JP2005523698A5 - - Google Patents
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- JP2005523698A5 JP2005523698A5 JP2003587937A JP2003587937A JP2005523698A5 JP 2005523698 A5 JP2005523698 A5 JP 2005523698A5 JP 2003587937 A JP2003587937 A JP 2003587937A JP 2003587937 A JP2003587937 A JP 2003587937A JP 2005523698 A5 JP2005523698 A5 JP 2005523698A5
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- JP
- Japan
- Prior art keywords
- influenza
- virus
- amino acid
- group
- encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000712461 unidentified influenza virus Species 0.000 claims 59
- 210000004027 cell Anatomy 0.000 claims 32
- 238000000034 method Methods 0.000 claims 32
- 102000039446 nucleic acids Human genes 0.000 claims 29
- 108020004707 nucleic acids Proteins 0.000 claims 29
- 150000007523 nucleic acids Chemical class 0.000 claims 29
- 238000006467 substitution reaction Methods 0.000 claims 28
- 239000013598 vector Substances 0.000 claims 27
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 241000713196 Influenza B virus Species 0.000 claims 25
- 241000712431 Influenza A virus Species 0.000 claims 24
- 150000001413 amino acids Chemical class 0.000 claims 24
- 206010022000 influenza Diseases 0.000 claims 19
- 238000012258 culturing Methods 0.000 claims 14
- 241000700605 Viruses Species 0.000 claims 13
- 208000037798 influenza B Diseases 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 238000004113 cell culture Methods 0.000 claims 12
- 102220229450 rs779409525 Human genes 0.000 claims 11
- 102200153303 rs863224613 Human genes 0.000 claims 11
- 230000035772 mutation Effects 0.000 claims 10
- 241000713174 Influenza B virus (B/Ann Arbor/1/1966 [wild- type]) Species 0.000 claims 9
- 208000037797 influenza A Diseases 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 241000282341 Mustela putorius furo Species 0.000 claims 6
- 238000003556 assay Methods 0.000 claims 6
- 230000002238 attenuated effect Effects 0.000 claims 6
- 230000008488 polyadenylation Effects 0.000 claims 5
- 229960005486 vaccine Drugs 0.000 claims 5
- 210000003501 vero cell Anatomy 0.000 claims 5
- 230000029812 viral genome replication Effects 0.000 claims 5
- 241001500351 Influenzavirus A Species 0.000 claims 4
- 230000002457 bidirectional effect Effects 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 230000003362 replicative effect Effects 0.000 claims 4
- 230000006978 adaptation Effects 0.000 claims 3
- 230000035945 sensitivity Effects 0.000 claims 3
- 229940124873 Influenza virus vaccine Drugs 0.000 claims 2
- 230000004071 biological effect Effects 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000000415 inactivating effect Effects 0.000 claims 2
- 229960001226 live attenuated influenza Drugs 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241001500350 Influenzavirus B Species 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- 210000000991 chicken egg Anatomy 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 238000004520 electroporation Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 229940033324 influenza A vaccine Drugs 0.000 claims 1
- -1 instructions Substances 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37567502P | 2002-04-26 | 2002-04-26 | |
| US39498302P | 2002-07-09 | 2002-07-09 | |
| US41057602P | 2002-09-12 | 2002-09-12 | |
| US41980202P | 2002-10-18 | 2002-10-18 | |
| US42070802P | 2002-10-23 | 2002-10-23 | |
| US45769903P | 2003-03-24 | 2003-03-24 | |
| US46236103P | 2003-04-10 | 2003-04-10 | |
| PCT/US2003/012728 WO2003091401A2 (en) | 2002-04-26 | 2003-04-25 | Multi plasmid system for the production of influenza virus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011103852A Division JP5303603B2 (ja) | 2002-04-26 | 2011-05-06 | インフルエンザウイルスの生産用多重プラスミドシステム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005523698A JP2005523698A (ja) | 2005-08-11 |
| JP2005523698A5 true JP2005523698A5 (enExample) | 2006-06-01 |
