JP2005514418A - カルボキサミジン誘導体及び血管疾患の治療におけるそれらの使用 - Google Patents
カルボキサミジン誘導体及び血管疾患の治療におけるそれらの使用 Download PDFInfo
- Publication number
- JP2005514418A JP2005514418A JP2003557981A JP2003557981A JP2005514418A JP 2005514418 A JP2005514418 A JP 2005514418A JP 2003557981 A JP2003557981 A JP 2003557981A JP 2003557981 A JP2003557981 A JP 2003557981A JP 2005514418 A JP2005514418 A JP 2005514418A
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- hydroxy
- group
- heterocycle
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0200109A HUP0200109D0 (en) | 2002-01-11 | 2002-01-11 | Compounds having pharmaceutical activity |
| HU0204362A HUP0204362D0 (en) | 2002-12-17 | 2002-12-17 | Compounds having pharmaceutical activity |
| PCT/HU2003/000003 WO2003057664A1 (en) | 2002-01-11 | 2003-01-10 | Carboxamidine derivatives and their use in the treatment of vascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005514418A true JP2005514418A (ja) | 2005-05-19 |
| JP2005514418A5 JP2005514418A5 (https=) | 2006-03-02 |
Family
ID=90001534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003557981A Pending JP2005514418A (ja) | 2002-01-11 | 2003-01-10 | カルボキサミジン誘導体及び血管疾患の治療におけるそれらの使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US7384936B2 (https=) |
| EP (1) | EP1492763A1 (https=) |
| JP (1) | JP2005514418A (https=) |
| KR (1) | KR20040089102A (https=) |
| CN (1) | CN1615296A (https=) |
| AU (1) | AU2003202104B8 (https=) |
| BR (1) | BR0306778A (https=) |
| CA (1) | CA2471752A1 (https=) |
| HR (1) | HRP20040558A2 (https=) |
| IL (1) | IL162941A0 (https=) |
| MX (1) | MXPA04006716A (https=) |
| NO (1) | NO20043029L (https=) |
| NZ (1) | NZ533795A (https=) |
| PL (1) | PL371251A1 (https=) |
| RS (1) | RS60604A (https=) |
| RU (1) | RU2320330C2 (https=) |
| WO (1) | WO2003057664A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005514418A (ja) * | 2002-01-11 | 2005-05-19 | ビオレックス クタトー エス フェイレストェー アールテー． | カルボキサミジン誘導体及び血管疾患の治療におけるそれらの使用 |
| US8540985B2 (en) | 2008-06-26 | 2013-09-24 | Orphazyme Aps | Use of Hsp70 as a regulator of enzymatic activity |
| RU2013125923A (ru) | 2010-11-30 | 2015-01-10 | Орфазиме Апс | СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70 |
| DK2892540T3 (en) * | 2012-09-06 | 2018-11-19 | Mcpharma Biotech Inc | TREATMENT OF DIARRES AND DRAWN DIARRES WITH RESISTANT POTATO STARCH |
| US10709700B2 (en) | 2014-09-15 | 2020-07-14 | Orphazyme A/S | Arimoclomol formulation |
| AU2017240042B2 (en) | 2016-04-01 | 2019-09-19 | 3M Innovative Properties Company | Hearing protection device and method of forming same |
| EP3442530A1 (en) | 2016-04-13 | 2019-02-20 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| KR20210059796A (ko) | 2016-04-29 | 2021-05-25 | 오르파짐 에이/에스 | 글루코세레브로시다제 연관 장애를 치료하기 위한 아리모클로몰 |
| KR20230128462A (ko) | 2020-11-19 | 2023-09-05 | 제브라 덴마크 에이/에스 | 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177578B (en) | 1976-08-27 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives |
| DE2651083A1 (de) * | 1976-11-09 | 1978-05-18 | Hoechst Ag | Neue o-alkylierte hydroxylamine, verfahren zu ihrer herstellung und ihre verwendung |
| IT1110460B (it) * | 1977-03-02 | 1985-12-23 | Ciba Geigy Ag | Prodotti che favoriscono la crescita delle piante e prodotti che proteggono le piante a base di eteri di ossime e di esteri di ossime loro preparazione e loro impiego |
| US4187220A (en) * | 1977-08-30 | 1980-02-05 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| EP0369944A1 (de) | 1988-11-18 | 1990-05-23 | Ciba-Geigy Ag | Substituierte Oxadiaminobutane |
| HUT54347A (en) * | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
| GB9017351D0 (en) | 1990-08-08 | 1990-09-19 | Wellcome Found | Medicaments for treatment of atherosclerosis |
| EP0495750A3 (en) | 1991-01-14 | 1992-09-16 | Ciba-Geigy Ag | Heterocyclic hydroxylamine |
| US5334600A (en) * | 1991-07-30 | 1994-08-02 | Ciba-Geigy Corporation | Isoquinolyl substituted hydroxylamine derivatives |
| US5780498A (en) * | 1993-11-01 | 1998-07-14 | Ciba-Geigy Japan Limited | Endothelin receptor antagonists |
| US5919796A (en) * | 1994-05-06 | 1999-07-06 | Biorex Kutato Es Fejleszto Rt. | Hydroximic acid derivatives, pharmaceutical compositions containing them, and processes for preparing the same |
| HU218480B (hu) | 1995-06-15 | 2000-09-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények |
| HU9502843D0 (en) | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells | |
| HU220971B1 (hu) | 1997-04-03 | 2002-07-29 | BIOREX Kutató és Fejlesztő Rt. | Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására |
| HUP9702365A3 (en) * | 1997-04-22 | 1999-09-28 | Biorex Kutato Fejlesztoe Kft | Application of hydroxilamin-derivatives, as well as process and composition for increase of weather extreme resistent by cultivated plants |
| HU226617B1 (en) | 1998-12-14 | 2009-04-28 | Cytrx Corp | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
| HUP9900475D0 (en) | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| HUP0001583A2 (hu) * | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
| JP2005514418A (ja) * | 2002-01-11 | 2005-05-19 | ビオレックス クタトー エス フェイレストェー アールテー． | カルボキサミジン誘導体及び血管疾患の治療におけるそれらの使用 |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
-
2003
- 2003-01-10 JP JP2003557981A patent/JP2005514418A/ja active Pending
- 2003-01-10 AU AU2003202104A patent/AU2003202104B8/en not_active Ceased
- 2003-01-10 RS YU60604A patent/RS60604A/sr unknown
- 2003-01-10 RU RU2004124378/15A patent/RU2320330C2/ru not_active IP Right Cessation
- 2003-01-10 NZ NZ533795A patent/NZ533795A/xx not_active IP Right Cessation
- 2003-01-10 US US10/501,029 patent/US7384936B2/en not_active Expired - Fee Related
- 2003-01-10 CN CNA03802151XA patent/CN1615296A/zh active Pending
- 2003-01-10 PL PL03371251A patent/PL371251A1/xx unknown
- 2003-01-10 BR BR0306778-5A patent/BR0306778A/pt not_active IP Right Cessation
- 2003-01-10 MX MXPA04006716A patent/MXPA04006716A/es active IP Right Grant
- 2003-01-10 WO PCT/HU2003/000003 patent/WO2003057664A1/en not_active Ceased
- 2003-01-10 IL IL16294103A patent/IL162941A0/xx unknown
- 2003-01-10 KR KR10-2004-7010650A patent/KR20040089102A/ko not_active Ceased
- 2003-01-10 CA CA002471752A patent/CA2471752A1/en not_active Abandoned
- 2003-01-10 EP EP03700962A patent/EP1492763A1/en not_active Withdrawn
- 2003-01-10 HR HR20040558A patent/HRP20040558A2/hr not_active Application Discontinuation
-
2004
- 2004-07-12 US US10/889,966 patent/US7361655B2/en not_active Expired - Fee Related
- 2004-07-13 NO NO20043029A patent/NO20043029L/no not_active Application Discontinuation
-
2007
- 2007-10-30 US US11/981,422 patent/US7550457B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/981,376 patent/US7691849B2/en not_active Expired - Fee Related
-
2009
- 2009-06-18 US US12/487,151 patent/US20090253690A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003202104A1 (en) | 2003-07-24 |
| IL162941A0 (en) | 2005-11-20 |
| RU2004124378A (ru) | 2005-04-20 |
| US7550457B2 (en) | 2009-06-23 |
| CN1615296A (zh) | 2005-05-11 |
| US20080058323A1 (en) | 2008-03-06 |
| PL371251A1 (en) | 2005-06-13 |
| NZ533795A (en) | 2006-03-31 |
| KR20040089102A (ko) | 2004-10-20 |
| US20050043295A1 (en) | 2005-02-24 |
| US7361655B2 (en) | 2008-04-22 |
| AU2003202104B8 (en) | 2008-10-02 |
| EP1492763A1 (en) | 2005-01-05 |
| MXPA04006716A (es) | 2004-11-10 |
| NO20043029L (no) | 2004-10-11 |
| RU2320330C2 (ru) | 2008-03-27 |
| RS60604A (sr) | 2006-12-15 |
| US20090075993A1 (en) | 2009-03-19 |
| CA2471752A1 (en) | 2003-07-17 |
| BR0306778A (pt) | 2004-12-28 |
| US20090253690A1 (en) | 2009-10-08 |
| US7384936B2 (en) | 2008-06-10 |
| WO2003057664A1 (en) | 2003-07-17 |
| US20060058294A1 (en) | 2006-03-16 |
| HRP20040558A2 (en) | 2004-10-31 |
| US7691849B2 (en) | 2010-04-06 |
| AU2003202104B2 (en) | 2008-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7691849B2 (en) | Carboxamidine derivatives and their use in the treatment of vascular diseases | |
| US3900481A (en) | Derivatives of pyrrolidine and piperidine | |
| US6737425B1 (en) | N,N-substituted cyclic amine derivatives | |
| CA2787248C (en) | Piperazine compound having a pgds inhibitory effect | |
| JPH0317046A (ja) | アリールオキシフエニルプロピルアミン、その製造方法及びその使用方法 | |
| WO1992000962A1 (en) | Diphenylmethylpiperazine derivative | |
| EP0254623B1 (fr) | Nouveaux dérivés amino alkyl thio de triazolopyridine ou triazoloquinoline, leurs procédés de préparation, médicaments les contenant, utiles notamment comme antalgiques | |
| BRPI0110184B1 (pt) | derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes | |
| US4727072A (en) | 3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents | |
| TWI236469B (en) | Diamine compound with condensed-ring groups | |
| BG63305B1 (bg) | Фармацевтични пиперазинови производни | |
| JP3158638B2 (ja) | 新規アミノフェノール誘導体及びその医薬用途 | |
| US5684004A (en) | Triaryl-ethylene derivatives | |
| JPS62212386A (ja) | ２−ピリジルメチルベンズイミダゾ−ル誘導体 | |
| US3954776A (en) | 1-[Methylated piperidino(and pyrrolidin-1-yl)]-3-(substituted phenoxy)-2propanols | |
| ZA200404996B (en) | Carboxamidine derivatives and their use in the treatment of vascular diseases | |
| TW403745B (en) | Novel substituted -amidinobenzene derivative and pharmaceutical compositions thereof | |
| HUP0402526A2 (hu) | Vaszkuláris betegségek gyógyítására használható hidroxilaminszármazékok, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| JPS62108863A (ja) | ２−ピリジル酢酸誘導体、その製法およびそれを含む医薬 | |
| UA77731C2 (en) | Carboxaniidine derivatives and use thereof in the treatment of vascular diseases | |
| RU2045521C1 (ru) | Производные 1,2,4-триазолилтиоамидов | |
| JPH03106873A (ja) | １―ピリジルフタラジン誘導体及びそれらを含有する血小板凝集抑制剤 | |
| JPH0253780A (ja) | Δ↑２‐１，２，４‐トリアゾリン‐５‐オン誘導体、その製造法およびそれを有効成分とする抗潰瘍剤 | |
| JPH02202857A (ja) | アミノアルコキシベンゼン誘導体 | |
| JPH05504778A (ja) | 新規３（２ｈ）―ピリダジノン、それを含む医薬組成物及びその調製方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060110 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060110 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20080627 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20090701 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090728 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20100105 |