JP2024119812A5 - - Google Patents
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- Publication number
- JP2024119812A5 JP2024119812A5 JP2024079079A JP2024079079A JP2024119812A5 JP 2024119812 A5 JP2024119812 A5 JP 2024119812A5 JP 2024079079 A JP2024079079 A JP 2024079079A JP 2024079079 A JP2024079079 A JP 2024079079A JP 2024119812 A5 JP2024119812 A5 JP 2024119812A5
- Authority
- JP
- Japan
- Prior art keywords
- pharma
- acceptable salt
- ceutically acceptable
- compound according
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000003376 axonal effect Effects 0.000 claims 4
- 230000007850 degeneration Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 101000685982 Homo sapiens NAD(+) hydrolase SARM1 Proteins 0.000 claims 1
- 102100023356 NAD(+) hydrolase SARM1 Human genes 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062958178P | 2020-01-07 | 2020-01-07 | |
| US62/958,178 | 2020-01-07 | ||
| US202063065736P | 2020-08-14 | 2020-08-14 | |
| US63/065,736 | 2020-08-14 | ||
| PCT/US2021/012333 WO2021142006A1 (en) | 2020-01-07 | 2021-01-06 | Inhibitors of sarm1 |
| JP2022541796A JP7490781B2 (ja) | 2020-01-07 | 2021-01-06 | Ｓａｒｍ１の阻害剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022541796A Division JP7490781B2 (ja) | 2020-01-07 | 2021-01-06 | Ｓａｒｍ１の阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024119812A JP2024119812A (ja) | 2024-09-03 |
| JP2024119812A5 true JP2024119812A5 (https=) | 2025-01-07 |
| JP7659110B2 JP7659110B2 (ja) | 2025-04-08 |
Family
ID=74505335
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022541796A Active JP7490781B2 (ja) | 2020-01-07 | 2021-01-06 | Ｓａｒｍ１の阻害剤 |
| JP2024079079A Active JP7659110B2 (ja) | 2020-01-07 | 2024-05-15 | Ｓａｒｍ１の阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022541796A Active JP7490781B2 (ja) | 2020-01-07 | 2021-01-06 | Ｓａｒｍ１の阻害剤 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US12331033B2 (https=) |
| EP (1) | EP4087838A1 (https=) |
| JP (2) | JP7490781B2 (https=) |
| KR (1) | KR20220164471A (https=) |
| CN (1) | CN115175900B (https=) |
| AU (2) | AU2021206651B2 (https=) |
| BR (1) | BR112022013388A2 (https=) |
| CA (1) | CA3163265A1 (https=) |
| CL (1) | CL2022001825A1 (https=) |
| CO (1) | CO2022009514A2 (https=) |
| CR (1) | CR20220375A (https=) |
| DO (1) | DOP2022000141A (https=) |
| EC (1) | ECSP22053394A (https=) |
| IL (1) | IL294507A (https=) |
| JO (1) | JOP20220167A1 (https=) |
| MX (1) | MX2022008395A (https=) |
| MY (1) | MY206478A (https=) |
| PE (1) | PE20230165A1 (https=) |
| TW (1) | TW202140437A (https=) |
| UA (1) | UA128949C2 (https=) |
| WO (1) | WO2021142006A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020132045A1 (en) | 2018-12-19 | 2020-06-25 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 in combination with neuroprotective agents |
| CN115916764B (zh) | 2020-04-09 | 2024-09-20 | 达萨玛治疗公司 | 作为sarm1抑制剂的吲唑衍生物 |
| US12606558B2 (en) | 2020-04-09 | 2026-04-21 | Disarm Therapeutics, Inc. | Condensed pyrazole derivatives as inhibitors of SARM1 |
| EP4192828A1 (en) | 2020-08-04 | 2023-06-14 | Nura Bio, Inc. | Substituted pyridine derivatives as sarm1 inhibitors |
| TW202334117A (zh) | 2020-08-24 | 2023-09-01 | 美商達薩瑪治療公司 | Ｓａｒｍ１之抑制劑 |
| CN116438171A (zh) * | 2020-09-16 | 2023-07-14 | 努拉生物公司 | 作为sarm1抑制剂的取代的吡啶衍生物 |
| MX2024001322A (es) | 2021-07-28 | 2024-04-30 | Nura Bio Inc | Derivados de piridina sustituida como inhibidores de sarm1. |
| JP2023030679A (ja) * | 2021-08-23 | 2023-03-08 | 国立大学法人 岡山大学 | 化合物、神経系疾患の予防又は治療薬 |
| EP4634156A1 (en) * | 2022-12-15 | 2025-10-22 | Sironax Ltd | Sarm1 modulators, preparations, and uses thereof |
| WO2024158775A1 (en) | 2023-01-24 | 2024-08-02 | Disarm Therapeutics, Inc. | Pyridazines as sarm1 inhibitors |
| JP2026503618A (ja) | 2023-01-24 | 2026-01-29 | ディスアーム セラピューティクス， インコーポレイテッド | Ｓａｒｍ１阻害剤としての置換された１ｈ－ピラゾール－４－カルボキサミド |
| WO2025045746A1 (en) * | 2023-08-25 | 2025-03-06 | F. Hoffmann-La Roche Ag | Pyrazole derivatives as sarm1 inhibitors useful for the treatment of neurodegenerative disorders |
| WO2025157895A1 (en) | 2024-01-25 | 2025-07-31 | UCB Biopharma SRL | Pyrrolidinone derivatives |
| TW202543611A (zh) * | 2024-03-27 | 2025-11-16 | 美商費斯製藥有限公司 | Ｈｐｄ抑制劑組成物及使用方法 |
| GB202408068D0 (en) | 2024-06-06 | 2024-07-24 | Univ London | Treatment of cancer of the central nervous system |
| CN118593490B (zh) * | 2024-06-28 | 2024-11-19 | 华中农业大学 | Ml216在制备抗猪德尔塔冠状病毒药物中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6787555B2 (en) | 2001-04-30 | 2004-09-07 | The Procter & Gamble Company | Triazole compounds useful in treating diseases associated with unwanted cytokine activity |
| EP1558607B1 (en) * | 2002-10-30 | 2010-05-05 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of rock and other protein kinases |
| CN1732164A (zh) * | 2002-10-30 | 2006-02-08 | 沃泰克斯药物股份有限公司 | 可用作rock及其他蛋白质激酶抑制剂的组合物 |
| US7361669B2 (en) * | 2003-01-02 | 2008-04-22 | Millennium Pharmaceuticals, Inc. | Compositions and method for inhibiting TGF-β |
| TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| US7585881B2 (en) | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| US7531556B2 (en) * | 2004-04-28 | 2009-05-12 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of rock and other protein kinases |
| ZA200704971B (en) * | 2004-12-16 | 2008-09-25 | Vertex Pharma | Pyrid-2-ones useful as inhibitors of Tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases |
| CA2591413A1 (en) * | 2004-12-16 | 2006-06-22 | Vertex Pharmaceuticals Incorporated | Pyrid-2-ones useful as inhibitors of tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases |
| EP2036905B1 (en) * | 2006-06-28 | 2012-12-12 | ASKA Pharmaceutical Co., Ltd. | Pyridylisoxazole derivative |
| BRPI0717097A2 (pt) * | 2006-09-21 | 2013-11-26 | Novartis Ag | Derivados de pirrol úteis para o tratamento de doenças mediadas por citocina |
| EP2240475B1 (en) | 2007-12-20 | 2013-09-25 | Novartis AG | Thiazole derivatives used as pi 3 kinase inhibitors |
| EP2238134A2 (en) * | 2007-12-20 | 2010-10-13 | Novartis AG | Bis-thiazole derivatives, process for their preparation and their use as medicaments |
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2010093849A2 (en) * | 2009-02-13 | 2010-08-19 | Amgen Inc. | Phenylalanine amide derivatives useful for treating insulin-related diseases and conditions |
