HUP0203121A2 - Szubsztituált benzimidazolokat tartalmazó gyógyszerkészítmény és alkalmazása - Google Patents

Szubsztituált benzimidazolokat tartalmazó gyógyszerkészítmény és alkalmazása

Info

Publication number
HUP0203121A2
HUP0203121A2 HU0203121A HUP0203121A HUP0203121A2 HU P0203121 A2 HUP0203121 A2 HU P0203121A2 HU 0203121 A HU0203121 A HU 0203121A HU P0203121 A HUP0203121 A HU P0203121A HU P0203121 A2 HUP0203121 A2 HU P0203121A2
Authority
HU
Hungary
Prior art keywords
sodium
active ingredient
polyethylene glycol
stable liquid
preparation
Prior art date
Application number
HU0203121A
Other languages
English (en)
Inventor
Mikael Brülls
Original Assignee
Astrazeneca Ab,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, filed Critical Astrazeneca Ab,
Publication of HUP0203121A2 publication Critical patent/HUP0203121A2/hu
Publication of HUP0203121A3 publication Critical patent/HUP0203121A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

A találmány tárgyát polietilénglikolt és hatóanyagként egy H+,K+-ATP-áz inhibitor nátrium- vagy káliumsóját, vagy a hatóanyag egyenantiomerének nátrium- vagy káliumsóját, valamint adott esetbengyógyszerészetileg elfogadható, a készítményben oldódó segédanyagokattartalmazó vízmentes vagy csaknem vízmentes, stabilis folyékonykészítmény képezi. A H+,K+-ATP-áz inhibitor előnyösen az omeprazolnátriumsója vagy az (S)-omeprazol nátriumsója. A polietilénglikol apolietilénglikol 200, 300 vagy 400 egyike, előnyösen a PEG 400. Akészítmény víztartalma 6 tömeg %-nál kisebb. A stabilis folyékonykészítményt úgy állítják elő, hogy a PEG-et és a hatóanyagotösszekeverik és adott esetben a keverékben oldódó segédanyagokat adnakhozzá, majd az oldatot nitrogénnel átfúvatva beprogramozott értékűvíztartalmat állítanak be. Úgyszintén a találmány tárgyát képezi afenti stabilis folyékony készítménynek a gastrointestinalis betegségekkezelésére való alkalmazása. Ó
HU0203121A 1999-10-22 2000-10-13 Pharmaceutical composition containing substituted benzimidazoles and its use HUP0203121A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903831A SE9903831D0 (sv) 1999-10-22 1999-10-22 Formulation of substituted benzimidazoles
PCT/SE2000/001992 WO2001028558A1 (en) 1999-10-22 2000-10-13 Formulation of substituted benzimidazoles

Publications (2)

Publication Number Publication Date
HUP0203121A2 true HUP0203121A2 (hu) 2003-01-28
HUP0203121A3 HUP0203121A3 (en) 2004-01-28

Family

ID=20417464

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203121A HUP0203121A3 (en) 1999-10-22 2000-10-13 Pharmaceutical composition containing substituted benzimidazoles and its use

Country Status (36)

Country Link
US (1) US6730685B1 (hu)
EP (1) EP1274427B1 (hu)
JP (1) JP2003512327A (hu)
KR (1) KR100785603B1 (hu)
CN (1) CN1213751C (hu)
AR (1) AR029005A1 (hu)
AT (1) ATE304851T1 (hu)
AU (1) AU782866B2 (hu)
BG (1) BG65580B1 (hu)
BR (1) BR0014895A (hu)
CA (1) CA2425199C (hu)
CO (1) CO5261533A1 (hu)
CY (1) CY1106055T1 (hu)
CZ (1) CZ20021375A3 (hu)
DE (1) DE60022789T2 (hu)
DK (1) DK1274427T3 (hu)
EE (1) EE05175B1 (hu)
ES (1) ES2246903T3 (hu)
HK (1) HK1051142A1 (hu)
HU (1) HUP0203121A3 (hu)
IL (2) IL149107A0 (hu)
IS (1) IS2196B (hu)
MX (1) MXPA02003900A (hu)
MY (1) MY131971A (hu)
NO (1) NO329545B1 (hu)
NZ (1) NZ518155A (hu)
PL (1) PL199868B1 (hu)
RU (1) RU2286782C2 (hu)
SE (1) SE9903831D0 (hu)
SI (1) SI1274427T1 (hu)
SK (1) SK286266B6 (hu)
TR (1) TR200201103T2 (hu)
TW (1) TWI236372B (hu)
UA (1) UA74347C2 (hu)
WO (1) WO2001028558A1 (hu)
ZA (1) ZA200202905B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1306375B1 (en) * 2000-08-04 2006-10-11 Takeda Pharmaceutical Company Limited Salts of benzimidazole compound and application thereof
CA2419067C (en) * 2000-08-18 2008-12-23 Takeda Chemical Industries, Ltd. Injectable composition comprising benzimidazole compound and strong alkali
MY137726A (en) * 2000-11-22 2009-03-31 Nycomed Gmbh Freeze-dried pantoprazole preparation and pantoprazole injection
GB2376231A (en) * 2001-06-06 2002-12-11 Cipla Ltd Benzimidazole-cyclodextrin inclusion complex
FR2845917B1 (fr) * 2002-10-21 2006-07-07 Negma Gild Composition pharmaceutique associant le tenatoprazole et un anti-inflammatoire
FR2845916B1 (fr) * 2002-10-21 2006-07-07 Negma Gild Composition pharmaceutique associant le tenatoprazole et un antagoniste des recepteurs h2 a l'histamine
FR2845915B1 (fr) * 2002-10-21 2006-06-23 Negma Gild Utilisation du tenatoprazole pour le traitement du reflux gastro-oesophagien
FR2848555B1 (fr) * 2002-12-16 2006-07-28 Negma Gild Enantiomere(-)du tenatoprazole et son application en therapeutique
CN100558726C (zh) * 2003-02-24 2009-11-11 田边三菱制药株式会社 泰妥拉唑的对映体及其在治疗中的应用
TWI372066B (en) * 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
US20060089376A1 (en) * 2004-10-27 2006-04-27 Joshi Ramesh A Tenatoprazole salts and process of preparation thereof
CA2649946A1 (en) * 2006-05-09 2007-11-15 Astrazeneca Ab New sterilized parenteral formulation
CN100411613C (zh) * 2006-12-08 2008-08-20 中国药科大学 一种奥美拉唑速释固体制剂及其制备方法
CN107109464B (zh) 2014-11-13 2021-03-30 3M创新有限公司 用于检测样品中细菌atp的包含atp-二磷酸水解酶的试剂盒
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
SE8301182D0 (sv) * 1983-03-04 1983-03-04 Haessle Ab Novel compounds
IL75400A (en) 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU4640985A (en) 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
JP2536173B2 (ja) * 1988-08-18 1996-09-18 武田薬品工業株式会社 注射剤
DK399389A (da) 1988-08-18 1990-02-19 Takeda Chemical Industries Ltd Injicerbare oploesninger
KR930000861B1 (ko) 1990-02-27 1993-02-08 한미약품공업 주식회사 오메프라졸 직장투여 조성물
NZ254237A (en) 1992-07-28 1995-12-21 Astra Ab Injectable solution of a 2-[(2-pyridyl)methylsulphinyl]-benzimidazole or a salt thereof; an injection kit
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
TW359614B (en) 1993-08-31 1999-06-01 Takeda Chemical Industries Ltd Composition containing benzimidazole compounds for rectal administration
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US5877205A (en) 1996-06-28 1999-03-02 Board Of Regents, The University Of Texas System Parenteral paclitaxel in a stable non-toxic formulation
SE510643C2 (sv) 1997-06-27 1999-06-14 Astra Ab Termodynamiskt stabil omeprazol natrium form B
CA2318128C (en) * 1998-01-20 2008-10-14 Applied Analytical Industries, Inc. Oral liquid compositions

Also Published As

Publication number Publication date
US6730685B1 (en) 2004-05-04
KR100785603B1 (ko) 2007-12-14
NZ518155A (en) 2004-07-30
KR20020059637A (ko) 2002-07-13
SI1274427T1 (sl) 2006-02-28
DK1274427T3 (da) 2005-12-27
NO20021860L (no) 2002-05-21
BG65580B1 (bg) 2009-01-30
CZ20021375A3 (cs) 2002-09-11
AU782866B2 (en) 2005-09-01
SE9903831D0 (sv) 1999-10-22
NO20021860D0 (no) 2002-04-19
HK1051142A1 (en) 2003-07-25
SK286266B6 (sk) 2008-06-06
IS6347A (is) 2002-04-17
TR200201103T2 (tr) 2002-08-21
ZA200202905B (en) 2003-07-14
AR029005A1 (es) 2003-06-04
CO5261533A1 (es) 2003-03-31
MY131971A (en) 2007-09-28
EE200200204A (et) 2003-04-15
EP1274427B1 (en) 2005-09-21
DE60022789D1 (de) 2006-02-02
DE60022789T2 (de) 2006-06-22
RU2286782C2 (ru) 2006-11-10
WO2001028558A1 (en) 2001-04-26
AU1182301A (en) 2001-04-30
HUP0203121A3 (en) 2004-01-28
SK5392002A3 (en) 2002-10-08
CA2425199A1 (en) 2001-04-26
BG106602A (en) 2002-12-29
CA2425199C (en) 2010-12-07
BR0014895A (pt) 2002-06-18
NO329545B1 (no) 2010-11-08
MXPA02003900A (es) 2002-09-30
ATE304851T1 (de) 2005-10-15
JP2003512327A (ja) 2003-04-02
CY1106055T1 (el) 2011-04-06
IL149107A (en) 2008-04-13
CN1213751C (zh) 2005-08-10
PL199868B1 (pl) 2008-11-28
TWI236372B (en) 2005-07-21
IL149107A0 (en) 2002-11-10
UA74347C2 (uk) 2005-12-15
PL354926A1 (en) 2004-03-22
IS2196B (is) 2007-01-15
EE05175B1 (et) 2009-06-15
CN1382048A (zh) 2002-11-27
ES2246903T3 (es) 2006-03-01
EP1274427A1 (en) 2003-01-15

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees