JP2005516002A5 - - Google Patents
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- Publication number
- JP2005516002A5 JP2005516002A5 JP2003550726A JP2003550726A JP2005516002A5 JP 2005516002 A5 JP2005516002 A5 JP 2005516002A5 JP 2003550726 A JP2003550726 A JP 2003550726A JP 2003550726 A JP2003550726 A JP 2003550726A JP 2005516002 A5 JP2005516002 A5 JP 2005516002A5
- Authority
- JP
- Japan
- Prior art keywords
- sarm compound
- compound according
- sarm
- muscular atrophy
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940083324 Selective androgen receptor modulator Drugs 0.000 claims 170
- 239000000849 selective androgen receptor modulator Substances 0.000 claims 170
- 150000001875 compounds Chemical class 0.000 claims 166
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 74
- 201000000585 muscular atrophy Diseases 0.000 claims 46
- 208000035475 disorder Diseases 0.000 claims 43
- 201000010099 disease Diseases 0.000 claims 31
- 239000003814 drug Substances 0.000 claims 27
- 239000000126 substance Substances 0.000 claims 17
- 230000001684 chronic effect Effects 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 230000007170 pathology Effects 0.000 claims 15
- 208000029402 Bulbospinal muscular atrophy Diseases 0.000 claims 10
- 208000027747 Kennedy disease Diseases 0.000 claims 10
- 150000001204 N-oxides Chemical class 0.000 claims 10
- 210000003169 central nervous system Anatomy 0.000 claims 10
- 239000002207 metabolite Substances 0.000 claims 10
- 239000008188 pellet Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 9
- 230000001419 dependent effect Effects 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 6
- 208000030507 AIDS Diseases 0.000 claims 5
- 208000007848 Alcoholism Diseases 0.000 claims 5
- 208000008035 Back Pain Diseases 0.000 claims 5
- 206010006895 Cachexia Diseases 0.000 claims 5
- 208000031229 Cardiomyopathies Diseases 0.000 claims 5
- 208000018380 Chemical injury Diseases 0.000 claims 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 5
- 206010014561 Emphysema Diseases 0.000 claims 5
- 208000031886 HIV Infections Diseases 0.000 claims 5
- 208000037357 HIV infectious disease Diseases 0.000 claims 5
- 208000002720 Malnutrition Diseases 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 208000010886 Peripheral nerve injury Diseases 0.000 claims 5
- 208000027418 Wounds and injury Diseases 0.000 claims 5
- 210000001766 X chromosome Anatomy 0.000 claims 5
- 201000007930 alcohol dependence Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 239000002775 capsule Substances 0.000 claims 5
- 208000020832 chronic kidney disease Diseases 0.000 claims 5
- 239000006071 cream Substances 0.000 claims 5
- 230000006378 damage Effects 0.000 claims 5
- 206010012601 diabetes mellitus Diseases 0.000 claims 5
- -1 elixir Substances 0.000 claims 5
- 239000000839 emulsion Substances 0.000 claims 5
- 208000028208 end stage renal disease Diseases 0.000 claims 5
- 201000000523 end stage renal failure Diseases 0.000 claims 5
- 239000000499 gel Substances 0.000 claims 5
- 230000002068 genetic effect Effects 0.000 claims 5
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 5
- 150000004677 hydrates Chemical class 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 5
- 230000002458 infectious effect Effects 0.000 claims 5
- 208000014674 injury Diseases 0.000 claims 5
- 208000017169 kidney disease Diseases 0.000 claims 5
- 230000001071 malnutrition Effects 0.000 claims 5
- 235000000824 malnutrition Nutrition 0.000 claims 5
- 201000006938 muscular dystrophy Diseases 0.000 claims 5
- 230000000926 neurological effect Effects 0.000 claims 5
