JP2005524702A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005524702A5 JP2005524702A5 JP2004500818A JP2004500818A JP2005524702A5 JP 2005524702 A5 JP2005524702 A5 JP 2005524702A5 JP 2004500818 A JP2004500818 A JP 2004500818A JP 2004500818 A JP2004500818 A JP 2004500818A JP 2005524702 A5 JP2005524702 A5 JP 2005524702A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- polymer
- release
- shell
- api
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 claims 18
- 229920000642 polymer Polymers 0.000 claims 12
- 239000008186 active pharmaceutical agent Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000000843 powder Substances 0.000 claims 8
- 239000007788 liquid Substances 0.000 claims 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 229920002689 polyvinyl acetate Polymers 0.000 claims 5
- 239000011118 polyvinyl acetate Substances 0.000 claims 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 4
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims 4
- 238000000151 deposition Methods 0.000 claims 4
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical group [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 claims 4
- 229960003447 pseudoephedrine hydrochloride Drugs 0.000 claims 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000000377 silicon dioxide Substances 0.000 claims 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 2
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 claims 2
- 241000416162 Astragalus gummifer Species 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- DBAKFASWICGISY-DASCVMRKSA-N Dexchlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C1([C@H](CCN(C)C)C=2N=CC=CC=2)=CC=C(Cl)C=C1 DBAKFASWICGISY-DASCVMRKSA-N 0.000 claims 2
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 2
- 239000001856 Ethyl cellulose Substances 0.000 claims 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 2
- 229920002148 Gellan gum Polymers 0.000 claims 2
- 229920002907 Guar gum Polymers 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 2
- 229920000161 Locust bean gum Polymers 0.000 claims 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 229920001615 Tragacanth Polymers 0.000 claims 2
- FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 claims 2
- 229960003556 aminophylline Drugs 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 229960003108 brompheniramine maleate Drugs 0.000 claims 2
- SRGKFVAASLQVBO-BTJKTKAUSA-N brompheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Br)C=C1 SRGKFVAASLQVBO-BTJKTKAUSA-N 0.000 claims 2
- 229960001948 caffeine Drugs 0.000 claims 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
- 229940046978 chlorpheniramine maleate Drugs 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims 2
- 229920001249 ethyl cellulose Polymers 0.000 claims 2
- 235000010492 gellan gum Nutrition 0.000 claims 2
- 239000000216 gellan gum Substances 0.000 claims 2
- 235000010417 guar gum Nutrition 0.000 claims 2
- 239000000665 guar gum Substances 0.000 claims 2
- 229960002154 guar gum Drugs 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 235000010420 locust bean gum Nutrition 0.000 claims 2
- 239000000711 locust bean gum Substances 0.000 claims 2
- 229920000609 methyl cellulose Polymers 0.000 claims 2
- 239000001923 methylcellulose Substances 0.000 claims 2
- 235000010981 methylcellulose Nutrition 0.000 claims 2
