JP2005518425A5 - - Google Patents
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- Publication number
- JP2005518425A5 JP2005518425A5 JP2003567367A JP2003567367A JP2005518425A5 JP 2005518425 A5 JP2005518425 A5 JP 2005518425A5 JP 2003567367 A JP2003567367 A JP 2003567367A JP 2003567367 A JP2003567367 A JP 2003567367A JP 2005518425 A5 JP2005518425 A5 JP 2005518425A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethyl
- dicyanomethylene
- ylidene
- dihydropyridine
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- -1 (1-butyl-2,6-dimethyl-1H-pyridine-4-ylidene) cyanoethyl Chemical group 0.000 claims description 11
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 7
- 239000001257 hydrogen Substances 0.000 claims description 7
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 125000006575 electron-withdrawing group Chemical group 0.000 claims description 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 3
- RAJYFCVQFDEAKR-UHFFFAOYSA-N 2-(1-dodecyl-2,6-dimethylpyridin-4-ylidene)propanedinitrile Chemical compound CCCCCCCCCCCCN1C(C)=CC(=C(C#N)C#N)C=C1C RAJYFCVQFDEAKR-UHFFFAOYSA-N 0.000 claims 2
- LMRBTJXTDRXQTD-UHFFFAOYSA-N 2-(2,6-diethyl-3,5-dimethylpyran-4-ylidene)propanedinitrile Chemical compound CCC1=C(C)C(=C(C#N)C#N)C(C)=C(CC)O1 LMRBTJXTDRXQTD-UHFFFAOYSA-N 0.000 claims 2
- RERUAFDDPHBHKW-UHFFFAOYSA-N 2-(3,5-diethyl-2,6-dipropylpyran-4-ylidene)propanedinitrile Chemical compound CCCC1=C(CC)C(=C(C#N)C#N)C(CC)=C(CCC)O1 RERUAFDDPHBHKW-UHFFFAOYSA-N 0.000 claims 2
- CAOXLXOILZYRED-UHFFFAOYSA-N 2-[1-(2-ethylhexyl)-2,6-dimethylpyridin-4-ylidene]propanedinitrile Chemical compound CCCCC(CC)CN1C(C)=CC(=C(C#N)C#N)C=C1C CAOXLXOILZYRED-UHFFFAOYSA-N 0.000 claims 2
- MBRAEFSYFOXYPZ-UHFFFAOYSA-N 2-[1-[3-(2-ethylhexoxy)propyl]-2,6-dimethylpyridin-4-ylidene]propanedinitrile Chemical compound CCCCC(CC)COCCCN1C(C)=CC(=C(C#N)C#N)C=C1C MBRAEFSYFOXYPZ-UHFFFAOYSA-N 0.000 claims 2
- ALVQESXYLTXSST-UHFFFAOYSA-N 2-[1-[3-[2-[2-[3-[4-(dicyanomethylidene)-2,6-dimethylpyridin-1-yl]propoxy]ethoxy]ethoxy]propyl]-2,6-dimethylpyridin-4-ylidene]propanedinitrile Chemical compound CC1=CC(=C(C#N)C#N)C=C(C)N1CCCOCCOCCOCCCN1C(C)=CC(=C(C#N)C#N)C=C1C ALVQESXYLTXSST-UHFFFAOYSA-N 0.000 claims 2
- HBDGMKMUKMYMRK-UHFFFAOYSA-N 2-[2,6-dimethyl-1-(3,5,5-trimethylhexyl)pyridin-4-ylidene]propanedinitrile Chemical compound CC(C)(C)CC(C)CCN1C(C)=CC(=C(C#N)C#N)C=C1C HBDGMKMUKMYMRK-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- CSUBGXUBKDUWDJ-UHFFFAOYSA-N 2-(1,2,6-trimethylpyridin-4-ylidene)propanedinitrile Chemical compound CN1C(C)=CC(=C(C#N)C#N)C=C1C CSUBGXUBKDUWDJ-UHFFFAOYSA-N 0.000 claims 1
- UEYVPWAQZUAKLX-UHFFFAOYSA-N 2-(1-butyl-2,6-dimethylpyridin-4-ylidene)propanedinitrile Chemical compound CCCCN1C(C)=CC(=C(C#N)C#N)C=C1C UEYVPWAQZUAKLX-UHFFFAOYSA-N 0.000 claims 1
- WOYWLLHHWAMFCB-UHFFFAOYSA-N 2-ethylhexyl acetate Chemical compound CCCCC(CC)COC(C)=O WOYWLLHHWAMFCB-UHFFFAOYSA-N 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000005702 oxyalkylene group Chemical group 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 125000002648 azanetriyl group Chemical group *N(*)* 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000002430 hydrocarbons Chemical group 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02002093 | 2002-02-12 | ||
| PCT/EP2003/001049 WO2003068183A1 (en) | 2002-02-12 | 2003-02-04 | Sunscreen compositions as well as dihydropyridines and dihydropyranes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005518425A JP2005518425A (ja) | 2005-06-23 |
| JP2005518425A5 true JP2005518425A5 (https=) | 2006-03-30 |
| JP4510466B2 JP4510466B2 (ja) | 2010-07-21 |
Family
ID=27675599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003567367A Expired - Fee Related JP4510466B2 (ja) | 2002-02-12 | 2003-02-04 | 日焼け止め組成物ならびにジヒドロピリジンおよびジヒドロピラン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7611696B2 (https=) |
| EP (1) | EP1474098B1 (https=) |
| JP (1) | JP4510466B2 (https=) |
| KR (1) | KR100969059B1 (https=) |
| CN (1) | CN100563622C (https=) |
| AT (1) | ATE334724T1 (https=) |
| AU (1) | AU2003206825B8 (https=) |
| BR (1) | BR0307335B1 (https=) |
| CA (1) | CA2473228C (https=) |
| DE (1) | DE60307234T2 (https=) |
| ES (1) | ES2269978T3 (https=) |
| WO (1) | WO2003068183A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004290493B2 (en) * | 2003-11-05 | 2009-09-24 | Dsm Ip Assets B.V. | Light protecting composition with reduced total amount of UV filter containing a polysiloxane-based UV filter |
| DE102004003000A1 (de) * | 2004-01-19 | 2005-08-04 | Beiersdorf Ag | Kosmetische und dermatologische Lichtschutzformulierungen |
| DE102004002999A1 (de) * | 2004-01-19 | 2005-08-11 | Beiersdorf Ag | Kosmetische und dermatologische Lichtschutzformulierungen |
| ES2809302T3 (es) | 2004-01-22 | 2021-03-03 | Univ Miami | Formulaciones de coenzima Q10 para tratar tumores sólidos mediante administración intravenosa |
| KR101182959B1 (ko) * | 2004-02-13 | 2012-09-18 | 디에스엠 아이피 어셋츠 비.브이. | 이온성 ｕｖ-ａ 일광차단제 및 이를 함유하는 조성물 |
| US8465729B2 (en) * | 2004-04-06 | 2013-06-18 | Playtex Products, Inc. | Sunscreen compositions with SPF enhancer |
| GB2416351A (en) | 2004-06-29 | 2006-01-25 | Ciba Sc Holding Ag | Use of myocyanine derivatives for the protection of human hair and skin from UV radiation |
| WO2006007563A1 (en) * | 2004-07-01 | 2006-01-19 | Aveda Corporation | Novel cleansing composition |
| JP2008518988A (ja) * | 2004-11-02 | 2008-06-05 | ディーエスエム アイピー アセッツ ビー．ブイ． | Ｕｖ−日焼け止め調製物のための添加剤 |
| MX301558B (es) * | 2005-07-29 | 2012-07-20 | Ciba Sc Holding Ag | Estabilizacion de productos para el cuidado del cuerpo y el hogar contra la degradacion por radiacion uv usando derivados de merocianina. |
| WO2007017179A1 (en) * | 2005-08-05 | 2007-02-15 | Dsm Ip Assets B.V. | Use of ionic uv-a sunscreens |
| JP5288521B2 (ja) * | 2006-02-20 | 2013-09-11 | 株式会社 資生堂 | 油中水型乳化日焼け止め化粧料 |
| JP4968706B2 (ja) * | 2006-02-20 | 2012-07-04 | 株式会社 資生堂 | 低粘度油中水型乳化化粧料 |
| JP5240967B2 (ja) * | 2006-02-20 | 2013-07-17 | 株式会社 資生堂 | 油中水型乳化日焼け止め化粧料 |
| US20080131381A1 (en) * | 2006-09-29 | 2008-06-05 | Chaudhuri Ratan K | Methods for photostabilizing ingredients within cosmetics, personal care and household products and compositions obtained therefrom |
| CA2680825C (en) | 2007-03-22 | 2013-10-29 | Cytotech Labs, Llc | Topical formulations having enhanced bioavailability |
| FR2914853B1 (fr) * | 2007-04-13 | 2010-07-30 | Oreal | Composition cosmetique comprenant une phase continue huileuse |
| DE102007024347A1 (de) * | 2007-05-22 | 2008-11-27 | Beiersdorf Ag | Kosmetische Zubereitung mit ionischem UV-A-Filter und Bis-Ethylhexyloxyphenol Methoxyphenyl Triazin |
| DE102007024348B4 (de) * | 2007-05-22 | 2025-07-24 | Beiersdorf Aktiengesellschaft | Kosmetische Zubereitung mit ionischem UV-A-Filter und 2,4,6-Tris-(biphenyl)-1,3,5-triazin |
| DE102007024345A1 (de) * | 2007-05-22 | 2008-11-27 | Beiersdorf Ag | Kosmetische Zubereitung mit ionischem UV-A-Filter, 4-(tert.-Butyl)-4'-methoxy-di-ben-zoylmethan und 2-Ethylhexyl-2cyano-3,3-di-phenyl-acrylat |