- 208000015380 nutritional deficiency disease Diseases 0.000 claims 5
- 208000005368 osteomalacia Diseases 0.000 claims 5
- 208000001076 sarcopenia Diseases 0.000 claims 5
- 239000000243 solution Substances 0.000 claims 5
- 239000000829 suppository Substances 0.000 claims 5
- 239000000725 suspension Substances 0.000 claims 5
- 239000003826 tablet Substances 0.000 claims 5
- 230000000699 topical effect Effects 0.000 claims 5
- 208000020339 Spinal injury Diseases 0.000 claims 4
- 206010028289 Muscle atrophy Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000020763 muscle atrophy Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000008934 Muscle Proteins Human genes 0.000 claims 1
- 108010074084 Muscle Proteins Proteins 0.000 claims 1
- 208000011623 Obstructive Lung disease Diseases 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- BXJWDRYVBYDEJD-INIZCTEOSA-N C[C@](COc(cc1F)ccc1I)(C(Nc(cc1C(F)(F)F)ccc1N=O)=O)O Chemical compound C[C@](COc(cc1F)ccc1I)(C(Nc(cc1C(F)(F)F)ccc1N=O)=O)O BXJWDRYVBYDEJD-INIZCTEOSA-N 0.000 description 2
- LLPPSWUKHHRGQD-UHFFFAOYSA-N OC(CCOC(C(C(C(F)=C1F)F)F)=C1F)Nc(cc1C(F)(F)F)ccc1N=O Chemical compound OC(CCOC(C(C(C(F)=C1F)F)F)=C1F)Nc(cc1C(F)(F)F)ccc1N=O LLPPSWUKHHRGQD-UHFFFAOYSA-N 0.000 description 2
- 0 B*C[C@](*)(C(N*)=*)I Chemical compound B*C[C@](*)(C(N*)=*)I 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33618501P | 2001-12-06 | 2001-12-06 | |
| PCT/US2002/036147 WO2003049675A2 (en) | 2001-12-06 | 2002-12-05 | Treating muscle wasting with selective androgen receptor modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010165864A Division JP2010254707A (ja) | 2001-12-06 | 2010-07-23 | 選択的アンドロゲンレセプタ修飾因子を用いた筋萎縮治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005516002A JP2005516002A (ja) | 2005-06-02 |
| JP2005516002A5 true JP2005516002A5 (https=) | 2006-01-05 |
| JP4605557B2 JP4605557B2 (ja) | 2011-01-05 |
Family
ID=23314937
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003550726A Expired - Fee Related JP4605557B2 (ja) | 2001-12-06 | 2002-12-05 | 選択的アンドロゲンレセプタ修飾因子を用いた筋萎縮治療 |
| JP2010165864A Pending JP2010254707A (ja) | 2001-12-06 | 2010-07-23 | 選択的アンドロゲンレセプタ修飾因子を用いた筋萎縮治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010165864A Pending JP2010254707A (ja) | 2001-12-06 | 2010-07-23 | 選択的アンドロゲンレセプタ修飾因子を用いた筋萎縮治療 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7547728B2 (https=) |
| EP (2) | EP1463497B1 (https=) |
| JP (2) | JP4605557B2 (https=) |
| KR (1) | KR100767317B1 (https=) |
| CN (1) | CN1617715B (https=) |
| AT (1) | ATE526959T1 (https=) |
| AU (1) | AU2002364949C1 (https=) |
| BR (1) | BR0215115A (https=) |
| CA (1) | CA2469340A1 (https=) |
| CY (1) | CY1112509T1 (https=) |
| DK (1) | DK1463497T3 (https=) |
| EA (1) | EA007921B1 (https=) |
| ES (1) | ES2372929T3 (https=) |
| GE (1) | GEP20063984B (https=) |
| HR (1) | HRP20040588A2 (https=) |
| IL (2) | IL162340A0 (https=) |
| MX (1) | MXPA04005519A (https=) |
| PT (1) | PT1463497E (https=) |
| TW (1) | TWI339118B (https=) |
| WO (1) | WO2003049675A2 (https=) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7759520B2 (en) | 1996-11-27 | 2010-07-20 | University Of Tennessee Research Foundation | Synthesis of selective androgen receptor modulators |
| US20090264534A1 (en) * | 1996-11-27 | 2009-10-22 | Dalton James T | Selective androgen receptor modulators |
| US7518013B2 (en) | 2000-08-24 | 2009-04-14 | University Of Tennessee Research Foundation | Selective androgen receptor modulators |
| US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US8008348B2 (en) * | 2001-12-06 | 2011-08-30 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
