IT1301679B1 - Derivati dell'iperforina, loro uso e formulazioni che licontengono. - Google Patents
Derivati dell'iperforina, loro uso e formulazioni che licontengono.Info
- Publication number
- IT1301679B1 IT1301679B1 IT1998MI001312A ITMI981312A IT1301679B1 IT 1301679 B1 IT1301679 B1 IT 1301679B1 IT 1998MI001312 A IT1998MI001312 A IT 1998MI001312A IT MI981312 A ITMI981312 A IT MI981312A IT 1301679 B1 IT1301679 B1 IT 1301679B1
- Authority
- IT
- Italy
- Prior art keywords
- derivatives
- hyperphorine
- formulations
- contain
- glicoside
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/647—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring
- C07C49/653—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring polycyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI001312A IT1301679B1 (it) | 1998-06-10 | 1998-06-10 | Derivati dell'iperforina, loro uso e formulazioni che licontengono. |
| PCT/EP1999/003880 WO1999064388A1 (en) | 1998-06-10 | 1999-06-04 | Hyperforin derivatives, the use thereof and formulations containing them |
| PL99344696A PL195797B1 (pl) | 1998-06-10 | 1999-06-04 | Pochodne hiperforynowe, kompozycje farmaceutyczneje zawierające i zastosowanie tych pochodnych |
| DE69927813T DE69927813T2 (de) | 1998-06-10 | 1999-06-04 | Hyperforin-derivate, ihre verwendung sowie diese enthaltende zubereitungen |
| KR1020007013866A KR100627933B1 (ko) | 1998-06-10 | 1999-06-04 | 하이퍼포린 유도체, 그의 용도 및 그를 함유한 제제 |
| HU0102226A HUP0102226A3 (en) | 1998-06-10 | 1999-06-04 | Hyperforin derivatives, the use thereof and formulations containing them |
| IL14015199A IL140151A0 (en) | 1998-06-10 | 1999-06-04 | Hyperforin derivatives, the use thereof and formulations containing them |
| DK99926516T DK1086071T3 (da) | 1998-06-10 | 1999-06-04 | Hyperforinforbindelser, anvendelse heraf og formuleringer indeholdende disse |
| CZ20004562A CZ298859B6 (cs) | 1998-06-10 | 1999-06-04 | Hyperforinové deriváty, jejich využití a prípravky je obsahující |
| RU2000131214/04A RU2240304C2 (ru) | 1998-06-10 | 1999-06-04 | Производные гиперфорина, их использование и препараты, содержащие эти производные |
| BRPI9910893-3B1A BR9910893B1 (pt) | 1998-06-10 | 1999-06-04 | Derivados de hyperforin, seus usos, e formulações contendo os mesmos |
| SK1871-2000A SK286049B6 (sk) | 1998-06-10 | 1999-06-04 | Hyperforínové deriváty, farmaceutický prostriedoks ich obsahom a ich použitie |
| AT99926516T ATE307103T1 (de) | 1998-06-10 | 1999-06-04 | Hyperforin-derivate, ihre verwendung sowie diese enthaltende zubereitungen |
| EP99926516A EP1086071B1 (en) | 1998-06-10 | 1999-06-04 | Hyperforin derivatives, the use thereof and formulations containing them |
| CA002334308A CA2334308C (en) | 1998-06-10 | 1999-06-04 | Hyperforin derivatives, the use thereof and formulations containing them |
| JP2000553398A JP4511726B2 (ja) | 1998-06-10 | 1999-06-04 | ハイパーフォリン誘導体、その利用及びこれを含む調剤 |
| CNB998071218A CN1246278C (zh) | 1998-06-10 | 1999-06-04 | 贯叶金丝桃素衍生物,其用途及含有它们的组合物 |
| SI9930840T SI1086071T1 (sl) | 1998-06-10 | 1999-06-04 | Derivati hiperforina, njihova uporaba in farmacevtske oblike, ki jih vsebujejo |
| ES99926516T ES2249893T3 (es) | 1998-06-10 | 1999-06-04 | Derivados de hiperforina, uso de los mismos y formulados que los contienen. |
