ITMI20020871A1 - Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono - Google Patents

Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono

Info

Publication number
ITMI20020871A1
ITMI20020871A1 IT2002MI000871A ITMI20020871A ITMI20020871A1 IT MI20020871 A1 ITMI20020871 A1 IT MI20020871A1 IT 2002MI000871 A IT2002MI000871 A IT 2002MI000871A IT MI20020871 A ITMI20020871 A IT MI20020871A IT MI20020871 A1 ITMI20020871 A1 IT MI20020871A1
Authority
IT
Italy
Prior art keywords
hyperphorine
formulations containing
halogenated derivatives
halogenated
derivatives
Prior art date
Application number
IT2002MI000871A
Other languages
English (en)
Inventor
Ezio Bombardelli
Paolo Morazzoni
Antonella Riva
Nicola Fuzzati
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Priority to IT2002MI000871A priority Critical patent/ITMI20020871A1/it
Publication of ITMI20020871A0 publication Critical patent/ITMI20020871A0/it
Priority to US10/511,894 priority patent/US7057078B2/en
Priority to RU2004131220/04A priority patent/RU2004131220A/ru
Priority to JP2003587761A priority patent/JP2005523916A/ja
Priority to CNB038089645A priority patent/CN1269783C/zh
Priority to AU2003233979A priority patent/AU2003233979B2/en
Priority to PCT/EP2003/003923 priority patent/WO2003091193A1/en
Priority to PL03372166A priority patent/PL372166A1/xx
Priority to EP03727312A priority patent/EP1497249A1/en
Priority to CA002483203A priority patent/CA2483203A1/en
Priority to KR10-2004-7016809A priority patent/KR20040111537A/ko
Publication of ITMI20020871A1 publication Critical patent/ITMI20020871A1/it
Priority to NO20044518A priority patent/NO20044518L/no
Priority to HK05107778A priority patent/HK1075653A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/457—Saturated compounds containing a keto group being part of a ring containing halogen
    • C07C49/467—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic
    • C07C49/473—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic a keto group being part of a condensed ring system
    • C07C49/477—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/693—Unsaturated compounds containing a keto groups being part of a ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IT2002MI000871A 2002-04-23 2002-04-23 Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono ITMI20020871A1 (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT2002MI000871A ITMI20020871A1 (it) 2002-04-23 2002-04-23 Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono
KR10-2004-7016809A KR20040111537A (ko) 2002-04-23 2003-04-15 하이퍼포린의 할로겐화된 유도체, 그의 용도 및 그를함유한 제제
PCT/EP2003/003923 WO2003091193A1 (en) 2002-04-23 2003-04-15 Hyperforin halogenated derivatives, the use thereof and formulations containing them
RU2004131220/04A RU2004131220A (ru) 2002-04-23 2003-04-15 Галогенпроизводные гиперфорина, использование таковых и составов, их содержащих
JP2003587761A JP2005523916A (ja) 2002-04-23 2003-04-15 ヒペルフォリンのハロゲン化誘導体、それらの使用、およびそれらを含む製剤
CNB038089645A CN1269783C (zh) 2002-04-23 2003-04-15 贯叶金丝桃素卤代衍生物、其用途和包含它们的制剂
AU2003233979A AU2003233979B2 (en) 2002-04-23 2003-04-15 Hyperforin halogenated derivatives, the use thereof and formulations containing them
US10/511,894 US7057078B2 (en) 2002-04-23 2003-04-15 Hyperforin halogenated derivatives, the use thereof and formulations containing them
PL03372166A PL372166A1 (en) 2002-04-23 2003-04-15 Hyperforin halogenated derivatives, the use thereof and formulations containing them
EP03727312A EP1497249A1 (en) 2002-04-23 2003-04-15 Hyperforin halogenated derivatives, the use thereof and formulations containing them
CA002483203A CA2483203A1 (en) 2002-04-23 2003-04-15 Hyperforin halogenated derivatives, the use thereof and formulations containing them
NO20044518A NO20044518L (no) 2002-04-23 2004-10-21 Halogenerte hyperfonnderivater, anvendelse derav samt formuleringer som inneholder dem
HK05107778A HK1075653A1 (en) 2002-04-23 2005-09-05 Hyperforin halogenated derivatives, the use thereof and formulations containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002MI000871A ITMI20020871A1 (it) 2002-04-23 2002-04-23 Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono

Publications (2)

Publication Number Publication Date
ITMI20020871A0 ITMI20020871A0 (it) 2002-04-23
ITMI20020871A1 true ITMI20020871A1 (it) 2003-10-23

Family

ID=11449766

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2002MI000871A ITMI20020871A1 (it) 2002-04-23 2002-04-23 Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono

Country Status (13)

Country Link
US (1) US7057078B2 (it)
EP (1) EP1497249A1 (it)
JP (1) JP2005523916A (it)
KR (1) KR20040111537A (it)
CN (1) CN1269783C (it)
AU (1) AU2003233979B2 (it)
CA (1) CA2483203A1 (it)
HK (1) HK1075653A1 (it)
IT (1) ITMI20020871A1 (it)
NO (1) NO20044518L (it)
PL (1) PL372166A1 (it)
RU (1) RU2004131220A (it)
WO (1) WO2003091193A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102772461B (zh) * 2011-05-11 2014-05-14 成都康弘药业集团股份有限公司 药物组合物在制备预防或治疗老年性痴呆的药物中的应用
BR112013030986A2 (pt) 2011-06-03 2016-12-06 Harvard College análogos de hiperforina, métodos de síntese e usos dos mesmos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU743956B2 (en) * 1998-02-13 2002-02-07 Dr. Willmar Schwabe Gmbh & Co Stable hyperforin salts, method for producing same and their use in the treatment of Alzheimer's disease
CA2320154A1 (en) * 1998-02-13 1999-08-19 Dr. Willmar Schwabe Gmbh & Co. Use of hyperforin and hyperforin-containing extracts for the treatment and prophylaxis of dementia diseases
IT1301679B1 (it) * 1998-06-10 2000-07-07 Indena Spa Derivati dell'iperforina, loro uso e formulazioni che licontengono.

Also Published As

Publication number Publication date
HK1075653A1 (en) 2005-12-23
WO2003091193A1 (en) 2003-11-06
CN1646461A (zh) 2005-07-27
CA2483203A1 (en) 2003-11-06
EP1497249A1 (en) 2005-01-19
AU2003233979B2 (en) 2008-02-21
CN1269783C (zh) 2006-08-16
RU2004131220A (ru) 2005-04-20
NO20044518L (no) 2004-11-19
US7057078B2 (en) 2006-06-06
PL372166A1 (en) 2005-07-11
KR20040111537A (ko) 2004-12-31
ITMI20020871A0 (it) 2002-04-23
US20050222274A1 (en) 2005-10-06
JP2005523916A (ja) 2005-08-11
AU2003233979A1 (en) 2003-11-10

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