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 claims 2
- 229960002237 metoprolol Drugs 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 2
- 235000012239 silicon dioxide Nutrition 0.000 claims 2
- 235000010413 sodium alginate Nutrition 0.000 claims 2
- 239000000661 sodium alginate Substances 0.000 claims 2
- 229940005550 sodium alginate Drugs 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 235000010487 tragacanth Nutrition 0.000 claims 2
- 239000000196 tragacanth Substances 0.000 claims 2
- 229940116362 tragacanth Drugs 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- 238000010146 3D printing Methods 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 101710110406 Rho GTPase-activating protein 17 Proteins 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- USFMMZYROHDWPJ-UHFFFAOYSA-N trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium Chemical compound CC(=C)C(=O)OCC[N+](C)(C)C USFMMZYROHDWPJ-UHFFFAOYSA-N 0.000 claims 1
- -1 trimethylammonio Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37844902P | 2002-05-06 | 2002-05-06 | |
| US60/378,449 | 2002-05-06 | ||
| US42509402P | 2002-11-08 | 2002-11-08 | |
| US60/425,094 | 2002-11-08 | ||
| PCT/US2003/014376 WO2003092633A2 (en) | 2002-05-06 | 2003-05-06 | Diffusion-controlled dosage form and method of fabrication including three dimensional printing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005524702A JP2005524702A (ja) | 2005-08-18 |
| JP2005524702A5 true JP2005524702A5 (https=) | 2006-06-08 |
| JP5041663B2 JP5041663B2 (ja) | 2012-10-03 |
Family
ID=29406838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004500818A Expired - Lifetime JP5041663B2 (ja) | 2002-05-06 | 2003-05-06 | 拡散支配剤形および三次元印刷を含む作製方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8088415B2 (https=) |
| EP (1) | EP1503741B1 (https=) |
| JP (1) | JP5041663B2 (https=) |
| AT (1) | ATE407665T1 (https=) |
| AU (1) | AU2003232078A1 (https=) |
| CA (1) | CA2483028C (https=) |
| DE (1) | DE60323482D1 (https=) |
| ES (1) | ES2316791T3 (https=) |
| WO (1) | WO2003092633A2 (https=) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60323482D1 (de) | 2002-05-06 | 2008-10-23 | Massachusetts Inst Technology | Diffusionskontrollierte arzneiform sowie herstellungsmethode mittels dreidimensionalem drucken |
| KR20060092255A (ko) * | 2003-09-26 | 2006-08-22 | 알자 코포레이션 | 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법 |
| US20060002594A1 (en) * | 2004-06-09 | 2006-01-05 | Clarke Allan J | Method for producing a pharmaceutical product |
| TWI356036B (en) * | 2004-06-09 | 2012-01-11 | Smithkline Beecham Corp | Apparatus and method for pharmaceutical production |
| US8101244B2 (en) * | 2004-06-09 | 2012-01-24 | Smithkline Beecham Corporation | Apparatus and method for producing or processing a product or sample |
| JPWO2006004069A1 (ja) * | 2004-07-01 | 2008-04-24 | 日本碍子株式会社 | 微小カプセルおよびその製造方法 |
| EP2131817A2 (en) * | 2007-03-09 | 2009-12-16 | Synthon B.V. | Pharmaceutical composition of quetiapine fumarate |
| CN101917975B (zh) * | 2007-12-21 | 2013-05-08 | 麦克内尔-Ppc股份有限公司 | 片剂的制造 |
| CN101716162B (zh) * | 2009-11-26 | 2012-11-14 | 扬州中宝制药有限公司 | 一种氨茶碱缓释胶囊及其制备方法 |
| US8251837B2 (en) * | 2010-08-11 | 2012-08-28 | Nike, Inc. | Floating golf ball |
| EP2651399A2 (en) | 2010-12-13 | 2013-10-23 | Purdue Pharma LP | Controlled release dosage forms |
