BR9910893A - Derivados de hyperforin, seus usos, e formulações contendo os mesmos - Google Patents

Derivados de hyperforin, seus usos, e formulações contendo os mesmos

Info

Publication number
BR9910893A
BR9910893A BR9910893-3A BR9910893A BR9910893A BR 9910893 A BR9910893 A BR 9910893A BR 9910893 A BR9910893 A BR 9910893A BR 9910893 A BR9910893 A BR 9910893A
Authority
BR
Brazil
Prior art keywords
same
formulations containing
hyperforin derivatives
hyperforin
derivatives
Prior art date
Application number
BR9910893-3A
Other languages
English (en)
Other versions
BR9910893B1 (pt
Inventor
Ezio Bombardelli
Paolo Marazzoni
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of BR9910893A publication Critical patent/BR9910893A/pt
Publication of BR9910893B1 publication Critical patent/BR9910893B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/647—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring
    • C07C49/653—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring polycyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Patente de Invenção para <B>DERIVADOS DE HYPERFORIN, SEUS USOS, E FORMULAçõES CONTENDO OS MESMOS''<D>Derivados de Hyperforin, de fórmula (I), onde R é um grupo acil ou glicosídeo, possuindo características farmacológicas vantajosas e boa estabilidade.
BRPI9910893-3B1A 1998-06-10 1999-06-04 Derivados de hyperforin, seus usos, e formulações contendo os mesmos BR9910893B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI001312A IT1301679B1 (it) 1998-06-10 1998-06-10 Derivati dell'iperforina, loro uso e formulazioni che licontengono.
PCT/EP1999/003880 WO1999064388A1 (en) 1998-06-10 1999-06-04 Hyperforin derivatives, the use thereof and formulations containing them

Publications (2)

Publication Number Publication Date
BR9910893A true BR9910893A (pt) 2001-03-06
BR9910893B1 BR9910893B1 (pt) 2013-10-29

Family

ID=11380210

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9910893-3B1A BR9910893B1 (pt) 1998-06-10 1999-06-04 Derivados de hyperforin, seus usos, e formulações contendo os mesmos

Country Status (23)

Country Link
US (1) US6656510B2 (pt)
EP (2) EP1607099A1 (pt)
JP (1) JP4511726B2 (pt)
KR (1) KR100627933B1 (pt)
CN (1) CN1246278C (pt)
AT (1) ATE307103T1 (pt)
AU (1) AU763889B2 (pt)
BR (1) BR9910893B1 (pt)
CA (1) CA2334308C (pt)
CZ (1) CZ298859B6 (pt)
DE (1) DE69927813T2 (pt)
DK (1) DK1086071T3 (pt)
ES (1) ES2249893T3 (pt)
HK (1) HK1036791A1 (pt)
HU (1) HUP0102226A3 (pt)
IL (2) IL140151A0 (pt)
IT (1) IT1301679B1 (pt)
MX (1) MXPA00012177A (pt)
NO (1) NO328444B1 (pt)
PL (1) PL195797B1 (pt)
RU (1) RU2240304C2 (pt)
SK (1) SK286049B6 (pt)
WO (1) WO1999064388A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1770700A (en) * 1998-11-04 2000-05-22 Dr. Willmar Schwabe Gmbh & Co Stable preparations with hyperforin
ITMI20020872A1 (it) * 2002-04-23 2003-10-23 Indena Spa Derivati dell'iperforina loro uso e formulazioni che li contengono
ITMI20020871A1 (it) * 2002-04-23 2003-10-23 Indena Spa Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono
US20060115555A1 (en) * 2004-12-01 2006-06-01 Foulger Sidney W Nutritional supplements containing xanthone extracts
US20060115556A1 (en) * 2004-12-01 2006-06-01 Foulger Sidney W Nutritional supplement drink containing xanthone extracts
BRPI0900614A2 (pt) 2009-02-13 2011-06-28 Univ Fed Do Rio Grande Do Sul Ufrgs extrato vegetal neuroativo, composição farmacêutica compreendendo o mesmo e processo para sua produção
CN103732568A (zh) * 2011-06-03 2014-04-16 哈佛大学的校长及成员们 贯叶金丝桃素类似物、其合成方法及其用途
ITMI20131012A1 (it) 2013-06-19 2014-12-20 Indena Spa Derivati dell'iperforina e loro uso nella malattia di alzheimer
RU2676100C1 (ru) * 2018-10-05 2018-12-26 федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский политехнический университет Петра Великого" (ФГАОУ ВО "СПбПУ") Применение производных пиперазина для лечения болезни Альцгеймера и деменций альцгеймеровского типа с нарушенной внутриклеточной кальциевой сигнализацией

