JP2005523917A5 - - Google Patents
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- Publication number
- JP2005523917A5 JP2005523917A5 JP2003587762A JP2003587762A JP2005523917A5 JP 2005523917 A5 JP2005523917 A5 JP 2005523917A5 JP 2003587762 A JP2003587762 A JP 2003587762A JP 2003587762 A JP2003587762 A JP 2003587762A JP 2005523917 A5 JP2005523917 A5 JP 2005523917A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- derivative according
- present
- butan
- oxo groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 organic base cation Chemical class 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- IWBJJCOKGLUQIZ-HQKKAZOISA-N hyperforin Chemical compound OC1=C(CC=C(C)C)C(=O)[C@@]2(CC=C(C)C)C[C@H](CC=C(C)C)[C@](CCC=C(C)C)(C)[C@]1(C(=O)C(C)C)C2=O IWBJJCOKGLUQIZ-HQKKAZOISA-N 0.000 claims 1
- QOVWXXKVLJOKNW-UHFFFAOYSA-N hyperforin Natural products CC(C)C(=O)C12CC(CC=C(C)C)(CC(CC=C(C)C)C1CCC=C(C)C)C(=C(CC=C(C)C)C2=O)O QOVWXXKVLJOKNW-UHFFFAOYSA-N 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- 229910052744 lithium Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000872A ITMI20020872A1 (it) | 2002-04-23 | 2002-04-23 | Derivati dell'iperforina loro uso e formulazioni che li contengono |
| PCT/EP2003/004100 WO2003091194A1 (en) | 2002-04-23 | 2003-04-18 | Hyperforin derivatives, the use thereof and formulations containing them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005523917A JP2005523917A (ja) | 2005-08-11 |
| JP2005523917A5 true JP2005523917A5 (https=) | 2006-06-15 |
| JP4315818B2 JP4315818B2 (ja) | 2009-08-19 |
Family
ID=11449767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003587762A Expired - Fee Related JP4315818B2 (ja) | 2002-04-23 | 2003-04-18 | ハイパーフォリン誘導体、それらの使用及びそれらを含有している製剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | USRE43280E1 (https=) |
| EP (1) | EP1497250B1 (https=) |
| JP (1) | JP4315818B2 (https=) |
| KR (1) | KR100944052B1 (https=) |
| CN (1) | CN1290816C (https=) |
| AT (1) | ATE404519T1 (https=) |
| CA (1) | CA2483205C (https=) |
| DE (1) | DE60322871D1 (https=) |
| DK (1) | DK1497250T3 (https=) |
| ES (1) | ES2311697T3 (https=) |
| IL (1) | IL164763A (https=) |
| IT (1) | ITMI20020872A1 (https=) |
| NO (1) | NO329176B1 (https=) |
| PL (1) | PL205829B1 (https=) |
| PT (1) | PT1497250E (https=) |
| RU (1) | RU2320636C2 (https=) |
| SI (1) | SI1497250T1 (https=) |
| WO (1) | WO2003091194A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772461B (zh) * | 2011-05-11 | 2014-05-14 | 成都康弘药业集团股份有限公司 | 药物组合物在制备预防或治疗老年性痴呆的药物中的应用 |
| US9321713B2 (en) * | 2011-06-03 | 2016-04-26 | President And Fellows Of Harvard College | Hyperforin analogs, methods of synthesis, and uses thereof |
| ITMI20131012A1 (it) * | 2013-06-19 | 2014-12-20 | Indena Spa | Derivati dell'iperforina e loro uso nella malattia di alzheimer |
| US20180071269A1 (en) | 2015-08-12 | 2018-03-15 | Tianxin Wang | Therapeutical methods, formulations and nutraceutical formulations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2162520T3 (es) * | 1998-02-13 | 2001-12-16 | Schwabe Willmar Gmbh & Co | Medicamentos basados en hiperforina y/o extractos de hiperforina. |
| AU743956B2 (en) | 1998-02-13 | 2002-02-07 | Dr. Willmar Schwabe Gmbh & Co | Stable hyperforin salts, method for producing same and their use in the treatment of Alzheimer's disease |
| IT1301679B1 (it) * | 1998-06-10 | 2000-07-07 | Indena Spa | Derivati dell'iperforina, loro uso e formulazioni che licontengono. |
-
2002
- 2002-04-23 IT IT2002MI000872A patent/ITMI20020872A1/it unknown
-
2003
- 2003-04-18 PL PL371347A patent/PL205829B1/pl unknown
- 2003-04-18 RU RU2004131210/04A patent/RU2320636C2/ru not_active IP Right Cessation
- 2003-04-18 AT AT03718778T patent/ATE404519T1/de active
- 2003-04-18 ES ES03718778T patent/ES2311697T3/es not_active Expired - Lifetime
- 2003-04-18 DE DE60322871T patent/DE60322871D1/de not_active Expired - Lifetime
- 2003-04-18 CA CA2483205A patent/CA2483205C/en not_active Expired - Fee Related
- 2003-04-18 DK DK03718778T patent/DK1497250T3/da active
- 2003-04-18 SI SI200331386T patent/SI1497250T1/sl unknown
- 2003-04-18 KR KR1020047016491A patent/KR100944052B1/ko not_active Expired - Fee Related
- 2003-04-18 EP EP03718778A patent/EP1497250B1/en not_active Expired - Lifetime
- 2003-04-18 US US12/896,158 patent/USRE43280E1/en not_active Expired - Fee Related
- 2003-04-18 PT PT03718778T patent/PT1497250E/pt unknown
- 2003-04-18 JP JP2003587762A patent/JP4315818B2/ja not_active Expired - Fee Related
- 2003-04-18 US US10/512,067 patent/US7105705B2/en not_active Ceased
- 2003-04-18 WO PCT/EP2003/004100 patent/WO2003091194A1/en not_active Ceased
- 2003-04-18 CN CNB038089319A patent/CN1290816C/zh not_active Expired - Fee Related
-
2004
- 2004-10-21 NO NO20044519A patent/NO329176B1/no not_active IP Right Cessation
- 2004-10-21 IL IL164763A patent/IL164763A/en not_active IP Right Cessation
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