JP2013502451A5 - - Google Patents
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- Publication number
- JP2013502451A5 JP2013502451A5 JP2012526125A JP2012526125A JP2013502451A5 JP 2013502451 A5 JP2013502451 A5 JP 2013502451A5 JP 2012526125 A JP2012526125 A JP 2012526125A JP 2012526125 A JP2012526125 A JP 2012526125A JP 2013502451 A5 JP2013502451 A5 JP 2013502451A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- motomeko
- alkyl
- independently selected
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 98
- 125000000217 alkyl group Chemical group 0.000 claims description 35
- 125000003342 alkenyl group Chemical group 0.000 claims description 26
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 26
- 125000005843 halogen group Chemical group 0.000 claims description 24
- 125000005842 heteroatom Chemical group 0.000 claims description 24
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 15
- 125000002252 acyl group Chemical group 0.000 claims description 14
- 125000003118 aryl group Chemical group 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 13
- 125000002947 alkylene group Chemical group 0.000 claims description 12
- 230000002401 inhibitory effect Effects 0.000 claims description 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 11
- 102000014654 Aromatase Human genes 0.000 claims description 10
- 108010078554 Aromatase Proteins 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 150000001721 carbon Chemical group 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 125000002619 bicyclic group Chemical group 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000001072 heteroaryl group Chemical group 0.000 claims description 2
- 125000002883 imidazolyl group Chemical group 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 125000002950 monocyclic group Chemical group 0.000 claims description 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 150000003568 thioethers Chemical class 0.000 claims description 2
- 125000001425 triazolyl group Chemical group 0.000 claims description 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- -1 aryl compound Chemical class 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 0 Cc1c(*)c(*)c(*)c(*)c1C Chemical compound Cc1c(*)c(*)c(*)c(*)c1C 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0914767.9 | 2009-08-24 | ||
| GBGB0914767.9A GB0914767D0 (en) | 2009-08-24 | 2009-08-24 | Compound |
| PCT/GB2010/051391 WO2011023989A1 (en) | 2009-08-24 | 2010-08-23 | Aromatase inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013502451A JP2013502451A (ja) | 2013-01-24 |
| JP2013502451A5 true JP2013502451A5 (https=) | 2013-09-05 |
| JP5828839B2 JP5828839B2 (ja) | 2015-12-09 |
Family
ID=41171838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012526125A Expired - Fee Related JP5828839B2 (ja) | 2009-08-24 | 2010-08-23 | アロマターゼ阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8846737B2 (https=) |
| EP (1) | EP2470512B1 (https=) |
| JP (1) | JP5828839B2 (https=) |
| CN (1) | CN102596919B (https=) |
| GB (1) | GB0914767D0 (https=) |
| RU (1) | RU2572244C2 (https=) |
| WO (1) | WO2011023989A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9682941B2 (en) | 2013-12-31 | 2017-06-20 | Estryx Pharma Limited | Substituted biphenyl analogues as dual inhibitors of aromatase and sulfatase |
| DE102017116299A1 (de) | 2017-07-19 | 2019-01-24 | Huf Hülsbeck & Fürst Gmbh & Co. Kg | Verfahren zum Zuordnen einer Reifendrucküberwachungseinheit zu einer Radposition eines Fahrzeugs |
| RU2764243C2 (ru) | 2017-09-22 | 2022-01-14 | ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи | Гетероциклические соединения в качестве ингибиторов PAD |
| AU2018352142B2 (en) | 2017-10-18 | 2022-08-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| US11629135B2 (en) | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