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2550266A (en) * 1948-12-11 1951-04-24 Swift & Co Preservation of food products
DE4239959A1 (de) * 1992-11-27 1994-06-01 Schwabe Willmar Gmbh & Co Johanniskraut-Trockenextrakt, Verfahren zu seiner Herstellung und seine Verwendung
DE19646977A1 (de) * 1995-09-29 1998-01-15 Schwabe Willmar Gmbh & Co Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen
DE19714450A1 (de) * 1997-04-08 1998-10-15 Schwabe Willmar Gmbh & Co Stabiler Extrakt aus Hypericum perforatum L., Verfahren zu seiner Herstellung und pharmazeutische Zubereitung
CA2317671A1 (en) * 1998-01-13 1999-07-22 Rexall Sundown, Inc. St. john's wort and methyl donor composition and uses thereof
US6224906B1 (en) * 1999-08-31 2001-05-01 Natreon Inc. St. John's wort composition

Also Published As

Publication number Publication date
PL344696A1 (en) 2001-11-19
AU763889B2 (en) 2003-07-31
US6656510B2 (en) 2003-12-02
MXPA00012177A (es) 2004-09-06
ITMI981312A1 (it) 1999-12-10
CZ20004562A3 (en) 2001-06-13
DK1086071T3 (da) 2006-01-23
SK286049B6 (sk) 2008-01-07
CA2334308C (en) 2009-06-02
DE69927813D1 (de) 2006-03-02
IL140151A0 (en) 2002-02-10
PL195797B1 (pl) 2007-10-31
KR100627933B1 (ko) 2006-09-22
IL140151A (en) 2006-12-10
NO328444B1 (no) 2010-02-22
HUP0102226A3 (en) 2003-07-28
NO20006230L (no) 2001-02-01
CZ298859B6 (cs) 2008-02-27
DE69927813T2 (de) 2006-04-20
BR9910893B1 (pt) 2013-10-29
AU4373999A (en) 1999-12-30
CN1304397A (zh) 2001-07-18
JP4511726B2 (ja) 2010-07-28
EP1086071B1 (en) 2005-10-19
KR20010052637A (ko) 2001-06-25
HK1036791A1 (en) 2002-01-18
US20010020040A1 (en) 2001-09-06
IT1301679B1 (it) 2000-07-07
ATE307103T1 (de) 2005-11-15
EP1607099A1 (en) 2005-12-21
WO1999064388A1 (en) 1999-12-16
JP2002517478A (ja) 2002-06-18
HUP0102226A2 (hu) 2001-10-28
NO20006230D0 (no) 2000-12-07
ES2249893T3 (es) 2006-04-01
CN1246278C (zh) 2006-03-22
SK18712000A3 (sk) 2001-06-11
RU2240304C2 (ru) 2004-11-20
EP1086071A1 (en) 2001-03-28
CA2334308A1 (en) 1999-12-16

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/10/2013, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2257 DE 08-04-2014 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B15K Others concerning applications: alteration of classification

Ipc: A61K 31/122 (2006.01), C07C 69/013 (2006.0