| RU2570907C2 (ru) * | 2013-10-21 | 2015-12-20 | Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" | Производные 3-ациламинопиридин-2(1h)-она, применимые как ингибиторы серин-треониновой протеинкиназы gsk3b в качестве лекарственных препаратов для лечения диабета ii типа. |
| WO2015112847A1 (en) * | 2014-01-24 | 2015-07-30 | Confluence Life Sciences, Inc. | Arylpyridinone itk inhibitors for treating inflammation and cancer |
| HK1248070A1 (zh) * | 2015-05-18 | 2018-10-12 | 转化药物开发有限责任公司 | 作为激酶抑制剂的杂环化合物 |
| WO2018057989A1 (en) | 2016-09-24 | 2018-03-29 | Washington University | INHIBITORS OF SARM1 NADase ACTIVITY AND USES THEREOF |
| UY37512A (es) * | 2016-12-09 | 2019-04-30 | Vertex Pharma | Compuestos pirazol 1,3-sustituido útiles para la reducción de los niveles de ácidos grasos de cadena muy larga |
| JP7481329B2 (ja) * | 2018-06-07 | 2024-05-10 | ディスアーム セラピューティクス， インコーポレイテッド | Ｓａｒｍ１阻害剤 |
| CN111253333A (zh) * | 2018-11-30 | 2020-06-09 | 青岛清原化合物有限公司 | N-(1,3,4-噁二唑-2-基)芳基甲酰胺类或其盐、制备方法、除草组合物和应用 |
| WO2020132045A1 (en) * | 2018-12-19 | 2020-06-25 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 in combination with neuroprotective agents |
| CA3141404A1 (en) | 2019-06-14 | 2020-12-17 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 |
| CN115916764B (zh) * | 2020-04-09 | 2024-09-20 | 达萨玛治疗公司 | 作为sarm1抑制剂的吲唑衍生物 |
| EP4192828A1 (en) * | 2020-08-04 | 2023-06-14 | Nura Bio, Inc. | Substituted pyridine derivatives as sarm1 inhibitors |
| CN116438171A (zh) * | 2020-09-16 | 2023-07-14 | 努拉生物公司 | 作为sarm1抑制剂的取代的吡啶衍生物 |
-
2021
- 2021-01-06 CR CR20220375A patent/CR20220375A/es unknown
- 2021-01-06 IL IL294507A patent/IL294507A/en unknown
- 2021-01-06 MX MX2022008395A patent/MX2022008395A/es unknown
- 2021-01-06 UA UAA202202347A patent/UA128949C2/uk unknown
- 2021-01-06 JP JP2022541796A patent/JP7490781B2/ja active Active
- 2021-01-06 PE PE2022001414A patent/PE20230165A1/es unknown
- 2021-01-06 CN CN202180019643.9A patent/CN115175900B/zh active Active
- 2021-01-06 TW TW110100350A patent/TW202140437A/zh unknown
- 2021-01-06 WO PCT/US2021/012333 patent/WO2021142006A1/en not_active Ceased
- 2021-01-06 CA CA3163265A patent/CA3163265A1/en active Pending
- 2021-01-06 AU AU2021206651A patent/AU2021206651B2/en active Active
- 2021-01-06 MY MYPI2022003584A patent/MY206478A/en unknown
- 2021-01-06 BR BR112022013388A patent/BR112022013388A2/pt unknown
- 2021-01-06 KR KR1020227027204A patent/KR20220164471A/ko not_active Ceased
- 2021-01-06 EP EP21703092.3A patent/EP4087838A1/en active Pending
- 2021-08-17 US US17/404,523 patent/US12331033B2/en active Active
-
2022
- 2022-07-05 CL CL2022001825A patent/CL2022001825A1/es unknown
- 2022-07-05 DO DO2022000141A patent/DOP2022000141A/es unknown
- 2022-07-06 CO CONC2022/0009514A patent/CO2022009514A2/es unknown
- 2022-07-07 EC ECSENADI202253394A patent/ECSP22053394A/es unknown
- 2022-07-07 JO JOP/2022/0167A patent/JOP20220167A1/ar unknown
-
2024
- 2024-02-06 AU AU2024200703A patent/AU2024200703A1/en not_active Withdrawn
- 2024-05-15 JP JP2024079079A patent/JP7659110B2/ja active Active
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