active Withdrawn
- 2002-05-01 AU AU2002309615A patent/AU2002309615B2/en not_active Ceased
- 2002-05-01 NZ NZ532774A patent/NZ532774A/en unknown
- 2002-05-01 IL IL16177402A patent/IL161774A0/xx unknown
- 2002-05-01 CA CA002465945A patent/CA2465945A1/en not_active Abandoned
- 2002-11-06 AU AU2002365155A patent/AU2002365155B2/en not_active Ceased
- 2002-11-06 JP JP2003552220A patent/JP2005528333A/ja active Pending
- 2002-11-06 CN CNA028265416A patent/CN1635907A/zh active Pending
- 2002-11-06 IL IL16177502A patent/IL161775A0/xx unknown
- 2002-11-06 EP EP02803307A patent/EP1536801A4/en not_active Withdrawn
- 2002-11-06 WO PCT/US2002/035701 patent/WO2003051287A2/en not_active Ceased
- 2002-11-06 MX MXPA04004377A patent/MXPA04004377A/es unknown
- 2002-11-06 NZ NZ532775A patent/NZ532775A/en unknown
- 2002-11-06 CA CA002465888A patent/CA2465888A1/en not_active Abandoned
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