| US9381154B2 (en) * | 2011-06-09 | 2016-07-05 | Xerox Corporation | Direct inkjet fabrication of drug delivery devices |
| US8888480B2 (en) | 2012-09-05 | 2014-11-18 | Aprecia Pharmaceuticals Company | Three-dimensional printing system and equipment assembly |
| BR112015004530A8 (pt) | 2012-09-05 | 2019-08-27 | Aprecia Pharmaceuticals Co | montagem de equipamento de impressão tridimensional e método para preparação de artigos impressos tridimensionalmente |
| US20140099351A1 (en) * | 2012-10-04 | 2014-04-10 | Axxia Pharmaceuticals, Llc | Process for making controlled release medical implant products |
| MX365513B (es) | 2013-03-15 | 2019-06-06 | Aprecia Pharmaceuticals LLC | Forma de dosificacion de dispersion rapida que contiene levetiracetam. |
| US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
| KR102171123B1 (ko) | 2013-08-16 | 2020-10-29 | 더 엑스원 컴퍼니 | ３차원 인쇄된 금속 주조용 몰드 및 그를 제조하기 위한 방법 |
| WO2015057761A1 (en) | 2013-10-17 | 2015-04-23 | The Exone Company | Three-dimensional printed hot isostatic pressing containers and processes for making same |
| EP2875933B1 (de) * | 2013-11-25 | 2019-04-03 | MTU Aero Engines GmbH | Dokumentation generativer Herstellungsverfahren |
| MX2016007786A (es) | 2013-12-16 | 2017-03-03 | Massachusetts Inst Technology | Formulaciones de sal de micronutrientes fortificadas. |
| AU2014364930B2 (en) | 2013-12-16 | 2017-06-15 | Massachusetts Institute Of Technology | Micromolded or 3-D printed pulsatile release vaccine formulations |
| US11001048B2 (en) | 2013-12-23 | 2021-05-11 | The Exone Company | Method of three-dimensional printing using a multi-component build powder |
| WO2015100086A1 (en) | 2013-12-23 | 2015-07-02 | The Exone Company | Methods and systems for three-dimensional printing utilizing multiple binder fluids |
| IL232696B (en) * | 2014-05-19 | 2018-08-30 | Technion Res & Dev Foundation | Compound and method for detecting molecules of interest |
| US20170120329A1 (en) | 2014-05-29 | 2017-05-04 | The Exone Company | Process for Making Nickel-Based Superalloy Articles by Three-Dimensional Printing |
| US20170203514A1 (en) | 2014-07-17 | 2017-07-20 | The Exone Company | Methods and Apparatuses for Curing Three-Dimensional Printed Articles |
| CN107107463B (zh) * | 2014-09-08 | 2019-10-25 | 中央兰开夏大学 | 固体剂型生产 |
| US9844930B2 (en) | 2014-11-05 | 2017-12-19 | Xerox Corporation | 3D printing of digestible shells for medicaments |
| US20180001551A1 (en) | 2014-12-03 | 2018-01-04 | The Exone Company | Process for Making Densified Carbon Articles by Three Dimensional Printing |
| CN113171350B (zh) * | 2015-06-03 | 2023-05-26 | 南京三迭纪医药科技有限公司 | 药品剂型及其使用 |
| CA3254279A1 (en) | 2015-06-03 | 2025-03-18 | Triastek, Inc. | PHARMACEUTICAL FORMS AND RELATED USES |
| US20180214383A1 (en) * | 2015-07-16 | 2018-08-02 | National University Of Singapore | Printing drug tablets with fully customizable release profiles for personalized medicine |
| CN116423825A (zh) | 2015-08-21 | 2023-07-14 | 阿普雷奇亚制药有限责任公司 | 三维打印系统和设备组件 |
| GB201519128D0 (en) * | 2015-10-29 | 2015-12-16 | Univ Central Lancashire | Solid forms and methods of preparing the same |
| CA3023278C (en) | 2016-05-05 | 2019-04-30 | Triastek, Inc. | Controlled release dosage form |
| US12303603B2 (en) * | 2016-06-20 | 2025-05-20 | Sciperio, Inc | Real-time compounding 3D printer |