Family
ID=29273967
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003587937A Withdrawn JP2005523698A (ja) | 2002-04-26 | 2003-04-25 | インフルエンザウイルスの生産用多重プラスミドシステム |
| JP2011103852A Expired - Lifetime JP5303603B2 (ja) | 2002-04-26 | 2011-05-06 | インフルエンザウイルスの生産用多重プラスミドシステム |
| JP2013089445A Pending JP2013179943A (ja) | 2002-04-26 | 2013-04-22 | インフルエンザウイルスの生産用多重プラスミドシステム |
| JP2013131951A Pending JP2013230156A (ja) | 2002-04-26 | 2013-06-24 | インフルエンザウイルスの生産用多重プラスミドシステム |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011103852A Expired - Lifetime JP5303603B2 (ja) | 2002-04-26 | 2011-05-06 | インフルエンザウイルスの生産用多重プラスミドシステム |
| JP2013089445A Pending JP2013179943A (ja) | 2002-04-26 | 2013-04-22 | インフルエンザウイルスの生産用多重プラスミドシステム |
| JP2013131951A Pending JP2013230156A (ja) | 2002-04-26 | 2013-06-24 | インフルエンザウイルスの生産用多重プラスミドシステム |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8012736B2 (enExample) |
| EP (2) | EP1499348B1 (enExample) |
| JP (4) | JP2005523698A (enExample) |
| KR (2) | KR101169468B1 (enExample) |
| CN (4) | CN1678345B (enExample) |
| AR (2) | AR039465A1 (enExample) |
| AU (2) | AU2003231083A1 (enExample) |
| CA (1) | CA2482946C (enExample) |
| DK (1) | DK1499348T3 (enExample) |
| ES (1) | ES2526191T3 (enExample) |
| TW (2) | TWI347363B (enExample) |
| WO (1) | WO2003091401A2 (enExample) |
Families Citing this family (83)
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| CN101580849B (zh) * | 2000-04-28 | 2012-11-21 | 圣朱德儿童研究医院 | 用于产生感染性流感病毒的dna转染系统 |
| DE50214379D1 (de) | 2001-06-05 | 2010-05-27 | Curevac Gmbh | Stabilisierte mRNA mit erhöhtem G/C-Gehalt für die Gentherapie |
| DK1499348T3 (en) * | 2002-04-26 | 2015-01-05 | Medimmune Llc | PROCEDURE FOR PREPARING INFECTIOUS INFLUENZA B-VIRA IN CELL CULTURE |
| US7465456B2 (en) * | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| US20060110406A1 (en) * | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
| CN101804202B (zh) | 2003-02-25 | 2014-06-18 | 米迪缪尼有限公司 | 制备流感疫苗组合物的方法 |
| CN1829799A (zh) * | 2003-05-28 | 2006-09-06 | 威斯康星旧生研究基金会 | 含polii启动子和核酶的重组流感载体 |
| US7566458B2 (en) | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| ES2345492T3 (es) * | 2003-12-23 | 2010-09-24 | Medimmune, Llc | Sistema multiplasmido para la produccion del virus de la gripe. |
| EP2995678A1 (en) * | 2004-05-24 | 2016-03-16 | MedImmune, LLC | Multi plasmid system for the production of attenuated influenza b virus |
| JP4980896B2 (ja) * | 2004-05-25 | 2012-07-18 | メディミューン，エルエルシー | インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体 |
| EP1797189A4 (en) * | 2004-09-02 | 2010-05-19 | Qun Chen | ENCAPSIDATION SYSTEM FOR THE PRODUCTION OF RECOMBINANT VIRUSELY PARTICLES |
| ATE489965T1 (de) * | 2004-09-09 | 2010-12-15 | Novartis Vaccines & Diagnostic | Verminderung von potentiellen iatrogenen risiken in verbindung mit influenza impfstoffen |
| US20080292658A1 (en) * | 2004-11-11 | 2008-11-27 | Emmie De Wit | Defective Influenza Virus Particles |
| RU2420577C2 (ru) * | 2004-11-11 | 2011-06-10 | Эбботт Байолоджикалз Б.В. | Условно дефектная частица вируса гриппа и способы ее получения (варианты) |
| KR20070086344A (ko) | 2004-11-19 | 2007-08-27 | 위스콘신 얼럼나이 리서어치 화운데이션 | 탠덤 전사 유닛을 갖는 재조합 인플루엔자 벡터 |
| US7510719B2 (en) | 2004-12-08 | 2009-03-31 | Medimmune, Llc | Methods of producing influenza vaccine compositions |
| US7670837B2 (en) | 2004-12-23 | 2010-03-02 | Medimmune, Llc | Non-tumorigenic MDCK cell line for propagating viruses |
| BRPI0518568A2 (pt) * | 2004-12-24 | 2008-11-25 | Solvay Pharm Bv | mÉtodo para produzir uma partÍcula do vÍrus da influenza replicativo sem o uso de vÍrus auxiliar, partÍcula de vÍrus da influenza replicativo, cÉlula, composiÇço, uso de uma composiÇço, mÉtodo para gerar proteÇço imunolàgica contra infecÇço de um indivÍduo com um vÍrus da influenza, e, Ácido nuclÉico |
| EP1856271A4 (en) | 2005-03-08 | 2009-11-18 | Medimmune Vaccines Inc | INFLUENZA HEMAGGLUTININE AND NEURAMINIDASE VARIANTS |
| US7959929B2 (en) | 2005-04-21 | 2011-06-14 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| US11865172B2 (en) | 2005-04-21 | 2024-01-09 | University Of Florida Research Foundation, Inc. | Materials and methods for respiratory disease control in canines |
| AU2006262380A1 (en) * | 2005-06-21 | 2007-01-04 | Medimmune, Llc | Methods and compositions for expressing a heterologous protease |
| US8354114B2 (en) | 2005-10-17 | 2013-01-15 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
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| DE602006019629D1 (de) * | 2005-11-01 | 2011-02-24 | Novartis Vaccines & Diagnostic | Von zellen stammende virale impfstoffe mit geringen mengen an rest-zell-dna |
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| US9072701B2 (en) | 2006-04-21 | 2015-07-07 | St. Jude Children's Research Hospital | Avian influenza viruses, vaccines, compositions, formulations, and methods |
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| AU2007286161B2 (en) * | 2006-08-09 | 2013-05-02 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
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| CA2690196A1 (en) | 2007-06-18 | 2008-12-24 | Medimmune, Llc | Influenza b viruses having alterations in the hemaglutinin polypeptide |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| EP2045323A1 (en) * | 2007-10-05 | 2009-04-08 | Avir Green Hills Biotechnology Research Development Trade Ag | Linear expression constructs for production of influenza virus particles |
| WO2009073330A2 (en) * | 2007-11-12 | 2009-06-11 | The Trustees Of The University Of Pennsylvania | Novel vaccines against multiple subtypes of influenza virus |
| BRPI0915487A2 (pt) * | 2008-07-11 | 2017-06-27 | Medimmune Inc | hemaglutina de nfluenza e variantes de neuraminidase |
| JP5548207B2 (ja) | 2008-09-24 | 2014-07-16 | メディミューン，エルエルシー | ウイルスの精製方法 |
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| CN107365751B (zh) | 2008-12-16 | 2021-07-09 | 纳米医疗公司 | 流感疫苗的生产 |
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| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
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| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
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| CN111511397A (zh) | 2017-12-22 | 2020-08-07 | 科达金尼克斯有限公司 | 具有密码子对去优化区域的重组病毒及其用于治疗癌症的用途 |
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| CN111363017B (zh) * | 2018-12-25 | 2022-03-15 | 中国科学院微生物研究所 | A型流感病毒核蛋白s69位突变序列及其突变体与应用 |
| US11241492B2 (en) | 2019-01-23 | 2022-02-08 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to genes in influenza viruses |
| US12419946B2 (en) | 2019-02-07 | 2025-09-23 | Duke University | Stabilized 9 and 10 segmented influenza viruses as a vaccine platform and methods of making and using same |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| US11214799B2 (en) * | 2019-03-12 | 2022-01-04 | The University Court Of The University Of Edinburg Old College | HA-specific influenza virus attenuated vaccine comprising mutations in segment 7, and uses therefor |
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| CN110713988A (zh) * | 2019-05-13 | 2020-01-21 | 广州医科大学附属第一医院（广州呼吸中心） | 一种防止接种于鸡蛋的季节性人流感h3n2病毒抗原性降低的方法 |
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| CN117946982B (zh) * | 2022-12-30 | 2025-06-03 | 中国科学院微生物研究所 | H1n1流感病毒冷适应疫苗骨架毒株cv1-pr8及其构建方法和应用 |
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- 2003-04-25 DK DK03724208.8T patent/DK1499348T3/en active
- 2003-04-25 EP EP03724208.8A patent/EP1499348B1/en not_active Expired - Lifetime
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- 2003-04-25 JP JP2003587937A patent/JP2005523698A/ja not_active Withdrawn
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- 2003-04-25 WO PCT/US2003/012728 patent/WO2003091401A2/en not_active Ceased
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