JP2005514358A5 - - Google Patents
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- Publication number
- JP2005514358A5 JP2005514358A5 JP2003545309A JP2003545309A JP2005514358A5 JP 2005514358 A5 JP2005514358 A5 JP 2005514358A5 JP 2003545309 A JP2003545309 A JP 2003545309A JP 2003545309 A JP2003545309 A JP 2003545309A JP 2005514358 A5 JP2005514358 A5 JP 2005514358A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- radical
- gallate
- alkyl
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical group OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 12
- -1 alkynyl radical Chemical class 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 9
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims 8
- 125000002947 alkylene group Chemical group 0.000 claims 8
- 150000003254 radicals Chemical class 0.000 claims 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 claims 5
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims 5
- 201000010153 skin papilloma Diseases 0.000 claims 5
- XMOCLSLCDHWDHP-SWLSCSKDSA-N (+)-gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-SWLSCSKDSA-N 0.000 claims 4
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 208000000260 Warts Diseases 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 3
- WMBWREPUVVBILR-NQIIRXRSSA-N (-)-gallocatechin gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-NQIIRXRSSA-N 0.000 claims 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 2
- 206010059313 Anogenital warts Diseases 0.000 claims 2
- 201000006082 Chickenpox Diseases 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 208000007514 Herpes zoster Diseases 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 241001631646 Papillomaviridae Species 0.000 claims 2
- 206010046980 Varicella Diseases 0.000 claims 2
- 208000012544 Viral Skin disease Diseases 0.000 claims 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 2
- MMKRHZKQPFCLLS-UHFFFAOYSA-N ethyl myristate Chemical compound CCCCCCCCCCCCCC(=O)OCC MMKRHZKQPFCLLS-UHFFFAOYSA-N 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 2
- 241001529453 unidentified herpesvirus Species 0.000 claims 2
- RSVQBAQLVQBVQO-UHFFFAOYSA-N (2-hydroxyphenyl) 3,4,5-trihydroxybenzoate Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=CC=CC=2)O)=C1 RSVQBAQLVQBVQO-UHFFFAOYSA-N 0.000 claims 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- AMEMLELAMQEAIA-UHFFFAOYSA-N 6-(tert-butyl)thieno[3,2-d]pyrimidin-4(3H)-one Chemical compound N1C=NC(=O)C2=C1C=C(C(C)(C)C)S2 AMEMLELAMQEAIA-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 208000000907 Condylomata Acuminata Diseases 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 208000004898 Herpes Labialis Diseases 0.000 claims 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 1
- 241000701806 Human papillomavirus Species 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 239000005639 Lauric acid Substances 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 206010067152 Oral herpes Diseases 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 239000004264 Petrolatum Substances 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 206010039796 Seborrhoeic keratosis Diseases 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 1
- 208000025009 anogenital human papillomavirus infection Diseases 0.000 claims 1
- 201000004201 anogenital venereal wart Diseases 0.000 claims 1
- 229940114079 arachidonic acid Drugs 0.000 claims 1
- 235000021342 arachidonic acid Nutrition 0.000 claims 1
- DHAZIUXMHRHVMP-UHFFFAOYSA-N butyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCC DHAZIUXMHRHVMP-UHFFFAOYSA-N 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 239000002359 drug metabolite Substances 0.000 claims 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims 1
- 229940093471 ethyl oleate Drugs 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 208000037824 growth disorder Diseases 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 229940033357 isopropyl laurate Drugs 0.000 claims 1