| US8445534B2 (en) | 2000-08-24 | 2013-05-21 | University Of Tennessee Research Foundation | Treating androgen decline in aging male (ADAM)-associated conditions with SARMs |
| US20040260108A1 (en) * | 2001-06-25 | 2004-12-23 | Dalton James T. | Metabolites of selective androgen receptor modulators and methods of use thereof |
| US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7855229B2 (en) | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| US7547728B2 (en) * | 2001-12-06 | 2009-06-16 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
| US7253210B2 (en) * | 2002-10-15 | 2007-08-07 | University Of Tennessee Research Foundation | Methylene-bridged selective androgen receptor modulators and methods of use thereof |
| US7026500B2 (en) * | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
| US7645898B2 (en) | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
| US8853266B2 (en) * | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US20070161608A1 (en) * | 2001-12-06 | 2007-07-12 | Dalton James T | Selective androgen receptor modulators for treating muscle wasting |
| PT1480634E (pt) | 2002-02-07 | 2011-10-12 | Univ Tennessee Res Foundation | Moduladores selectivos do receptor do androgénio (sarms) para o tratamento da hiperplasia benigna da próstata |
| EP1487458B1 (en) * | 2002-02-28 | 2011-11-16 | University Of Tennessee Research Foundation | Multi-substituted selective androgen receptor modulators and methods of use thereof |
| US7803970B2 (en) | 2002-02-28 | 2010-09-28 | University Of Tennessee Research Foundation | Multi-substitued selective androgen receptor modulators and methods of use thereof |
| GEP20074209B (en) * | 2002-02-28 | 2007-10-10 | , | Multi-substitued selective androgen receptor modulators and methods of use thereof |
| EP2266577B8 (en) * | 2002-02-28 | 2015-01-21 | University Of Tennessee Research Foundation | Multi-substituted selective androgen receptor modulators and methods of use thereof |
| US20060064767A1 (en) * | 2002-08-19 | 2006-03-23 | Gen Sobue | Nonhuman animal reproducing pathogenic conditions of spinal and bulbar muscular atrophy and remedy for spinal and bulbar muscular atrophy |
| US20060276539A1 (en) * | 2002-10-16 | 2006-12-07 | Dalton James T | Treating Androgen Decline in Aging Male (ADAM)- associated conditions with SARMS |
| WO2004035739A2 (en) * | 2002-10-16 | 2004-04-29 | Gtx, Inc. | Treating androgen decline in aging male (adam)-associated conditions with sarms |
| US8309603B2 (en) * | 2004-06-07 | 2012-11-13 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| DE602004026583D1 (de) * | 2003-06-27 | 2010-05-27 | Orion Corp | Als androgenrezeptormodulatoren geeignete propionamidderivate |
| CN100462353C (zh) * | 2003-06-27 | 2009-02-18 | 奥赖恩公司 | 用作雄激素受体调节剂的丙酰胺衍生物 |
| FI20030958A0 (fi) * | 2003-06-27 | 2003-06-27 | Orion Corp | Uusia yhdisteitä |
| CA2535953C (en) * | 2003-10-14 | 2012-07-03 | Gtx, Inc. | Treating bone-related disorders with selective androgen receptor modulators |
| CA2522874A1 (en) * | 2003-12-16 | 2005-07-07 | Gtx, Inc. | Prodrugs of selective androgen receptor modulators and methods of use thereof |
| JP2007532621A (ja) * | 2004-04-13 | 2007-11-15 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲンモジュレータ |
| US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
| US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
| ATE552235T1 (de) * | 2004-06-07 | 2012-04-15 | Univ Tennessee Res Foundation | Selektive androgen-rezeptor-modulator und anwendungsverfahren dafür |
| US20110237664A1 (en) * | 2004-06-07 | 2011-09-29 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