| DE102007024346A1 (de) * | 2007-05-22 | 2008-11-27 | Beiersdorf Ag | Kosmetische Zubereitung mit ionischem UV-A-Filter und 2-(4'-Diethylamino-2'hydoxybenzoyl)-benzoesäurehexylester |
| DE102007063134A1 (de) * | 2007-12-24 | 2009-06-25 | Sasol Germany Gmbh | Verfahren zur Herstellung von Öl in Wasser Emulsionen aus selbstemulgierenden Gelkonzentraten |
| JP5382904B2 (ja) | 2008-02-19 | 2014-01-08 | 株式会社 資生堂 | 油中水型乳化日焼け止め化粧料 |
| AU2009233785B2 (en) | 2008-04-11 | 2015-08-20 | Berg Llc | Methods and use of inducing apoptosis in cancer cells |
| US20100129303A1 (en) * | 2008-10-17 | 2010-05-27 | Dueva-Koganov Olga V | Sunscreen and personal care compositions comprising a random terpolymer |
| AU2010247800A1 (en) | 2009-05-11 | 2011-12-15 | Berg Llc | Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
| CN105168135A (zh) | 2010-03-12 | 2015-12-23 | 博格有限责任公司 | 辅酶Q10(CoQ10)的静脉内制剂及其使用方法 |
| CA2832324C (en) | 2011-04-04 | 2022-03-15 | Berg Llc | Methods of treating central nervous system tumors |
| US10973763B2 (en) | 2011-06-17 | 2021-04-13 | Berg Llc | Inhalable pharmaceutical compositions |
| US20140271513A1 (en) * | 2013-03-15 | 2014-09-18 | Makule Yesim Basar | Foot odor reduction composition and system and method of use of same |
| SG10201903112WA (en) | 2013-04-08 | 2019-05-30 | Berg Llc | Treatment of cancer using coenzyme q10 combination therapies |
| KR102370843B1 (ko) | 2013-09-04 | 2022-03-04 | 버그 엘엘씨 | 코엔자임 q10의 연속주입에 의한 암치료 방법 |
| WO2017087576A1 (en) | 2015-11-16 | 2017-05-26 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| CN109310609B (zh) * | 2016-06-27 | 2022-06-28 | 帝斯曼知识产权资产管理有限公司 | 包含微颜料的组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4283487A (en) * | 1979-11-29 | 1981-08-11 | Minnesota Mining And Manufacturing Company | Thermolabile acutance dyes for dry silver |
| GB8421398D0 (en) * | 1984-08-23 | 1984-09-26 | Minnesota Mining & Mfg | Sublimation transfer imaging system |
| US4937370A (en) * | 1987-06-02 | 1990-06-26 | The Procter & Gamble Company | Novel chromophores, sunscreen compositions and methods for preventing sunburn |
| LU86703A1 (fr) | 1986-12-08 | 1988-07-14 | Oreal | Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b |
| US6033649A (en) * | 1995-12-18 | 2000-03-07 | Roche Vitamins Inc. | Light screening agents |
| JP4334859B2 (ja) * | 2001-12-06 | 2009-09-30 | 三菱化学メディア株式会社 | 新規化合物、光学記録媒体及び光学記録方法 |
-
2003
- 2003-02-04 WO PCT/EP2003/001049 patent/WO2003068183A1/en not_active Ceased
- 2003-02-04 US US10/494,500 patent/US7611696B2/en not_active Expired - Fee Related
- 2003-02-04 CN CNB038036940A patent/CN100563622C/zh not_active Expired - Fee Related
- 2003-02-04 AT AT03704523T patent/ATE334724T1/de not_active IP Right Cessation
- 2003-02-04 AU AU2003206825A patent/AU2003206825B8/en not_active Ceased
- 2003-02-04 KR KR1020047012466A patent/KR100969059B1/ko not_active Expired - Fee Related
- 2003-02-04 CA CA2473228A patent/CA2473228C/en not_active Expired - Fee Related
- 2003-02-04 JP JP2003567367A patent/JP4510466B2/ja not_active Expired - Fee Related
- 2003-02-04 BR BRPI0307335-1A patent/BR0307335B1/pt not_active IP Right Cessation
- 2003-02-04 DE DE60307234T patent/DE60307234T2/de not_active Expired - Lifetime
- 2003-02-04 EP EP03704523A patent/EP1474098B1/en not_active Expired - Lifetime
- 2003-02-04 ES ES03704523T patent/ES2269978T3/es not_active Expired - Lifetime
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