| MXPA00012177A MXPA00012177A (es) | 1998-06-10 | 1999-06-04 | Derivados de hiperforina, uso de los mismos y formulaciones que los contienen. |
| EP05015870A EP1607099A1 (en) | 1998-06-10 | 1999-06-04 | Use of hyperforin derivatives as an antidepressant agent |
| AU43739/99A AU763889B2 (en) | 1998-06-10 | 1999-06-04 | Hyperforin derivatives, the use thereof and formulations containing them |
| US09/730,536 US6656510B2 (en) | 1998-06-10 | 2000-12-07 | Hyperforin derivatives, use thereof and formulations containing them |
| NO20006230A NO328444B1 (no) | 1998-06-10 | 2000-12-07 | Hyperforinderivat, anvendelse derav og farmasoytisk sammensetning inneholdende det |
| IL140151A IL140151A (en) | 1998-06-10 | 2000-12-07 | Hyperforin derivatives are used by Ben and the compositions containing them |
| HK01107738A HK1036791A1 (en) | 1998-06-10 | 2001-11-06 | Hyperforin derivatives, the use thereof and formulations containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI001312A IT1301679B1 (it) | 1998-06-10 | 1998-06-10 | Derivati dell'iperforina, loro uso e formulazioni che licontengono. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI981312A1 ITMI981312A1 (it) | 1999-12-10 |
| IT1301679B1 true IT1301679B1 (it) | 2000-07-07 |
Family
ID=11380210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1998MI001312A IT1301679B1 (it) | 1998-06-10 | 1998-06-10 | Derivati dell'iperforina, loro uso e formulazioni che licontengono. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6656510B2 (it) |
| EP (2) | EP1607099A1 (it) |
| JP (1) | JP4511726B2 (it) |
| KR (1) | KR100627933B1 (it) |
| CN (1) | CN1246278C (it) |
| AT (1) | ATE307103T1 (it) |
| AU (1) | AU763889B2 (it) |
| BR (1) | BR9910893B1 (it) |
| CA (1) | CA2334308C (it) |
| CZ (1) | CZ298859B6 (it) |
| DE (1) | DE69927813T2 (it) |
| DK (1) | DK1086071T3 (it) |
| ES (1) | ES2249893T3 (it) |
| HK (1) | HK1036791A1 (it) |
| HU (1) | HUP0102226A3 (it) |
| IL (2) | IL140151A0 (it) |
| IT (1) | IT1301679B1 (it) |
| MX (1) | MXPA00012177A (it) |
| NO (1) | NO328444B1 (it) |
| PL (1) | PL195797B1 (it) |
| RU (1) | RU2240304C2 (it) |
| SK (1) | SK286049B6 (it) |
| WO (1) | WO1999064388A1 (it) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1126882B1 (de) * | 1998-11-04 | 2009-12-30 | Dr. Willmar Schwabe GmbH & Co. KG | Stabile zubereitungen mit hyperforin |
| ITMI20020871A1 (it) | 2002-04-23 | 2003-10-23 | Indena Spa | Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono |
| ITMI20020872A1 (it) | 2002-04-23 | 2003-10-23 | Indena Spa | Derivati dell'iperforina loro uso e formulazioni che li contengono |
| US20060115555A1 (en) * | 2004-12-01 | 2006-06-01 | Foulger Sidney W | Nutritional supplements containing xanthone extracts |
| US20060115556A1 (en) * | 2004-12-01 | 2006-06-01 | Foulger Sidney W | Nutritional supplement drink containing xanthone extracts |
| BRPI0900614A2 (pt) | 2009-02-13 | 2011-06-28 | Univ Fed Do Rio Grande Do Sul Ufrgs | extrato vegetal neuroativo, composição farmacêutica compreendendo o mesmo e processo para sua produção |
| RU2013157954A (ru) * | 2011-06-03 | 2015-07-20 | Президентс Энд Феллоуз Оф Гарвард Колледж | Аналоги гиперфорина, способы их синтеза и применения |
