RU2004131220A - Галогенпроизводные гиперфорина, использование таковых и составов, их содержащих - Google Patents
Галогенпроизводные гиперфорина, использование таковых и составов, их содержащих Download PDFInfo
- Publication number
- RU2004131220A RU2004131220A RU2004131220/04A RU2004131220A RU2004131220A RU 2004131220 A RU2004131220 A RU 2004131220A RU 2004131220/04 A RU2004131220/04 A RU 2004131220/04A RU 2004131220 A RU2004131220 A RU 2004131220A RU 2004131220 A RU2004131220 A RU 2004131220A
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- hyperforin
- positions
- present
- hyperphorin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/457—Saturated compounds containing a keto group being part of a ring containing halogen
- C07C49/467—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic
- C07C49/473—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic a keto group being part of a condensed ring system
- C07C49/477—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic a keto group being part of a condensed ring system having two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
- C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
- C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
- C07C49/693—Unsaturated compounds containing a keto groups being part of a ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (7)
1. Соединения формулы (I)
где Х является атомом галогена, R является метилом или этилом и, альтернативно:
а) R1 представляет 3-метил-2-бутен-1-ил и в 1- и 10-положениях присутствуют оксогруппы;
b) R1 представляет 3-метил-бут-1-ил и в 1- и 10-положениях присутствуют оксогруппы;
с) R1 представляет 3-метил-2-бутен-1-ил и в 1- и 10-положениях присутствуют гидроксигруппы;
d) R1 представляет 3-метил-бут-1-ил и в 1- и 10-положениях присутствуют гидроксигруппы;
и их фармацевтически приемлемые соли или сложные эфиры.
2. Соединения по п.1, где Х является хлором или бромом.
3. Соединения по п.1, где Х является хлором.
5. Соединения по любому из пп.1-4 для использования в качестве лекарственного средства.
6. Использование соединений по любому из пп.1-4 для получения лекарственных средств для лечения депрессии и болезни Альцгеймера.
7. Фармацевтическая композиция, содержащая соединение по любому из пп.1-4 в смеси с подходящим наполнителем или носителем.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002MI000871A ITMI20020871A1 (it) | 2002-04-23 | 2002-04-23 | Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono |
ITMI2002A000871 | 2002-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2004131220A true RU2004131220A (ru) | 2005-04-20 |
Family
ID=11449766
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2004131220/04A RU2004131220A (ru) | 2002-04-23 | 2003-04-15 | Галогенпроизводные гиперфорина, использование таковых и составов, их содержащих |
Country Status (13)
Country | Link |
---|---|
US (1) | US7057078B2 (ru) |
EP (1) | EP1497249A1 (ru) |
JP (1) | JP2005523916A (ru) |
KR (1) | KR20040111537A (ru) |
CN (1) | CN1269783C (ru) |
AU (1) | AU2003233979B2 (ru) |
CA (1) | CA2483203A1 (ru) |
HK (1) | HK1075653A1 (ru) |
IT (1) | ITMI20020871A1 (ru) |
NO (1) | NO20044518L (ru) |
PL (1) | PL372166A1 (ru) |
RU (1) | RU2004131220A (ru) |
WO (1) | WO2003091193A1 (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102772461B (zh) * | 2011-05-11 | 2014-05-14 | 成都康弘药业集团股份有限公司 | 药物组合物在制备预防或治疗老年性痴呆的药物中的应用 |
BR112013030986A2 (pt) * | 2011-06-03 | 2016-12-06 | Harvard College | análogos de hiperforina, métodos de síntese e usos dos mesmos |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE204759T1 (de) * | 1998-02-13 | 2001-09-15 | Schwabe Willmar Gmbh & Co | Verwendung von hyperforin und hyperforinhaltigen extrakten zur behandlung und prophylaxe von demenzerkrankungen |
WO1999041220A1 (de) * | 1998-02-13 | 1999-08-19 | Dr. Willmar Schwabe Gmbh & Co. | Stabile hyperforin-salze, verfahren zu ihrer herstellung und verwendung zur therapie der alzheimerschen krankheit |
IT1301679B1 (it) * | 1998-06-10 | 2000-07-07 | Indena Spa | Derivati dell'iperforina, loro uso e formulazioni che licontengono. |
-
2002
- 2002-04-23 IT IT2002MI000871A patent/ITMI20020871A1/it unknown
-
2003
- 2003-04-15 CA CA002483203A patent/CA2483203A1/en not_active Abandoned
- 2003-04-15 US US10/511,894 patent/US7057078B2/en not_active Expired - Fee Related
