JP2005523916A - ヒペルフォリンのハロゲン化誘導体、それらの使用、およびそれらを含む製剤 - Google Patents

ヒペルフォリンのハロゲン化誘導体、それらの使用、およびそれらを含む製剤 Download PDF

Info

Publication number
JP2005523916A
JP2005523916A JP2003587761A JP2003587761A JP2005523916A JP 2005523916 A JP2005523916 A JP 2005523916A JP 2003587761 A JP2003587761 A JP 2003587761A JP 2003587761 A JP2003587761 A JP 2003587761A JP 2005523916 A JP2005523916 A JP 2005523916A
Authority
JP
Japan
Prior art keywords
methyl
hyperforin
positions
compounds
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2003587761A
Other languages
English (en)
Japanese (ja)
Inventor
エツィオ ボムバルデッリ、
パオロ モラッツォーニ、
アントネッラ リヴァ、
ニコラ フッツァーティ、
Original Assignee
インデナ エッセ ピ ア
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by インデナ エッセ ピ ア filed Critical インデナ エッセ ピ ア
Publication of JP2005523916A publication Critical patent/JP2005523916A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/457—Saturated compounds containing a keto group being part of a ring containing halogen
    • C07C49/467—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic
    • C07C49/473—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic a keto group being part of a condensed ring system
    • C07C49/477—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/693—Unsaturated compounds containing a keto groups being part of a ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2003587761A 2002-04-23 2003-04-15 ヒペルフォリンのハロゲン化誘導体、それらの使用、およびそれらを含む製剤 Withdrawn JP2005523916A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI000871A ITMI20020871A1 (it) 2002-04-23 2002-04-23 Derivati alogenati dell'iperforina loro uso e formulazioni che li contengono
PCT/EP2003/003923 WO2003091193A1 (en) 2002-04-23 2003-04-15 Hyperforin halogenated derivatives, the use thereof and formulations containing them

Publications (1)

Publication Number Publication Date
JP2005523916A true JP2005523916A (ja) 2005-08-11

Family

ID=11449766

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003587761A Withdrawn JP2005523916A (ja) 2002-04-23 2003-04-15 ヒペルフォリンのハロゲン化誘導体、それらの使用、およびそれらを含む製剤

Country Status (13)

Country Link
US (1) US7057078B2 (ru)
EP (1) EP1497249A1 (ru)
JP (1) JP2005523916A (ru)
KR (1) KR20040111537A (ru)
CN (1) CN1269783C (ru)
AU (1) AU2003233979B2 (ru)
CA (1) CA2483203A1 (ru)
HK (1) HK1075653A1 (ru)
IT (1) ITMI20020871A1 (ru)
NO (1) NO20044518L (ru)
PL (1) PL372166A1 (ru)
RU (1) RU2004131220A (ru)
WO (1) WO2003091193A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102772461B (zh) * 2011-05-11 2014-05-14 成都康弘药业集团股份有限公司 药物组合物在制备预防或治疗老年性痴呆的药物中的应用
KR20140041610A (ko) * 2011-06-03 2014-04-04 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 하이퍼포린 유사체, 합성 방법 및 그의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999040905A2 (de) * 1998-02-13 1999-08-19 Dr. Willmar Schwabe Gmbh & Co. Verwendung von hyperforin und hyperforinhaltigen extrakten zur behandlung und prophylaxe von demenzerkrankungen
CA2320091A1 (en) * 1998-02-13 1999-08-19 Dr. Willmar Schwabe Gmbh & Co. Stable hyperforin salts, methods of manufacturing them, and their use for the treatment of alzheimer's disease
IT1301679B1 (it) * 1998-06-10 2000-07-07 Indena Spa Derivati dell'iperforina, loro uso e formulazioni che licontengono.

Also Published As

Publication number Publication date
CN1269783C (zh) 2006-08-16
CN1646461A (zh) 2005-07-27
US7057078B2 (en) 2006-06-06
KR20040111537A (ko) 2004-12-31
RU2004131220A (ru) 2005-04-20
AU2003233979B2 (en) 2008-02-21
ITMI20020871A0 (it) 2002-04-23
US20050222274A1 (en) 2005-10-06
ITMI20020871A1 (it) 2003-10-23
EP1497249A1 (en) 2005-01-19
HK1075653A1 (en) 2005-12-23
WO2003091193A1 (en) 2003-11-06
AU2003233979A1 (en) 2003-11-10
NO20044518L (no) 2004-11-19
CA2483203A1 (en) 2003-11-06
PL372166A1 (en) 2005-07-11

Similar Documents

Publication Publication Date Title
Challand et al. Photochemical synthesis. XXV. Photochemical cycloaddition. Some applications of the use of enolized. beta.-diketones
JP5606660B2 (ja) エストロゲンおよび抗増殖活性を有するホップ抽出物の製造
Brooks et al. Practical total synthesis of (.+-.)-strigol
Witiak et al. Synthesis of ethyl 6-substituted-chroman-and-chromone-2-carboxylates. Comparative structure-activity study employing the 6-phenyl and phenoxy analogs in the triton hyperlipidemic rat model
Assefa et al. Enantioselective synthesis and complement inhibitory assay of A/B-ring partial analogues of oleanolic acid
CH633766A5 (de) Verfahren zur herstellung von regioisomeren von naphthacentrionverbindungen.
Ireland et al. Total synthesis of terpenes. XV. Synthesis of 3, 10-dimethoxy-6a. beta., 12b. beta.-dimethyl-5, 6, 6a, 6b. alpha., 7, 8, 12b, 13-octahydropicene, a potential intermediate in triterpene synthesis
Cohen et al. Steroid total synthesis. X. Optically active estrone precursors and racemic equilenin methyl ether
JP2005523916A (ja) ヒペルフォリンのハロゲン化誘導体、それらの使用、およびそれらを含む製剤
US7105705B2 (en) Hyperforin derivatives, the use thereof and formulations containing them
Achari et al. Studies on indian medicinal plants, part LXXIX: Synthesis proves the structure of aristolindiqu inone
AU2003222828B2 (en) Hyperforin derivatives, the use thereof and formulations containing them
YOSHII et al. Syntheses of 5, 6-Benzo-and 5, 6-Naphtho-(1R, 3R, 4S, 8R)-4, 8-dihydroxy-3-methyl-2-oxabicyclo [2.2. 2] oct-5-ene Derivatives
Castellanos et al. Stereoselective synthesis of (–)-4-epiaxinyssamine
Vlad et al. Asymmetric dihydroxylation of drim-7-en-11-ol: synthesis of diastereomerically pure driman-7α, 8α, 11-triol and its elaboration into novel chlorinated norlabdanic compounds
Hill et al. STRUCTURAL ELUCIDATION OF NEXT GENERATION INHIBITORS OF PROTEIN PHOSPHATASE 5 USING NMR SPECTROSCOPY
Kasturi et al. Acid-catalysed cyclisation of 2-methyl-2 [3-(2, 4-dimethoxyphenyl)-5-methoxypent-2-enyl]-cyclopentane-1, 3-dione: Structure of a novel product
Sane The total synthesis of (±)-morphine and (-)-galanthamine
JP2002114738A (ja) 新規ケトン化合物とそれを用いたトリメチルシクロヘキサンカルボン酸類の製造法
JP2002053520A (ja) ２，２，６−トリメチルシクロヘキサンカルボン酸の製造方法
GB1593643A (en) Antiandrogen hydrobenzo-pyranoxanthenones
TW201105613A (en) Method of preparing 1-hydroxy-1,3,3,5,5-pentamethylcyclohexane

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060411

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20070330