- 229940074928 isopropyl myristate Drugs 0.000 claims 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims 1
- 229940075495 isopropyl palmitate Drugs 0.000 claims 1
- 229940089456 isopropyl stearate Drugs 0.000 claims 1
- 230000000366 juvenile effect Effects 0.000 claims 1
- 210000000867 larynx Anatomy 0.000 claims 1
- 229960004488 linolenic acid Drugs 0.000 claims 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 claims 1
- 210000002200 mouth mucosa Anatomy 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 229960002446 octanoic acid Drugs 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- 229940055577 oleyl alcohol Drugs 0.000 claims 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims 1
- 208000003154 papilloma Diseases 0.000 claims 1
- 150000002972 pentoses Chemical class 0.000 claims 1
- 235000019271 petrolatum Nutrition 0.000 claims 1
- 229940066842 petrolatum Drugs 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000223 polyglycerol Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 claims 1
- DPBVJRXPSXTHOL-UHFFFAOYSA-N propyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCC DPBVJRXPSXTHOL-UHFFFAOYSA-N 0.000 claims 1
- 229940093625 propylene glycol monostearate Drugs 0.000 claims 1
- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 235000010356 sorbitol Nutrition 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims 1
- 230000008719 thickening Effects 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33170501P | 2001-11-19 | 2001-11-19 | |
| DE10156794A DE10156794B4 (de) | 2001-11-19 | 2001-11-19 | Arzneimittel zur Behandlung von Warzen |
| PCT/EP2002/012919 WO2003043628A1 (de) | 2001-11-19 | 2002-11-18 | Arzneimittel zur behandlung von viralen haut- und tumorerkrankungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514358A JP2005514358A (ja) | 2005-05-19 |
| JP2005514358A5 true JP2005514358A5 (https=) | 2006-01-12 |
| JP4495459B2 JP4495459B2 (ja) | 2010-07-07 |
Family
ID=26010614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545309A Expired - Fee Related JP4495459B2 (ja) | 2001-11-19 | 2002-11-18 | ウイルス性皮膚疾患及び腫瘍疾患の治療用薬剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US7858662B2 (https=) |
| EP (2) | EP1448186B1 (https=) |
| JP (1) | JP4495459B2 (https=) |
| KR (1) | KR100956369B1 (https=) |
| CN (1) | CN1323660C (https=) |
| AT (1) | ATE417611T1 (https=) |
| BR (1) | BRPI0214256B8 (https=) |
| CA (1) | CA2466720C (https=) |
| CY (1) | CY1108882T1 (https=) |
| DE (2) | DE122009000073I1 (https=) |
| DK (1) | DK1448186T3 (https=) |
| ES (1) | ES2319626T3 (https=) |
| IL (2) | IL161625A0 (https=) |
| MX (1) | MXPA04004532A (https=) |
| PT (1) | PT1448186E (https=) |
| RU (1) | RU2302861C3 (https=) |
| WO (1) | WO2003043628A1 (https=) |
| ZA (1) | ZA200403287B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04004532A (es) | 2001-11-19 | 2004-08-11 | Medigene Ag | Medicamento para el tratamiento de enfermedades tumorales y virales de la piel. |
| ITMI20030210A1 (it) * | 2003-02-07 | 2004-08-08 | Res & Innovation Soc Coop A R L | Composti endocannabinoido-simili e loro impiego |
| US20050058673A1 (en) | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| US7910138B2 (en) | 2003-10-09 | 2011-03-22 | Medigene Ag | Use of a polyphenol for the treatment of a cancerous or precancerous lesion of the skin |
| US20050079235A1 (en) * | 2003-10-09 | 2005-04-14 | Eggert Stockfleth | Use of a polyphenol for the treatment of actinic keratosis |
| KR100665315B1 (ko) | 2004-03-25 | 2007-01-09 | 한국원자력연구소 | 신규한 갈릭산-콘쥬게이티드 리놀레산 지방 에스테르, 이의 제조방법 및 이를 함유하는 조성물 |
| BRPI0608691A2 (pt) | 2005-03-10 | 2010-12-07 | 3M Innovative Properties Company | composição antimicrobiana, e, métodos para matar ou inativar microorganismos em tecido da mucosa de um mamìfero, para tratar uma lesão ou ferimento infectado, para descolonização de microorganismos, para proporcionar eficácia antimicrobiana residual sobre uma superfìcie e para tratar uma condição |