| US10765658B2 (en) | 2016-06-22 | 2020-09-08 | Mastix LLC | Oral compositions delivering therapeutically effective amounts of cannabinoids |
| GB201612853D0 (en) | 2016-07-25 | 2016-09-07 | Univ Central Lancashire | Solid dosage form production |
| EP3321002A1 (en) * | 2016-11-15 | 2018-05-16 | Höganäs AB | Feedstock for an additive manufacturing method, additive manufacturing method using the same, and article obtained therefrom |
| DE102017200773A1 (de) | 2017-01-18 | 2018-07-19 | Eos Gmbh Electro Optical Systems | Verfahren zum Nachbehandeln und Nachbehandlungssytem |
| KR20190107712A (ko) | 2017-01-26 | 2019-09-20 | 트리아스텍 인코포레이티드 | 특정 위장 부위에서의 제어 방출의 투여 형태 |
| US10369557B2 (en) | 2017-04-12 | 2019-08-06 | International Business Machines Corporation | Three-dimensional printed objects for chemical reaction control |
| WO2018199998A1 (en) * | 2017-04-28 | 2018-11-01 | Hewlett-Packard Development Company, L.P. | Producing diffusion-controlled release devices |
| WO2019025869A1 (en) * | 2017-07-31 | 2019-02-07 | Teva Pharmaceutical Industries Limited | GALENIC FORMS WITH CONTROLLED RELEASE MANUFACTURED IN ADDITIVE MANNER |
| US11642841B2 (en) | 2017-10-13 | 2023-05-09 | Ut-Battelle, Llc | Indirect additive manufacturing process |
| US10350822B1 (en) * | 2018-01-09 | 2019-07-16 | Triastek Inc. | Dosage forms with desired release profiles and methods of designing and making thereof |
| CN116270513A (zh) | 2018-01-09 | 2023-06-23 | 南京三迭纪医药科技有限公司 | 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型 |
| ES3040411T3 (en) | 2018-03-22 | 2025-10-30 | Incarda Therapeutics Inc | A novel method to slow ventricular rate |
| DE102018107585B3 (de) * | 2018-03-29 | 2019-03-28 | Universität Rostock | Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen |
| WO2019199328A1 (en) * | 2018-04-13 | 2019-10-17 | Hewlett-Packard Development Company, L.P. | Three-dimensional printing |
| CN108939162B (zh) * | 2018-07-10 | 2021-11-19 | 上海理工大学 | 一种介孔生物玻璃/海藻酸钠-海藻酸钠分层骨组织工程支架的制备方法 |
| GB201813186D0 (en) | 2018-08-13 | 2018-09-26 | Univ Central Lancashire | Solid dosage from production |
| CA3112618A1 (en) * | 2018-09-14 | 2020-03-19 | Merck Patent Gmbh | Process for the preparation of a coated solid pharmaceutical dosage form |
| WO2020081561A1 (en) | 2018-10-15 | 2020-04-23 | Aprecia Pharmaceuticals LLC | Method and system for forming a dosage form within a packaging |
| US11254617B2 (en) | 2019-01-09 | 2022-02-22 | Ut-Battelle, Llc | Indirect additive manufacturing process using amine-containing adhesive polymers |
| US12103229B2 (en) * | 2019-03-15 | 2024-10-01 | Ricoh Company, Ltd. | Jettable temporary binders to create removable support materials |
| US11724486B2 (en) | 2019-07-09 | 2023-08-15 | Kyndryl, Inc. | Printing customized medication based on current user data and medical records of the user |
| EP4013602A1 (en) * | 2019-08-14 | 2022-06-22 | Merck Patent GmbH | Method for additive manufacture of a product, manufacturing device and solid pharmaceutical dosage form |
| GB201913972D0 (en) | 2019-09-27 | 2019-11-13 | Univ Ulster | Pharmaceutical Delivery Device and method of manufacture |
| ES2828509B2 (es) | 2019-11-26 | 2022-03-09 | Fund Idonial | Composicion para la impresion 3d de farmacos semisolidos |
| EP3871859A1 (en) * | 2020-02-26 | 2021-09-01 | Hewlett-Packard Development Company, L.P. | Three-dimensional printing |
| JP7624750B2 (ja) | 2020-03-02 | 2025-01-31 | クラフト ヘルス プライベート リミテッド | 持続的薬物放出のための経口剤形 |
| JP7776145B2 (ja) | 2020-05-13 | 2025-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | ポリマーマイクロデバイスの組成物およびがん免疫療法におけるその使用 |
| AU2021296908A1 (en) | 2020-06-26 | 2023-02-16 | Aprecia Pharmaceuticals LLC | Rapidly-orodispersible tablets having an interior cavity |
| WO2022089588A1 (zh) | 2020-10-30 | 2022-05-05 | 南京三迭纪医药科技有限公司 | 胃滞留药物剂型 |
| US12251208B2 (en) | 2020-11-30 | 2025-03-18 | International Business Machines Corporation | Time controlled medication |
| KR102723494B1 (ko) * | 2020-12-24 | 2024-10-31 | 동아제약 주식회사 | 적층 방식으로 제조된 방출 조절용 약제학적 조성물 |
| CN112940690B (zh) * | 2021-02-05 | 2021-11-02 | 中国科学院苏州纳米技术与纳米仿生研究所南昌研究院 | 一种具有豆荚结构的相变储能材料及其制备方法与应用 |
| EP4618958A1 (en) * | 2022-11-18 | 2025-09-24 | Aprecia Pharmaceuticals LLC | Functionally-dividable orodispersive dosage form |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US948297A (en) * | 1909-07-24 | 1910-02-01 | John A Stone | Corn-husker. |
| US986148A (en) * | 1910-05-09 | 1911-03-07 | Hoechst Ag | Derivative of oxyarylarsinic acids and process of making same. |
| ZA822995B (en) * | 1981-05-21 | 1983-12-28 | Wyeth John & Brother Ltd | Slow release pharmaceutical composition |
| DE3586600T2 (de) * | 1984-02-10 | 1993-02-18 | Benzon Pharma As | Dosierungsform eine vielzahl mit einer diffusionshuelle ueberzogener einheiten enthaltend. |
| US4810502A (en) * | 1987-02-27 | 1989-03-07 | Alza Corporation | Pseudoephedrine brompheniramine therapy |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5204055A (en) * | 1989-12-08 | 1993-04-20 | Massachusetts Institute Of Technology | Three-dimensional printing techniques |
| NZ242065A (en) * | 1991-03-26 | 1996-06-25 | Csl Ltd | Delayed release implant having a degradable or rupturable polymeric coating |
| US5775402A (en) * | 1995-10-31 | 1998-07-07 | Massachusetts Institute Of Technology | Enhancement of thermal properties of tooling made by solid free form fabrication techniques |
| US5490882A (en) * | 1992-11-30 | 1996-02-13 | Massachusetts Institute Of Technology | Process for removing loose powder particles from interior passages of a body |
| US6280771B1 (en) * | 1997-02-20 | 2001-08-28 | Therics, Inc. | Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof |
| US5490962A (en) * | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
| DE69732983T2 (de) * | 1996-09-13 | 2006-02-16 | Shionogi & Co., Ltd. | Zubereitung mit verlängerter freisetzung unter verwendung einer thermischen umwandlung sowie verfahren zu deren herstellung |
| AU736912B2 (en) * | 1997-02-20 | 2001-08-02 | Therics, Inc. | Dosage form exhibiting rapid disperse properties, methods of use and process for the manufacture of same |
| CA2288201A1 (en) * | 1997-03-31 | 1998-10-08 | Therics, Inc. | Method for dispensing of powders |
| US6213168B1 (en) * | 1997-03-31 | 2001-04-10 | Therics, Inc. | Apparatus and method for dispensing of powders |
| US6547994B1 (en) * | 1998-11-13 | 2003-04-15 | Therics, Inc. | Rapid prototyping and manufacturing process |
| US6485746B1 (en) * | 2000-08-25 | 2002-11-26 | Neurocrine Biosciences, Inc. | Controlled-release sedative-hypnotic compositions and methods related thereto |
| DE19961897A1 (de) * | 1999-12-20 | 2001-06-28 | Basf Ag | Verwendung eines Filmüberzuges als geschmacksmaskierendes Coating von pharmazeutischen Darreichungsformen |