| EP1768984B1 (en) | 2004-07-16 | 2010-10-20 | Sunesis Pharmaceuticals, Inc. | Thienopyrimidines useful as aurora kinase inhibitors |
| US7655700B2 (en) * | 2005-08-25 | 2010-02-02 | Michigan State University | Transgenic mouse model and methods for treatment of neuro muscular disease by interfering with androgen-androgen receptor interaction in skeletal muscles |
| JP2009506119A (ja) * | 2005-08-31 | 2009-02-12 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | 選択的アンドロゲン受容体モジュレーターを用いる腎疾患、熱傷、創傷および脊髄損傷の処置 |
| PT2038252T (pt) * | 2006-07-12 | 2016-12-16 | Univ Tennessee Res Found | Acilanilidos substituidos e métodos de utilização dos mesmos |
| CN101528214B (zh) | 2006-08-24 | 2013-06-05 | 田纳西大学研究基金会 | 取代的n-酰基苯胺及其使用方法 |
| US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| PL2176220T3 (pl) | 2007-08-07 | 2013-08-30 | Takeda Pharmaceuticals Co | Pochodne pirolidyn-2-onu jako modulatory receptora androgenowego |
| HRP20180500T1 (hr) * | 2007-09-11 | 2018-06-01 | Gtx, Inc. | Kristalni polimorf selektivnih modulatora androgena (r) ili (s)-n-(4-cijano-3-(trifluorometil)fenil)-3-(4-cijanofenoksi)-2-hidroksi-2-metilpropanamida |
| US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| KR101595238B1 (ko) | 2007-12-21 | 2016-02-18 | 리간드 파마슈티칼스 인코포레이티드 | 선택적 안드로겐 수용체 조절제(ｓａｒｍ) 및 이의 용도 |
| WO2011146768A1 (en) | 2010-05-20 | 2011-11-24 | University Of Iowa Research Foundation | Methods for inhibiting muscle atrophy |
| US11090313B2 (en) | 2010-05-20 | 2021-08-17 | University Of Iowa Research Foundation | Methods for inhibiting muscle atrophy |
| US8395552B2 (en) | 2010-11-23 | 2013-03-12 | Metamagnetics, Inc. | Antenna module having reduced size, high gain, and increased power efficiency |
| AU2012268036B2 (en) | 2011-06-06 | 2017-04-06 | THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF STATE OF THE DEPARTMENT OF VETERANS AFFAIRS | Methods of inhibiting muscle atrophy |
| US20140371188A1 (en) * | 2011-11-23 | 2014-12-18 | University Of Iowa Research Foundation | Compositions and methods for inhibiting muscle atrophy and inducing muscle hypertrophy |
| WO2013152170A1 (en) * | 2012-04-04 | 2013-10-10 | Catylix, Inc. | Selective androgen receptor modulators |
| PT2872482T (pt) | 2012-07-13 | 2020-09-22 | Oncternal Therapeutics Inc | Método de tratamento de cancro de mama com modulador seletivo do recetor de andrógeno (sarm) |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| JP2015071549A (ja) * | 2013-10-02 | 2015-04-16 | 株式会社ファンケル | アトロジン−１抑制剤 |
| EP3094323A4 (en) | 2014-01-17 | 2017-10-11 | Ligand Pharmaceuticals Incorporated | Methods and compositions for modulating hormone levels |
| MX2017004819A (es) * | 2014-10-16 | 2018-06-12 | Gtx Inc | Metodos de tratamiento de transtornos urológicos usando sarm. |
| KR101919081B1 (ko) * | 2017-05-11 | 2018-11-16 | (주)녹십자웰빙 | 인간 태반 추출물을 유효성분으로 포함하는 근 위축증 또는 근육감소증의 예방 또는 치료용 및 근육 기능 개선용 조성물 |
| AU2020257397B2 (en) | 2019-04-19 | 2026-02-26 | Ligand Pharmaceuticals Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
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| GB1360001A (en) | 1971-06-16 | 1974-07-17 | Scherico Ltd | Pharmaceutical compositions comprising substituted anilides |
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| US5847076A (en) * | 1993-05-20 | 1998-12-08 | Board Of Regents, The University Of Texas System | Regulators of the proteasome |
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| US5609849A (en) * | 1994-03-11 | 1997-03-11 | The Trustees Of The University Of Pennsylvania | Serotonin (5-HT1A) receptor ligands and imaging agents |
| DE4435368A1 (de) * | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
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| US6995284B2 (en) * | 2000-08-24 | 2006-02-07 | The University Of Tennessee Research Foundation | Synthesis of selective androgen receptor modulators |
| US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
| US6160011A (en) * | 1997-05-30 | 2000-12-12 | The University Of Tennessee Research Corporation | Non-steroidal agonist compounds and their use in male hormone therapy |
| WO1998055153A1 (en) | 1997-06-04 | 1998-12-10 | The University Of Tennessee Research Corporation | Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging |
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| PL354620A1 (en) | 1999-10-19 | 2004-02-09 | Nobex Corporation | Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof |
| CN1413188A (zh) | 1999-10-27 | 2003-04-23 | 诺贝克斯公司 | 基本纯的比卡鲁胺合成中中间体的拆分 |
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| BR0111298A (pt) | 2000-06-28 | 2005-05-10 | Bristol Myers Squibb Co | Moduladores seletivos dos receptores de andrógenos e métodos para identificação, projeto e uso dos mesmos |
| EP1401801B1 (en) * | 2000-08-24 | 2006-11-02 | The University Of Tennessee Research Corporation | Selective androgen receptor modulators and methods of use thereof |
| US7026500B2 (en) * | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
| US7547728B2 (en) * | 2001-12-06 | 2009-06-16 | University Of Tennessee Research Foundation | Treating muscle wasting with selective androgen receptor modulators |
| IL154425A0 (en) * | 2000-08-24 | 2003-09-17 | Univ Tennessee Res H Corp | Selective androgen receptor modulators and methods of use thereof |
| FI20030958A0 (fi) | 2003-06-27 | 2003-06-27 | Orion Corp | Uusia yhdisteitä |
-
2002
- 2002-12-05 US US10/310,150 patent/US7547728B2/en not_active Expired - Fee Related
- 2002-12-05 CA CA002469340A patent/CA2469340A1/en not_active Abandoned
- 2002-12-05 BR BR0215115-4A patent/BR0215115A/pt not_active Application Discontinuation
- 2002-12-05 IL IL16234002A patent/IL162340A0/xx unknown
- 2002-12-05 EP EP02802565A patent/EP1463497B1/en not_active Expired - Lifetime
- 2002-12-05 CN CN028279050A patent/CN1617715B/zh not_active Expired - Fee Related
- 2002-12-05 GE GE5641A patent/GEP20063984B/en unknown
- 2002-12-05 AT AT02802565T patent/ATE526959T1/de active
- 2002-12-05 PT PT02802565T patent/PT1463497E/pt unknown
- 2002-12-05 JP JP2003550726A patent/JP4605557B2/ja not_active Expired - Fee Related
- 2002-12-05 DK DK02802565.8T patent/DK1463497T3/da active
- 2002-12-05 EA EA200400774A patent/EA007921B1/ru not_active IP Right Cessation
- 2002-12-05 AU AU2002364949A patent/AU2002364949C1/en not_active Ceased
- 2002-12-05 WO PCT/US2002/036147 patent/WO2003049675A2/en not_active Ceased
- 2002-12-05 ES ES02802565T patent/ES2372929T3/es not_active Expired - Lifetime
- 2002-12-05 EP EP10075696.4A patent/EP2289503B1/en not_active Expired - Lifetime
- 2002-12-05 HR HR20040588A patent/HRP20040588A2/hr not_active Application Discontinuation
- 2002-12-05 MX MXPA04005519A patent/MXPA04005519A/es active IP Right Grant
- 2002-12-05 KR KR1020047008659A patent/KR100767317B1/ko not_active Expired - Fee Related
- 2002-12-06 TW TW091136268A patent/TWI339118B/zh not_active IP Right Cessation
-
2004
- 2004-06-03 IL IL162340A patent/IL162340A/en not_active IP Right Cessation
-
2010
- 2010-07-23 JP JP2010165864A patent/JP2010254707A/ja active Pending
-
2012
- 2012-01-04 CY CY20121100004T patent/CY1112509T1/el unknown
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