| WO2006099325A2 (en) | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Methods of treating ear infections |
| BRPI0608690B8 (pt) | 2005-03-10 | 2021-05-25 | 3M Innovative Properties Co | uso de uma composição antimicrobiana |
| EP2179722A1 (en) * | 2008-10-24 | 2010-04-28 | Heinrich-Pette-Institut für experimentelle Virologie und Immunologie | Topical formation for preventing sexual transmission of viral infection |
| CN102949387B (zh) * | 2011-08-19 | 2017-03-01 | 奥古斯塔大学研究所公司 | 用于治疗单纯疱疹病毒的组合物和方法 |
| JP5796006B2 (ja) * | 2011-12-14 | 2015-10-21 | 有限会社 ワーコム農業研究所 | 抗菌剤 |
| RU2600033C2 (ru) * | 2014-10-16 | 2016-10-20 | Юрий Николаевич Родионов | Способ получения вещества для разрушения микроциркуляторного русла удаляемого кожного образования |
| JP2018512450A (ja) | 2015-03-19 | 2018-05-17 | ウェンディ アン エプスタインＥＰＳＴＥＩＮ， Ｗｅｎｄｙ Ａｎｎｅ | 女性の性的障害を治療するための化合物及び剤型 |
| CN107349197A (zh) * | 2017-07-13 | 2017-11-17 | 黄冈师范学院 | 一种儿茶素在制备治疗皮肤乳头状瘤的药物上的应用 |
| KR102906039B1 (ko) | 2022-04-19 | 2025-12-29 | 고려대학교 산학협력단 | 카테콜 화합물 또는 이의 유도체 화합물을 유효성분으로 포함하는 엡스타인-바 바이러스에 대한 항바이러스용 조성물 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4002775A (en) * | 1973-07-09 | 1977-01-11 | Kabara Jon J | Fatty acids and derivatives of antimicrobial agents |
| JPS55105677A (en) | 1979-02-07 | 1980-08-13 | Norin Suisansyo Chiyagiyou Shikenjo | Production of catechins |
| EP0087161A3 (en) * | 1982-02-24 | 1984-04-04 | Key Pharmaceuticals, Inc. | Isopropylmyristate 4-alkyl-2,6-(bis-tert-butyl)-phenol medicament |
| JPS59219384A (ja) | 1983-05-30 | 1984-12-10 | Mitsui Norin Kk | 天然抗酸化剤の製造方法 |
| JPS6013780A (ja) | 1983-07-05 | 1985-01-24 | Mitsui Norin Kk | 茶カテキン類の製造方法 |
| JPS61238728A (ja) | 1985-04-16 | 1986-10-24 | Mitsui Norin Kk | 茶葉抽出物と活性水酸化アルミニウムとの抗潰瘍性複合体 |
| SE462894B (sv) | 1985-10-28 | 1990-09-17 | Biogram Ab | Mikrokapslar, foerfarande foer framstaellning daerav samt anvaendning |
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-
2002
- 2002-11-18 MX MXPA04004532A patent/MXPA04004532A/es active IP Right Grant
- 2002-11-18 CA CA2466720A patent/CA2466720C/en not_active Expired - Lifetime
- 2002-11-18 EP EP02803380A patent/EP1448186B1/de not_active Expired - Lifetime
- 2002-11-18 US US10/495,889 patent/US7858662B2/en active Active - Reinstated
- 2002-11-18 KR KR1020047006612A patent/KR100956369B1/ko not_active Expired - Fee Related
- 2002-11-18 CN CNB028227506A patent/CN1323660C/zh not_active Expired - Lifetime
- 2002-11-18 ES ES02803380T patent/ES2319626T3/es not_active Expired - Lifetime
- 2002-11-18 BR BRPI0214256A patent/BRPI0214256B8/pt not_active IP Right Cessation
- 2002-11-18 DE DE122009000073C patent/DE122009000073I1/de active Pending
- 2002-11-18 WO PCT/EP2002/012919 patent/WO2003043628A1/de not_active Ceased
- 2002-11-18 EP EP08021728.4A patent/EP2055300B1/de not_active Expired - Lifetime
- 2002-11-18 DK DK02803380T patent/DK1448186T3/da active
- 2002-11-18 DE DE50213137T patent/DE50213137D1/de not_active Expired - Lifetime
- 2002-11-18 PT PT02803380T patent/PT1448186E/pt unknown
- 2002-11-18 JP JP2003545309A patent/JP4495459B2/ja not_active Expired - Fee Related
- 2002-11-18 RU RU2004118667A patent/RU2302861C3/ru active Protection Beyond IP Right Term
- 2002-11-18 IL IL16162502A patent/IL161625A0/xx unknown
- 2002-11-18 AT AT02803380T patent/ATE417611T1/de active
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2004
- 2004-04-26 IL IL161625A patent/IL161625A/en active Protection Beyond IP Right Term
- 2004-04-30 ZA ZA2004/03287A patent/ZA200403287B/en unknown
-
2009
- 2009-03-17 CY CY20091100293T patent/CY1108882T1/el unknown
-
2010
- 2010-09-21 US US12/887,250 patent/US9770406B2/en not_active Expired - Lifetime
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2017
- 2017-08-18 US US15/680,819 patent/US10434059B2/en not_active Expired - Fee Related
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2019
- 2019-08-19 US US16/543,763 patent/US20200054552A1/en not_active Abandoned
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