- 2003-04-15 AU AU2003233979A patent/AU2003233979B2/en not_active Expired - Fee Related
- 2003-04-15 JP JP2003587761A patent/JP2005523916A/ja not_active Withdrawn
- 2003-04-15 RU RU2004131220/04A patent/RU2004131220A/ru not_active Application Discontinuation
- 2003-04-15 CN CNB038089645A patent/CN1269783C/zh not_active Expired - Fee Related
- 2003-04-15 PL PL03372166A patent/PL372166A1/xx unknown
- 2003-04-15 KR KR10-2004-7016809A patent/KR20040111537A/ko not_active Application Discontinuation
- 2003-04-15 WO PCT/EP2003/003923 patent/WO2003091193A1/en not_active Application Discontinuation
- 2003-04-15 EP EP03727312A patent/EP1497249A1/en not_active Withdrawn
-
2004
- 2004-10-21 NO NO20044518A patent/NO20044518L/no not_active Application Discontinuation
-
2005
- 2005-09-05 HK HK05107778A patent/HK1075653A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ITMI20020871A1 (it) | 2003-10-23 |
CN1269783C (zh) | 2006-08-16 |
AU2003233979B2 (en) | 2008-02-21 |
WO2003091193A1 (en) | 2003-11-06 |
AU2003233979A1 (en) | 2003-11-10 |
CN1646461A (zh) | 2005-07-27 |
NO20044518L (no) | 2004-11-19 |
CA2483203A1 (en) | 2003-11-06 |
US7057078B2 (en) | 2006-06-06 |
ITMI20020871A0 (it) | 2002-04-23 |
PL372166A1 (en) | 2005-07-11 |
KR20040111537A (ko) | 2004-12-31 |
HK1075653A1 (en) | 2005-12-23 |
EP1497249A1 (en) | 2005-01-19 |
JP2005523916A (ja) | 2005-08-11 |
US20050222274A1 (en) | 2005-10-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2324684C2 (ru) | Пиримидиновые производные | |
RU2325389C2 (ru) | Композиция и производные замещенного азаиндолоксоацетапиперазина, обладающие противовирусной активностью | |
RU2010150799A (ru) | НОВАЯ КРИСТАЛЛИЧЕСКАЯ И АМОРФНАЯ ФОРМА ТРИАЗОЛО(4,5-d)ПИРИМИДИНА | |
RU2007124329A (ru) | ПРОИЗВОДНЫЕ 5-ГИДРОКСИБЕНЗОТИАЗОЛА В КАЧЕСТВЕ АГОНИСТОВ β2 АДРЕНОРЕЦЕПТОРОВ | |
RU2002107975A (ru) | Глюкопиранозилоксипиразольные производные, лекарственные композиции, содержащие эти производные, и промежуточные соединения для их получения | |
RU2005107314A (ru) | Пиримидопроизводные, характеризующиеся антипролиферативной активностью | |
EA200400762A1 (ru) | Новые соединения, их использование в медицине, способ их изготовления и содержащие их фармацевтические композиции | |
RU98102128A (ru) | Производные бензо[g]хинолина | |
RU99127433A (ru) | Эрголиновые производные и их применение в качестве антагонистов рецепторов соматостатина | |
SE450251B (sv) | Xantatforeningar for terapeutisk anvendning, nya xantatforeningar samt terapeutiska kompositioner innehallande dessa foreningar | |
DE69200045T2 (de) | Thiazolopyrimidinderivate als Angiotensin-II-Rezeptorantagonisten: Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen. | |
RU2004101229A (ru) | Дейтерированные n-и альфа-замещенные аминоалкилэфиры дифенилакоксиуксуной кислоты, а также лекарственные средства, содержащие эти соединения | |
RU2218334C2 (ru) | Замещенные 1,2,3,4,5,6-гексагидро-2,6-метано-3-бензазоцин-10-олы и фармацевтическая композиция на их основе | |
RU2009105097A (ru) | ТЕТРАГИДРОФУРО(3,2-b)ПИРРОЛ-3-ОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ КАТЕПСИНА К | |
UY28688A1 (es) | Derivados de amida | |
RU2008138749A (ru) | Производные камптотецина и их применение | |
RU2004114278A (ru) | Амид 8-амино-[1.2.4]триазоло-[1.5-а]пиридин-6-карбоновой кислоты | |
RU2007141564A (ru) | Аминоалкиламидометилзамещенные производные 2-(4-сульфониламино)-3-гидрокси-2н-хроман-6-ила и лекарственные средства, содержащие эти соединения | |
RU2004131220A (ru) | Галогенпроизводные гиперфорина, использование таковых и составов, их содержащих | |
RU2005125636A (ru) | Производные бензоксазола и их применение в качестве лигандов рецептора аденозина | |
RU2004102398A (ru) | Производные бензо[g]хинолина для лечения глаукомы и близорукости | |
RU2005139715A (ru) | Производные бензотиазола и их применение при лечении заболеваний, связанных с аденозиновыми а2а-рецепторами | |
EA200600022A1 (ru) | Применение производных бицикло [2.2.1] гептана для приготовления нейропротекторных фармацевтических композиций | |
EA200100725A2 (ru) | Новые бензотиадиазиновые соединения, способ их получения и их содержащие фармацевтические композиции | |
RU2004131210A (ru) | Производные гиперфорина, их применение и содержащие их составы |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20070625 |