| DE10015479A1 (de) * | 2000-03-29 | 2001-10-11 | Basf Ag | Feste orale Darreichungsformen mit retardierter Wirkstofffreisetzung und hoher mechanischer Stabilität |
| CA2408956C (en) * | 2000-05-18 | 2011-07-12 | Therics, Inc. | Method and form of a drug delivery device,such as encapsulating a toxic core within a non-toxic region in an oral dosage form |
| EP1370365A2 (en) * | 2000-11-10 | 2003-12-17 | Therics, Inc. | A wetting-resistant nozzle for dispensing small volumes of liquid and a method for manufacturing a wetting-resistant nozzle |
| DE60323482D1 (de) | 2002-05-06 | 2008-10-23 | Massachusetts Inst Technology | Diffusionskontrollierte arzneiform sowie herstellungsmethode mittels dreidimensionalem drucken |
| US20050015728A1 (en) * | 2003-07-17 | 2005-01-20 | International Business Machines Corporation | Method, system, and program product for customizing a user interface |
-
2003
- 2003-05-06 DE DE60323482T patent/DE60323482D1/de not_active Expired - Lifetime
- 2003-05-06 AU AU2003232078A patent/AU2003232078A1/en not_active Abandoned
- 2003-05-06 CA CA2483028A patent/CA2483028C/en not_active Expired - Lifetime
- 2003-05-06 AT AT03747680T patent/ATE407665T1/de not_active IP Right Cessation
- 2003-05-06 ES ES03747680T patent/ES2316791T3/es not_active Expired - Lifetime
- 2003-05-06 WO PCT/US2003/014376 patent/WO2003092633A2/en not_active Ceased
- 2003-05-06 US US10/431,353 patent/US8088415B2/en active Active
- 2003-05-06 JP JP2004500818A patent/JP5041663B2/ja not_active Expired - Lifetime
- 2003-05-06 EP EP03747680A patent/EP1503741B1/en not_active Expired - Lifetime
-
2011
- 2011-11-29 US US13/306,393 patent/US8465777B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005524702A5 (https=) | ||
| AU760006B2 (en) | Method for making granules with masked taste and instant release of the active particle | |
| KR101147666B1 (ko) | 위 정체 제제 | |
| CN1655767B (zh) | 持续释放的包衣颗粒和含有这种颗粒的片剂 | |
| ES2202374T3 (es) | Preparacion farmaceutica que contiene metformina y procedimiento para su fabricacion. | |
| US6515010B1 (en) | Carvedilol methanesulfonate | |
| JP5285913B2 (ja) | 経口投与できる固体の放出改変型医薬投与形 | |
| JP5199084B2 (ja) | 胃保持型製剤およびそれらの製造方法 | |
| RU2000131592A (ru) | Фармацевтическая композиция, покрытая энтеросолюбильной оболочкой, и способ ее получения | |
| EP0335560A2 (en) | Controlled release pharmaceutical preparation and method for producing the same | |
| CA2318008A1 (en) | Solid oral pharmaceutical formulation of modified release that contains an acid labile benzimidazole compound | |
| JP2001522874A (ja) | オメプラゾールの配合物 | |
| JP2002523443A (ja) | オメプラゾール製剤 | |
| CA2483028A1 (en) | Diffusion-controlled dosage form and method of fabrication including three dimensional printing | |
| WO2008122993A1 (en) | Controlled release formulation of coated microparticles | |
| WO1999006032A2 (es) | Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion | |
| JP4234427B2 (ja) | 活性成分をベースとする微小顆粒およびその製造方法 | |
| JP2002529399A (ja) | 粒状化結晶性イブプロフェンで被覆した粒子 | |
| JP2023036901A5 (https=) | ||
| WO2009057138A2 (en) | Controlled release pharmaceutical compositions of tolterodine | |
| JP4447166B2 (ja) | 硫酸モルヒネマイクロ顆粒剤、製法および医薬調製物 | |
| JP2005306778A (ja) | 徐放性製剤及びその製造方法 | |
| JP4296562B2 (ja) | 硫酸モルヒネ微小顆粒、その調製方法およびそれを含有する組成物 | |
| JP2000256195A (ja) | ニフェジピン小丸薬およびニフェジピン小丸薬の調製方法 | |
| KR20070000439A (ko) | 벤라팍신 히드로클로라이드의 방출연장형 코팅 미니정제 |