JP2013508288A5 - - Google Patents

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Publication number
JP2013508288A5
JP2013508288A5 JP2012534357A JP2012534357A JP2013508288A5 JP 2013508288 A5 JP2013508288 A5 JP 2013508288A5 JP 2012534357 A JP2012534357 A JP 2012534357A JP 2012534357 A JP2012534357 A JP 2012534357A JP 2013508288 A5 JP2013508288 A5 JP 2013508288A5
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JP
Japan
Prior art keywords
optionally substituted
compound
pharmaceutically acceptable
prodrug
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2012534357A
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English (en)
Japanese (ja)
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JP2013508288A (ja
JP5758395B2 (ja
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Priority claimed from PCT/US2010/052674 external-priority patent/WO2011047156A1/en
Publication of JP2013508288A publication Critical patent/JP2013508288A/ja
Publication of JP2013508288A5 publication Critical patent/JP2013508288A5/ja
Application granted granted Critical
Publication of JP5758395B2 publication Critical patent/JP5758395B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2012534357A 2009-10-15 2010-10-14 疼痛を治療するためのセピアプテリンレダクターゼ阻害薬 Expired - Fee Related JP5758395B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25201309P 2009-10-15 2009-10-15
US61/252,013 2009-10-15
PCT/US2010/052674 WO2011047156A1 (en) 2009-10-15 2010-10-14 Sepiapterin reductase inhibitors for the treatment of pain

Publications (3)

Publication Number Publication Date
JP2013508288A JP2013508288A (ja) 2013-03-07
JP2013508288A5 true JP2013508288A5 (https=) 2013-12-05
JP5758395B2 JP5758395B2 (ja) 2015-08-05

Family

ID=43876540

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012534357A Expired - Fee Related JP5758395B2 (ja) 2009-10-15 2010-10-14 疼痛を治療するためのセピアプテリンレダクターゼ阻害薬

Country Status (6)

Country Link
US (2) US9169234B2 (https=)
EP (1) EP2488025A4 (https=)
JP (1) JP5758395B2 (https=)
AU (1) AU2010306750B2 (https=)
CA (1) CA2777782C (https=)
WO (1) WO2011047156A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8884020B2 (en) 2006-08-07 2014-11-11 Ironwood Pharmaceuticals, Inc. Indole compounds
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
CN102329263A (zh) * 2011-10-17 2012-01-25 上海化学试剂研究所 一种n-乙酰基-5-甲氧基色胺的制备方法
BR112015025686B1 (pt) 2013-04-15 2020-10-27 Fmc Corporation composto, composições fungicidas e método para o controle das doenças dos vegetais
EP3068766B1 (en) * 2013-11-15 2018-01-10 Bayer CropScience Aktiengesellschaft Catalytic hydrogenation of nitriles
US10365267B2 (en) * 2014-10-31 2019-07-30 Children's Medical Center Corporation Methods and assays relating to sepiapterin reductase inhibition
DK3356345T3 (da) * 2015-09-30 2024-02-12 Max Planck Gesellschaft Heteroaryl-derivater som sepiapterin-reduktase-inhibitorer
US10576072B2 (en) * 2016-01-26 2020-03-03 Ataturk Universitesi Bilimsel Arastirma Projeleri Birimi N3,N6-bis(2-(5-methoxy-1H-indole-3-yl)ethyl)-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxamide and use thereof in the field of neurotoxicity
US20170291372A1 (en) * 2016-04-09 2017-10-12 Velo3D, Inc. Generating three-dimensional objects by three-dimensional printing with rotation
WO2017189893A1 (en) 2016-04-27 2017-11-02 University Of Puerto Rico 1,5-disubstituted 1,2,3-triazoles are inhibitors of rac/cdc42 gtpases
JP7110200B2 (ja) 2016-12-21 2022-08-01 バイエル・クロップサイエンス・アクチェンゲゼルシャフト ニトリルの接触水素化
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
CN108689856A (zh) * 2018-07-09 2018-10-23 上海华堇生物技术有限责任公司 一种3-羟基-β-硝基苯乙烯的新制备方法
US10720217B1 (en) * 2019-01-29 2020-07-21 Silicon Storage Technology, Inc. Memory device and method for varying program state separation based upon frequency of use
WO2021210586A1 (ja) 2020-04-14 2021-10-21 日産化学株式会社 縮合複素環化合物
WO2022104475A1 (en) 2020-11-19 2022-05-27 Magicmed Industries Inc. Nitrilated psilocybin derivatives and methods of using
IL308184A (en) * 2021-05-05 2024-01-01 Kare Chemical Tech Inc Processes for the preparation of catalytic tryptamines and starting materials
CN113214133B (zh) * 2021-05-08 2023-03-07 河北维达康生物科技有限公司 一种褪黑素的合成方法
CN113960317A (zh) * 2021-08-19 2022-01-21 深圳市辅酶医科技有限公司 一种测量生物样品中nad+浓度的生物传感器及方法
CN113788780B (zh) * 2021-10-15 2023-06-16 河北维达康生物科技有限公司 一种n-乙酰基-5-甲氧基色胺的合成方法
JP2025524721A (ja) 2022-07-08 2025-07-30 アンスティテュ・クリー メタロトーシス関連障害の処置において使用するためのセロトニン類似体
JP2025172328A (ja) * 2024-05-13 2025-11-26 和彦 中村 Ｉｇｆ－１産生促進剤およびその応用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2437398A1 (fr) * 1978-06-20 1980-04-25 Commissariat Energie Atomique Compose iode utilisable comme traceur en radio-immunologie
DE3613623A1 (de) * 1986-04-23 1987-10-29 Bayer Ag N-dihydroindolylethyl-sulfonamide
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
EP0620222A3 (en) * 1993-04-14 1995-04-12 Lilly Co Eli Tetrahydro-beta-carbolines.
DK0746544T3 (da) 1994-02-22 1999-06-07 Merrell Pharma Inc Indolderivater til behandling af østrogenafhængige neoplasmer og sygdomme
SK283970B9 (sk) * 1996-03-08 2004-10-05 Takeda Chemical Industries Ltd Tricyklické zlúčeniny, spôsob výroby a farmaceutický prípravok ich obsahujúci
RU2141483C1 (ru) * 1997-07-04 1999-11-20 Небольсин Владимир Евгеньевич Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция
US6306890B1 (en) * 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
US6448281B1 (en) * 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
GB0031315D0 (en) 2000-12-21 2001-02-07 Glaxo Group Ltd Indole derivatives
US6593331B2 (en) 2001-04-17 2003-07-15 Laboratories Upsa Method for treatment of pain
EP1406872B1 (en) 2001-06-20 2007-12-19 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment of diabetes
JP4657605B2 (ja) * 2001-12-03 2011-03-23 ワイス・エルエルシー 細胞質内ホスホリパーゼａ２の阻害剤
DE10252665A1 (de) 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
US7084154B2 (en) * 2003-02-11 2006-08-01 Pharmacopeia Drug Disclovery, Inc. 2-(aminomethyl) arylamide analgesics
EP1696877A4 (en) 2003-11-13 2010-06-09 Gen Hospital Corp PROCESS FOR PAIN TREATMENT
US7074775B2 (en) * 2004-09-14 2006-07-11 Miller Landon C G Aminobutyramide conjugate and a pharmaceutical composition for treatment of neuronal disorders
EP1828171B1 (en) 2004-12-10 2014-03-12 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Heterocycle derivatives as histone deacetylase (hdac) inhibitors
WO2007006739A1 (en) * 2005-07-12 2007-01-18 Bayer Cropscience Sa Benzoheterocyclylethylcarboxamide derivatives
JP2009504656A (ja) 2005-08-10 2009-02-05 ノバルティス アクチエンゲゼルシャフト デアセチラーゼ阻害剤の使用法
US7902251B2 (en) * 2005-10-19 2011-03-08 Allergan, Inc. Method for treating pain
AU2006319245A1 (en) * 2005-12-01 2007-06-07 F. Hoffmann-La Roche Ag Novel vinylogous acids derivatives
JP5142513B2 (ja) * 2005-12-05 2013-02-13 大塚製薬株式会社 医薬
MY146514A (en) 2005-12-05 2012-08-15 Otsuka Pharma Co Ltd Diarylether derivatives as antitumor agents
JP5089185B2 (ja) * 2006-02-02 2012-12-05 大塚製薬株式会社 コラーゲン産生抑制剤。
FR2898358B1 (fr) 2006-03-08 2008-05-30 Macef Sa Association d'un antagoniste du recepteur 5ht2 et d'activateur du recepteur 5ht2 par modulation allosterique et leurs utilisations comme produits medicaux
RU2303597C1 (ru) * 2006-05-12 2007-07-27 Иващенко Андрей Александрович Фармацевтическая композиция, способы ее получения и применения
US20080009485A1 (en) 2006-05-26 2008-01-10 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis
US7893055B2 (en) * 2006-06-28 2011-02-22 Bristol-Myers Squibb Company HIV integrase inhibitors
BRPI0714409A2 (pt) * 2006-07-14 2013-03-12 Novartis Ag derivados de pirimidina como inibidores de alk-5
US8884020B2 (en) 2006-08-07 2014-11-11 Ironwood Pharmaceuticals, Inc. Indole compounds
JP2008115175A (ja) * 2006-10-13 2008-05-22 Otsuka Pharmaceut Co Ltd 複素環化合物
AR063302A1 (es) 2006-10-13 2009-01-21 Otsuka Pharma Co Ltd Derivados de 4-benzo[b]tiofen-4-il-piperazin-1-il con accion antagonista del receptor 5-ht2a de serotonina y receptor de adrenalina alfa1 y agonista parcial del receptor d2, una composicion farmaceutica que lo comprende y un proceso para producirla.
FR2907451B1 (fr) * 2006-10-18 2008-12-12 Servier Lab "nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
KR20090094125A (ko) 2006-12-08 2009-09-03 엑셀리시스, 인코포레이티드 Ｌｘｒ 및 ｆｘｒ 조절자
US20080287452A1 (en) * 2007-05-16 2008-11-20 Wyeth Heteroaryl/aryl pyrimidine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
TW200914437A (en) * 2007-06-20 2009-04-01 Ironwood Pharmaceuticals Inc FAAH inhibitors
CA2709784A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
RU2373934C1 (ru) * 2008-03-19 2009-11-27 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств
GB0910003D0 (en) * 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases

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