| ITMI20131012A1 (it) | 2013-06-19 | 2014-12-20 | Indena Spa | Derivati dell'iperforina e loro uso nella malattia di alzheimer |
| RU2676100C1 (ru) * | 2018-10-05 | 2018-12-26 | федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский политехнический университет Петра Великого" (ФГАОУ ВО "СПбПУ") | Применение производных пиперазина для лечения болезни Альцгеймера и деменций альцгеймеровского типа с нарушенной внутриклеточной кальциевой сигнализацией |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2550266A (en) * | 1948-12-11 | 1951-04-24 | Swift & Co | Preservation of food products |
| DE4239959A1 (de) * | 1992-11-27 | 1994-06-01 | Schwabe Willmar Gmbh & Co | Johanniskraut-Trockenextrakt, Verfahren zu seiner Herstellung und seine Verwendung |
| DE19646977A1 (de) * | 1995-09-29 | 1998-01-15 | Schwabe Willmar Gmbh & Co | Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen |
| DE19714450A1 (de) * | 1997-04-08 | 1998-10-15 | Schwabe Willmar Gmbh & Co | Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitung |
| US6096317A (en) * | 1998-01-13 | 2000-08-01 | Rexall Sundown | St. John's Wort and methyl donor composition and uses thereof |
| US6224906B1 (en) * | 1999-08-31 | 2001-05-01 | Natreon Inc. | St. John's wort composition |
-
1998
- 1998-06-10 IT IT1998MI001312A patent/IT1301679B1/it active IP Right Grant
-
1999
- 1999-06-04 AT AT99926516T patent/ATE307103T1/de active
- 1999-06-04 KR KR1020007013866A patent/KR100627933B1/ko not_active IP Right Cessation
- 1999-06-04 IL IL14015199A patent/IL140151A0/xx active IP Right Grant
- 1999-06-04 EP EP05015870A patent/EP1607099A1/en not_active Withdrawn
- 1999-06-04 JP JP2000553398A patent/JP4511726B2/ja not_active Expired - Fee Related
- 1999-06-04 PL PL99344696A patent/PL195797B1/pl not_active IP Right Cessation
- 1999-06-04 ES ES99926516T patent/ES2249893T3/es not_active Expired - Lifetime
- 1999-06-04 SK SK1871-2000A patent/SK286049B6/sk not_active IP Right Cessation
- 1999-06-04 RU RU2000131214/04A patent/RU2240304C2/ru not_active IP Right Cessation
- 1999-06-04 EP EP99926516A patent/EP1086071B1/en not_active Expired - Lifetime
- 1999-06-04 WO PCT/EP1999/003880 patent/WO1999064388A1/en active IP Right Grant
- 1999-06-04 CZ CZ20004562A patent/CZ298859B6/cs not_active IP Right Cessation
- 1999-06-04 DE DE69927813T patent/DE69927813T2/de not_active Expired - Lifetime
- 1999-06-04 DK DK99926516T patent/DK1086071T3/da active
- 1999-06-04 AU AU43739/99A patent/AU763889B2/en not_active Ceased
- 1999-06-04 BR BRPI9910893-3B1A patent/BR9910893B1/pt not_active IP Right Cessation
- 1999-06-04 MX MXPA00012177A patent/MXPA00012177A/es active IP Right Grant
- 1999-06-04 CA CA002334308A patent/CA2334308C/en not_active Expired - Fee Related
- 1999-06-04 HU HU0102226A patent/HUP0102226A3/hu unknown
- 1999-06-04 CN CNB998071218A patent/CN1246278C/zh not_active Expired - Fee Related
-
2000
- 2000-12-07 NO NO20006230A patent/NO328444B1/no not_active IP Right Cessation
- 2000-12-07 US US09/730,536 patent/US6656510B2/en not_active Expired - Lifetime
- 2000-12-07 IL IL140151A patent/IL140151A/en not_active IP Right Cessation
-
2001
- 2001-11-06 HK HK01107738A patent/HK1036791A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |