JP2005514381A5 - - Google Patents
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- Publication number
- JP2005514381A5 JP2005514381A5 JP2003548836A JP2003548836A JP2005514381A5 JP 2005514381 A5 JP2005514381 A5 JP 2005514381A5 JP 2003548836 A JP2003548836 A JP 2003548836A JP 2003548836 A JP2003548836 A JP 2003548836A JP 2005514381 A5 JP2005514381 A5 JP 2005514381A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- ethyl ester
- ethyl acetate
- acid ethyl
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0128996.6A GB0128996D0 (en) | 2001-12-04 | 2001-12-04 | Organic compounds |
| PCT/EP2002/013670 WO2003047581A1 (en) | 2001-12-04 | 2002-12-03 | Acetylene derivatives having mglur 5 antagonistic activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008179005A Division JP5036648B2 (ja) | 2001-12-04 | 2008-07-09 | Ｍｇｌｕｒ５アンタゴニスト活性を有するアセチレン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514381A JP2005514381A (ja) | 2005-05-19 |
| JP2005514381A5 true JP2005514381A5 (https=) | 2006-01-05 |
| JP4176020B2 JP4176020B2 (ja) | 2008-11-05 |
Family
ID=9926969
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003548836A Expired - Lifetime JP4176020B2 (ja) | 2001-12-04 | 2002-12-03 | Ｍｇｌｕｒ５アンタゴニスト活性を有するアセチレン誘導体 |
| JP2008179005A Expired - Lifetime JP5036648B2 (ja) | 2001-12-04 | 2008-07-09 | Ｍｇｌｕｒ５アンタゴニスト活性を有するアセチレン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008179005A Expired - Lifetime JP5036648B2 (ja) | 2001-12-04 | 2008-07-09 | Ｍｇｌｕｒ５アンタゴニスト活性を有するアセチレン誘導体 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US7348353B2 (https=) |
| EP (1) | EP1453512B8 (https=) |
| JP (2) | JP4176020B2 (https=) |
| KR (2) | KR100959204B1 (https=) |
| CN (2) | CN100430059C (https=) |
| AR (2) | AR037682A1 (https=) |
| AT (1) | ATE327755T1 (https=) |
| AU (1) | AU2002358585B2 (https=) |
| BR (1) | BR0214666A (https=) |
| CA (1) | CA2466560C (https=) |
| CO (1) | CO5590929A2 (https=) |
| CY (1) | CY1105460T1 (https=) |
| DE (1) | DE60211944T2 (https=) |
| DK (1) | DK1453512T3 (https=) |
| EC (1) | ECSP045139A (https=) |
| EG (1) | EG24936A (https=) |
| ES (1) | ES2263842T3 (https=) |
| GB (1) | GB0128996D0 (https=) |
| HU (1) | HU229429B1 (https=) |
| IL (1) | IL161990A0 (https=) |
| MX (1) | MXPA04005456A (https=) |
| MY (1) | MY137774A (https=) |
| NO (1) | NO327005B1 (https=) |
| NZ (1) | NZ533266A (https=) |
| PE (1) | PE20030640A1 (https=) |
| PL (1) | PL212996B1 (https=) |
| PT (1) | PT1453512E (https=) |
| RU (1) | RU2341515C2 (https=) |
| TW (1) | TWI328578B (https=) |
| WO (1) | WO2003047581A1 (https=) |
| ZA (1) | ZA200403713B (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0128996D0 (en) | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| GB0325956D0 (en) * | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| GB0503646D0 (en) * | 2005-02-22 | 2005-03-30 | Novartis Ag | Organic compounds |
| GB0508318D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| GB0508314D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| GB0508319D0 (en) * | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
| GB0514296D0 (en) * | 2005-07-12 | 2005-08-17 | Novartis Ag | Organic compounds |
| EP2272509A1 (en) * | 2006-09-11 | 2011-01-12 | Novartis AG | New Uses of metabotropic glutamate receptors |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2527360B1 (en) | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| KR101572280B1 (ko) * | 2007-10-12 | 2015-11-26 | 노파르티스 아게 | 파킨슨병의 치료를 위한 대사성 글루타메이트 수용체 조절제 |
| AU2012254934B2 (en) * | 2007-10-12 | 2013-10-17 | Novartis Ag | Metabotropic glutamate receptor modulators for the treatment of Parkinson's disease |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2320892A2 (en) * | 2008-06-30 | 2011-05-18 | Novartis AG | Combination products |
| RU2513856C2 (ru) * | 2008-08-12 | 2014-04-20 | Новартис Аг | Способы получения метилового эфира 4-оксооктагидроиндол-1-карбоновой кислоты и ее производные |
| US8334287B2 (en) | 2009-07-17 | 2012-12-18 | Hoffmann-La Roche Inc. | Imidazoles |
| CN102573842A (zh) | 2009-07-23 | 2012-07-11 | 诺瓦提斯公司 | 氮杂双环烷基衍生物或吡咯烷-2-酮衍生物的用途 |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| WO2011048150A1 (en) | 2009-10-20 | 2011-04-28 | Novartis Ag | Use of 1h-quinazoline-2,4-diones |
| US20130052644A1 (en) | 2010-04-30 | 2013-02-28 | Baltazar Gomez-Mancilla | Predictive Markers Useful in the Treatment of Fragile X Syndrome (FXS) |
| JP2013529622A (ja) | 2010-06-24 | 2013-07-22 | ノバルティス アーゲー | １ｈ−キナゾリン−２，４−ジオンの使用 |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| WO2012084873A1 (en) | 2010-12-20 | 2012-06-28 | Novartis Ag | 4- (hetero) aryl - ethynyl - octahydro - indole - 1 - carboxylic acid esters |
| WO2012101058A1 (en) | 2011-01-24 | 2012-08-02 | Novartis Ag | 4-tolyl-ethynyl-octahydro-indole-1-ester derivatives |
| KR20140003580A (ko) | 2011-01-27 | 2014-01-09 | 노파르티스 아게 | 니코틴성 아세틸콜린 수용체 알파 7 활성화제의 용도 |
| WO2012127393A1 (en) | 2011-03-18 | 2012-09-27 | Novartis Ag | COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE |
| CN103889427A (zh) | 2011-09-07 | 2014-06-25 | 诺华股份有限公司 | 1h-喹唑啉-2,4-二酮用于预防或治疗光敏性癫痫的应用 |
| WO2013131981A1 (en) | 2012-03-08 | 2013-09-12 | Novartis Ag | Predictive markers useful in the diagnosis and treatment of fragile x syndrome (fxs) |
| GB201215033D0 (en) | 2012-08-23 | 2012-10-10 | Novartis Ag | Diazepinone derivatives |
| CN105263492B (zh) | 2013-01-15 | 2018-04-10 | 诺华有限公司 | α7烟碱型乙酰胆碱受体激动剂在治疗发作性睡病中的应用 |
| BR112015016992A8 (pt) | 2013-01-15 | 2018-01-23 | Novartis Ag | uso de agonistas do receptor alfa 7 nicotínico de acetilcolina |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| SI3004138T1 (sl) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Limited | Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo |
| KR102290249B1 (ko) | 2013-06-12 | 2021-08-17 | 노파르티스 아게 | 변형 방출 제제 |
| GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
| CN105669686B (zh) * | 2014-11-19 | 2018-08-03 | 上海合全药业股份有限公司 | 一种6-(叔丁氧羰基)八氢呋喃[2,3-c]吡啶-4-羧酸的合成方法 |
| CA3067688A1 (en) | 2017-07-31 | 2019-02-07 | Novartis Ag | Use of mavoglurant in the reduction of alcohol use or in preventing relapse into alcohol use |
| CA3066711A1 (en) | 2017-07-31 | 2019-02-07 | Novartis Ag | Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use |
| CA3124931A1 (en) | 2019-01-29 | 2020-08-06 | Novartis Ag | The use of an mglur5 antagonist for treating opioid analgesic tolerance |
| BR112022005579A2 (pt) * | 2019-11-05 | 2022-06-21 | Claes Thulin | 4-[5-[(rac)-1-[5-(3-clorofenil)-3-isoxazolil]etoxi]-4-metil-4h-1,2,4-triazol-3-il]piridina para uso na prevenção e/ou no tratamento de surmenage em um mamífero |
| MX2023000664A (es) * | 2020-07-17 | 2023-02-27 | Novartis Ag | Uso de antagonistas de mglur5. |
| IL303248A (en) | 2020-12-11 | 2023-07-01 | Novartis Ag | Use of mglur5 antagonists for treating amphetamine addiction |
| AU2021404023A1 (en) | 2020-12-14 | 2023-06-29 | Novartis Ag | Use of mglur5 antagonists for treating gambling disorder |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2741009A1 (de) * | 1976-09-22 | 1978-03-23 | Sandoz Ag | 4-styryl-4-indolinol-derivate, ihre verwendung und herstellung |
| DE2802833A1 (de) | 1978-01-23 | 1979-07-26 | Sandoz Ag | 4-styryl-4-indolinol-derivate, ihre verwendung und herstellung |
| US5264456A (en) | 1989-12-29 | 1993-11-23 | Allergan, Inc. | Acetylenes disubstituted with a furyl group and a substituted phenyl group having retinoid like activity |
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5593994A (en) | 1994-09-29 | 1997-01-14 | The Dupont Merck Pharmaceutical Company | Prostaglandin synthase inhibitors |
| DE69634822T2 (de) | 1995-08-22 | 2006-04-27 | Japan Tobacco Inc. | Amid-verbindungen und ihre anwendung |
| CA2258728C (en) | 1996-06-19 | 2011-09-27 | Rhone Poulenc Rorer Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| DE69915472T2 (de) | 1998-06-04 | 2004-08-19 | Kumiai Chemical Industry Co., Ltd. | Phenylacetylenderivate und bakterizide für landwirtschaft und gartenbau |
| EP1117403B1 (en) | 1998-10-02 | 2003-12-10 | Novartis AG | Mglur5 antagonists for the treatment of pain and anxiety |
| EP1200073B1 (en) | 1999-07-06 | 2007-01-10 | Eli Lilly And Company | SELECTIVE iGluR 5? RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE |
| GB0007108D0 (en) | 2000-03-23 | 2000-05-17 | Novartis Ag | Organic compounds |
| MXPA03009130A (es) | 2000-10-20 | 2004-02-26 | Biocryst Pharm Inc | Compuestos de biarilo que funcionan como inhibidores de proteasa serina. |
| MXPA03004862A (es) * | 2000-12-04 | 2005-02-14 | Hoffmann La Roche | Derivados de feniletenilo o feniletinilo como antagonistas del receptor de glutamato. |
| GB0103045D0 (en) | 2001-02-07 | 2001-03-21 | Novartis Ag | Organic Compounds |
| US7138404B2 (en) | 2001-05-23 | 2006-11-21 | Hoffmann-La Roche Inc. | 4-aminopyrimidine derivatives |
| JP2005517640A (ja) | 2001-12-04 | 2005-06-16 | エフ．ホフマン−ラ ロシュ アーゲー | 置換２−アミノ−シクロアルカンカルボキサアミドならびにシステインプロテアーゼインヒビターとしてのその使用 |
| TW200303309A (en) | 2001-12-04 | 2003-09-01 | Bristol Myers Squibb Co | Novel n-[4-(1h-imidazol-1-yl)-2-fluorophenyl]-3-trifluoromethyl)-1h-pyrazole-5-carboxamides as factor Xa inhibitors |
