CN1290816C - 贯叶金丝桃素衍生物,其应用以及包含它们的制剂 - Google Patents

贯叶金丝桃素衍生物,其应用以及包含它们的制剂 Download PDF

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Publication number
CN1290816C
CN1290816C CNB038089319A CN03808931A CN1290816C CN 1290816 C CN1290816 C CN 1290816C CN B038089319 A CNB038089319 A CN B038089319A CN 03808931 A CN03808931 A CN 03808931A CN 1290816 C CN1290816 C CN 1290816C
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CN
China
Prior art keywords
hyperforin
methyl
positions
hydrogen
hydroxyl groups
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Expired - Fee Related
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CNB038089319A
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English (en)
Chinese (zh)
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CN1646462A (zh
Inventor
E·邦巴尔代利
P·莫拉佐尼
A·里瓦
N·菲扎提
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Indena SpA
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Indena SpA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/733—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Semiconductor Lasers (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNB038089319A 2002-04-23 2003-04-18 贯叶金丝桃素衍生物,其应用以及包含它们的制剂 Expired - Fee Related CN1290816C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI000872A ITMI20020872A1 (it) 2002-04-23 2002-04-23 Derivati dell'iperforina loro uso e formulazioni che li contengono
ITMI2002A000872 2002-04-23

Publications (2)

Publication Number Publication Date
CN1646462A CN1646462A (zh) 2005-07-27
CN1290816C true CN1290816C (zh) 2006-12-20

Family

ID=11449767

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038089319A Expired - Fee Related CN1290816C (zh) 2002-04-23 2003-04-18 贯叶金丝桃素衍生物,其应用以及包含它们的制剂

Country Status (18)

Country Link
US (2) USRE43280E1 (https=)
EP (1) EP1497250B1 (https=)
JP (1) JP4315818B2 (https=)
KR (1) KR100944052B1 (https=)
CN (1) CN1290816C (https=)
AT (1) ATE404519T1 (https=)
CA (1) CA2483205C (https=)
DE (1) DE60322871D1 (https=)
DK (1) DK1497250T3 (https=)
ES (1) ES2311697T3 (https=)
IL (1) IL164763A (https=)
IT (1) ITMI20020872A1 (https=)
NO (1) NO329176B1 (https=)
PL (1) PL205829B1 (https=)
PT (1) PT1497250E (https=)
RU (1) RU2320636C2 (https=)
SI (1) SI1497250T1 (https=)
WO (1) WO2003091194A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102772461B (zh) * 2011-05-11 2014-05-14 成都康弘药业集团股份有限公司 药物组合物在制备预防或治疗老年性痴呆的药物中的应用
US9321713B2 (en) * 2011-06-03 2016-04-26 President And Fellows Of Harvard College Hyperforin analogs, methods of synthesis, and uses thereof
ITMI20131012A1 (it) * 2013-06-19 2014-12-20 Indena Spa Derivati dell'iperforina e loro uso nella malattia di alzheimer
US20180071269A1 (en) 2015-08-12 2018-03-15 Tianxin Wang Therapeutical methods, formulations and nutraceutical formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2162520T3 (es) * 1998-02-13 2001-12-16 Schwabe Willmar Gmbh & Co Medicamentos basados en hiperforina y/o extractos de hiperforina.
AU743956B2 (en) 1998-02-13 2002-02-07 Dr. Willmar Schwabe Gmbh & Co Stable hyperforin salts, method for producing same and their use in the treatment of Alzheimer's disease
IT1301679B1 (it) * 1998-06-10 2000-07-07 Indena Spa Derivati dell'iperforina, loro uso e formulazioni che licontengono.

Also Published As

Publication number Publication date
HK1075654A1 (en) 2005-12-23
RU2004131210A (ru) 2005-04-10
DK1497250T3 (da) 2008-12-01
AU2003222828A1 (en) 2003-11-10
ES2311697T3 (es) 2009-02-16
USRE43280E1 (en) 2012-03-27
RU2320636C2 (ru) 2008-03-27
CN1646462A (zh) 2005-07-27
ATE404519T1 (de) 2008-08-15
US7105705B2 (en) 2006-09-12
IL164763A (en) 2010-02-17
NO20044519L (no) 2004-11-02
CA2483205A1 (en) 2003-11-06
EP1497250A1 (en) 2005-01-19
NO329176B1 (no) 2010-09-06
CA2483205C (en) 2011-07-05
JP2005523917A (ja) 2005-08-11
WO2003091194A1 (en) 2003-11-06
KR100944052B1 (ko) 2010-02-24
DE60322871D1 (de) 2008-09-25
KR20040111519A (ko) 2004-12-31
ITMI20020872A1 (it) 2003-10-23
ITMI20020872A0 (it) 2002-04-23
JP4315818B2 (ja) 2009-08-19
US20050165117A1 (en) 2005-07-28
SI1497250T1 (sl) 2008-12-31
PL371347A1 (en) 2005-06-13
PT1497250E (pt) 2008-11-12
IL164763A0 (en) 2005-12-18
PL205829B1 (pl) 2010-05-31
EP1497250B1 (en) 2008-08-13

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