| PT3704120T (pt) | 2017-11-24 | 2024-07-03 | Jubilant Episcribe Llc | Compostos heterocíclicos como inibidores de prmt5 |
| PT3728207T (pt) | 2017-12-21 | 2023-03-14 | Ribon Therapeutics Inc | Quinazolinonas como inibidores de parp14 |
| MX2020009517A (es) | 2018-03-13 | 2021-01-20 | Jubilant Prodel LLC | Compuestos biciclicos como inhibidores de la interaccion/activacio n de pdl/pd-l1. |
| PL239999B1 (pl) * | 2018-06-18 | 2022-02-07 | Politechnika Gdanska | A midosiarczanowe pochodne 4-(1-fenylo-1H-[1,2,3]triazol- -4-ylo)-fenolu, ich zastosowanie medyczne i diagnostyczne, oraz sposób otrzymywania amidosiarczanowych pochodnych 4-(1-fenylo- 1H-[1,2,3]triazol-4-ylo)-fenolu |
| CN113387894B (zh) * | 2021-06-22 | 2023-02-24 | 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) | 1-n-苯乙腈基氨基-三氮唑和嘧啶衍生物及其制备方法和应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| CA2002864C (en) * | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives |
| GB9003939D0 (en) | 1990-02-21 | 1990-04-18 | Imperial College | Sulphatase inhibitors |
| TW210334B (https=) * | 1990-12-12 | 1993-08-01 | Ciba Geigy Ag | |
| CH683151A5 (de) | 1991-04-24 | 1994-01-31 | Ciba Geigy Ag | Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus. |
| GB9118478D0 (en) | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| GB9118465D0 (en) | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| FI940988L (fi) | 1991-09-02 | 1994-04-05 | Yamanouchi Pharma Co Ltd | Triatsolyloitu tertiäärinen amiiniyhdiste ja sen suola |
| GB2273704B (en) * | 1992-12-16 | 1997-01-22 | Orion Yhtymae Oy | Triazolyl diaryl selective aromatase inhibiting compounds |
| GB9422777D0 (en) | 1994-11-11 | 1995-01-04 | Imperial College | Assay |
| US5723315A (en) | 1996-08-23 | 1998-03-03 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| WO1998005635A1 (en) | 1996-08-07 | 1998-02-12 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
| EP2065396A1 (en) | 1996-08-30 | 2009-06-03 | Human Genome Sciences, Inc. | Interleukin-19 |
| US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| ES2217428T3 (es) | 1996-09-25 | 2004-11-01 | Ss Pharmaceutical Co., Ltd. | Derivados de vinilpiridina sustituidos y medicamentos que los contienen. |
| US6297239B1 (en) * | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US6585954B1 (en) | 1998-03-26 | 2003-07-01 | Kyowa Hakko Kogyo Co., Ltd. | Method for searching steroid sulfatase inhibitors |
| GB9807779D0 (en) | 1998-04-09 | 1998-06-10 | Ciba Geigy Ag | Organic compounds |
| US20020019527A1 (en) | 2000-04-27 | 2002-02-14 | Wei-Bo Wang | Substituted phenyl farnesyltransferase inhibitors |
| CA2464770C (en) | 2001-11-21 | 2011-08-16 | Sterix Limited | Compound |
| EP1431292A1 (en) * | 2002-12-16 | 2004-06-23 | Laboratoire Theramex | 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors |
| US8476455B2 (en) | 2003-12-15 | 2013-07-02 | Laboratoire Theramex | 1-N-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them |
| EP1544195A1 (en) | 2003-12-15 | 2005-06-22 | Laboratoire Theramex | 1-N-phenyl-amino- 1H-imidazole derivatives and pharmaceutical compositions containing them |
| GB0411562D0 (en) | 2004-05-24 | 2004-06-23 | Sterix Ltd | Compound |
| CN101511341A (zh) * | 2006-06-22 | 2009-08-19 | 诺瓦提斯公司 | 芳香酶抑制剂的缓释制剂 |
-
2009
- 2009-08-24 GB GBGB0914767.9A patent/GB0914767D0/en not_active Ceased
-
2010
- 2010-08-23 CN CN201080037827.XA patent/CN102596919B/zh not_active Expired - Fee Related
- 2010-08-23 RU RU2012111119/04A patent/RU2572244C2/ru not_active IP Right Cessation
- 2010-08-23 WO PCT/GB2010/051391 patent/WO2011023989A1/en not_active Ceased
- 2010-08-23 JP JP2012526125A patent/JP5828839B2/ja not_active Expired - Fee Related
- 2010-08-23 EP EP10750154.6A patent/EP2470512B1/en active Active
- 2010-08-23 US US13/392,206 patent/US8846737B2/en active Active
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