| GB0128996D0 (en) * | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
-
2001
- 2001-12-04 GB GBGB0128996.6A patent/GB0128996D0/en not_active Ceased
-
2002
- 2002-12-01 EG EG2002121297A patent/EG24936A/xx active
- 2002-12-02 AR ARP020104641A patent/AR037682A1/es not_active Application Discontinuation
- 2002-12-02 TW TW091134933A patent/TWI328578B/zh not_active IP Right Cessation
- 2002-12-02 PE PE2002001157A patent/PE20030640A1/es not_active Application Discontinuation
- 2002-12-03 IL IL16199002A patent/IL161990A0/xx not_active IP Right Cessation
- 2002-12-03 AT AT02792867T patent/ATE327755T1/de active
- 2002-12-03 EP EP02792867A patent/EP1453512B8/en not_active Expired - Lifetime
- 2002-12-03 NZ NZ533266A patent/NZ533266A/en not_active IP Right Cessation
- 2002-12-03 KR KR1020047008477A patent/KR100959204B1/ko not_active Expired - Fee Related
- 2002-12-03 PL PL368739A patent/PL212996B1/pl unknown
- 2002-12-03 KR KR1020107002745A patent/KR100980901B1/ko not_active Expired - Fee Related
- 2002-12-03 HU HU0402191A patent/HU229429B1/hu unknown
- 2002-12-03 CN CNB028232968A patent/CN100430059C/zh not_active Expired - Lifetime
- 2002-12-03 JP JP2003548836A patent/JP4176020B2/ja not_active Expired - Lifetime
- 2002-12-03 DK DK02792867T patent/DK1453512T3/da active
- 2002-12-03 DE DE60211944T patent/DE60211944T2/de not_active Expired - Lifetime
- 2002-12-03 WO PCT/EP2002/013670 patent/WO2003047581A1/en not_active Ceased
- 2002-12-03 MX MXPA04005456A patent/MXPA04005456A/es active IP Right Grant
- 2002-12-03 ES ES02792867T patent/ES2263842T3/es not_active Expired - Lifetime
- 2002-12-03 CN CN200810166366.0A patent/CN101366714B/zh not_active Expired - Lifetime
- 2002-12-03 MY MYPI20024525A patent/MY137774A/en unknown
- 2002-12-03 US US10/497,363 patent/US7348353B2/en not_active Expired - Lifetime
- 2002-12-03 PT PT02792867T patent/PT1453512E/pt unknown
- 2002-12-03 AU AU2002358585A patent/AU2002358585B2/en not_active Ceased
- 2002-12-03 RU RU2004120781/04A patent/RU2341515C2/ru not_active IP Right Cessation
- 2002-12-03 CA CA2466560A patent/CA2466560C/en not_active Expired - Fee Related
- 2002-12-03 BR BR0214666-5A patent/BR0214666A/pt not_active Application Discontinuation
-
2004
- 2004-05-14 ZA ZA2004/03713A patent/ZA200403713B/en unknown
- 2004-06-04 EC EC2004005139A patent/ECSP045139A/es unknown
- 2004-06-07 CO CO04053105A patent/CO5590929A2/es active IP Right Grant
- 2004-06-25 NO NO20042673A patent/NO327005B1/no not_active IP Right Cessation
-
2006
- 2006-08-03 CY CY20061101091T patent/CY1105460T1/el unknown
-
2008
- 2008-02-29 US US12/040,081 patent/US20080146647A1/en not_active Abandoned
- 2008-07-09 JP JP2008179005A patent/JP5036648B2/ja not_active Expired - Lifetime
-
2011
- 2011-09-22 US US13/239,467 patent/US8536229B2/en not_active Expired - Lifetime
-
2012
- 2012-11-20 AR ARP120104356A patent/AR088921A2/es not_active Application Discontinuation
-
2013
- 2013-08-15 US US13/967,719 patent/US20130331568A1/en not_active Abandoned
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