JP2005516064A5 - - Google Patents

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Publication number
JP2005516064A5
JP2005516064A5 JP2003564005A JP2003564005A JP2005516064A5 JP 2005516064 A5 JP2005516064 A5 JP 2005516064A5 JP 2003564005 A JP2003564005 A JP 2003564005A JP 2003564005 A JP2003564005 A JP 2003564005A JP 2005516064 A5 JP2005516064 A5 JP 2005516064A5
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JP
Japan
Prior art keywords
added
water
quinolin
cyclopropyl
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003564005A
Other languages
English (en)
Japanese (ja)
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JP2005516064A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/EP2003/000804 external-priority patent/WO2003064382A2/en
Publication of JP2005516064A publication Critical patent/JP2005516064A/ja
Publication of JP2005516064A5 publication Critical patent/JP2005516064A5/ja
Pending legal-status Critical Current

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JP2003564005A 2002-01-28 2003-01-27 有機化合物の製造方法 Pending JP2005516064A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35231602P 2002-01-28 2002-01-28
US38318802P 2002-05-24 2002-05-24
PCT/EP2003/000804 WO2003064382A2 (en) 2002-01-28 2003-01-27 Process for the manufacture of organic compounds

Publications (2)

Publication Number Publication Date
JP2005516064A JP2005516064A (ja) 2005-06-02
JP2005516064A5 true JP2005516064A5 (https=) 2006-03-09

Family

ID=27669055

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003564005A Pending JP2005516064A (ja) 2002-01-28 2003-01-27 有機化合物の製造方法

Country Status (19)

Country Link
US (3) US6835838B2 (https=)
EP (1) EP1472227B1 (https=)
JP (1) JP2005516064A (https=)
KR (2) KR20040077883A (https=)
CN (2) CN100378081C (https=)
AU (4) AU2003239294B2 (https=)
BR (1) BR0307236A (https=)
CA (1) CA2472340A1 (https=)
CO (1) CO5601045A2 (https=)
EC (1) ECSP045202A (https=)
IL (1) IL162817A0 (https=)
MX (1) MXPA04007308A (https=)
NO (1) NO327363B1 (https=)
NZ (3) NZ554366A (https=)
PL (1) PL371383A1 (https=)
RU (1) RU2360903C2 (https=)
SG (2) SG161742A1 (https=)
WO (1) WO2003064382A2 (https=)
ZA (1) ZA200405239B (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04000322A (es) 2001-07-13 2005-09-08 Astrazeneca Uk Ltd Preparacion de compuestos de aminopirimidina.
KR100919941B1 (ko) 2001-11-14 2009-10-05 닛산 가가쿠 고교 가부시키 가이샤 광학활성 옥소헵텐산 에스테르의 제조방법
PL370658A1 (en) * 2002-01-31 2005-05-30 Novartis Ag Process for the manufacture of hmg-coa reductase inhibitors
US7339062B2 (en) * 2002-09-20 2008-03-04 Nissan Chemical Industries, Ltd. Method for producing a 3,5-dihydroxy-6-heptenoate
CN101219992B (zh) * 2003-02-12 2011-08-31 日产化学工业株式会社 匹伐他汀钙的晶形
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
TWI328006B (en) * 2003-12-26 2010-08-01 Nissan Chemical Ind Ltd Crystal form of quinoline compound and process for its production
CN1763015B (zh) * 2004-10-22 2011-06-22 四川抗菌素工业研究所有限公司 一种罗舒伐他汀及其药用盐的制备方法及中间体
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
EP2024341B1 (en) * 2006-05-03 2015-12-02 MSN Laboratories Private Limited Novel process for statins and its pharmaceutically acceptable salts thereof
US8404841B2 (en) * 2006-10-09 2013-03-26 Msn Laboratories Limited Process for the preparation of statins and their pharmaceutically acceptable salts thereof
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
WO2010089770A2 (en) * 2009-01-19 2010-08-12 Msn Laboratories Limited Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
RU2425034C1 (ru) * 2010-01-11 2011-07-27 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУ ВПО "КубГТУ") Способ получения производных (e)-4-(6,7-диметокси-2-метил-3-хинолил)-3-бутен-2-она
US8987444B2 (en) 2010-01-18 2015-03-24 Msn Laboratories Private Limited Process for the preparation of amide intermediates and their use thereof
EP2423195A1 (en) 2010-07-26 2012-02-29 LEK Pharmaceuticals d.d. Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
JP2013536219A (ja) * 2010-08-25 2013-09-19 カディラ・ヘルスケア・リミテッド ピタバスタチンカルシウムおよびその調製方法
EP3178812A1 (en) * 2010-11-12 2017-06-14 Hetero Research Foundation Novel polymorphs of pitavastatin calcium
WO2012140490A2 (en) 2011-04-11 2012-10-18 Aurobindo Pharma Limited Process for preparing quinoline derivative
CN103755568B (zh) * 2013-12-10 2015-10-28 江西科技师范大学 IeodomycinA和B立体选择性合成方法
US10676441B2 (en) 2015-08-05 2020-06-09 Api Corporation Method for producing pitavastatin calcium
CN108976168B (zh) * 2017-06-02 2020-09-25 浙江京新药业股份有限公司 一种匹伐他汀半钙盐晶型及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906624A (en) * 1987-09-08 1990-03-06 Warner-Lambert Company 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
NZ230121A (en) * 1988-08-29 1993-08-26 Squibb & Sons Inc Pyridine and quinoline terminal groups for hmg-coenzyme a reductase inhibitors and pharmaceutical compositions for lowering blood serum cholesterol levels
JP3528186B2 (ja) 1991-06-24 2004-05-17 日産化学工業株式会社 光学活性キノリンメバロン酸のジアステレオマー塩
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
JP3130342B2 (ja) * 1991-10-04 2001-01-31 日産化学工業株式会社 動脈硬化性血管内膜肥厚抑制薬
JP3554036B2 (ja) * 1994-09-06 2004-08-11 宇部興産株式会社 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法
KR100919941B1 (ko) * 2001-11-14 2009-10-05 닛산 가가쿠 고교 가부시키 가이샤 광학활성 옥소헵텐산 에스테르의 제조방법
WO2008096257A1 (en) * 2007-02-08 2008-08-14 Aurobindo Pharma Limited An improved process for preparation of rosuvastatin calcium

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